BCR-ABL1 is a secondary event after JAK2V617F in a patient with essential thrombocythemia who develop chronic myeloid leukemia.

IF 1.5 Q3 HEMATOLOGY
Yanqing Zhang, Hailiang Bi, Ying Wang, Long Chen, Jiaqi Pan, Ping Xu, Wei Wang, Shaobin Yang
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Abstract

Several cases such as myeloproliferative neoplasms (MPN) with the coexistence of JAK2 and BCR-ABL have been reported. However, cases of transformation of essential thrombocythemia (ET) into chronic myeloid leukemia (CML) during the disease progression were rarely reported. Here, we report the case of a patient with JAK2 V617F- positive ET who subsequently acquired BCR-ABL1, which transformed the disease into CML after 10 years from the initial diagnosis. In this study, we dynamically monitored JAK2 V617F and BCR-ABL and observed multiple gene mutations, including IDH2, IDH1, ASXL1, KRAS, and RUNX1. It is important to be aware of this potentially clone evolution in disease progression.

Abstract Image

BCR-ABL1是JAK2V617F后原发性血小板增多症并发慢性髓性白血病患者的次要事件。
一些病例如骨髓增生性肿瘤(MPN)与JAK2和BCR-ABL共存已被报道。然而,在疾病进展过程中,原发性血小板增多症(ET)转化为慢性髓性白血病(CML)的病例很少报道。在这里,我们报告了JAK2 V617F-阳性ET患者随后获得BCR-ABL1的病例,该病例在最初诊断10年后将疾病转化为CML。在本研究中,我们对JAK2 V617F和BCR-ABL进行动态监测,观察到IDH2、IDH1、ASXL1、KRAS和RUNX1等多个基因突变。重要的是要意识到这种潜在的克隆进化在疾病进展中。
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CiteScore
1.70
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