diulfiram是一种醛脱氢酶抑制剂,作为一种有效的药物,通过NETosis, pyroptosis, apoptosis, ferroptosis和cuprotosis治疗败血症和癌症。

IF 1.5 Q3 HEMATOLOGY
Dingrui Nie, Cunte Chen, Yangqiu Li, Chengwu Zeng
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引用次数: 9

摘要

调节细胞死亡(RCD)对维持细胞稳态和预防疾病至关重要。除了经典的细胞凋亡外,还报道了几种新的非凋亡形式的RCD,包括NETosis, pyroptosis, ferroptosis和cuprotosis,并且越来越多地与各种癌症和炎症有关。双硫仑(DSF)是一种醛脱氢酶抑制剂,作为抗酒精药物在临床上已经使用了几十年。新的研究表明,DSF通过调节这些新型RCD具有有效的抗炎和抗癌作用。本文就其作用机制进行综述,并对其在肿瘤和炎性疾病治疗中的潜在应用进行探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis.

Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer via NETosis, pyroptosis, apoptosis, ferroptosis, and cuproptosis.

Regulated cell death (RCD) is essential for maintaining cell homeostasis and preventing diseases. Besides classical apoptosis, several novel nonapoptotic forms of RCD including NETosis, pyroptosis, ferroptosis, and cuproptosis have been reported and are increasingly being implicated in various cancers and inflammation. Disulfiram (DSF), an aldehyde dehydrogenase inhibitor, has been used clinically for decades as an anti-alcoholic drug. New studies have shown that DSF possesses potent anti-inflammatory and anti-cancer effects by regulating these new types of RCD. Here, we summarize the mechanisms and discuss the potential application of DSF in the treatment of cancers and inflammatory diseases.

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CiteScore
1.70
自引率
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