Biomaterials Science最新文献_第8页

Anisotropic conductive scaffolds for post-infarction cardiac repair 各向异性导电支架在梗死后心脏修复中的应用。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-11 DOI: 10.1039/D4BM01109K

Shimin Li, Wenming Yin, Yali Liu, Chang Yang, Zitong Zhai, Mingxiang Xie, Ziyi Ye and Xiaoping Song

{"title":"Anisotropic conductive scaffolds for post-infarction cardiac repair","authors":"Shimin Li, Wenming Yin, Yali Liu, Chang Yang, Zitong Zhai, Mingxiang Xie, Ziyi Ye and Xiaoping Song","doi":"10.1039/D4BM01109K","DOIUrl":"10.1039/D4BM01109K","url":null,"abstract":"Myocardial infarction (MI) remains one of the most common and lethal cardiovascular diseases (CVDs), leading to the deterioration of cardiac function due to myocardial cell necrosis and fibrous scar tissue formation. Myocardial infarction (MI) remains one of the most common and lethal cardiovascular diseases (CVDs), leading to the deterioration of cardiac function due to myocardial cell necrosis and fibrous scar tissue formation. After MI, the anisotropic structural properties of myocardial tissue are destroyed, and its mechanical and electrical microenvironment also undergoes a series of pathological changes, such as ventricular wall stiffness, abnormal contraction, conduction network disruption, and irregular electrical signal propagation, which may further induce myocardial remodeling and even lead to heart failure. Therefore, bionic reconstruction of the anisotropic structural–mechanical–electrical microenvironment of the infarct area is key to repairing damaged myocardium. This article first summarizes the pathological changes in muscle fibre structure and conductive microenvironment after cardiac injury, and focuses on the classification and preparation methods of anisotropic conductive materials. In addition, the effects of these anisotropic conductive materials on the behavior of cardiac resident cells after myocardial infarction, such as directional growth, maturation, proliferation and migration, and the differentiation fate of stem cells and the possible molecular mechanisms involved are summarized. The design strategies for anisotropic conductive scaffolds for myocardial repair in future clinical research are also discussed, with the aim of providing new insights for researchers in related fields.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 542-567"},"PeriodicalIF":5.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes† 阴离子聚合物涂层增强Cas9 mRNA和sgRNA纳米复合物的递送。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-11 DOI: 10.1039/D4BM01290A

Siyu Chen, Simone Pinto Carneiro and Olivia M. Merkel

{"title":"Anionic polymer coating for enhanced delivery of Cas9 mRNA and sgRNA nanoplexes†","authors":"Siyu Chen, Simone Pinto Carneiro and Olivia M. Merkel","doi":"10.1039/D4BM01290A","DOIUrl":"10.1039/D4BM01290A","url":null,"abstract":"Polymeric carriers have long been recognized as some of the most effective and promising systems for nucleic acid delivery. In this study, we utilized an anionic di-block co-polymer, PEG-PLE, to enhance the performance of lipid-modified PEI (C14-PEI) nanoplexes for delivering Cas9 mRNA and sgRNA targeting KRAS G12S mutations in lung cancer cells. Our results demonstrated that PEG-PLE, when combined with C14-PEI at a weight-to-weight ratio of 0.2, produced nanoplexes with a size of approximately 140 nm, a polydispersity index (PDI) of 0.08, and a zeta potential of around −1 mV. The PEG-PLE/C14-PEI nanoplexes at this ratio were observed to be both non-cytotoxic and effective in encapsulating Cas9 mRNA and sgRNA. Confocal microscopy imaging revealed efficient endosomal escape and intracellular distribution of the RNAs. Uptake pathway inhibition studies indicated that the internalization of PEG-PLE/C14-PEI primarily involves scavenger receptors and clathrin-mediated endocytosis. Compared to C14-PEI formulations, PEG-PLE/C14-PEI demonstrated a significant increase in luciferase mRNA expression and gene editing efficiency, as confirmed by T7EI and ddPCR, in A549 cells. Sanger sequencing identified insertions and/or deletions around the PAM sequence, with a total of 69% indels observed. Post-transfection, the KRAS-ERK pathway was downregulated, resulting in significant increases in cell apoptosis and inhibition of cell migration. Taken together, this study reveals a new and promising formulation for CRISPR delivery as potential lung cancer treatment.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 659-676"},"PeriodicalIF":5.8,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications and prospects of indirect 3D printing technology in bone tissue engineering 间接3D打印技术在骨组织工程中的应用与展望。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-09 DOI: 10.1039/D4BM01374C

Mingxin Qiao, Weimin Wu, Wen Tang, Yifan Zhao, Jian Wang, Xibo Pei, Bowen Zhang and Qianbing Wan

{"title":"Applications and prospects of indirect 3D printing technology in bone tissue engineering","authors":"Mingxin Qiao, Weimin Wu, Wen Tang, Yifan Zhao, Jian Wang, Xibo Pei, Bowen Zhang and Qianbing Wan","doi":"10.1039/D4BM01374C","DOIUrl":"10.1039/D4BM01374C","url":null,"abstract":"In bone tissue engineering, manufacturing bone tissue constructs that closely replicate physiological features for regenerative repair remains a significant challenge. In recent years, the advent of indirect 3D printing technology has overcome the stringent material demands, confined resolution, and structural control challenges inherent to direct 3D printing. By utilizing sacrificial templates, the natural structures and physiological functions of bone tissues can be precisely duplicated. It facilitates the fabrication of vascularized and biomimetic bone constructs that are similar to natural counterparts. Hence, indirect 3D printing technology is increasingly recognized as a promising option for bone regenerative therapies. Based on the aforementioned research hotspots, this review outlines the classification and techniques of indirect 3D printing, along with the associated printing materials and methodologies. More importantly, a detailed summary of the clinical application prospects of indirect 3D printing in the regeneration of bone, cartilage and osteochondral tissues is provided, along with exploring the current challenges and outlook of this technology.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 587-605"},"PeriodicalIF":5.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: A biotin-stabilized HKUST-1/ADM scaffold for facilitating MSC endothelial differentiation and vascularization in diabetic wound healing 更正：生物素稳定的HKUST-1/ADM支架促进糖尿病伤口愈合中的间质内皮分化和血管化。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-09 DOI: 10.1039/D4BM90094D

Qiong Zhang, Linghong Kong, Qi Wang, Hui Wang, Yongzhen Yang, Jinping Fu, Yue Zhang, Jianyue Dong, Changchun Zeng and Hanping Liu

引用次数: 0

Self-assembled eumelanin nanoparticles enhance IFN-I activation and cilia-driven intercellular communication to defend against Tulane virus, a human norovirus surrogate† 自组装的真黑素纳米颗粒增强IFN-I激活和纤毛驱动的细胞间通讯，以防御人类诺如病毒替代物杜兰病毒。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-09 DOI: 10.1039/D4BM01283F

Wen Song, Jillinda Toh, Shurui Chen, Ronge Xing and Dan Li

{"title":"Self-assembled eumelanin nanoparticles enhance IFN-I activation and cilia-driven intercellular communication to defend against Tulane virus, a human norovirus surrogate†","authors":"Wen Song, Jillinda Toh, Shurui Chen, Ronge Xing and Dan Li","doi":"10.1039/D4BM01283F","DOIUrl":"10.1039/D4BM01283F","url":null,"abstract":"Norovirus (NoV) infection is a leading cause of gastroenteritis and poses global health threats, with increasing incidence reported in immunocompromised individuals, which is further exacerbated by the globalization of the food industry. Eumelanin has demonstrated its potential in antiviral treatments, but its role in preventing viral infections remains underexplored. Therefore, in this study, we investigated the antiviral properties and potential mechanisms of self-assembled eumelanin nanoparticles (EmNPs) against Tulane virus (TuV), a surrogate with a similar infection mechanism to NoVs. EmNPs exhibited low cytotoxicity and strong antiviral activity in pre-incubated cells. Additionally, EmNPs stimulated the growth and endocytosis of cilia on the cell surface, exposing internal long-nanoparticle chains to interact with the cell membrane while promoting cilia growth and enhancing intercellular connections in cells. EmNPs were then transported to lysosomes via vesicles, leading to a perinuclear lysosome clustering. EmNPs activated several key intracellular signaling pathways, including Toll-like receptor (TLR) and C-type lectin receptor (CLR) pathways, along with activating NF-κB, Rap1, TNF, and Hippo pathways. This regulatory action initiated innate cellular immunity, significantly enhancing the production of type I interferons (IFN-α/β) and promoting the localization of lysosomes to the perinuclear region. Therefore, this study illustrated that EmNPs effectively stimulated immune responses, improved intercellular communication, and facilitated transport mechanisms, thereby bolstering resistance to subsequent viral infections. These findings position EmNPs as promising candidates for the prevention of norovirus infections.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 777-794"},"PeriodicalIF":5.8,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acid-triggered size reduction of nanomedicines for enhancing tumor therapy efficacy† 酸触发的纳米药物缩小尺寸以提高肿瘤治疗效果。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/D4BM01121J

Chongzhi Wang, YiKai Tang, Cheng Li, Wei Wu and Xiqun Jiang

引用次数: 0

Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency 更正：一种瓶刷结构葡聚糖多原药作为酸性反应载体，用于提高化疗效率。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/D4BM90089H

Tian Zhang, Yajun Wang, Xianbin Ma, Cuilan Hou, Shuangyu Lv, Die Jia, Yi Lu, Peng Xue, Yuejun Kang and Zhigang Xu

引用次数: 0

Magnetic resonance imaging contrast agents based on albumin nanoparticles 基于白蛋白纳米颗粒的磁共振成像造影剂。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/D4BM01226G

Yuan Yuan, Hui Gao, Sunmin Jiang, Qingjun You, Juan Zhou and Jinghua Chen

引用次数: 0

Expression of concern: An ‘on-demand’ photothermal antibiotic release cryogel patch: evaluation of efficacy on an ex vivo model for skin wound infection 关注表达：一种“按需”光热抗生素释放低温凝胶贴片：在皮肤伤口感染的离体模型上的疗效评估。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-04 DOI: 10.1039/D4BM90090A

Léa Rosselle, Anna Rita Cantelmo, Alexandre Barras, Nadia Skandrani, Michael Pastore, Duygu Aydin, Laura Chambre, Rana Sanyal, Amitav Sanyal, Rabah Boukherroub and Sabine Szunerits

引用次数: 0

A metal–phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy† 一种金属酚纳米调谐器诱导肿瘤热亡用于超声免疫治疗。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-12-03 DOI: 10.1039/D4BM01292E

Guohao Wang, Dongmei Wang, Huimin Tian, Lu Xia, Dongyan Shen, Zhanxiang Wang and Yunlu Dai

{"title":"A metal–phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy†","authors":"Guohao Wang, Dongmei Wang, Huimin Tian, Lu Xia, Dongyan Shen, Zhanxiang Wang and Yunlu Dai","doi":"10.1039/D4BM01292E","DOIUrl":"10.1039/D4BM01292E","url":null,"abstract":"Although ultrasound therapy is efficacious and safe in clinical oncology, its capacity to elicit an anti-tumor immune response is constrained by ultrasound-induced apoptosis. Pyroptosis, which releases immunogenic damage-associated molecular patterns (DAMPs), can significantly enhance immune activation. It necessitates robust Gasdermin E (GSDME) expression in cancer cells for caspase-3-mediated pyroptosis. An epigenetic strategy is introduced to induce cancer pyroptosis during sonotherapy using a nanocoordinator (HTA) constructed through metal-phenolic coordination involving Aza (a DNA methyltransferase inhibitor), TiO2 nanoparticles, and polyphenol-modified hyaluronic acid. While Aza restores GSDME expression, TiO2 generates reactive oxygen species (ROS) under ultrasound stimulation, activating caspase-3 and inducing pyroptosis via GSDME cleavage. In an orthotopic breast cancer model, HTA enhanced anti-tumor immunity and improved the efficacy of sonodynamic therapy (SDT). This approach presents a novel strategy for augmenting SDT through epigenetically induced pyroptosis.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 2","pages":" 446-456"},"PeriodicalIF":5.8,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0