Biomaterials Science最新文献

{"title":"Expression of concern: The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents","authors":"Anqi Chen, Jinghua Sun, Shijie Liu, Liping Li, Xiaoyang Peng, Lixin Ma and Ruiping Zhang","doi":"10.1039/D5BM90061A","DOIUrl":"10.1039/D5BM90061A","url":null,"abstract":"<p >Expression of Concern for ‘The effect of metal ions on endogenous melanin nanoparticles used as magnetic resonance imaging contrast agents’ by Anqi Chen <em>et al.</em>, <em>Biomater. Sci.</em>, 2020, <strong>8</strong>, 379–390, https://doi.org/10.1039/C9BM01580A.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5215-5217"},"PeriodicalIF":5.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm90061a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing extracellular vesicles as an emerging diagnostic and therapeutic strategy for osteoporosis","authors":"Gaiyue Yue, Xuan Dai, Hanfen Shi, Jin Shen, Haochen Guo, Ruiqiong Liang, Zhengze Dai, Yongqi Li, Sihua Gao, Guangtong Dong, Lili Wang, Jianhui Rong and Dongwei Zhang","doi":"10.1039/D5BM00537J","DOIUrl":"10.1039/D5BM00537J","url":null,"abstract":"<p >Osteoporosis (OP) is a prevalent chronic bone disorder that causes reduction of bone mass, deterioration of bone microarchitecture, and increase of fragility and fracture risk. Current therapeutic strategies mainly alleviate these pathological features but often fail to fully restore bone quality. Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication and have recently emerged as groundbreaking candidates for restoring bone homeostasis. This review systematically explores the multifaceted potential of EVs as therapeutics, diagnostic biomarkers, and drug delivery systems for OP. EVs from diverse biological sources (<em>e.g.</em>, mammals, plants, and microbial species) are critically evaluated as innovative modulators of bone metabolism. EVs carry dynamic biomarkers of OP progression which not only possess diagnostic value but also provide novel insights into disease mechanisms. Moreover, EVs could be further bioengineered for bone-targeted drug delivery. Indeed, preclinical studies validate the transformative potential of EVs, although challenges remain in clinical translation. We report current advancements, identify translational barriers, and emphasize the need for interdisciplinary collaboration to accelerate the transition from basic research to clinical applications.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 19","pages":" 5260-5277"},"PeriodicalIF":5.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144936057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of CAP-p15 functionalization on the bioactivity of rough TiO2-coated 316L stainless steel surfaces","authors":"Guadalupe Ureiro-Cueto, Sandra E. Rodil, José Ocotlán Flores-Flores, Lía Hoz-Rodríguez, Higinio Arzate and Gonzalo Montoya-Ayala","doi":"10.1039/D5BM00294J","DOIUrl":"10.1039/D5BM00294J","url":null,"abstract":"<p >Stainless steel 316L (316L SS) is frequently used in implants and medical devices because of its low cost, high mechanical strength, and adequate biocompatibility. However, its bioinert nature limits osseointegration, often confining its applications to temporary uses. To address this issue, surface modifications such as oxide coatings and peptide adsorption have emerged as promising strategies to enhance the bioactivity of 316L SS. This study explores the surface modification of 316L SS substrates through sandblasting, followed by the deposition of a TiO<small>₂</small> layer and subsequent biofunctionalization with a cementum attachment protein-derived peptide (CAP-p15) <em>via</em> physisorption using three different concentrations. The modified surfaces were characterized using X-ray photoelectron spectroscopy (XPS), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM/EDX), surface roughness analysis, and water contact angle measurements (WCA). Samples were incubated in artificial saliva (AS) for 21 days. The resulting peptide release, surface microstructure, the morphology and chemical composition of the deposits were evaluated. Additionally, human periodontal ligament cells (hPDLCs) were cultured on the modified surfaces to assess cell viability and attachment. Characterization revealed significant changes in surface chemistry, roughness, and wettability following functionalization. <em>In vitro</em> testing in AS demonstrated the formation of carbonated apatite, indicative of enhanced bioactivity. Furthermore, hPDLCs cultured on functionalized surfaces exhibited enhanced viability, improved adhesion, and enhanced cell spreading. These results suggest that peptide-based functionalization with CAP-p15 is a promising strategy for enhancing the osseointegration potential of 316L SS, offering valuable prospects for bone tissue regeneration.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5122-5133"},"PeriodicalIF":5.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00294j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters","authors":"Mengsi Zhan, Dayuan Wang, Lingzhou Zhao, Liang Chen, Zhijun Ouyang, Serge Mignani, Jean-Pierre Majoral, Jinhua Zhao, Guixiang Zhang, Xiangyang Shi and Mingwu Shen","doi":"10.1039/D5BM90060C","DOIUrl":"10.1039/D5BM90060C","url":null,"abstract":"<p >Correction for ‘Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters’ by Mengsi Zhan <em>et al.</em>, <em>Biomater. Sci.</em>, 2023, <strong>11</strong>, 7387–7396.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5218-5219"},"PeriodicalIF":5.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm90060c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified chitosan-fabricated antifungal transdermal array for dermatophytosis therapy","authors":"Feng Feng, Xing Ge, Tianye Fang, Kaiyang Chen, Jiaying Zhu, Jun Yang, Lei Tao, Jianjun Dai and Yanmin Ju","doi":"10.1039/D5BM00844A","DOIUrl":"10.1039/D5BM00844A","url":null,"abstract":"<p >Dermatophytosis is a complex and prevalent fungal skin infection that affects a significant portion of the global population. Conventional antifungal therapies are often compromised by their inability to effectively penetrate fungal biofilms and limited skin permeability, ultimately leading to unsatisfactory clinical results. To address these issues, we proposed a novel dissolvable microneedle (MN) patch (denoted as TB/QCS MNs) that encapsulated terbinafine (TB) within the quaternary ammonium chitosan (QCS) MN tips. The combination of QCS and TB exhibited a pronounced synergistic effect against <em>Trichophyton mentagrophytes</em> (<em>T. mentagrophytes</em>). Importantly, TB/QCS MNs effectively disrupted fungal biofilms and damaged extracellular polymeric substances. In comparison to TB alone, TB/QCS MNs effectively accelerated fungal clearance, shortened treatment time, and enhanced skin recovery in <em>T. mentagrophytes</em>-infected C57BL/6 mice. These findings demonstrated that TB/QCS MNs significantly improve therapeutic efficacy for dermatophytosis, offering a promising alternative for clinical treatment of skin fungal infections.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5111-5121"},"PeriodicalIF":5.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of hair follicle spheroids with growth factor transfection and various cell combinations","authors":"Hyeon-Min Nam, Subin Jeong and Gun Yong Sung","doi":"10.1039/D5BM00998G","DOIUrl":"10.1039/D5BM00998G","url":null,"abstract":"<p >As the number of hair loss patients increases, research conducted on hair follicles and hair has recently become more active. However, most current hair follicle research models are limited in their ability to reproduce several key functions of the hair follicle microenvironment. To solve this problem, hair growth genes were injected into hair follicle cells, and long-term culture was performed for up to 90 days. DPCs (dermal papilla cells), KCs (keratinocytes), HUVECs (human umbilical vein endothelial cells) or HDMECs (human dermal microvascular endothelial cells), and FBs (fibroblasts) injected with hair follicle growth factors LEF1 and Wnt1 were mixed to produce spheroids, and the growth factor expression and growth behavior according to the type of cell and the presence or absence of transfection according to the culture period were analyzed using SEM, H&amp;E staining, and IF imaging. As the culture period increased, the size of the spheroids increased, and the number decreased due to the association between spheroids; long fibers that appeared to be hair expression were observed. We also compared the differences between HUVECs and HDMECs, which have different phenotypes of vascular cells. In spheroids that did not contain FBs, the expression of HUVECs was more promoted, whereas in spheroids that contained FBs, the expression of HDMECs tended to be more promoted. These results are expected to contribute to dermatology and new drug development for the prevention of intractable skin diseases and hair loss using skin models with a microbiome environment in the future.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5184-5201"},"PeriodicalIF":5.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized transdermal collagen mimetic peptides for efficient repair of subacute aged skin","authors":"Jingting Zhang, Guangyu Liu, Yi Yang, Yi Xie, Linyan Yao and Jianxi Xiao","doi":"10.1039/D5BM00940E","DOIUrl":"10.1039/D5BM00940E","url":null,"abstract":"<p >Skin aging compromises both aesthetic appearance and barrier function, presenting significant challenges for dermal regeneration. Collagen represents a crucial target for anti-aging interventions; however, they suffer from the risk of virus transmission, large molecular weight and difficulty in transdermal transmission. Herein, we designed a series of transdermal collagen mimetic peptides (TSTPs) and a functionalized transdermal collagen mimetic peptide for efficient repair of subacute aged skin. TSTP-2, with the sequence (GPO)<small>₈</small>KLPVM, was identified as the optimal peptide according to its superior biocompatibility and skin permeability. Mechanistic analysis indicated that TSTP-2 improved transdermal delivery by perturbing skin lipids, engaging with keratin proteins, and altering hydration dynamics. The functionalized transdermal collagen mimetic peptide (TNC), engineered through GFOGER incorporation into TSTP-2, exhibited a stable triple-helical structure, effective transdermal delivery and high biological activity, significantly promoting fibroblast proliferation, adhesion, migration, and myofibroblast differentiation. The results of the DermaLab® Combo skin analyzer and histological analysis demonstrated that TNC promoted subacute aged skin repair by increasing epidermal thickness, stimulating collagen and elastic fiber regeneration, improving hydration, and reducing oxidative stress. The use of functionalized transdermal collagen mimetic peptides represents an alternative strategy for collagen transdermal delivery, showing potential applications in skin rejuvenation and regenerative medicine.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 19","pages":" 5495-5511"},"PeriodicalIF":5.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From microparticles to bulk hydrogels: emerging granular hydrogels in cartilage tissue engineering","authors":"Akshat Joshi, Akhilesh Agrawal, Saswat Choudhury, Subha Narayana Rath, Akshay Joshi, Kushal Taori, Savadamoorthi Kamatchi Subramani, Sabari Murugesan, Ujjayan Majumdar, Ji-hoo Lee and Suk-Jung Oh","doi":"10.1039/D5BM00801H","DOIUrl":"10.1039/D5BM00801H","url":null,"abstract":"<p >Articular cartilage exhibits a limited capacity for self-repair, prompting extensive research into advanced biomaterials that can support tissue regeneration. Among these, injectable hydrogels have gained attention for their minimally invasive delivery and suitability for bioprinting applications. However, conventional nanoporous bulk hydrogels often lack the necessary microporosity and architectural complexity to fully support effective tissue regeneration. To overcome these shortcomings, recent innovations have turned toward granular hydrogels—injectable materials fabricated by dense packing of hydrogel microparticles into cohesive, microporous bulk hydrogels. These granular systems offer improved injectability, superior microporosity, and the ability to form heterogeneous bioinks/injectables that better replicate the natural extracellular matrix, thereby promoting more efficient regeneration. This review delves into the advancements in granular hydrogel technology, with a focus on the fabrication of hydrogel microparticles and the jamming strategies used to assemble them into granular injectables/bioinks. It further explores their potential in cartilage tissue repair, emphasizing the benefits of such emerging microporous bulk assemblies in minimally invasive procedures (MIPs) or as smart bioinks for fabricating patient specific implants. Finally, the review outlines key opportunities and challenges in translating these innovative materials into clinical applications, highlighting the growing promise of granular hydrogels in addressing current limitations in cartilage regeneration.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 4916-4951"},"PeriodicalIF":5.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction strategies of whole tumor cell vaccines","authors":"Xilin Wang, Hanye Xu, Hongyi Wang, Runjia Hua, Shuwang Wu, Jingwei Xu, Xiaju Cheng and Haibin Shi","doi":"10.1039/D5BM00914F","DOIUrl":"10.1039/D5BM00914F","url":null,"abstract":"<p >Whole tumor cell vaccines (WTCVs), which utilize the entire tumor antigen repertoire to elicit robust and personalized anti-tumor immunity, have emerged as a promising strategy to overcome tumor heterogeneity and immune evasion. However, the development of WTCVs has very limited benefits in the clinical setting. This paper systematically reviews the cutting-edge construction strategies of WTCVs including dead tumor cell-based vaccines and engineered living tumor cell-based vaccines with a particular focus on the impact of structural integrity on the immune response of WTCVs. Moreover, current challenges and prospects are also discussed, aiming to achieve better therapeutic efficacy by fabricating WTCVs with great biosafety and strong immunogenicity, hoping to promote the clinical translation of WTCVs.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 4885-4897"},"PeriodicalIF":5.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AntiCD44 antibody-conjugated gold nanoparticles for targeted photothermal therapy of endometriotic cells","authors":"Cristina Volpini, Nora Bloise, Claudio Casali, Benedetta Albini, Mattia Dominoni, Fabio Barra, Marco Biggiogera, Pietro Galinetto, Barbara Gardella, Valerio Gaetano Vellone, Simone Ferrero, Paolo Minzioni and Livia Visai","doi":"10.1039/D5BM00701A","DOIUrl":"10.1039/D5BM00701A","url":null,"abstract":"<p >Endometriosis is a chronic gynecologic disease that needs newer and safer treatments. The proposed work aims to develop a nanosystem based on gold nanoparticles (AuNPs) to actively target human endometriosis CD44(+) cells and significantly reduce their viability by photothermal therapy (PTT). AuNPs stabilized by lipoic acid-Poly(ethylene glycol)-Maleimide (LA-PEG-Mal) (Au@P) were decorated with antiCD44 antibodies (Au@P_AbCD44) through maleimide chemistry. The physicochemical and biochemical approaches revealed the presence of the antibody on Au@P_AbCD44. The <em>in vitro</em> studies were conducted against overexpressing CD44 cells (12Z), low-expressing CD44 cells (HESC), and the normal fibroblast cell line (NIH-3T3). Following the internalization through the clathrin-mediated endocytosis, the PTT of the cell-internalized Au@P_AbCD44 was investigated using two distinct laser types, due to the differing Au@P's LSPR properties. Au@P_AbCD44 exhibited significant PTT efficacy against 12Z cells; however, GNS@P_AbCD44 required lower energy input compared to GNP@P_AbCD44. This enhanced performance is attributed to the LSPR-mediated photothermal conversion efficiency of GNS over GNPs.In both cases, the apoptotic pathway was selected by dying cells over necrotic cells. The results revealed a better photothermal ability of GNS@P_AbCD44 compared to GNP@P_AbCD44. Our findings highlight the clinical potential of gold nanostars as advanced photosensitizers for targeted photothermal therapy, offering a promising strategy for more effective and less invasive treatment of endometriosis.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5164-5183"},"PeriodicalIF":5.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00701a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}