Modified chitosan-fabricated antifungal transdermal array for dermatophytosis therapy

IF 5.7 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2025-07-31 DOI:10.1039/D5BM00844A

Feng Feng, Xing Ge, Tianye Fang, Kaiyang Chen, Jiaying Zhu, Jun Yang, Lei Tao, Jianjun Dai and Yanmin Ju

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Abstract

Dermatophytosis is a complex and prevalent fungal skin infection that affects a significant portion of the global population. Conventional antifungal therapies are often compromised by their inability to effectively penetrate fungal biofilms and limited skin permeability, ultimately leading to unsatisfactory clinical results. To address these issues, we proposed a novel dissolvable microneedle (MN) patch (denoted as TB/QCS MNs) that encapsulated terbinafine (TB) within the quaternary ammonium chitosan (QCS) MN tips. The combination of QCS and TB exhibited a pronounced synergistic effect against Trichophyton mentagrophytes (T. mentagrophytes). Importantly, TB/QCS MNs effectively disrupted fungal biofilms and damaged extracellular polymeric substances. In comparison to TB alone, TB/QCS MNs effectively accelerated fungal clearance, shortened treatment time, and enhanced skin recovery in T. mentagrophytes-infected C57BL/6 mice. These findings demonstrated that TB/QCS MNs significantly improve therapeutic efficacy for dermatophytosis, offering a promising alternative for clinical treatment of skin fungal infections.

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改良壳聚糖制备的抗真菌透皮阵列用于皮肤病治疗。

皮肤真菌病是一种复杂而普遍的真菌皮肤感染，影响着全球人口的很大一部分。传统的抗真菌疗法往往因其无法有效穿透真菌生物膜和皮肤渗透性有限而受到损害，最终导致临床结果不理想。为了解决这些问题，我们提出了一种新型的可溶解微针（MN）贴片（标记为TB/QCS MN），该贴片将特比萘芬（TB）封装在季铵壳聚糖（QCS） MN尖端内。QCS与TB联合使用对mentagrophytes （T. mentagrophytes）具有明显的协同作用。重要的是，TB/QCS MNs有效地破坏了真菌生物膜并破坏了细胞外聚合物物质。与单独使用TB相比，TB/QCS MNs可以有效地加速真菌清除，缩短治疗时间，并增强真菌感染C57BL/6小鼠的皮肤恢复。这些结果表明，TB/QCS MNs显著提高了皮肤真菌病的治疗效果，为临床治疗皮肤真菌感染提供了一种有希望的替代方案。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.