Biomaterials Science最新文献_第9页

Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer†

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-02-04 DOI: 10.1039/D4BM01541J

Seojung Cho, Miyuki Hori, Ryosuke Ueki, Yutaro Saito, Yukiko Nagai, Haruka Iki, Akira Tsuchiya, Tomohiro Konno, Kensuke Owari, Haishun Piao, Kazunobu Futami and Shinsuke Sando

{"title":"Zwitterionic polymer with minimal reactivity against PEG antibodies to enhance the therapeutic effects of cytokine-targeting DNA aptamer†","authors":"Seojung Cho, Miyuki Hori, Ryosuke Ueki, Yutaro Saito, Yukiko Nagai, Haruka Iki, Akira Tsuchiya, Tomohiro Konno, Kensuke Owari, Haishun Piao, Kazunobu Futami and Shinsuke Sando","doi":"10.1039/D4BM01541J","DOIUrl":"10.1039/D4BM01541J","url":null,"abstract":"Overcoming poor in vivo pharmacokinetics is a critical challenge in developing therapeutic aptamers, and conjugation to poly(ethylene glycol) (PEG) is a well-established technique for aptamers to prolong blood circulation. However, the existence of antibodies that specifically recognize PEG and their adverse effects on in vivo behaviors have been increasingly reported, highlighting the necessity of alternative modification strategies for aptamers. To address this issue, we focused on a zwitterionic polymer, particularly poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), as a PEG alternative to modify DNA aptamers. We conjugated PMPC to a DNA aptamer targeting IFN-gamma and investigated the properties of the PMPC-conjugated DNA aptamer as a therapeutic agent. PMPC modification did not affect the neutralizing activity of the aptamer. PMPC demonstrated lower reactivity against anti-PEG antibodies than PEG-like aptamer modifiers previously reported to exhibit low reactivity against PEG antibodies. In addition, PMPC extended the blood circulation time of the aptamer as long as or longer than PEG with a similar molecular size. In the LPS-induced inflammation animal model, the survival rate after treatment with the PMPC-aptamer conjugate was significantly superior to that with unmodified aptamer. These results indicate that PMPC has potential as an aptamer or other nucleic acid drug modifier to replace or be compatible with PEG.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1347-1353"},"PeriodicalIF":5.8,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d4bm01541j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery†

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-02-03 DOI: 10.1039/D4BM01315H

Sophia J. Bailey, Noah Eckman, Elisa S. Brunel, Carolyn K. Jons, Samya Sen and Eric A. Appel

{"title":"A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery†","authors":"Sophia J. Bailey, Noah Eckman, Elisa S. Brunel, Carolyn K. Jons, Samya Sen and Eric A. Appel","doi":"10.1039/D4BM01315H","DOIUrl":"10.1039/D4BM01315H","url":null,"abstract":"Polymer–nanoparticle (PNP) hydrogels are a promising injectable biomaterial platform that has been used for a wide range of biomedical applications including adhesion prevention, adoptive cell delivery, and controlled drug release. By tuning the chemical, mechanical, and erosion properties of injected hydrogel depots, additional control over cell compatibility and pharmaceutical release kinetics may be realized. Here, we employ thiol–ene click chemistry to prepare a library of modified hydroxypropylmethylcellulose (HPMC) derivatives for subsequent use in PNP hydrogel applications. When combined with poly(ethylene glycol)-b-poly(lactic acid) nanoparticles, we demonstrate that systematically altering the hydrophobic, steric, or pi stacking character of HPMC modifications can readily tailor the mechanical properties of PNP hydrogels. Additionally, we highlight the compatibility of the synthetic platform for the incorporation of cysteine-bearing peptides to access PNP hydrogels with improved bioactivity. Finally, through leveraging the tunable physical properties afforded by this method, we show hydrogel retention time in vivo can be dramatically altered without sacrificing mesh size or cargo diffusion rates. This work offers a route to optimize PNP hydrogels for a variety of translational applications and holds promise in the highly tunable delivery of pharmaceuticals and adoptive cells.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1323-1334"},"PeriodicalIF":5.8,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focal adhesion dynamics-mediated cell migration and proliferation on silica bead arrays†

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-02-01 DOI: 10.1039/D4BM01659A

Yi-Seul Park, Yerin Choi and Jin Seok Lee

{"title":"Focal adhesion dynamics-mediated cell migration and proliferation on silica bead arrays†","authors":"Yi-Seul Park, Yerin Choi and Jin Seok Lee","doi":"10.1039/D4BM01659A","DOIUrl":"10.1039/D4BM01659A","url":null,"abstract":"Interactions between cells and the extracellular matrix (ECM) alter cellular behaviors, including adhesion, migration, proliferation, and differentiation via focal adhesions that link the ECM to the actin cytoskeleton as an intracellular signaling pathway. Although nanomaterials with various mechanical, geometrical, and topographical features have been used to provide a variety of cell–ECM interactions, it remains unclear how their nanostructured surfaces affect cellular behavior. In this study, we investigated focal adhesion dynamics during the migration and proliferation of HeLa cells on silica bead (SB) arrays with various nanotopographies. Cell adhesion was altered according to the surface curvature and pinhole size of the SB arrays, and cell morphology was determined by the ratio of the adhesive and non-adhesive areas of cells on the SB arrays. In turn, this triggered different focal adhesion dynamics in cells. In addition, we demonstrated the rapid migration and high proliferation characteristics of rounded cells with weak adhesion based on confocal microscopy analysis and migration trajectory on SB arrays, indicating focal adhesion dynamics-mediated cell migration and proliferation on nanostructured surfaces.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 7","pages":" 1849-1857"},"PeriodicalIF":5.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Color-coded galectin fusion proteins as novel tools in biomaterial science†

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-29 DOI: 10.1039/D4BM01148A

Carina Dey, Isabel K. Sommerfeld, Pavla Bojarová, Nikol Kodra, David Vrbata, Miluše Zimolová Vlachová, Vladimír Křen, Andrij Pich and Lothar Elling

{"title":"Color-coded galectin fusion proteins as novel tools in biomaterial science†","authors":"Carina Dey, Isabel K. Sommerfeld, Pavla Bojarová, Nikol Kodra, David Vrbata, Miluše Zimolová Vlachová, Vladimír Křen, Andrij Pich and Lothar Elling","doi":"10.1039/D4BM01148A","DOIUrl":"10.1039/D4BM01148A","url":null,"abstract":"The inherent carbohydrate-binding specificities of human galectins can serve as recognition elements in both biotechnological and biomedical applications. The combination of the carbohydrate-recognition domain (CRD) of galectins fused to peptides or proteins for purification, immobilization, and imaging enables multifunctional utilization within a single protein. We present here a library of color-coded galectin fusion proteins that incorporate a His6-tag, a fluorescent protein, and a SpyCatcher or SpyTag unit to enable immobilization procedures. These galectin fusion proteins exhibit similar binding properties to the non-fused galectins with micromolar apparent binding affinities. N- and C-terminal fusion partners do not interfere with the SpyCatcher/SpyTag immobilization. By applying SpyCatcher/SpyTag-mediated SC–ST-Gal-3 conjugates, we show the stepwise formation of a three-layer ECM-like structure in vitro. Additionally, we demonstrate the SpyCatcher/SpyTag-mediated immobilization of galectins in microgels, which can serve as a transport platform for localized targeting applications. The proof of concept is provided by the galectin-mediated binding of microgels to colorectal cancer cells.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 6","pages":" 1482-1500"},"PeriodicalIF":5.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d4bm01148a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D bioprinted poly(lactic acid) scaffolds infused with curcumin-loaded nanostructured lipid carriers: a promising approach for skin regeneration

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-29 DOI: 10.1039/D4BM01550A

Renuka Vijayaraghavan, M. Vidyavathi, R. V. Suresh Kumar, Sravanthi Loganathan and Ravi Babu Valapa

{"title":"3D bioprinted poly(lactic acid) scaffolds infused with curcumin-loaded nanostructured lipid carriers: a promising approach for skin regeneration","authors":"Renuka Vijayaraghavan, M. Vidyavathi, R. V. Suresh Kumar, Sravanthi Loganathan and Ravi Babu Valapa","doi":"10.1039/D4BM01550A","DOIUrl":"10.1039/D4BM01550A","url":null,"abstract":"Nanotechnology and 3D bioprinted scaffolds are revolutionizing the field of wound healing and skin regeneration. By facilitating proper cellular movement and providing a customizable structure that replicates the extracellular matrix, such technologies not only expedite the healing process but also ensure the seamless integration of new skin layers, enhancing tissue repair and promoting overall cell growth. This study centres on the creation and assessment of a nanostructured lipid carrier containing curcumin (CNLC), which is integrated into a 3D bioprinted PLA scaffold system. The goal is to investigate its potential as a vehicle for delivering poorly soluble curcumin for enhanced wound healing. The developed CNLC exhibited an oval morphology and average particle size of 292 nm. The entrapment efficiency (EE) was 81.37 ± 0.85%, and the drug loading capacity was 6.59 ± 1.61%. CNLC was then integrated into PLA-based 3D bioprinted scaffolds, and physicochemical analyses were conducted to evaluate their properties. Cell viability studies carried out using fibroblast cells demonstrated that the PLA/CNLC scaffolds are non-cytotoxic. In vivo experiments showed that the PLA/CNLC scaffolds exhibited complete wound contraction and closure of full-thickness wounds within a period of 21 days. The findings confirmed the scaffold's capacity as a tool for accelerating wound healing. The research emphasises the need for using biomimetic 3D printed scaffold materials and the promise of nanobiotechnology in enhancing treatment efficacy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1286-1303"},"PeriodicalIF":5.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-28 DOI: 10.1039/D4BM01394H

Xi Shi, Weilong He, Ashwin Gupta, Kyran To, Leonardo Clark, Nitya Mirle, Thomas Wynn, Daniel Wang, Akash Ganesh, Helena M. Zeng and Huiliang Wang

{"title":"Extracellular vesicles as drug and gene delivery vehicles in central nervous system diseases","authors":"Xi Shi, Weilong He, Ashwin Gupta, Kyran To, Leonardo Clark, Nitya Mirle, Thomas Wynn, Daniel Wang, Akash Ganesh, Helena M. Zeng and Huiliang Wang","doi":"10.1039/D4BM01394H","DOIUrl":"10.1039/D4BM01394H","url":null,"abstract":"Extracellular vesicles (EVs) are secreted by almost all cell types and contain DNA, RNA, proteins, lipids and other metabolites. EVs were initially believed to be cellular waste but now recognized for their role in cell-to-cell communication. Later, EVs from immune cells were discovered to function similarly to their parent cells, paving the way for their use as gene and drug carriers. EVs from different cell types or biological fluids carry distinct cargo depending on their origin, and they perform diverse functions. For instance, EVs derived from stem cells possess pluripotent properties, reflecting the cargo from their parent cells. Over the past two decades, substantial preclinical and clinical research has explored EVs-mediated drug and gene delivery to various organs, including the brain. Natural or intrinsic EVs may be effective for certain applications, but as drug or gene carriers, they demonstrate broader and more efficient potential across various diseases. Here, we review research on using EVs to treat central nervous system (CNS) diseases, such as Alzheimer's Disease, Parkinson diseases, depression, anxiety, dementia, and acute ischemic strokes. We first reviewed the naïve EVs, especially mesenchymal stem cell (MSC) derived EVs in CNS diseases and summarized the clinical trials of EVs in treating CNS diseases and highlighted the reports of two complete trials. Then, we overviewed the preclinical research of EVs as drug and gene delivery vehicles in CNS disease models, including the most recent two years’ progress and discussed the mechanisms and new methods of engineered EVs for targeting CNS. Finally, we discussed challenges and future directions and of EVs as personalized medicine for CNS diseases.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1161-1178"},"PeriodicalIF":5.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living material-derived intelligent micro/nanorobots

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-28 DOI: 10.1039/D4BM01685H

Shuhuai Wang, Ya Liu, Shuangjiao Sun, Qinyi Gui, Wei Liu and Wei Long

引用次数: 0

Mung bean-derived carbon dots suppress ferroptosis of Schwann cells via the Nrf2/HO-1/GPX4 pathway to promote peripheral nerve repair.

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-27 DOI: 10.1039/d4bm01570c

Fei Zheng, Yumin Zhang, Hui Zhou, Jiangnan Li, Junyang Gao, Xiaoli Qu, Xuejian Wu, Siyu Lu, Yuanyi Wang, Nan Zhou

{"title":"Mung bean-derived carbon dots suppress ferroptosis of Schwann cells via the Nrf2/HO-1/GPX4 pathway to promote peripheral nerve repair.","authors":"Fei Zheng, Yumin Zhang, Hui Zhou, Jiangnan Li, Junyang Gao, Xiaoli Qu, Xuejian Wu, Siyu Lu, Yuanyi Wang, Nan Zhou","doi":"10.1039/d4bm01570c","DOIUrl":"https://doi.org/10.1039/d4bm01570c","url":null,"abstract":"Schwann cells (SCs) can potentially transform into the repair-related cell phenotype after injury, which can promote nerve repair. Ferroptosis occurs in the SCs of injured tissues, causing damage to the SCs and exacerbating nerve injury. Targeting ferroptosis in SCs is a promising therapeutic strategy for effective repair; however, research on ferroptosis in the peripheral nervous system remains limited. In this study, we generated and characterized novel distinctive carbon dots, mung bean-derived carbon dots (MB-CDs). Our results demonstrated that MB-CDs have the advantages of low toxicity, good biocompatibility, high stability, the specific effect of ferric ions (Fe3+) on fluorescence, and antioxidant activity. We demonstrated that MB-CDs promoted functional recovery after peripheral nerve injury (PNI), preventing gastrocnemius atrophy. Further research indicated that MB-CDs boosted the repair-related phenotypes of SCs. We used lipopolysaccharide (LPS) to induce an inflammatory model of SCs and co-cultured them with MB-CDs. Then, we examined the effects of MB-CDs by dividing the cells into four groups: the control group (CTRL), MB-CD treatment group (CDs-SCs), LPS treatment group (LPS-SCs), and LPS and MB-CD treatment group (LPS-CDs). RNA sequencing of LPS-CDs and LPS-SCs indicated that LPS-CDs significantly upregulated heme oxygenase-1 (HO-1) expression. Furthermore, western blotting and immunofluorescence techniques demonstrated that MB-CDs suppressed the ferroptosis of SCs via the Nrf2/HO-1/GPX4 signaling pathway after PNI. Overall, this study further uncovered the connection between ferroptosis and the repair-related phenotypes of SCs, filling this gap in the existing knowledge; accordingly, they may be promising agents for treating PNI.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strengthening the cellular function of dermal fibroblasts and dermal papilla cells using nanovesicles extracted from stem cells using blue light-based photobiomodulation technology†

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-27 DOI: 10.1039/D4BM01591F

Jiyu Hyun, Sang Yoon Lee, Jiseon An, You Bin Lee and Suk Ho Bhang

{"title":"Strengthening the cellular function of dermal fibroblasts and dermal papilla cells using nanovesicles extracted from stem cells using blue light-based photobiomodulation technology†","authors":"Jiyu Hyun, Sang Yoon Lee, Jiseon An, You Bin Lee and Suk Ho Bhang","doi":"10.1039/D4BM01591F","DOIUrl":"10.1039/D4BM01591F","url":null,"abstract":"Human dermal fibroblasts (hDFs) play a critical role in skin health by producing extracellular matrix (ECM) components essential for structural stability, while hair follicle dermal papilla cells (HFDPCs) are key to hair follicle growth and regeneration. However, factors such as UV radiation, oxidative stress, and aging impair the functions of hDFs and HFDPCs, leading to decrement in ECM production and skin maintenance and hair loss conditions like alopecia. Recent advances in nanovesicles (NVs) derived from human adipose-derived stem cells (hADSCs) have shown an innovative way in the regenerative medicine field, particularly with promise for enhancing the functionality of diverse cell types. NVs, filled with diverse bioactive molecules, are non-immunogenic, biologically stable, and capable of promoting cellular activities. To further enhance the therapeutic potential of NVs, photobiomodulation (PBM) using blue light has emerged as a promising application. Optimized blue light irradiation can induce moderate levels of reactive oxygen species production in hADSCs, activating signaling pathways that upregulate angiogenic and regenerative markers in hADSCs. In this study, blue light-irradiated NVs demonstrated superior efficacy in promoting hDF proliferation, ECM synthesis, and the functionality of HFDPCs, resulting in enhanced skin maintenance and hair follicle regeneration. This approach presents a safer and more efficient way for treating skin and hair disorders, highlighting the potential use of blue light-irradiated NVs as an innovative therapeutic strategy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1209-1221"},"PeriodicalIF":5.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in near-infrared organic photosensitizers for photodynamic cancer therapy 用于光动力癌症治疗的近红外有机光敏剂的最新进展。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-01-27 DOI: 10.1039/D4BM01457J

Van-Nghia Nguyen, Minh Viet Nguyen, Huong Pham Thi, Anh-Tuan Vu and Truong Xuan Nguyen

{"title":"Recent advances in near-infrared organic photosensitizers for photodynamic cancer therapy","authors":"Van-Nghia Nguyen, Minh Viet Nguyen, Huong Pham Thi, Anh-Tuan Vu and Truong Xuan Nguyen","doi":"10.1039/D4BM01457J","DOIUrl":"10.1039/D4BM01457J","url":null,"abstract":"With the advancement of photodynamic therapy, various photosensitizers have been developed to enhance the efficacy of cancer treatment while minimizing side effects. Recently, near-infrared organic fluorophores have gained significant attention as promising photodynamic agents for cancer therapy due to their tunable photophysical properties, structural versatility, good biocompatibility, high biosafety, and synthetic flexibility. In particular, near-infrared organic photosensitizers offer several notable advantages, including deep tissue penetration, a low fluorescence background for bioimaging, and reduced damage to biological tissues compared to traditional visible-spectrum photosensitizers. In this minireview, we will discuss the current developments in near-infrared organic photosensitizers for photodynamic cancer therapy. Furthermore, we will briefly highlight the challenges and prospects in this field. This minireview aims to encourage more researchers to develop advanced near-infrared organic photosensitizers and facilitate their transition from laboratory research to preclinical studies and ultimately to clinical use.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 5","pages":" 1179-1188"},"PeriodicalIF":5.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0