Biomaterials Science最新文献_第9页

Comparative evaluation of recombinant thrombin and fibrin hydrogel systems for extracellular vesicle delivery† 用于细胞外囊泡递送的重组凝血酶和纤维蛋白水凝胶系统的比较评价。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-28 DOI: 10.1039/D5BM00705D

Sriya Yeleswarapu, Yourka Tchoukalova, Kevin T. Dicker, Ava Koehler De Celaya, Dina Gadalla, Dominique B. Hoelzinger, Amanda M. Richards, Nan Zhang, Cheryl E. Myers and David G. Lott

{"title":"Comparative evaluation of recombinant thrombin and fibrin hydrogel systems for extracellular vesicle delivery†","authors":"Sriya Yeleswarapu, Yourka Tchoukalova, Kevin T. Dicker, Ava Koehler De Celaya, Dina Gadalla, Dominique B. Hoelzinger, Amanda M. Richards, Nan Zhang, Cheryl E. Myers and David G. Lott","doi":"10.1039/D5BM00705D","DOIUrl":"10.1039/D5BM00705D","url":null,"abstract":"Extracellular vesicles (EVs) represent promising therapeutic agents in regenerative medicine due to their capacity to modulate cellular functions through cargo transport. However, their clinical effectiveness is limited by rapid systemic clearance and degradation, constraints potentially addressed through encapsulation within biocompatible hydrogel matrices. This study evaluates a novel fibrin hydrogel formulation derived from recombinant thrombin (Recothrom®) and residual fibrinogen present in purified exosome product (PEP) as an alternative to conventional fibrin sealant (TISSEEL®). We conducted comprehensive analyses of physicochemical properties, release kinetics, and cellular responses across four distinct hydrogel formulations: two conventional fibrin constructs with elevated fibrinogen-to-thrombin ratios (1) fibrin hydrogel with PEP supplementation (FG/T + PEP) and (2) non-supplemented fibrin hydrogel control (FG/T), and two Recothrom®-based variants with reduced fibrinogen-to-thrombin ratios (3) Recothrom® 25 units per ml + PEP (hrT25/PEP) and (4) Recothrom® 50 units per ml + PEP (hrT50/PEP). The Recothrom®-based formulations demonstrated significantly reduced mechanical stiffness characterized by thinner, more extensively branched fiber network architecture and decreased pore sizes. Although EV release dynamics were comparable across all groups, these structural characteristics facilitated enhanced cellular functionality promoting endothelial cell proliferation, upregulation of endothelial-specific markers, and improved fibroblast spreading, directional alignment, contractility, and type I collagen (COL-1) synthesis. These findings establish Recothrom®-based hydrogels as superior microenvironments for promoting angiogenesis and fibroblast-mediated extracellular matrix production, with significant implications for therapeutic EV delivery in tissue engineering applications.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5040-5051"},"PeriodicalIF":5.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laminin-functionalized 3D-printed PEGDA-acrylic acid scaffolds with enhanced neuronal adhesion and electrical activity 层粘连蛋白功能化的3d打印聚乙二醇丙烯酸支架具有增强的神经元粘附性和电活性。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-28 DOI: 10.1039/D5BM00663E

Qian Yu, Tao Chen, Yanping Zhang, Yu Zhao and Anchen Guo

{"title":"Laminin-functionalized 3D-printed PEGDA-acrylic acid scaffolds with enhanced neuronal adhesion and electrical activity","authors":"Qian Yu, Tao Chen, Yanping Zhang, Yu Zhao and Anchen Guo","doi":"10.1039/D5BM00663E","DOIUrl":"10.1039/D5BM00663E","url":null,"abstract":"The development of neural tissue engineering demands biocompatible scaffolds capable of supporting neuronal adhesion and network formation. Polyethylene glycol diacrylate (PEGDA) hydrogel has emerged as an ideal candidate due to its excellent biocompatibility, tunable mechanical properties, and stability. However, its inherent resistance to protein adsorption limits cell adhesion. To overcome this challenge, this study combines 3D printing and functional surface modification to create a PEGDA-acrylic acid (AA)-laminin scaffold for promoting neuronal adhesion. High-precision 3D PEGDA-AA scaffolds were fabricated by light-curing 3D printing technology, followed by modification with laminin. The effects of varying AA and PEGDA ratios on the morphology, mechanical properties, and cytocompatibility of the 3D-printed scaffolds were evaluated. The scaffold, composed of 40% (w/v) PEGDA and 20% (w/v) acrylic acid, with subsequent 50 μg mL−1 laminin surface modification, demonstrated excellent biocompatibility and enhanced neuronal adhesion (40%) compared to the unmodified PEGDA scaffold (3%). Additionally, neurons within the scaffold exhibited directional migration. Microelectrode array analysis of neuronal electrophysiological activity confirmed that this 3D scaffold supported primary cortical neurons in forming functional synaptic networks, with enhanced synchronization of neuronal electrical activity. This PEGDA-AA-laminin 3D scaffold represents an ideal cell culture platform for brain-like construction and nerve repair in neural tissue engineering.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5052-5070"},"PeriodicalIF":5.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer-engineered PROTAC nanovehicles amplify synergistic effects with temozolomide by BRD4 degradation† 聚合物工程PROTAC纳米载体通过降解BRD4增强了与替莫唑胺的协同效应。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-25 DOI: 10.1039/D5BM00443H

Yun Guo, Haoyu You, Yiyang Li, Zheng Zhou, Zonghua Tian, Chen Jiang and Tao Sun

引用次数: 0

Advances in cell membrane-coated nanoparticles: multifunctional platforms for targeted drug delivery, precision phototherapy, and enhanced immunotherapy 细胞膜包被纳米颗粒的研究进展：靶向药物递送、精确光疗和增强免疫治疗的多功能平台。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-25 DOI: 10.1039/D5BM00660K

Papia Sultana, Young Kyun Kim, Sung Jun Cho, Md Asadujjaman and Jun-Pil Jee

{"title":"Advances in cell membrane-coated nanoparticles: multifunctional platforms for targeted drug delivery, precision phototherapy, and enhanced immunotherapy","authors":"Papia Sultana, Young Kyun Kim, Sung Jun Cho, Md Asadujjaman and Jun-Pil Jee","doi":"10.1039/D5BM00660K","DOIUrl":"10.1039/D5BM00660K","url":null,"abstract":"Nanoparticles (NPs) are nanometer-sized structures typically ranging from 1 to 100 nm in all three dimensions. Nanoparticles (NPs) have emerged as powerful tools in modern medicine, but their clinical translation has been hindered by issues such as rapid immune clearance, limited targeting, and off-target toxicity. Recent advances in cell membrane-coated nanoparticles (CM–NPs) provide an innovative solution by combining synthetic nanocarriers with natural cell membrane functionalities. By coating nanoparticles with membranes derived from red blood cells, cancer cells, immune cells, or platelets, CM–NPs inherit properties such as immune evasion, prolonged circulation, biocompatibility, and homotypic targeting. In drug delivery, CM–NPs enhance drug targeting and minimize off-target effects, especially in cancer therapy, where they selectively deliver chemotherapeutics to tumor cells. In phototherapy, these NPs enable precise tumor targeting for photothermal and photodynamic therapies, reducing damage to healthy tissues. In immunotherapy, immune cell-derived NPs modulate immune responses and improve cancer treatment efficacy by delivering immune modulators directly to the tumor microenvironment. Overall, CM–NPs provide a versatile platform to enhance the specificity, safety, and efficacy of drug delivery, phototherapy, and immunotherapy, with substantial potential for clinical translation and disease treatment. This review provides a comprehensive overview of CM–NP preparation methods, highlights their versatile biomedical applications, and critically discusses the remaining challenges and future directions. The insights presented here aim to guide the development of next-generation biomimetic nanomedicines with transformative clinical potential.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 19","pages":" 5232-5259"},"PeriodicalIF":5.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outstanding Reviewers for Biomaterials Science in 2024 2024年生物材料科学杰出审稿人。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-25 DOI: 10.1039/D5BM90056E

引用次数: 0

Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels. 负载细胞明胶甲基丙烯酰水凝胶中光引发剂选择的设计考虑。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-23 DOI: 10.1039/d5bm00550g

Elvan Dogan, Ann Austin, Ayda Pourmostafa, Swaprakash Yogeshwaran, Hossein Goodarzi Hosseinabadi, Amir K Miri

{"title":"Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels.","authors":"Elvan Dogan, Ann Austin, Ayda Pourmostafa, Swaprakash Yogeshwaran, Hossein Goodarzi Hosseinabadi, Amir K Miri","doi":"10.1039/d5bm00550g","DOIUrl":"10.1039/d5bm00550g","url":null,"abstract":"Light-assisted bioprinting of protein-derived hydrogels has been widely used for tissue engineering and regenerative medicine. The practical challenges of the photoinitiators (PIs) are often overlooked in using photo-crosslinkable bioinks for in situ and in vitro applications. A higher concentration of PI is believed to increase the network density of a hydrogel thus reducing its mass transfer capacity, but PI can form reactive oxygen species (ROS) and cause unwanted side reactions around biological compartments. This study systematically investigates the role of ROS generation on mesenchymal stem cells encapsulated in gelatin-methacryloyl hydrogels when using type I PIs-e.g. lithium phenyl(2,4,6-trimethyl-benzoyl)phosphinate and 2-hydroxy-1-(4-hydroxyethyl-phenyl)-2-methyl-1-propanone, and type II PI-e.g. Eosin Y. The results reveal that higher concentrations of type I PIs provide a higher elastic modulus at the expense of enhanced ROS generation and a proportional decrease in viability. We report a novel hydrogel system with minimal PI loading where a reduction in elastic modulus is accompanied by a simultaneous decrease in pore size and ROS level leading to a significant increase in stem cell viability over one week of in vitro culture. In contrast, the type II PI reveals a moderate fluctuation of elastic modulus over a range of PI concentration correlated to fluctuations in ROS generation. Monitoring ROS level variations enables evaluation of each PI's impact on cell response, providing a strategy for the biofabrication of cell-laden constructs. This framework can inform the rational design of photo-crosslinkable hydrogels for light-assisted bioprinting and in situ crosslinking applications in regenerative medicine.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable lubricant-coated hyaluronic acid−dopamine for the repair of early osteoarthritis† 注射涂膜透明质酸多巴胺修复早期骨关节炎。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-22 DOI: 10.1039/D5BM00603A

Hang Yao, Chirun Wang, Qi Tao, Jian Yang, Dianwei Liu, Xianfeng Shang, Zhonglian Wu, Xu Hu, Zehao Gu, Zhilin Cheng, Jihang Dai and Dong-an Wang

{"title":"Injectable lubricant-coated hyaluronic acid−dopamine for the repair of early osteoarthritis†","authors":"Hang Yao, Chirun Wang, Qi Tao, Jian Yang, Dianwei Liu, Xianfeng Shang, Zhonglian Wu, Xu Hu, Zehao Gu, Zhilin Cheng, Jihang Dai and Dong-an Wang","doi":"10.1039/D5BM00603A","DOIUrl":"10.1039/D5BM00603A","url":null,"abstract":"Osteoarthritis (OA) is an irreversible disease of continuous degradation of cartilage, and natural joint super-lubrication is thought to provide hydrated lubrication to articular cartilage. Synovial joint fluid consists of hyaluronic acid (HA) and numerous brush-like macromolecules, exhibits a high affinity for cartilage proteins, and forms a hydrated layer on the cartilage surface. When cartilage friction increases, the surface layer of the cartilage becomes ruptured or damaged, and the cartilage hydration layer is destroyed, subsequently evolving into early OA. In this study, dopamine (DOPA) was coupled with HA to modify it by utilizing the hydrophilicity of HA and the adhesive properties of DOPA. On the one hand, it enhances cartilage lubrication by prolonging the retention time of HA in cartilage and restoring the hydrated layer on the cartilage surface by adhering to the type II collagen network. The successful synthesis of hyaluronic acid−DOPA (HAD) was confirmed by nuclear magnetic resonance (NMR) hydrogen spectroscopy, infrared spectroscopy, and ultraviolet (UV) absorption spectroscopy. The morphology and hydrophilicity of HAD were demonstrated using atomic force microscopy (AFM) and contact angle measurements. Additionally, the interaction of HAD with cartilage matrix proteins was verified through confocal microscopy imaging, while the biocompatibility and feasibility of injection of HAD were confirmed by cellular and animal experiments. On the other hand, the effect of protecting and even regenerating cartilage was achieved by remodeling the cartilage microenvironment. The cartilage protection and even regeneration ability of HAD was confirmed by injecting HAD at different times after OA modeling and characterizing the joints in sections.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 17","pages":" 4816-4829"},"PeriodicalIF":5.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalization of rare-earth nanoparticles with hybrid silica-lipid shells for T-cell labeling 具有杂化硅脂壳的稀土纳米粒子功能化用于t细胞标记。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-22 DOI: 10.1039/D5BM00561B

Swati Kataria and Angela M. Belcher

{"title":"Functionalization of rare-earth nanoparticles with hybrid silica-lipid shells for T-cell labeling","authors":"Swati Kataria and Angela M. Belcher","doi":"10.1039/D5BM00561B","DOIUrl":"10.1039/D5BM00561B","url":null,"abstract":"Lanthanide-doped nanophosphors are an emergent class of optical materials very attractive for biological imaging as they offer deep tissue penetration lengths, high contrast and minimal autofluorescence. An exciting and relatively unexplored application of these nanoparticles is the ability to label and track immune cell populations non-invasively. However, biological application of these nanoparticles is often limited by the challenges in surface functionalization of these nanocrystals. In this study, we engineer methods to functionalize NaYF4 (Yb, Er) nanoparticles with hybrid silica-lipid shells and demonstrate successful and stable labelling of immune cells (T-lymphocytes) for the formation of near-infrared fluorescent immune cells. We use super-resolution microscopy to characterize cell labeling at nanoscale resolution and show individual nanoparticles bound or internalized to T-cells. These surface medication methods are modular and customizable to enable targeting to a variety of cell types, with the potential for broad applications in a variety of disease phenomena such as non-invasive visualization of cell-based therapies.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 5134-5144"},"PeriodicalIF":5.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12326241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of structural modifications in synthetic vectors of lipid adjuvants on mRNA vaccine delivery 脂质佐剂合成载体结构修饰对mRNA疫苗递送的影响

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-21 DOI: 10.1039/D5BM00839E

Shruthilaya Chilumula, Pallavi Hanchate, Srilakshmi V. Patri and Srujan Marepally

{"title":"Influence of structural modifications in synthetic vectors of lipid adjuvants on mRNA vaccine delivery","authors":"Shruthilaya Chilumula, Pallavi Hanchate, Srilakshmi V. Patri and Srujan Marepally","doi":"10.1039/D5BM00839E","DOIUrl":"10.1039/D5BM00839E","url":null,"abstract":"Lipid adjuvants act as a fundamental element in mRNA vaccine technology by performing as diverse functional parts: augmenting immune responses, assisting genetic payload delivery to target cells, and optimizing antigen presentation. They offer various advantages, such as particle stabilization, targeted delivery, refined endosomal escape mechanisms, and self-adjuvant characteristics that amplify immune activation. The lipid adjuvant structure is crucial for both maximizing delivery accuracy and unlocking tunable immune responses, positioning lipid adjuvants as critical components of next-generation vaccines. Understanding the structural alterations of the lipid adjuvants is necessary for the rational design and synthesis of next-generation novel lipid adjuvants that elicit superior immune responses in mRNA vaccines. To magnify the potency and safety of lipid adjuvants, researchers are investigating the fundamental aspects of designing an innovative lipid that leverages biodegradable linkages. This strategy emphasizes the critical roles of numerous lipids, such as ionizable/cationic lipids, helper lipids, phospholipids, and PEGylated lipids, for enhancing the stability, targeting precision, and immunogenic efficacy of mRNA vaccine delivery. Moreover, it elucidates the structural changes of recently developed cationic/ionizable lipid adjuvants, highlighting how their structure impacts vaccine efficacy, especially linkers. By leveraging these advancements, researchers are exploring the potential for highly effective and targeted mRNA vaccine platforms, paving the way for next-generation immunization strategies.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 18","pages":" 4952-4969"},"PeriodicalIF":5.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00839e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance† 利用优化机械性能的Ta@Ca-Alg微球进行图像引导栓塞。

IF 5.7 3区医学

Biomaterials Science Pub Date : 2025-07-21 DOI: 10.1039/D5BM00797F

Peng Chen, Shaphan Jernigan, Keren Zhao, George Varghese P J, Mitesha Saha, Charles Kim, Amirhossein Arzani, Gregory Buckner and Jingjie Hu

{"title":"Image-guided embolization using Ta@Ca-Alg microspheres with optimized mechanical performance†","authors":"Peng Chen, Shaphan Jernigan, Keren Zhao, George Varghese P J, Mitesha Saha, Charles Kim, Amirhossein Arzani, Gregory Buckner and Jingjie Hu","doi":"10.1039/D5BM00797F","DOIUrl":"10.1039/D5BM00797F","url":null,"abstract":"Transcatheter arterial embolization (TAE) is a minimally invasive technique used to treat hypervascular tumors, hemorrhage, and vascular abnormalities. Though microspheres (MSs) have achieved widespread clinical use as embolic agents, they often lack imaging opacity, optimal morphology and mechanical properties which can lead to unpredictable trajectories, non-target delivery, and suboptimal embolization. This study developed tantalum-loaded calcium alginate (Ta@Ca-Alg) MSs with intrinsic radiopacity, tunable density, and mechanical properties. Ta@Ca-Alg MSs were synthesized using a gas-shearing method and analyzed for size, morphology, swelling behavior, density, radiopacity, and optimized mechanical properties. The results demonstrated that Ta@Ca-Alg MSs maintained a narrow size distribution, with increasing Ta concentration enhancing radiopacity to levels comparable with the clinical contrast agent OMNIPAQUE 350. Density and Young's modulus corresponding to different Ta concentrations were also investigated. Phantom model testing validated effective vessel occlusion and controlled penetration. In vitro hemocompatibility, sterility, and cytotoxicity studies confirmed excellent biocompatibility. These findings suggest that Ta@Ca-Alg MSs are a promising radiopaque embolic agent with optimized radiopacity, density, and mechanical properties, offering excellent potential for TAE procedures.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 17","pages":" 4786-4802"},"PeriodicalIF":5.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0