Biomaterials Science最新文献_第9页

Pyroptosis-preconditioned mesenchymal stromal cell-derived extracellular vesicles as advanced nanomedicines for treating inflammatory diseases† 热疗预处理间充质基质细胞衍生的细胞外囊泡作为治疗炎性疾病的先进纳米药物。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-27 DOI: 10.1039/D4BM01505C

Qianyi Wu, Shuyun Liu, Meng Zhao, Yizhuo Wang, Ke Lv, Jiaying Zhu and Jingping Liu

{"title":"Pyroptosis-preconditioned mesenchymal stromal cell-derived extracellular vesicles as advanced nanomedicines for treating inflammatory diseases†","authors":"Qianyi Wu, Shuyun Liu, Meng Zhao, Yizhuo Wang, Ke Lv, Jiaying Zhu and Jingping Liu","doi":"10.1039/D4BM01505C","DOIUrl":"10.1039/D4BM01505C","url":null,"abstract":"Uncontrolled inflammation is one of the major causes of various forms of tissue injury, and nanomedicines with immunoregulatory effects are needed. Mesenchymal stromal cell-derived extracellular vesicles (e.g., MSC-EVs) have been proposed as promising therapies, but the highly efficient generation of EVs with desirable properties is still a considerable challenge in this field. Here, we report that preconditioning MSCs with a critical immune process (pyroptosis) is a robust method for improving both the yield and anti-inflammatory potency of MSC-EVs. In brief, pyroptosis-preconditioned MSCs using a combined lipopolysaccharide (LPS) and adenosine triphosphate (ATP) stimulation showed elevated EV yields compared with those of MSCs cultured under normal conditions. Pyroptosis preconditioning upregulated multiple pathways (e.g., cell proliferation, DNA repair, and the immune response) in MSCs, leading to the enrichment of immunoregulatory cargos (e.g., PD-L2 and STC2) in MSC-EVs. In vitro, pyroptosis-preconditioned MSC-EVs (P-EVs) treatment has greater potential to suppress cytokine expression and cell death in pyroptotic macrophages than treatment with normal MSC-EVs (N-EVs). Compared with N-EV treatment, P-EV treatment showed superior potency in attenuating proinflammatory cell infiltration, cytokine/chemokine expression, resident tissue cell death, and the severity of pathological injury in different models of inflammatory diseases (acute lung or kidney injury), and these effects are likely the joint result of diverse functional cargos delivered by such EVs. This study highlights that pyroptosis preconditioning is a promising strategy for the highly efficient production of MSC-EVs with advanced therapeutic potential for treating diverse inflammatory diseases.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 10","pages":" 2690-2703"},"PeriodicalIF":5.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-27 DOI: 10.1039/D5BM00093A

Zhen Wang, Zhen Zhang, Chaoliang He and Quan Wang

{"title":"Advances in the application of hydrogel adhesives for wound closure and repair in abdominal digestive organs","authors":"Zhen Wang, Zhen Zhang, Chaoliang He and Quan Wang","doi":"10.1039/D5BM00093A","DOIUrl":"https://doi.org/10.1039/D5BM00093A","url":null,"abstract":"The abdominal cavity houses the majority of the digestive system organs, which frequently suffer from diseases with limited responsiveness to pharmacological treatments, such as bleeding, perforation, cancer, and mechanical obstruction. Invasive procedures, including endoscopy and surgery, are typically employed to manage these conditions. Currently, sutures and staplers remain the gold standard for internal wound closure. However, these methods inevitably cause secondary tissue damage. Unlike superficial organs such as the skin, the abdominal cavity presents a relatively confined environment where postoperative complications tend to be more severe. To achieve wound closure and repair, hydrogel adhesives have garnered attention due to their minimal invasiveness, robust sealing, and ease of application. Nonetheless, the application of hydrogel adhesives within the abdominal cavity faces several challenges, including adhesion in moist environments, selective adhesion, and resistance to acids and digestive enzymes. To date, there has been no comprehensive review focused on the use of hydrogel adhesives for wound closure in abdominal digestive organs. This review introduces the design principles of hydrogel adhesives tailored for abdominal organs and provides a detailed overview of recent advances in their applications for esophageal endoscopic submucosal dissection, gastric perforation, hepatic bleeding, pancreatic leakage, and intestinal anastomotic leakage. Additionally, the current challenges and future directions of hydrogel adhesives are discussed. This review aims to provide valuable insights for the development of next-generation hydrogel adhesives for wound closure and repair in abdominal digestive organs.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 10","pages":" 2606-2627"},"PeriodicalIF":5.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression† 天然产品集成微针贴片抗炎和抑制血管生成治疗类风湿性关节炎。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-27 DOI: 10.1039/D5BM00036J

Peng Hua, Suleixin Yang, Lin Yu, Yongzhuo Huang and Meiwan Chen

{"title":"Natural product-integrated microneedle patch for rheumatoid arthritis treatment through anti-inflammation and angiogenesis suppression†","authors":"Peng Hua, Suleixin Yang, Lin Yu, Yongzhuo Huang and Meiwan Chen","doi":"10.1039/D5BM00036J","DOIUrl":"10.1039/D5BM00036J","url":null,"abstract":"Synovitis and angiogenesis are two essential pathological factors that synergistically aggravate rheumatoid arthritis (RA), in which the highly inflammatory environment promotes new blood vessel formation while constant angiogenesis renders recruitment of more inflammatory macrophages. Herein, we developed a micelle-embedded dissolvable microneedle to realize both anti-inflammation and anti-angiogenesis effects for enhanced anti-arthritis therapy. Anti-arthritis natural products, berberine (Ber) and sinomenine (Sin), were encapsulated in the reactive oxygen species (ROS)-responsive micelles (B/S-TMs) and self-assembled using thioketal-modified amphiphilic copolymer PLGA-TK-PEG, followed by their integration into a carboxymethyl cellulose-based microneedle to achieve effective transdermal delivery and rapid cargo release. B/S-TMs were accumulated in the RA joint via passive targeting, and they released Ber and Sin through thioketal bond cleavage under a high ROS level environment. Interestingly, Ber or Sin individually exerted anti-inflammatory effect via simultaneously promoting M2 macrophage polarization and anti-angiogenesis effect by decreasing the endothelial cell migration and tube formation. The combined Ber and Sin further amplified these effects. The therapeutic microneedle patch (B/S-TM@MN) significantly decreased the expression of CD68-positive macrophages and CD31-stained blood vessel, attaining improved anti-arthritis efficacy compared with monotherapies in the collagen-induced arthritis (CIA) mouse model. Our work represents a promising strategy for targeting multiple pathological factors for enhanced anti-RA therapy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 9","pages":" 2462-2474"},"PeriodicalIF":5.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00036j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicine 利用纳米粒子和生物正交化学提高核医学精度。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-26 DOI: 10.1039/D4BM01387E

Gayathri R. Ediriweera, Mengdie Li, Nicholas L. Fletcher, Zachary H. Houston, Muneer Ahamed, Idriss Blakey and Kristofer J. Thurecht

{"title":"Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicine","authors":"Gayathri R. Ediriweera, Mengdie Li, Nicholas L. Fletcher, Zachary H. Houston, Muneer Ahamed, Idriss Blakey and Kristofer J. Thurecht","doi":"10.1039/D4BM01387E","DOIUrl":"10.1039/D4BM01387E","url":null,"abstract":"The convergence of nanotechnology, radiopharmaceutical development and molecular imaging has unveiled exciting opportunities for the progress of innovative diagnostic and therapeutic strategies, paving the way for significant advancements in biomedical research, especially in relation to cancer. For example, the use of highly sensitive and quantitative nuclear imaging techniques including PET and SPECT, together with nanoparticles for tumour imaging and therapy has recently expanded rapidly. While the long circulating properties of many nanomaterials are beneficial for prodrug chemotherapy formulations, due to the constant decay processes involved in nuclear medicines, directly labelled materials result in prolonged systemic radiation exposure and reduced therapeutic indices due to the unfavourable target-to-background ratios. This is due to the tendency for long circulating nanomaterials to distribute within the blood to other organs, such as the liver and spleen. The recent integration of bioorthogonal chemistry with nanotechnology and molecular imaging/radiotherapy has revolutionized the field by allowing the decoupling of the targeting molecule (i.e. nanomaterial with a bioorthogonal tag) and the imaging/therapeutic radioisotope. In this way, the detection/therapeutic element can be administered as a secondary “chase” molecule that contains the bioorthogonal partner, thereby creating an avenue to improve therapeutic index and provide imaging and treatments with reduced risk. This review will provide an overview of the progress made thus far in the field of nuclear imaging and radiotherapy for cancer using the combination of nanomaterials and bioorthogonal chemistry. We also provide a critical evaluation of the challenges and opportunities for using these approaches to better understand disease and treatment mechanisms, with the potential for downstream clinical translation.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 9","pages":" 2297-2319"},"PeriodicalIF":5.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity† 通过调整纳米粒子核心疏水性来控制刺激敏感性。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-26 DOI: 10.1039/D5BM00163C

Xiao Zhang, Bowen Zhao, Shiwei Fu, Ronald S. Seruya, Hannah E. Fanos, Ashley A. Petrisor, Yilin Liu, Zixin Yang and Fuwu Zhang

引用次数: 0

GalNAc-functionalized metal–organic frameworks for targeted siRNA delivery: enhancing survivin silencing in hepatocellular carcinoma† 靶向siRNA递送的galnac功能化金属有机框架：增强肝细胞癌的survivin沉默。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-26 DOI: 10.1039/D5BM00363F

Xiuyan Wan, Yingli Ge, Wanqi Zhu, Jie Zhang, Wei Pan, Na Li and Bo Tang

{"title":"GalNAc-functionalized metal–organic frameworks for targeted siRNA delivery: enhancing survivin silencing in hepatocellular carcinoma†","authors":"Xiuyan Wan, Yingli Ge, Wanqi Zhu, Jie Zhang, Wei Pan, Na Li and Bo Tang","doi":"10.1039/D5BM00363F","DOIUrl":"10.1039/D5BM00363F","url":null,"abstract":"Small interfering RNA (siRNA) is a potent method for silencing survivin mRNA within cells, offering a promising option for treating hepatocellular carcinoma (HCC) since survivin is specifically overexpressed in HCC cells. However, the clinical use of gene therapy with siRNA is limited by factors such as rapid enzyme degradation, low cell uptake, and non-specific distribution in the body. In this study, we investigate the use of a specially selected metal–organic framework (MOF) to encapsulate siRNA, with the aim of silencing survivin mRNA in HCC cells and reducing the survivin protein level. The MOF was functionalized with triantennary N-acetylgalactosamine (GalNAc), which has high affinity for asialoglycoprotein receptors that are overexpressed in HCC cells. Both in vitro and in vivo experiments showed that the GalNAc-decorated MOF specifically accumulated in HCC tumor tissue and was effectively endocytosed by HCC cells. The protective properties of the MOF increased the stability of siRNA and allowed for significant downregulation of survivin expression in HCC tumors, contributing to tumor inhibition through the suppression of cell proliferation and the induction of apoptosis. These findings highlight the potential of MOF-based siRNA delivery systems for targeted cancer therapy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 10","pages":" 2704-2712"},"PeriodicalIF":5.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A light-activated Fe2+ release nanosystem for enhanced chemodynamic/chemo therapy via cascade amplification of ROS generation† 一种光激活Fe2+释放纳米系统，通过级联扩增ROS生成来增强化学动力学/化疗。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-26 DOI: 10.1039/D4BM01425A

Wei Guo, Min Wang, Xisha Chen, Mei Wang and Yingcai Meng

{"title":"A light-activated Fe2+ release nanosystem for enhanced chemodynamic/chemo therapy via cascade amplification of ROS generation†","authors":"Wei Guo, Min Wang, Xisha Chen, Mei Wang and Yingcai Meng","doi":"10.1039/D4BM01425A","DOIUrl":"10.1039/D4BM01425A","url":null,"abstract":"Ferrous iron (Fe2+)-based chemodynamic therapy (CDT) shows great potential for improving chemotherapeutic efficacy and reducing side effects. However, spontaneous oxidation and biological matrixes can influence the catalytic reactive oxygen species (ROS) generation of Fe2+, thereby limiting the efficacy of CDT. Herein, we reported a simple and convenient method to construct hyaluronic acid (HA)-stabilized iron/zinc oxide nanoparticles (IZ@H NPs), which showed intrinsic peroxidase (POD)-like activity and excellent light-activated Fe2+ release performance. Moreover, we demonstrate that catalytic ROS generation follows a cascade amplification manner due to the light-activated release of Fe2+ from IZ@H NPs, leading to formation of iron-DNA complexes (IDCs). After loading doxorubicin (DOX), the nanosystem (termed IZD@H NPs) exhibits tumor cell targeting, robust ROS generation and high cytotoxicity, significantly suppressing tumor growth in xenograft mouse models while maintaining good biosafety. This work gives novel insight into amplifying Fe2+-mediated catalytic ROS generation and presents a new strategy for in vivo Fe2+ delivery to enhance chemodynamic/chemotherapy.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 10","pages":" 2713-2727"},"PeriodicalIF":5.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium-vacancy-mediated NiCoSe nanoplatforms with NIR-II amplified nanozymes for methicillin-resistant Staphylococcus aureus-infected pneumonia† 含NIR-II扩增纳米酶的硒空位介导的NiCoSe纳米平台用于耐甲氧西林金黄色葡萄球菌感染的肺炎

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-25 DOI: 10.1039/D5BM00188A

Liqin Wu, Lida Jin, Xintong Zou, Xiaojun He, Yuanrong Dai and Jianan Huang

{"title":"Selenium-vacancy-mediated NiCoSe nanoplatforms with NIR-II amplified nanozymes for methicillin-resistant Staphylococcus aureus-infected pneumonia†","authors":"Liqin Wu, Lida Jin, Xintong Zou, Xiaojun He, Yuanrong Dai and Jianan Huang","doi":"10.1039/D5BM00188A","DOIUrl":"10.1039/D5BM00188A","url":null,"abstract":"The clinical management of bacterial pneumonia (BP) induced by multidrug-resistant (MDR) pathogens poses substantial therapeutic challenges, necessitating urgent development of novel antibacterial agents and treatment paradigms, particularly those targeting deep-tissue biofilms. While reactive oxygen species (ROS)-mediated nanozyme-catalyzed therapy represents a promising therapeutic strategy, its effectiveness remains limited by the suboptimal nanozyme biocatalytic efficiency and restricted therapeutic efficacy of monomodal approaches. To address these challenges, we engineered selenium vacancy-enriched nickel–cobalt selenide (NiCoSe) nanoplatforms demonstrating dual functional capabilities: exceptional biocatalytic performance and superior photothermal conversion efficiency within the second near-infrared window (NIR-II). Systematic evaluations revealed that the NiCoSe platform facilitates robust ROS generation, achieving potent bactericidal effects while synergistically accelerating biofilm eradication through NIR-II photothermal activation. This combined therapeutic modality establishes NiCoSe as a promising candidate for anti-infective treatment of MDR-BP. Our findings not only present an innovative strategy for combating deep-seated bacterial infections but also advance the translational potential of nanozyme-based therapeutics in clinical nanomedicine.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 11","pages":" 2994-3005"},"PeriodicalIF":5.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acid responsive molybdenum (Mo)-based nanoparticles inhibit the cGAS-STING signaling pathway for sepsis therapy† 酸反应性钼纳米颗粒抑制cGAS-STING信号通路用于败血症治疗。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-25 DOI: 10.1039/D5BM00007F

Xinyu Wang, Qingbin He, Lining Wang, Chengzhilin Li, Wenyu Zhang, Zhonghou Rong, Qingqing Yin and Yingchun Zhao

{"title":"Acid responsive molybdenum (Mo)-based nanoparticles inhibit the cGAS-STING signaling pathway for sepsis therapy†","authors":"Xinyu Wang, Qingbin He, Lining Wang, Chengzhilin Li, Wenyu Zhang, Zhonghou Rong, Qingqing Yin and Yingchun Zhao","doi":"10.1039/D5BM00007F","DOIUrl":"10.1039/D5BM00007F","url":null,"abstract":"Sepsis, an inflammatory disease caused by bacterial infection, has become a global public health crisis. Excessive reactive oxygen species (ROS) in sepsis patients act as the primary trigger for activating intracellular immune pathways, ultimately leading to multiple organ dysfunction syndrome. The overexpression of acidic metabolites and ROS, characteristic of the infected microenvironment, significantly impedes sepsis treatment. Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, plays a key role in inflammatory diseases. The detrimental effects of STING in sepsis have been well documented. Here, we developed a pH-responsive nanotherapy platform (DMSNM@C-178/PAA) that combines ROS scavenging with cGAS-STING pathway inhibition for anti-inflammatory therapy. This nanoparticle is selectively released in the infected microenvironment, where reduced molybdenum-based polyoxometalates (Mo-POM) efficiently neutralize toxic ROS in vivo, while C-178 selectively inhibits the cGAS-STING pathway, thereby attenuating the inflammatory response and preventing organ deterioration. In vitro and in vivo studies demonstrate that DMSNM@C-178/PAA treats sepsis by eliminating excess ROS and modulating autoimmune dysfunction via the cGAS-STING pathway, providing a novel therapeutic strategy for sepsis management.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 9","pages":" 2410-2421"},"PeriodicalIF":5.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional biomimetic liposomal nucleic acid scavengers inhibit the growth and metastasis of breast cancer† 多功能仿生脂质体核酸清除剂抑制乳腺癌的生长和转移。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2025-03-24 DOI: 10.1039/D4BM01721H

Yuhang Miao, Kaizhen Wang, Xin Liu, Xin Wang, Yanwei Hu, Zhenwei Yuan and Dawei Deng

{"title":"Multifunctional biomimetic liposomal nucleic acid scavengers inhibit the growth and metastasis of breast cancer†","authors":"Yuhang Miao, Kaizhen Wang, Xin Liu, Xin Wang, Yanwei Hu, Zhenwei Yuan and Dawei Deng","doi":"10.1039/D4BM01721H","DOIUrl":"10.1039/D4BM01721H","url":null,"abstract":"Chemotherapy and surgery, though effective in cancer treatment, trigger the release of nucleic acid-containing pro-inflammatory compounds from damaged tumor cells, known as nucleic acid-associated damage-associated molecular patterns (NA-DAMPs). This inflammation promotes tumor metastasis, and currently, no effective treatment exists for this treatment-induced inflammation and subsequent tumor metastasis. To address this challenge, we developed a biomimetic liposome complex (Lipo-Rh2) incorporating a hybrid structure of liposomes and dendritic polymers, mimicking cell membrane morphology. Lipo-Rh2 leverages the multivalent surface properties of dendritic polymers to clear cell-free nucleic acids while serving as both a structural stabilizer and targeting ligand via embedded ginsenoside Rh2. Experimental data show that Lipo-Rh2 effectively reduces free nucleic acids in mouse serum through charge interactions, downregulates Toll-like receptor expression, decreases inflammatory cytokine secretion, and inhibits both primary tumor growth and metastasis. Compared to the current nucleic acid scavenger PAMAM-G3, Lipo-Rh2 demonstrates stronger antitumor effects, lower toxicity, and enhanced targeting capabilities. This biomimetic liposome-based nucleic acid scavenger represents a novel approach to nucleic acid clearance, expanding the framework for designing effective therapeutic agents.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 9","pages":" 2475-2488"},"PeriodicalIF":5.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0