Biomaterials Science最新文献_第7页

Development of ZmT-PEG hydrogels through Michael addition reaction and protein self-assembly for 3D cell culture 通过迈克尔加成反应和蛋白质自组装技术开发用于三维细胞培养的 ZmT-PEG 水凝胶。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-09 DOI: 10.1039/D4BM00643G

Yunhui Fu, Yiwen Zhou, Yiying Chen, Zhedan Zhang, Chen Zhang, Changping Deng, Xikui Tong, Wenyun Zheng, Meiyan Wang and Xingyuan Ma

{"title":"Development of ZmT-PEG hydrogels through Michael addition reaction and protein self-assembly for 3D cell culture","authors":"Yunhui Fu, Yiwen Zhou, Yiying Chen, Zhedan Zhang, Chen Zhang, Changping Deng, Xikui Tong, Wenyun Zheng, Meiyan Wang and Xingyuan Ma","doi":"10.1039/D4BM00643G","DOIUrl":"10.1039/D4BM00643G","url":null,"abstract":"Bioactive protein-derived hydrogels are highly attractive three-dimensional (3D) platforms for in vitro cell culture. However, most protein and polypeptide hydrogels are extracted from animal tissues or chemically synthesized, with many drawbacks. Herein, we fabricated an optically transparent ZmT-PEG hydrogel via a facile one-pot strategy. The modified Z1Z2 (Zm) was obtained by introducing cysteine at the C-terminus of Z1Z2 (ZC) and inserting the RGD sequence into the low conserved (CD) loop (ZR). A Michael addition reaction occurred between Zm and 4-arm PEG-MAL, and Zm-PEG self-assembled with truncated Telethonin (Tm) to form the hydrogel. We expressed the Zm and Tm proteins in Escherichia coli. CD spectroscopy showed that genetic modification and the reaction with 4-arm PEG-MAL had no effect on the secondary structure of the Zm protein. When Zm was at 10 wt% and the ratio of Zm : 4-arm PEG-MAL : Tm was 2 : 1 : 1, the gelation time was 6–8 hours. SEM results revealed that the hydrogels had an interconnected porous structure with pore diameters of 20–150 μm. Cell experiments showed that MCF-7 cells could grow and proliferate significantly on the hydrogel after 7 days of culture. Immunofluorescence results suggested that MCF-7 cells on the ZmT hydrogel had a spherical structure similar to that on Matrigel. These results indicate that the ZmT-PEG hydrogel can be used for cell culture in vitro and is promising for large-scale production.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5803-5811"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting† 从小鼠背真皮中提取生物活性添加剂，用于增强三维生物打印中的血管形成。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-08 DOI: 10.1039/D4BM00957F

Yu Feng, Linhao Hou, Chao Zhang, Liting Liang, Qinghua Liu, Zhao Li, Wei Song, Yi Kong, Yaxin Tan, Yuyan Huang, Xu Guo, Mengde Zhang, Yuzhen Wang, Jinpeng Du and Sha Huang

{"title":"Bioactive additives from the dorsal dermis of mice for enhanced vascularization in 3D bioprinting†","authors":"Yu Feng, Linhao Hou, Chao Zhang, Liting Liang, Qinghua Liu, Zhao Li, Wei Song, Yi Kong, Yaxin Tan, Yuyan Huang, Xu Guo, Mengde Zhang, Yuzhen Wang, Jinpeng Du and Sha Huang","doi":"10.1039/D4BM00957F","DOIUrl":"10.1039/D4BM00957F","url":null,"abstract":"Effective angiogenesis is essential for creating complex vascular networks in tissue engineering; however, there is a scarcity of safe and potent pro-angiogenic factors. Although a decellularized extracellular matrix (dECM) offers excellent biocompatibility and is widely used in tissue engineering as a pro-angiogenic additive, its conventional extraction technique resulting in significant loss of bioactivity limits clinical potential. The dorsal dermal tissue has rich blood perfusion and its dECM is rich in angiogenic factors. In this study, the dECM components from the dorsal dermis of mice (DD) were produced to enhance in vitro and in vivo pro-angiogenic abilities using a novel physical method. Morphological studies showed no significant difference between DD-wild-type (DD-wt) and DD-wild-type-newborn (DD-wtn), and there was also no difference in DNA or RNA concentration. In addition, DD-wtn outperformed DD-wt in maintaining the stemness of MSCs, promoting inflammatory response and facilitating endothelial cell differentiation. It is of greater significance to note that the dermal combined fibrous capsule thickness is greater in the DD-wt treated group than in the DD-wtn group. Furthermore, the number of blood vessels in the subcutaneously implanted scaffold with DD-wtn increased by 233%. Consequently, our current finding provides a promising strategy to produce a novel pro-angiogenic bioink additive for enhancing vascularization in 3D bioprinting.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 23","pages":" 6019-6032"},"PeriodicalIF":5.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermosensitive hydrogel doped with osteoconductive fillers for the treatment of periodontitis periapicalis chronica: from synthesis to clinical trial 掺入骨传导填料的热敏水凝胶用于治疗慢性根尖周炎：从合成到临床试验。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-08 DOI: 10.1039/D4BM00927D

Monika Dobrzyńska-Mizera, Monika Knitter, Marta Kamińska, Daria Szymanowska, Anna Sobczyk-Guzenda, Sylwia Różańska, Jacek Różański, Michał Mikulski, Małgorzata Muzalewska, Marek Wyleżoł, Małgorzata Smuga-Kogut, Zofia Modrzejewska and Maria Laura Di Lorenzo

{"title":"Thermosensitive hydrogel doped with osteoconductive fillers for the treatment of periodontitis periapicalis chronica: from synthesis to clinical trial","authors":"Monika Dobrzyńska-Mizera, Monika Knitter, Marta Kamińska, Daria Szymanowska, Anna Sobczyk-Guzenda, Sylwia Różańska, Jacek Różański, Michał Mikulski, Małgorzata Muzalewska, Marek Wyleżoł, Małgorzata Smuga-Kogut, Zofia Modrzejewska and Maria Laura Di Lorenzo","doi":"10.1039/D4BM00927D","DOIUrl":"10.1039/D4BM00927D","url":null,"abstract":"Herein, a chitosan-based thermosensitive hydrogel (CH) containing hydroxyapatite (HAp), poly(lactic acid) (PLDLLA) or their mixture is proposed as an innovative, biomimetic composition with antimicrobial and bone-forming properties for guided bone regeneration. The modified hydrogels were synthesized and characterized to verify their suitability for the treatment of periodontitis periapicalis chronica. Compared to the unmodified hydrogel, both CH_HAp and CH_PLDLLA revealed improved mechanical properties, as evidenced by rotational rheology. FTIR analysis proved that no chemical interplay existed between the components. All the tested samples displayed no cytotoxicity against osteoblast-like cell culture and confirmed antimicrobial features, both crucial from an application perspective. Radiation sterilization dosage was tailored for the tested samples to maintain sterility for a minimum of 8 weeks of storage and limit crosslinking of the samples. Finally, the hydrogel was used in a clinical trial to treat a patient with chronic inflammation of periapical tissues in teeth 26 and 27. The medical procedure proved the safety, nontoxicity, non-allergenicity, and, most importantly, bone-forming properties of the hydrogel formulation. The kinetics of new bone formation was analyzed in-depth using graphical cross-sections of anatomical structures obtained from pre- and post-operative CBCT scans.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 23","pages":" 6063-6081"},"PeriodicalIF":5.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting nanocarrier permeation across the human intestine in vitro: model matters† 预测纳米载体在体外通过人体肠道的渗透性：模型很重要。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-08 DOI: 10.1039/D4BM01092B

Nathalie Jung, Jonas Schreiner, Florentin Baur, Sarah Vogel-Kindgen and Maike Windbergs

{"title":"Predicting nanocarrier permeation across the human intestine in vitro: model matters†","authors":"Nathalie Jung, Jonas Schreiner, Florentin Baur, Sarah Vogel-Kindgen and Maike Windbergs","doi":"10.1039/D4BM01092B","DOIUrl":"10.1039/D4BM01092B","url":null,"abstract":"For clinical translation of oral nanocarriers, simulation of the intestinal microenvironment during in vitro testing is crucial to evaluate interactions with the intestinal mucosa. However, studies are often conducted using simplistic cell culture models, overlooking key physiological factors, and potentially leading to an overestimation of nanocarrier permeation. In this study, we systematically investigate different tissue models of the human intestine under static cultivation and dynamic flow conditions and analyze the impact of altered tissue characteristics on nanocarrier permeation. Our results reveal that the selection of cell types as well as the respective culture condition have a notable impact on the physiological characteristics of the resulting tissues. Tissue layer thickness, mucus secretion, and barrier impairment, all increase with increasing amounts of goblet cells and the application of dynamic flow conditions. Permeation studies with poly(lactic-co-glycolic acid) (PLGA) nanocarriers with and without polyethylene glycol (PEG) coating elucidate that the amount of mucus present in the respective model is the limiting factor for the permeation of PLGA nanocarriers, while tissue topography presents the key factor influencing PEG–PLGA nanocarrier permeation. Furthermore, both nanocarriers exhibit diametrically opposite permeation kinetics compared to soluble compounds. In summary, these findings reveal the critical role of the implemented test systems on permeation assessment and emphasize that, in the context of preclinical nanocarrier testing, the choice of in vitro model matters.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5775-5788"},"PeriodicalIF":5.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm01092b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of antithrombotic and antimicrobial ultra-thin structures on a polyethylene terephthalate implant via the surface grafting of heparin brushes† 通过肝素刷表面接枝在聚对苯二甲酸乙二醇酯植入物上构建抗血栓和抗菌超薄结构。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-08 DOI: 10.1039/D4BM00778F

Haobo Zhang, Dingxuan Wang, Lilong Wei, Weihan Wang, Zhaorong Ren, Sayyed Asim Ali Shah, Junying Zhang, Jue Cheng and Feng Gao

{"title":"Construction of antithrombotic and antimicrobial ultra-thin structures on a polyethylene terephthalate implant via the surface grafting of heparin brushes†","authors":"Haobo Zhang, Dingxuan Wang, Lilong Wei, Weihan Wang, Zhaorong Ren, Sayyed Asim Ali Shah, Junying Zhang, Jue Cheng and Feng Gao","doi":"10.1039/D4BM00778F","DOIUrl":"10.1039/D4BM00778F","url":null,"abstract":"It remains a challenge to endow a polymeric material with antithrombotic ability by surface grafting without disturbing the bulk properties of the substrate. Heparin-based functional structures of less than 80 nm were fabricated and covalently grafted on a polyethylene terephthalate surface via carbene chemistry (Hep-g-PET). Heparin was oxidized with the minimum antithrombrin sequence retained, creating an aldehyde group on the chain terminus. Oxidized heparin was then covalently attached to a poly(amidoamine) (PAMAM)-grafted PET substrate. The interface between blood and PET was improved by the surface functionality, and the amount of attached platelets decreased to 29 ± 12.1% of its initial value. The bulk properties of the functionalized film were hardly influenced, and the visible light transmittance remained more than 96%. The tethered structures also showed the ability to kill attached S. aureus and E. coli efficiently. The functionalized membrane showed negligible ex vivo cell cytotoxicity and a low hemolysis ratio. Hep-g-PET was implanted in between rat skin and muscle, and showed an outstanding histological response and antimicrobial ability. The influences of the graft thickness and the heparin chain length were explored. The strategies reported in this work may help to improve the design of polymeric implant bio-devices.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 23","pages":" 6099-6113"},"PeriodicalIF":5.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-functionalized nanoparticles for ulcerative colitis-targeted therapy: a comparative study of oral administration and intravenous injection† 用于溃疡性结肠炎靶向治疗的透明质酸功能化纳米颗粒：口服与静脉注射的比较研究

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-08 DOI: 10.1039/D4BM00898G

Jinhua Liu, Chunhua Yang, Didier Merlin and Bo Xiao

{"title":"Hyaluronic acid-functionalized nanoparticles for ulcerative colitis-targeted therapy: a comparative study of oral administration and intravenous injection†","authors":"Jinhua Liu, Chunhua Yang, Didier Merlin and Bo Xiao","doi":"10.1039/D4BM00898G","DOIUrl":"10.1039/D4BM00898G","url":null,"abstract":"Targeted delivery of anti-inflammatory drugs to macrophages has attracted great attention for selectively alleviating the symptoms of ulcerative colitis (UC), while minimizing adverse effects. Herein, we aimed to compare the in vivo pharmacokinetics and therapeutic outcomes of macrophage-targeted nanoparticles (NPs) via oral administration and intravenous injection. Polymeric NPs were employed to load an anti-inflammatory drug (curcumin, CUR), followed by surface functionalization with hyaluronic acid (HA). The resulting HA-CUR-NPs had an average diameter of 281 nm and a negatively charged surface. These NPs showed excellent biocompatibility and a significantly higher cell internalization efficiency in RAW 264.7 macrophages compared with their counterparts (carboxymethyl cellulose-functionalized CUR-encapsulated NPs, CUL-CUR-NPs). Moreover, HA-CUR-NPs exhibited a dramatically stronger capacity to inhibit the mRNA expression levels of the typical pro-inflammatory cytokines from lipopolysaccharide-stimulated macrophages compared with CUL-CUR-NPs. In vivo experiments revealed that HA-CUR-NPs after i.v. injection could improve the pharmacokinetics of CUR, and that it showed much better UC therapeutic outcomes compared with the oral administration way. Collectively, in comparison with HA-CUR-NPs (oral), HA-CUR-NPs (i.v.) possess a higher CUR delivery efficiency to the colitis mucosa, which can be developed as an efficient platform for UC treatment.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5834-5844"},"PeriodicalIF":5.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ modified mesoporous silica nanoparticles: synthesis, properties and theranostic applications 原位修饰介孔二氧化硅纳米颗粒：合成、特性和治疗应用。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-07 DOI: 10.1039/D4BM00094C

Chloe Trayford and Sabine van Rijt

{"title":"In situ modified mesoporous silica nanoparticles: synthesis, properties and theranostic applications","authors":"Chloe Trayford and Sabine van Rijt","doi":"10.1039/D4BM00094C","DOIUrl":"10.1039/D4BM00094C","url":null,"abstract":"Over the last 20 years, mesoporous silica nanoparticles (MSNs) have drawn considerable attention in the biomedical field due to their large surface area, porous network, biocompatibility, and abundant modification possibilities. In situ MSN modification refers to the incorporation of materials such as alkoxysilanes, ions and nanoparticles (NPs) in the silica matrix during synthesis. Matrix modification is a popular approach for endowing MSNs with additional functionalities such as imaging properties, bioactivity, and degradability, while leaving the mesopores free for drug loading. As such, in situ modified MSNs are considered promising theranostic agents. This review provides an extensive overview of different materials and modification strategies that have been used and their effect on MSN properties. We also highlight how in situ modified MSNs have been applied in theranostic applications, oncology and regenerative medicine. We conclude with perspectives on the future outlooks and current challenges for the widespread clinical use of in situ modified MSNs.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 21","pages":" 5450-5467"},"PeriodicalIF":5.8,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11457002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional nanochaperones for PEGylated insulin delivery in long-term glycemic control† 在长期血糖控制中输送聚乙二醇化胰岛素的功能性纳米伴侣。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-04 DOI: 10.1039/D4BM01163E

Xiaohui Wu, Yanli Zhang, Shuoshuo Song, Sainan Liu, Feihe Ma, Rujiang Ma and Linqi Shi

{"title":"Functional nanochaperones for PEGylated insulin delivery in long-term glycemic control†","authors":"Xiaohui Wu, Yanli Zhang, Shuoshuo Song, Sainan Liu, Feihe Ma, Rujiang Ma and Linqi Shi","doi":"10.1039/D4BM01163E","DOIUrl":"10.1039/D4BM01163E","url":null,"abstract":"PEGylation is a promising strategy for modulating the physicochemical properties and improving the therapeutic efficacy of protein drugs. However, the application of multi-PEGylation frequently results in diminished protein activity. A single low molecular weight PEG (5 kDa) modified at the amino terminus of the B chain preserves the biological activity of insulin and moderately improves its pharmacokinetics. Nonetheless, this modification offers limited protein stabilization. Furthermore, overdoses still carry the risk of hypoglycemia, posing challenges for the clinical application of PEGylated insulin. Here, we constructed multifunctional nanochaperones featuring phenylboronic acid (PBA) modified hydrophobic microdomains and nitrilotriacetic acid (NTA)-based coordination domains (PN-nChaps) for PEGylated insulin delivery. This delivery strategy effectively overcomes the limitations associated with PEGylation by enhancing the stability and reducing the immunogenicity of PEGylated insulin, while enabling glucose-responsive controlled release. PEGylated insulin with nanochaperone carrier demonstrates a prolonged half-life (t1/2 = 18.66 h), facilitates on-demand release, and minimizes the risk of hypoglycemia. This approach provides a safe and effective strategy for long-term glycemic management in diabetic patients.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5742-5752"},"PeriodicalIF":5.8,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loureirin hydrogel promotes healing of radionuclide-contaminated wounds by regulating angiogenesis and immune cells† Loureirin 水凝胶通过调节血管生成和免疫细胞，促进放射性核素污染伤口的愈合。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-03 DOI: 10.1039/D4BM00813H

Zhuojun Wu, Longjiang Xu, Xiaoting Xu, Jun Hou, Wenlin Li, Guibin Luo, Yufan Xu, Qiu Chen and Fengmei Cui

{"title":"Loureirin hydrogel promotes healing of radionuclide-contaminated wounds by regulating angiogenesis and immune cells†","authors":"Zhuojun Wu, Longjiang Xu, Xiaoting Xu, Jun Hou, Wenlin Li, Guibin Luo, Yufan Xu, Qiu Chen and Fengmei Cui","doi":"10.1039/D4BM00813H","DOIUrl":"10.1039/D4BM00813H","url":null,"abstract":"Radionuclide-contaminated wounds face clinical dilemmas such as repeated erosion and ulceration and are difficult to heal. In this work, we aimed to develop a biodegradable hydrogel with a beneficial effect on radionuclide-contaminated wounds and initially investigated the mechanism of action of the hydrogel. The hydrogel was produced through the ring-opening polymerization of polycaprolactone (PCL) triggered by polyethylene glycol (PEG), and its physicochemical properties were characterized by gel permeation chromatography, nuclear magnetic resonance, rheological properties testing, and other techniques. The low critical solution temperatures were 30 °C and 46 °C, which are suitable for the human body to realize the degradable properties of the hydrogel. A radionuclide-contaminated wound model was established, which proved that the biodegradable hydrogel had good healing properties and did not form secondary lesions. The effect was better than clinically used EGF or VB12. Pathological results showed that mature granulation tissue formed on the 7th day after the injury, and by the 10th day after the injury, the scab had completely fallen off, the epithelial coverage had reached over 70% and the wound was essentially completely healed. Additionally, the hydrogel affects immune metabolism, regulates immune cell function, promotes the formation of new blood vessels and granular tissue, and effectively accelerates the healing process of radionuclide-contaminated wounds.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5789-5802"},"PeriodicalIF":5.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyroptosis induced by natural products and their derivatives for cancer therapy 用于癌症治疗的天然产品及其衍生物诱导的火化作用。

IF 5.8 3区医学

Biomaterials Science Pub Date : 2024-10-01 DOI: 10.1039/D4BM01023J

Yingfei Wen, You Li, Bin-bin Li, Peng Liu, Miaojuan Qiu, Zihang Li, Jiaqi Xu, Bo Bi, Shiqiang Zhang, Xinyi Deng, Kaiyuan Liu, Shangbo Zhou, Qiang Wang and Jing Zhao

{"title":"Pyroptosis induced by natural products and their derivatives for cancer therapy","authors":"Yingfei Wen, You Li, Bin-bin Li, Peng Liu, Miaojuan Qiu, Zihang Li, Jiaqi Xu, Bo Bi, Shiqiang Zhang, Xinyi Deng, Kaiyuan Liu, Shangbo Zhou, Qiang Wang and Jing Zhao","doi":"10.1039/D4BM01023J","DOIUrl":"10.1039/D4BM01023J","url":null,"abstract":"Natural products, which are compounds extracted and/or refined from plants and microbes in nature, have great potential for the discovery of therapeutic agents, especially for infectious diseases and cancer. In recent years, natural products have been reported to induce multiple cell death pathways to exhibit antitumor effects. Among them, pyroptosis is a unique programmed cell death (PCD) characterized by continuous cell membrane permeability and intracellular content leakage. According to the canonical and noncanonical pathways, the formation of gasdermin-N pores involves a variety of transcriptional targets and post-translational modifications. Thus, tailored control of PCD may facilitate dying cells with sufficient immunogenicity to activate the immune system to eliminate other tumor cells. Therefore, we summarized the currently reported natural products or their derivatives and their nano-drugs that induce pyroptosis-related signaling pathways. We reviewed six main categories of bioactive compounds extracted from natural products, including flavonoids, terpenoids, polyphenols, quinones, artemisinins, and alkaloids. Correspondingly, the underlying mechanisms of how these compounds and their derivatives engage in pyroptosis are also discussed. Moreover, the synergistic effect of natural bioactive compounds with other antitumor therapies is proposed as a novel therapeutic strategy for traditional chemotherapy, radiotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, hyperthermal therapy, and sonodynamic therapy. Consequently, we provide insights into natural products to develop a novel antitumor therapy or qualified adjuvant agents by inducing pyroptosis, which may eventually be applied clinically.","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5656-5679"},"PeriodicalIF":5.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0