Biomaterials Science最新文献

{"title":"Metal (M = Cr, Mo, W, Re) carbonyl complexes with porphyrin and carborane isocyanide ligands: light-induced oxidation and carbon oxide release for antitumor efficacy†","authors":"Victoria M. Alpatova, Minh Tuan Nguyen, Evgeny G. Rys, Georgy K. Liklikadze, Elena G. Kononova, Alexander F. Smol'yakov, Yuri A. Borisov, Anton E. Egorov, Alexey A. Kostyukov, Anna V. Shibaeva, Ivan D. Burtsev, Alexander S. Peregudov, Vladimir A. Kuzmin, Alexander A. Shtil, Alina A. Markova and Valentina A. Ol'shevskaya","doi":"10.1039/D4BM01293C","DOIUrl":"10.1039/D4BM01293C","url":null,"abstract":"<p >The tetrapyrrolic macrocycle as a scaffold for various chemical modifications provides broad opportunities for the preparation of complex multifunctional conjugates suitable for binary antitumor therapies. Typically, illumination with monochromatic light triggers the photochemical generation of reactive oxygen species (ROS) (photodynamic effect). However, more therapeutically valuable effects can be achieved upon photoactivation of tetrapyrrole derivatives. Herein we report the novel porphyrin-based complexes of transition metals with isocyanide and carbonyl ligands. Synthesis of complexes presumed the use of 5-(<em>p</em>-isocyanophenyl)-10,15,20-triphenylporphyrin as a ligand in reactions with metal carbonyl complexes, M(CO)<small>₆</small> (M = Cr, Mo, W), Re<small>₂</small>(CO)<small>₁₀</small> and Re(CO)<small>₅</small>Cl. Based on these complexes and isocyanocarborane, the heteroleptic carbonyl complexes with porphyrin and carborane isocyanide ligands were prepared. In cell-free systems, the new compounds retained photochemical characteristics of the parental porphyrin derivative, such as triplet state formation and ROS generation, upon light-induced activation. In the cell culture, the carborane-containing derivatives demonstrated a more pronounced intracellular accumulation than their nonboronated counterparts. As expected, illumination at the Soret band (405 nm) of cells loaded with the new complexes caused photodynamic cell damage. In contrast, illumination at 530 nm instead initiated the release of carbon oxide (CO) followed by cell death independently of the photodynamic effect. Light-induced CO release was analyzed using second derivatives of UV-Vis spectra and our originally developed <strong>S</strong>pectrophotometric elimi<strong>NA</strong>tion of <strong>P</strong>hotoinduced <strong>S</strong>ide reactions (SNAPS) method. The yield of CO release decreased in the raw depending on metals in the carbonyl moiety: Mo ≥ Cr &gt; W &gt; Re ≥ Re<small>₂</small>. Overall, our novel metal carbonyl complexes with porphyrin and carborane isocyanide ligands emerge as potent bi-functional conjugates for combined photodynamic and photoinducible CO-releasing antitumor agents.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 711-730"},"PeriodicalIF":5.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive electrospun polylactic acid/chlorogenic acid-modified chitosan bilayer sponge for acute infection wound healing and rapid coagulation†","authors":"Huiling Zhong, Zhen Zhang, Mohong Wang, Yifei Fang, Ke Liu, Junqiang Yin, Jun Wu and Jianhang Du","doi":"10.1039/D4BM01388C","DOIUrl":"10.1039/D4BM01388C","url":null,"abstract":"<p >Acute severe trauma is often associated with rapid blood loss and a high risk of infection. Based on these concerns, this study successfully constructed a multifunctional dual-layer bioactive sponge PCCT with rapid hemostatic and infection-preventing ability. Its external surface is an electrospun poly(lactic acid) (PLA) nanofiber thin film layer, which ensures its high air permeability and effectively protects against external bacterial invasion. <em>In vitro</em> results showed that the film is effectively resistant to invasion by typical Gram-negative (<em>E. coli</em>) and Gram-positive (<em>S. aureus</em>) bacteria. The inner sponge layer was formed by chlorogenic acid (CGA) grafted with chitosan (CS) and loaded with tranexamic acid (TA). The abundant cationic groups on the sponge interacted with negatively charged erythrocytes and achieved rapid hemostasis at the wound site under the action of TA. In addition, the high porosity and bioactivity of the CS-CGA sponge scaffold endowed the hydrogel with good water absorption, antibacterial properties and anti-inflammatory activity, which effectively accelerated the healing of acute infected wounds in rats and demonstrated favorable biosafety.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 697-710"},"PeriodicalIF":5.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A flexible, water anchoring, and colorimetric ionogel for sweat monitoring†","authors":"Hui Zhi, Yingxi Qin, Yang Li, Fengya Wang and Liang Feng","doi":"10.1039/D4BM01482K","DOIUrl":"10.1039/D4BM01482K","url":null,"abstract":"<p >As water-saturated polymer networks, the easy water loss of hydrogels directly affects their end-use applications. Minimizing the ratio of free water and increasing the ratio of bound water in the gel system has become key to extending the service life. In this work, an ionogel is prepared that effectively regulates the proportion of free water and bound water through the formation of wrinkle angles by the hydrophilic and hydrophobic chains in the gel system and the non-volatile nature of the ionic liquid. Acrylamide and <em>N</em>-acryloyl phenylalanine are used as free radical comonomers, and phenol red is used as an acid–base indicator. The ionic liquid is used as a dispersant to stabilize the whole framework. Due to the hydrogen bonding interactions, electrostatic interactions, and ion–ion interactions, the ionogel exhibits good stretchability, adhesion, pH sensitivity, and stability. The ionogel can be stretched in multiple directions without cracking and can be bent 180° after being left in air for 45 days. Assembling the ionogel into a wearable device can effectively monitor the pH value of sweat during exercise. The detection results are displayed in the form of RGB values, providing a preliminary diagnosis of the health of the human body.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 677-687"},"PeriodicalIF":5.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming drug delivery challenges with lipid-based nanofibers for enhanced wound repair.","authors":"Aaqib Javaid, Krishana Kumar Sharma, Prakhar Varshney, Anurag Verma, Shyam Lal Mudavath","doi":"10.1039/d4bm01536c","DOIUrl":"https://doi.org/10.1039/d4bm01536c","url":null,"abstract":"<p><p>Wound healing is a dynamic, multi-phase process that includes haemostasis, tissue regeneration, cellular proliferation, and matrix modification. Traditional wound care procedures frequently encounter complications such as delayed healing and infection, demanding new therapeutic approaches. In this context, nanomaterial-based devices provide considerable benefits due to their capacity to improve medication delivery and tissue healing. We suggest a lipid-based nanofiber formulation for wound treatment that overcomes the restricted skin penetration of hydrophilic niacin, a strong wound healing agent. Niacin-loaded nanofibers (NLNFs) were manufactured utilizing glyceryl monostearate (GMS) by a self-assembly process, which included high-pressure homogenization and probe sonication for optimum nanostructure creation. The NLNFs were physicochemically characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, scanning electron microscopy (SEM) and surface profilometry to determine their morphology and homogeneity, and a drop shape analyser was used to determine hydrophobicity. <i>In vitro</i> tests revealed prolonged drug release, great cytocompatibility, and strong antioxidant activity, indicating superior free radical scavenging capacity. <i>Ex vivo</i> tests, such as the Draize skin irritation test, skin permeation test, and drug retention assays, revealed low skin irritation, increased permeability, and efficient drug retention in skin layers. <i>In vivo</i> experiments showed rapid wound closure and positive histological results, which were backed by hemocompatibility tests such as hemolysis and whole blood clot analysis, validating the formulation's safety. ELISA results indicated that the NLNF-treated group had higher levels of critical wound-healing indicators than the controls. Overall, our findings suggest that NLNFs have tremendous potential as a unique and effective treatment alternative for controlling and improving wound healing processes.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on hydroxyapatite fabrication: from powders to additive manufactured scaffolds","authors":"Ananthika Vijayan, Jithin Vishnu, Revathi A, Balakrishnan Shankar and Sreedha Sambhudevan","doi":"10.1039/D4BM00972J","DOIUrl":"10.1039/D4BM00972J","url":null,"abstract":"<p >Hydroxyapatite (HA), the main inorganic bone component, is the most widely researched bioceramic for bone repair. This paper presents a comprehensive review of recent advancements in HA synthesis methods and their integration into additive manufacturing (AM) processes. Synthesis methodologies discussed include wet, dry, and biomimetic routes, emphasizing their impact on tailoring the physicochemical properties of HA for biomedical applications. The incorporation of dopants and additives during synthesis is explored for optimizing the mechanical, biological, and osteogenic characteristics of HA-based materials. Moreover, the evolution of AM technologies from conventional 3D printing to advanced 4D and 5D printing is detailed, covering material selection, process parameters, and post-processing strategies vital for fabricating intricate, patient-specific scaffolds, implants, and drug delivery systems utilizing HA. The review underscores the importance of achieving precise control over microstructure and porosity to mimic native tissue architectures accurately. Furthermore, emerging applications of HA-based constructs in tissue engineering, regenerative medicine, drug delivery, and orthopedic implants are discussed, highlighting their potential to address critical clinical needs. Despite the glimmer of hope provided by the advent and progress of such AM capabilities, several aspects need to be addressed to develop efficient HA-based bone substitutes, which are explored in detail in this review.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 4","pages":" 913-945"},"PeriodicalIF":5.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulate PD-L1's membrane orientation thermodynamics with hydrophobic nanoparticles†","authors":"Xiaoqian Lin and Xubo Lin","doi":"10.1039/D4BM01469C","DOIUrl":"10.1039/D4BM01469C","url":null,"abstract":"<p >Tumor cells can escape from immune killing by binding their programmed death ligand-1 (PD-L1) to the programmed cell death protein 1 (PD-1) of T cells. These immune checkpoint proteins (PD-L1/PD-1) have become very important drug targets, since blocking PD-L1 or PD-1 can recover the killing capability of T cells against tumor cells. Instead of targeting the binding interface between PD-L1 and PD-1, we explored the possibility of regulating the membrane orientation thermodynamics of PD-L1 with ligand-modified ultra-small hydrophobic nanoparticles (NPs) using μs-scale coarse-grained molecular dynamics (MD) simulations in this work. Our MD results indicate that embedded hydrophobic NPs can significantly change the membrane orientation thermodynamics of the extracellular domain of PD-L1, enhancing the probability in the “stand up” state for better binding to PD-1. Meanwhile, embedded hydrophobic NPs promote the tilt of the transmembrane domain of PD-L1. Besides, effects on both extracellular and transmembrane domains are determined by the ligand length and NP concentration. Our study may provide an alternative strategy to achieve PD-L1-related immunotherapy with nanomedicine.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 826-835"},"PeriodicalIF":5.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect.","authors":"Guadalupe H Luevano-Colmenero, Rosalinda Rocha-Juache, Juan Vargas-Mancilla, Jorge M Flores-Moreno, Francisco J Rojo, Gustavo V Guinea, Birzabith Mendoza-Novelo","doi":"10.1039/d4bm00846d","DOIUrl":"https://doi.org/10.1039/d4bm00846d","url":null,"abstract":"<p><p>Repair of damaged or faulty complex modular organs such as the urinary bladder is a current clinical challenge. The design of constructs for reconstructive urological surgery can draw advantage from the bioactivity of natural extracellular matrix (ECM) bioscaffolds, as well as the activity provided by cells seeded into constructs. Considering these benefits, this work compares the performance of pericardial ECM bioscaffolds and constructs seeded with gel-supported urothelial cells in the repair of urinary bladder defects in rabbits. The bioscaffolds considered in this study are of porcine (pM) and bovine (bM) origin and exhibited a residual composition that confers bioactivity in mesh presentation. Coating an ECM gel on the bioscaffolds promoted the adhesion and viability of urothelial cells. Repairing a full-thickness urinary bladder defect in a rabbit model with the bioscaffolds and constructs resulted in the integration with the host bladder; meanwhile, bladder volumetric capacity was promoted using bM and constructs. Although no contribution of gel/cell seeding to the failure of mechanical properties of the urinary neobladder was observed, this seeding technique is suitable for integration with different strategies to engineer constructs for urinary bladder reconstructive surgery.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Permeation enhancer decorated nanoparticles for oral delivery of insulin: manipulating the surface density of borneol and PEG for absorption barriers†","authors":"Xiaoyu Yang, Jidong Zhang, Jitang Chen, Yunxuan Xie, Tianci Hu, Qin Luo, Tianhao Peng, Han Luo, Linlin Shi, Jiangling Wan, Jianxin Wang, Xiangliang Yang and Jianyong Sheng","doi":"10.1039/D4BM01210K","DOIUrl":"10.1039/D4BM01210K","url":null,"abstract":"<p >Oral protein drugs’ delivery faces challenges due to multiple absorption barriers for macromolecules. Co-administration with permeation enhancers and encapsulation in nano-carriers are two promising strategies to enhance their oral absorption. Herein, the poly(lactic-<em>co</em>-glycolic acid) nanoparticles (PLGA NPs) are decorated with polyethylene glycol (PEG) and a traditional Chinese medicine-derived permeation enhancer borneol (BO) for oral insulin delivery. Compared with a physical mixture of BO and PEG-decorated PLGA NPs, PLGA–PEG–BO NPs significantly facilitate insulin permeation across intestinal epithelia through various transcytosis pathways. The relationship among the BO surface density, physico-chemical properties and multiple barriers penetration ability is further investigated. Increasing the BO density boosts penetration through the epithelial cell layer but reduces enzyme and mucus barrier penetration. When the surface PEG density is at 90% and BO density is at 10%, the NPs possess the strongest overall ability to overcome both the mucus layer barrier and epithelial cell barrier, as illustrated by the highest permeation efficiency through Caco-2/HT29-MTX cell co-cultural monolayers. In diabetic rodents, PLGA–PEG<small>_90%</small>–BO<small>_10%</small> NPs exhibit high intestinal safety and a substantial hypoglycemic effect, with insulin availability at 6.22 ± 2.30%, double that of orally delivered insulin PLGA–PEG NPs and far superior to a physical mixture with BO. This study reveals the importance of tailored absorption enhancer decoration for oral protein delivery.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 3","pages":" 743-757"},"PeriodicalIF":5.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing","authors":"Qinglin Zou, Hongdong Duan, Shimin Fang, Wenlong Sheng, Xiaobin Li, Rostyslav Stoika, Nataliya Finiuk, Rostyslav Panchuk, Kechun Liu and Lizhen Wang","doi":"10.1039/D4BM90099E","DOIUrl":"10.1039/D4BM90099E","url":null,"abstract":"<p >Correction for ‘Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing’ by Qinglin Zou <em>et al.</em>, <em>Biomater. Sci.</em>, 2024, <strong>12</strong>, 2394–2407, https://doi.org/10.1039/d3bm02068a.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 2","pages":" 529-530"},"PeriodicalIF":5.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d4bm90099e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Hybrid cell membranes camouflage liposomes containing payloads to improve breast cancer chemo and photodynamic therapy","authors":"Chengfang Wang and Size Wu","doi":"10.1039/D4BM90100B","DOIUrl":"10.1039/D4BM90100B","url":null,"abstract":"<p >Correction for ‘Hybrid cell membranes camouflage liposomes containing payloads to improve breast cancer chemo and photodynamic therapy’ by Chengfang Wang <em>et al.</em>, <em>Biomater. Sci.</em>, 2024, <strong>12</strong>, 4980–4992, https://doi.org/10.1039/D4BM00772G.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 2","pages":" 528-528"},"PeriodicalIF":5.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d4bm90100b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}