Biomaterials Science最新文献

{"title":"Retraction: PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer","authors":"Yingru Zhang, Chunpu Li, Ru Jia, Ruixuan Gao, Yiyang Zhao, Qing Ji, Jianfeng Cai, Qi Li and Yan Wang","doi":"10.1039/D4BM90078B","DOIUrl":"10.1039/D4BM90078B","url":null,"abstract":"<p >Retraction of ‘PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer’ by Yingru Zhang <em>et al.</em>, <em>Biomater. Sci.</em>, 2021, <strong>9</strong>, 3705–3717, https://doi.org/10.1039/D1BM00160D.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5871-5871"},"PeriodicalIF":5.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm90078b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A novel nano delivery system targeting different stages of osteoclasts","authors":"Bosong Zhang, Juzhi Zhao, Hongji Yan, Yufang Zhao, Hui Tian, Cao Wang, Ruiqi Wang, Jiaming Jin, Yue Chen, Chaofan Yang, Chunfeng LI, Yanwen Jiao, Kaipeng Zheng, Fuxing Zhu and Weiming Tian","doi":"10.1039/D4BM90069C","DOIUrl":"10.1039/D4BM90069C","url":null,"abstract":"<p >Correction for ‘A novel nano delivery system targeting different stages of osteoclasts’ by Bosong Zhang <em>et al.</em>, <em>Biomater. Sci.</em>, 2022, <strong>10</strong>, 1821–1830, https://doi.org/10.1039/D2BM00076H.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5870-5870"},"PeriodicalIF":5.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm90069c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid method to screen biomaterial angiogenesis in vivo using fluorescence imaging in mice†","authors":"Boram Kim, Joseph W. R. Swain, Martha J. Fowler, Claire Y. Yang, Dilrasobonu Vohidona, Jeffrey D. Hartgerink and Omid Veiseh","doi":"10.1039/D4BM00626G","DOIUrl":"10.1039/D4BM00626G","url":null,"abstract":"<p >Effective vascularization is crucial for repairing and enhancing the longevity of engineered tissues and organs. As the field advances, there is a vital need for efficient and reliable methods for assessing vascularization in real-time. The integration and performance of constructed biomaterials in living organisms rely on angiogenesis and vascularization, making it essential to evaluate vascular development and networks within biomaterials. Current histology-based methods are limited and labor-intensive. On the other hand, fluorescence imaging offers promise for efficient, real-time evaluation of angiogenesis, reducing the time needed for screening many compounds and offering a high-throughput alternative to histology-based methods. Here, we investigated a novel, non-invasive method for quick and repeated analysis of the angiogenic and vascularization process in biomaterials <em>via</em> fluorescence IVIS imaging. Multi-domain peptides (MDPs), self-assembling peptide hydrogels that can possess pro-angiogenic properties depending on their primary sequence, were synthesized and utilized as angiogenic biomaterials and screened with a fluorescence IVIS probe to demonstrate real-time rapid angiogenesis <em>in vivo</em>. The fluorescence-based imaging showed the influence of the peptide chemistry, volume, and concentration on angiogenesis, with one particular MDP, SLanc, promoting robust angiogenesis after one week at 2 w/v%. Through this method, we were able to identify the optimal peptide for rapid and sustained angiogenesis. This approach enables real-time monitoring of angiogenic responses and vascularization processes in the same living subject. It promotes the development of new biomaterials that facilitate vascularization and validates an advanced <em>in vivo</em> screening technique for angiogenesis.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5824-5833"},"PeriodicalIF":5.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomes derived from mucoperiosteum Krt14+Ctsk+ cells promote bone regeneration by coupling enhanced osteogenesis and angiogenesis†","authors":"Rong Zhou, Rui Huang, Yue Xu, Dandan Zhang, Li Gu, Yun Su, Xirui Chen, Wodong Shi, Jing Sun, Ping Gu, Ni Ni and Xiaoping Bi","doi":"10.1039/D4BM00673A","DOIUrl":"10.1039/D4BM00673A","url":null,"abstract":"<p >Repair of large bone defects is a sophisticated physiological process involving the meticulous orchestration of cell activation, proliferation, and differentiation. Cellular interactions between different cell types are paramount for successful bone regeneration, making it a challenging yet fascinating area of research and clinical practice. With increasing evidence underscoring the essential role of exosomes in facilitating intercellular and cell–microenvironment communication, they have emerged as an encouraging therapeutic strategy to promote bone repair due to their non-immunogenicity, diverse sources, and potent bioactivity. In this study, we characterized a distinctive population of Krt14<small>⁺</small>Ctsk<small>⁺</small> cells from the orbital mucoperiosteum. <em>In vitro</em> experiments confirmed that exosomes from Krt14<small>⁺</small>Ctsk<small>⁺</small> cells dramatically boosted the capacities of human umbilical vein endothelial cells (HUVECs) to proliferate, migrate, and induce angiogenesis. Additionally, the exosomes notably elevated the expression of osteogenic markers, thereby indicating their potential to augment osteogenic capabilities. Furthermore, <em>in vivo</em> experiments utilizing a rat calvarial defect model verified that exosome-loaded sodium alginate (SA) hydrogels accelerated local vascularized bone regeneration within the defective regions. Collectively, these findings suggest that exosomes secreted by Krt14<small>⁺</small>Ctsk<small>⁺</small> cells offer an innovative method to accelerate bone repair <em>via</em> coupling enhanced osteogenesis and angiogenesis, highlighting the therapeutic potential in bone repair.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5753-5765"},"PeriodicalIF":5.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00673a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142398738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic nanoparticle-facilitated rapid mass production of high affinity polymeric materials (nanoMIPs) for protein recognition and biosensing†","authors":"Subrayal M. Reddy, Andrei N. Stephen, Mark A. Holden, William J. Stockburn and Sarah R. Dennison","doi":"10.1039/D4BM00990H","DOIUrl":"10.1039/D4BM00990H","url":null,"abstract":"<p >Molecularly imprinted polymers (MIPs) have been investigated extensively for broad applications in diagnostics, imaging and therapeutics due to their antibody-like specificity, high stability, and low-cost and rapid production when compared with biological antibodies. Yet, their wide-scale adoption and commercial viability are limited due to low yields and relatively lengthy preparations of current methods. We report the novel application of protein-functionalised magnetic nanoparticles (MNPs) to enable the rapid mass production of nanoMIPs for protein recognition. An aldehyde-functionalised MNP (MNP@CHO) precursor was synthesised using a one-pot microwave method in less than 20 minutes, resulting in 330 mg yield for a 30 mL reaction volume. The MNP@CHO precursor (10 mg) was subsequently functionalised with 600 μg of a target template protein, giving MNP@protein. In the presence of an <em>N</em>-hydroxymethylacrylamide (NHMA) functional monomer and <em>N</em>,<em>N</em>′-methylene bisacrylamide as a crosslinker, the MNP@protein particles served as nucleants for the mass production of nanoMIPs in a 20–30 minute synthesis process. Subsequently, the nanoMIPs could be harvested with sonication and then retrieved using a magnet, leaving the MNP@protein particles to be recycled and re-used at least 5 times for further nanoMIP production cycles. In general, 10 mg of MNP@protein produced 10 mg of nanoMIP with a 20% decrease in the yield over the 5 synthesis cycles. For the bovine haemoglobin nanoMIP, the <em>K</em><small>_D</small> was determined to be 3.47 × 10<small>⁻¹¹</small> M, a binding affinity rivalling values found for monoclonal antibodies. We also demonstrate that the methodology is generic by producing high-affinity nanoMIPs for other proteins including albumin, lysozyme and SARS-CoV-2 recombinant protein. We therefore present a facile route to produce nanoMIPs in large industrially relevant quantities (hundreds of mg) and at short timescales (within a day). Our method offers realistic opportunities for the industry to adopt such materials as an antibody replacement technology in diagnostics, biological extraction and therapeutics.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5845-5855"},"PeriodicalIF":5.8,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00990h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic therapy using hybrid nanoparticles comprising of upconversion nanoparticles and chlorin e6-bearing pullulan†","authors":"Riku Kawasaki, Takuro Eto, Nanami Kono, Reo Ohdake, Keita Yamana, Hidetoshi Hirano, Shogo Kawamura, Naoki Tarutani, Kiyofumi Katagiri and Atsushi Ikeda","doi":"10.1039/D4BM00769G","DOIUrl":"10.1039/D4BM00769G","url":null,"abstract":"<p >With its minimal invasiveness, photodynamic therapy (PDT) is considered one of the most elegant modalities in cancer treatment. In this study, a facile hybrid nanoparticle was developed, composed of upconversion nanoparticles and chlorin e6-bearing pullulan, which can serve as a photosensitizer activated by a near-infrared red laser. Cell death induction in cancer cells was achieved through energy transfer from the near-infrared red laser emitted by the upconversion nanoparticles to chlorin e6. The therapeutic efficacy of our hybrid system surpassed that of the clinically available photosensitizer, Photofrin, and hybrid liposomes comprising upconversion nanoparticles and chlorin e6 were employed as control. Accumulation of our system in tumor tissue in tumor xenograft mice was primarily achieved through the enhanced permeability and retention (EPR) effect. The administered hybrids were excreted from each organ within 21 days after administration, minimizing the risk of undesirable side effects. Notably, our system exhibited 400 times higher PDT activity in tumor-bearing mice compared to the control groups. It also effectively inhibited metastasis.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5766-5774"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/bm/d4bm00769g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of metal–organic frameworks and their biomolecule composites for osteoporosis therapeutic applications","authors":"Jiahui Li, Shihai Yin, Luyi Zhou, Alireza Nezamzadeh-Ejhieh, Ying Pan, Longhai Qiu, Jianqiang Liu and Zhikun Zhou","doi":"10.1039/D4BM01081G","DOIUrl":"10.1039/D4BM01081G","url":null,"abstract":"<p >With the population aging, osteoporosis (OP) is becoming more and more common, seriously affecting patients’ quality of life and their families, and how to prevent and treat osteoporosis has become a hot topic. However, the current conventional method of treating OP is oral anti-osteoporosis medication, which has drawbacks such as first-pass elimination and gastrointestinal adverse effects. At the same time, osteoporosis can lead to microbial infections and the need to promote angiogenesis for bone healing, among other needs that often cannot be met with conventional treatments, and there is a risk of resistance to oral antibiotics for microbial infections. Metal–organic frameworks (MOFs) having a high specific surface area, high porosity, controlled degradation, and variable composition; they can not only be used as a carrier to control drug release, but can also play multiple roles in the treatment of OP and microbial infections by releasing metal ions, <em>etc.</em>, so they have inherent advantages for OP, which is a disease that requires long-term treatment. Therefore, this paper reviews the research progress of MOFs and their biomacromolecular composites in therapeutic applications for osteoporosis, categorized by MOF type, and briefly describes the mechanism of osteoporosis, and different synthesis methods of MOFs and MOF-based composites, and finally presents the main existing problems and future perspectives, aiming to make MOFs more helpful for OP treatment.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 23","pages":" 5912-5932"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronan nanoplatelets exhibit extended residence time compared to spherical and ellipsoidal nanomaterials with equivalent surface potentials and volumes after oral delivery in rats†","authors":"Hicheme Hadji, Catherine Cailleau, Benoit Chassaing, Mickaël Bourge, Gilles Ponchel and Kawthar Bouchemal","doi":"10.1039/D4BM00672K","DOIUrl":"10.1039/D4BM00672K","url":null,"abstract":"<p >The physicochemical properties of colloidal particles—such as size, surface properties, and morphology—play a crucial role in determining their behaviors and transit through the gastrointestinal (GI) tract. While some data exist for nonspherical nanomaterials (NMs) composed of silica or polystyrene, there is limited understanding of NMs composed of polysaccharides and polymers. This study explores the fate and GI tract residence time of hyaluronan-based NMs with distinctive hexagonal morphology and flat surfaces (nanoplatelets) following administration to rats. The behavior of these nanoplatelets was compared to NMs with spherical and ellipsoidal morphologies. The three types of NMs were labeled with a near-infrared dye (Cy5.5) and administered in single doses to healthy rats, followed by real-time <em>in vivo</em> imaging over 24 hours. The results revealed that altering NM morphology from spherical to ellipsoidal did not significantly affect GI tract residence time or toxicity profiles <em>in vitro</em> and <em>in vivo</em>. However, nanoplatelets exhibited a stronger Cy5.5 fluorescence signal in the abdominal region and demonstrated slower gastric emptying than spherical and ellipsoidal NMs. <em>Ex vivo</em> analysis of excised GI tracts rinsed with saline indicated that nanoplatelets adhered more effectively to the tightly bound mucus layer. Furthermore, histological examination of colon sections showed that nanoplatelets induced a minimal global inflammation score comparable to that of healthy rats. This study underscores the potential of hyaluronan-based nanoplatelets for oral administration, offering promising directions for both fundamental research and practical applications in nanomedicine.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5812-5823"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AQ4N nanocomposites for hypoxia-associated tumor combination therapy","authors":"Amrah Inam, Shuo Zhang, Shuai Zhang and Daocheng Wu","doi":"10.1039/D4BM00883A","DOIUrl":"10.1039/D4BM00883A","url":null,"abstract":"<p >Hypoxia in solid tumors increases their invasiveness and resistance to therapy, presenting a formidable obstacle in tumor therapy. The hypoxia prodrug banoxantrone (AQ4N) undergoes conversion into its topoisomerase II inhibitor form AQ4 under hypoxic conditions, which inhibits tumor cells while leaving normal cells unharmed. Numerous studies have found that AQ4N significantly enhances the tumor effect while minimizing toxicity to normal tissues when combined with other drugs or therapeutic approaches. Thus, to maximize AQ4N's effectiveness, co-delivery of AQ4N with other therapeutic agents to the tumor site is paramount, leading to the development of multifunctional multicomponent AQ4N nanocomposites thereby emerging as promising candidates for combination therapy in tumor treatment. However, currently there is a lack of systematic analysis and reviews focusing on AQ4N. Herein, this review provides a comprehensive retrospect and analysis of the recent advancements in AQ4N nanocomposites. Specifically, we discuss the synergistic effects observed when AQ4N is combined with chemotherapeutic drugs, radiotherapy, phototherapy, starvation, sonodynamic therapy and immunotherapy in preclinical models. Moreover, the advantages, limitations, and future perspectives of different AQ4N nanocomposites are highlighted, providing researchers from diverse fields with novel insights into tumor treatment.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 23","pages":" 5883-5911"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures†","authors":"James Johnston, Hyunsu Jeon, Yun Young Choi, Gaeun Kim, Tiger Shi, Courtney Khong, Hsueh-Chia Chang, Nosang Vincent Myung and Yichun Wang","doi":"10.1039/D4BM00504J","DOIUrl":"10.1039/D4BM00504J","url":null,"abstract":"<p >Small extracellular vesicles (sEVs) have great promise as effective carriers for drug delivery. However, the challenges associated with the efficient production of sEVs hinder their clinical applications. Herein, we report a stimulative 3D culture platform for enhanced sEV production. The proposed platform consists of a piezoelectric nanofibrous scaffold (PES) coupled with acoustic stimulation to enhance sEV production of cells in a 3D biomimetic microenvironment. Combining cell stimulation with a 3D culture platform in this stimulative PES enables a 15.7-fold increase in the production rate per cell with minimal deviations in particle size and protein composition compared with standard 2D cultures. We find that the enhanced sEV production is attributable to the activation and upregulation of crucial sEV production steps through the synergistic effect of stimulation and the 3D microenvironment. Moreover, changes in cell morphology lead to cytoskeleton redistribution through cell–matrix interactions in the 3D cultures. This in turn facilitates intracellular EV trafficking, which impacts the production rate. Overall, our work provides a promising 3D cell culture platform based on piezoelectric biomaterials for enhanced sEV production. This platform is expected to accelerate the potential use of sEVs for drug delivery and broad biomedical applications.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 22","pages":" 5728-5741"},"PeriodicalIF":5.8,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}