Biomaterials Science最新文献

{"title":"Magnetically actuated superparamagnetic liposomes for accurate photothermal therapy and <i>in situ</i> antitumor immunoactivation.","authors":"Han Gong, Aiqing Ma, Jiacheng Ouyang, Rui Hao, Shichao Zhang, Wei Qiu","doi":"10.1039/d5bm00279f","DOIUrl":"https://doi.org/10.1039/d5bm00279f","url":null,"abstract":"<p><p>Liposomes are widely employed in drug delivery due to their biocompatibility and biodegradability. However, their therapeutic efficacy remains constrained by passive diffusion and limited targeting specificity. Although ligand modification has the potential to enhance the targeting ability of liposomes, a series of challenges, including complex synthesis, high costs, and potential immunogenicity, tend to hinder its broader clinical translation. Here, we present a simple yet effective strategy for tumor-targeted drug delivery and multimodal synergistic therapy by integrating magnetically actuated liposomal particles with an external magnetic field. The Lipo-ION system, which is formulated by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within liposomes, can achieve targeted accumulation at tumor sites under the guidance of a magnetic field, significantly improving delivery efficiency. Moreover, SPIONs enable photothermal effects and reactive oxygen species (ROS) generation under near-infrared (NIR) irradiation, leading to tumor cell apoptosis and macrophage polarization toward the pro-inflammatory M1 phenotype. Such immune modulation effectively reshapes the tumor microenvironment, enhancing anti-tumor efficacy. By circumventing the complex liposomal modification steps and elaborate manufacturing processes, this approach achieves targeted accumulation and multimodal synergy, presenting a promising clinical strategy for precise, efficient, and low-toxicity anti-tumor therapy.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined sustained and triggered release for sequential viral-transduction from collagen-based scaffolds for tissue regeneration.","authors":"John J Amante, Bridget Twombly, Naaz Thotathil, Cathal J Kearney","doi":"10.1039/d5bm00623f","DOIUrl":"10.1039/d5bm00623f","url":null,"abstract":"<p><p>Chronic wounds are a major healthcare issue that are recalcitrant to many traditional treatments. Increasingly, tissue engineering scaffolds are being developed and translated to promote their healing. To control signaling in the wound environment, gene therapy approaches are being explored, with adeno-associated virus (AAV) becoming increasingly popular. One critical challenge in chronic wound healing is that the wounds do not progress through the typical wound healing cascade, with signaling getting stuck in the inflammatory/immature tissue formation phase. This motivated us to develop a system capable of triggered sequential release of viral vectors to drive coordinated signaling. By housing this system within a collagen-glycosaminoglycan (GAG) scaffold, we aim to provide a proven extracellular matrix template as well as the correct signaling profile for closure of chronic wounds. Our system consists of two alginate pockets within the collagen-GAG scaffold, which we use to control the release of AAV. The first pocket allows diffusion of one AAV therapeutic and the second pocket can be ultrasound-triggered using low-frequency stimulation to release the second therapeutic. Initially, we developed and characterized the system using a reporter AAV. At our high AAV loading, we got sustained release and GFP expression over 9 days from our system <i>in vitro</i>, but lower loading had minimal transduction. When this lower group was triggered with ultrasound, cells were successfully transduced. Finally, we demonstrated sequential release of AAV encoding clinically-relevant genes for angiogenesis. This system has the potential for broad applicability as it can be readily adapted to mimic a range of biological pathways.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The regenerative capacity of cell imprinting and collagen/PCL scaffolds in gastrocnemius tendon defect.","authors":"Seyed Aliakbar Hosseini Toopghara, Shahin Bonakdar, Sara Nayyeri, Morteza Mehrjoo, Fatemeh Ale Ebrahim, Hossein Aminianfar, Farzad Mohammadian Sabour, Leila Montazeri, Mohammad Amin Hajari, Mohammad Ali Shokrgozar, Sang-Won Park, Mohammad Mehdi Dehghan","doi":"10.1039/d5bm00534e","DOIUrl":"https://doi.org/10.1039/d5bm00534e","url":null,"abstract":"<p><p>Traumatic tendon injuries are among the most common types of injuries, often characterized by insufficient and slow recovery. The current study aims to evaluate the regenerative capacity of a tissue-engineered tendon graft in a rabbit gastrocnemius tendon defect. This graft comprises gap-electrospun collagen-coated parallel polycaprolactone (PCL) fibers seeded with adipose-derived stem cells (ADSCs), which promoted to adopt a tenogenic phenotype using a tenocyte-imprinted substrate for the first time. Scanning electron microscopy (SEM) images confirmed the parallel structure and successful cell attachment to the scaffold. Sirius red staining, high-performance X-ray photoelectron spectroscopy, and water contact angle showed that collagen successfully coated and changed the surface hydrophilicity of the scaffold. Imprinted substrates showed tenocyte patterns in SEM images. In an <i>in vitro</i> evaluation, ICC and real-time polymerase chain reaction confirmed that the stem cells acquired tenogenic traits. In addition, histopathology scoring outcomes showed significant improvement in the Pattern group and an almost 2.58 times increase in the total score average compared to the control group. <i>In vitro</i> and <i>in vivo</i> therapy results show that differentiated ADSCs seeded on the collagen-coated PCL scaffold for tendon repair have astounding therapeutic potential.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired nanovesicles: efficient targeting of biomaterials with improved anti-infective therapy","authors":"Syed Faheem Askari Rizvi, Yun Zeng, Syeda Samar Mustafa and Gang Liu","doi":"10.1039/D5BM00450K","DOIUrl":"10.1039/D5BM00450K","url":null,"abstract":"<p >Pathogenic bacterial virulence has become a serious public health problem worldwide. The development of novel antibiotics has achieved success in addressing these bacterial infections. Unfortunately, the emergence of multidrug resistance against these antibiotics results in devastating therapeutic effects, leading to a higher mortality rate. By leveraging natural materials, biologics provide creative inspiration for designing and constructing superficial nanomaterials. Bioinspired nanomaterials are promising in biomedical fields, including drug delivery, cell and tissue engineering, cancer therapy, and antibacterial and antiviral activities. Various innovative strategies have been employed for the surface modification of cell membrane nanovesicles (MNVs) with bioinspired receptor-expressing functional proteins and antimicrobial sonodynamic therapeutic (aSDT) entities. This review summarizes the recent advancements in synergistic nanotechnology and biotechnology aimed at designing novel extracellular vesicles (EVs) with potential modification functionalities and a customizable approach for site-specific delivery of small biomolecules and enhanced therapeutic potentials. We also discuss the design concept and synthesis routes of various bioinspired MNVs, such as enzyme-catalyzed nanoplates, sonodynamic nanoliposomes and magnetic microswimmers, and their specific biomedical antibacterial applications. Moreover, future perspectives for the exciting development of such novel nanovesicle-based bio-therapeutics are also provided.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4097-4106"},"PeriodicalIF":5.8,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic double network hydrogels of chondroitin sulfate and synthetic polypeptides for cartilage tissue engineering†","authors":"Juhi Singh, Jacob C. Kadir, Jason D. Orlando and Stefanie A. Sydlik","doi":"10.1039/D5BM00296F","DOIUrl":"10.1039/D5BM00296F","url":null,"abstract":"<p >Articular cartilage defects are common, and the progressive deterioration of cartilage frequently results in the onset of osteoarthritis. However, the intrinsic regenerative capacity of articular cartilage is minimal. Synthetic therapeutic solutions for treating cartilage damage are being developed. However, current scaffolds and hydrogels employed in cartilage tissue engineering face limitations in promoting cellular activity and providing sufficient load-bearing strength. This is primarily due to suboptimal crosslinking methods for the synthetic scaffolds composed of natural proteins and glycosaminoglycans (GAGs). Synthetic polypeptides, owing to their customizable reactive functional groups, present an exciting opportunity to enhance crosslinking through both physical and chemical approaches. This study introduces a strategy for the development of injectable, shape-adaptive double network hydrogels that closely replicate the structural integrity and mechanical properties of native cartilage. These hydrogels are composed of photocrosslinkable GAGs, specifically methacrylated chondroitin sulfate A (CSMA), combined with a synthetic polypeptide, poly(<small>L</small>-lysine) (PLL). By varying the degree of polymerization (DP) of PLL and weight percentage of PLL in the composition, the hydrogels can be optimized for desired material properties. Varying DP of PLLs varies the molecular weight between crosslinks, thus leading to tunable rigidity (yield strength, ultimate compression strength, storage modulus) and toughness. We further this tunability through the integration of photoresponsive components, enabling controlled, non-invasive post-injection modifications. Initial testing indicates that these double network hydrogels exhibit significantly improved mechanical strength compared to hydrogels formed solely from CSMA, positioning them as strong candidates for minimally invasive cartilage defect repair. This innovative method offers the potential to accelerate recovery, restore joint function, and improve patients’ overall quality of life.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4211-4231"},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/bm/d5bm00296f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naturally-derived injectable hydrogels for antitumor therapeutics","authors":"Chi Zhang, Huixin Li, Ziqin Li, Kai Hao and Huayu Tian","doi":"10.1039/D5BM00656B","DOIUrl":"10.1039/D5BM00656B","url":null,"abstract":"<p >As novel localized drug delivery platforms, injectable hydrogels demonstrate significant potential in precision tumor therapy. By enabling spatiotemporally controlled drug release at target sites, they not only reduce systemic toxicity but also facilitate synergistic codelivery of chemotherapeutic agents, immunomodulators and gene therapy carriers. However, synthetic polymer-based hydrogel scaffolds face major challenges in clinical translation due to complex fabrication processes, potential immunogenicity and metabolic toxicity. In recent years, natural biomaterials such as chitosan, gelatin, and hyaluronic acid have emerged as preferred matrices for constructing antitumor hydrogel carriers, owing to their inherent biocompatibility, tunable biodegradability and clinical feasibility. This review systematically summarizes the structural advantages of natural biomaterials and their design principles in developing injectable hydrogels for antitumor applications, with particular focus on their cargo-loading mechanisms for diverse therapeutic agents. Additionally, it provides an in-depth discussion of key challenges in the clinical translation of natural material-based injectable hydrogels, aiming to guide the development of novel antitumor hydrogel platforms.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4044-4061"},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupling biophysical stimuli with functional scaffolds to overcome the current limitations of peripheral nerve regeneration: a review","authors":"Larissa Ribeiro Lourenço, Erik Felix dos Santos, Luccas Correa Teruel de Jesus, Ezegbe Chekwube Andrew, Francesco Baino, Roger Borges and Juliana Marchi","doi":"10.1039/D4BM01531B","DOIUrl":"10.1039/D4BM01531B","url":null,"abstract":"<p >Peripheral nerve injuries are common occurrences that can lead to the loss of sensibility and function, strongly impairing the patient's quality of life. The current techniques acting on nervous tissue regeneration rely on grafts, which are autologous or synthetic nerve guidance conduits produced by tissue engineering methods. However, even using these procedures, functional recovery is limited to a success rate of around 50%, which indicates the need for improvement in the peripheral nerve regeneration approach. Scaffolds with biomimetic characteristics and functional properties are increasingly being developed based on nanotechnology principles. Moreover, different external biophysical stimuli can be applied to achieve even better results. This review discusses the limiting factors that preclude complete nerve recovery and addresses four biophysical strategies to improve regeneration: electric, magnetic, light, and ion-release-based stimulations. The literature has shown that combining these techniques with nanomaterial-based nerve guidance conduits yields an improved nerve repair process. Furthermore, understanding the biological mechanisms underlying regenerative principles of nerve repair can drive new strategies of nerve tissue engineering under biophysical stimuli, overcoming current limitations of peripheral nerve regeneration.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4062-4080"},"PeriodicalIF":5.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication.","authors":"Hwanyong Choi, Jinah Jang","doi":"10.1039/d5bm00160a","DOIUrl":"10.1039/d5bm00160a","url":null,"abstract":"<p><p>Magnetic-based tissue engineering (MagTE) is a rapidly advancing interdisciplinary field that integrates magnetic materials and external magnetic fields with tissue engineering principles to manipulate cells, biomaterials, and biological environments for developing functional tissue substitutes. This review provides a comprehensive overview of MagTE, covering its fundamentals, applications, and future directions within the biofabrication domain. The magnetic properties of paramagnetic, ferromagnetic, ferrimagnetic, and superparamagnetic materials are discussed, along with mechanisms of magnetic actuation through forces and torques. MagTE applications are categorized into cell manipulation and stimulation. Direct and indirect manipulation techniques also enable precise control of cell alignment, patterning, and assembly into complex three-dimensional structures, such as cell sheets, spheroids, and organoids. Stimulation approaches-mechanical, thermal, electrical, and biochemical-exploit interactions between magnetic particles and external fields to elicit specific physiological responses and support tissue regeneration. We then conclude by addressing the current limitations of MagTE and proposing strategies to overcome these challenges.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional metal–organic frameworks and their heterojunction materials for cancer theranostics","authors":"Wei Wang, Yuzi Huang, Yan Li, Peng Geng, Haichuang Lan, Dan Luo and Shuzhang Xiao","doi":"10.1039/D5BM00544B","DOIUrl":"10.1039/D5BM00544B","url":null,"abstract":"<p >Malignant tumours continue to present a significant challenge to global public health, with early theranostics serving as critical strategies to enhance patient prognosis. Advancements in nanotechnology have catalyzed the development of innovative approaches, where the synergy between nanomaterials and therapeutic modalities offers promising solutions to overcome the limitations of traditional cancer treatments. Among these innovations, metal–organic frameworks (MOFs) have emerged as a focal point of research in cancer theranostics. Their three-dimensional porous structure, precisely tunable pore sizes, excellent biocompatibility, and versatile surface functionalization make them particularly attractive. Additionally, the controllable synthesis and ordered structural characteristics of MOFs enable the integration of functional nanoparticles through hierarchical assembly strategies, resulting in heterojunction systems with various configurations, such as “core–shell”, “moon–star”, “yolk–shell”, and “Janus” structures. These materials demonstrate synergistic effects in cancer treatment, often outperforming single MOF materials. This review comprehensively discusses the latest advancements in single and double metal MOFs, as well as their heterojunction-derived materials, in tumour visualization, targeted therapy, and integrated theranostics. The insights provided offer important theoretical foundations and technical references for the clinical translation of MOF-based nanomedicines.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4081-4096"},"PeriodicalIF":5.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing a hemostatic sponge loaded with copper nanoparticles and carboxymethyl chitosan for wound hemostasis and infection prevention†","authors":"Huiting Fu, Marziya Amantay, Jua Kim, Tao Jiang, Haobo Pan and Yingbo Wang","doi":"10.1039/D5BM00556F","DOIUrl":"10.1039/D5BM00556F","url":null,"abstract":"<p >Uncontrolled hemorrhage and infection pose serious risks to patient survival, highlighting the critical need for multifunctional hemostatic materials that are safe, effective, and highly biocompatible. In response to this clinical demand, we have developed a novel design strategy that rapidly achieves hemostasis and prevents infection. This research introduces a dual-network multifunctional hemostatic sponge, CMC/PDA@Cu, crafted from polysaccharide materials and specifically engineered for application at bleeding sites compromised by drug-resistant bacteria. Utilizing the natural hemostatic properties of carboxymethyl cellulose (CMC), this material facilitates swift coagulation <em>via</em> electrostatic interactions that enhance the adhesion and aggregation of blood cells. Concurrently, copper nanoparticles (Cu-NPs) are synthesized <em>in situ</em> through redox reactions with copper ions and the catechol groups in polydopamine (PDA), enabling the prolonged release of copper ions and achieving 48 hours of antibacterial activity. The synergistic photothermal properties of PDA and Cu-NPs increased the photothermal conversion efficiency to 27.5%, significantly reducing the time required for bacterial elimination from 24 hours to just 3 hours. Furthermore, copper ions serve as cationic coagulation enhancers, bolstering hemostatic efficiency. The resultant material offers a combined solution for effective hemostasis and infection management. In experimental applications using a rat liver hemorrhage model, the CMC/PDA@Cu sponge dramatically minimized blood loss to 0.02 ± 0.01 mg, marking the fastest recorded hemostasis time of 37.17 ± 3.76 seconds. In a separate rat tail amputation model, the sponge reduced the blood loss to 0.91 ± 0.47 g, with a hemostasis time of 75.01 ± 4.52 seconds. These results lay a foundational mechanistic basis for the rational design of advanced, safe, and controllable hemostatic materials, elucidating the critical structure–function relationships in terms of material composition, surface characteristics, and their impact on hemostasis, antimicrobial efficacy, and biocompatibility. This work sets the stage for the future development of next-generation hemostatic materials aligning with clinical requirements.</p>","PeriodicalId":65,"journal":{"name":"Biomaterials Science","volume":" 15","pages":" 4245-4263"},"PeriodicalIF":5.8,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}