Magnetic-based tissue engineering: principles, applications, and future prospects in biofabrication.

IF 5.7 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2025-06-20 DOI:10.1039/d5bm00160a

Hwanyong Choi, Jinah Jang

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引用次数: 0

Abstract

Magnetic-based tissue engineering (MagTE) is a rapidly advancing interdisciplinary field that integrates magnetic materials and external magnetic fields with tissue engineering principles to manipulate cells, biomaterials, and biological environments for developing functional tissue substitutes. This review provides a comprehensive overview of MagTE, covering its fundamentals, applications, and future directions within the biofabrication domain. The magnetic properties of paramagnetic, ferromagnetic, ferrimagnetic, and superparamagnetic materials are discussed, along with mechanisms of magnetic actuation through forces and torques. MagTE applications are categorized into cell manipulation and stimulation. Direct and indirect manipulation techniques also enable precise control of cell alignment, patterning, and assembly into complex three-dimensional structures, such as cell sheets, spheroids, and organoids. Stimulation approaches-mechanical, thermal, electrical, and biochemical-exploit interactions between magnetic particles and external fields to elicit specific physiological responses and support tissue regeneration. We then conclude by addressing the current limitations of MagTE and proposing strategies to overcome these challenges.

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磁性组织工程：原理、应用及在生物制造中的未来展望。

磁性组织工程（MagTE）是一个快速发展的跨学科领域，它将磁性材料和外部磁场与组织工程原理相结合，以操纵细胞，生物材料和生物环境来开发功能性组织替代品。这篇综述提供了一个全面的概述，包括其基本原理，应用，并在生物制造领域的未来发展方向。讨论了顺磁性、铁磁性、亚铁磁性和超顺磁性材料的磁性，以及通过力和力矩进行磁致动的机制。MagTE应用分为细胞操作和刺激。直接和间接操作技术也可以精确控制细胞排列、图案和组装成复杂的三维结构，如细胞片、球体和类器官。刺激方法——机械的、热的、电的和生化的——利用磁粒子和外场之间的相互作用来引发特定的生理反应和支持组织再生。然后，我们通过解决当前MagTE的局限性并提出克服这些挑战的策略来结束。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.