Magnetically actuated superparamagnetic liposomes for accurate photothermal therapy and in situ antitumor immunoactivation.

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Han Gong, Aiqing Ma, Jiacheng Ouyang, Rui Hao, Shichao Zhang, Wei Qiu
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引用次数: 0

Abstract

Liposomes are widely employed in drug delivery due to their biocompatibility and biodegradability. However, their therapeutic efficacy remains constrained by passive diffusion and limited targeting specificity. Although ligand modification has the potential to enhance the targeting ability of liposomes, a series of challenges, including complex synthesis, high costs, and potential immunogenicity, tend to hinder its broader clinical translation. Here, we present a simple yet effective strategy for tumor-targeted drug delivery and multimodal synergistic therapy by integrating magnetically actuated liposomal particles with an external magnetic field. The Lipo-ION system, which is formulated by encapsulating superparamagnetic iron oxide nanoparticles (SPIONs) within liposomes, can achieve targeted accumulation at tumor sites under the guidance of a magnetic field, significantly improving delivery efficiency. Moreover, SPIONs enable photothermal effects and reactive oxygen species (ROS) generation under near-infrared (NIR) irradiation, leading to tumor cell apoptosis and macrophage polarization toward the pro-inflammatory M1 phenotype. Such immune modulation effectively reshapes the tumor microenvironment, enhancing anti-tumor efficacy. By circumventing the complex liposomal modification steps and elaborate manufacturing processes, this approach achieves targeted accumulation and multimodal synergy, presenting a promising clinical strategy for precise, efficient, and low-toxicity anti-tumor therapy.

用于精确光热治疗和原位抗肿瘤免疫激活的磁驱动超顺磁脂质体。
脂质体因其生物相容性和生物可降解性而广泛应用于给药领域。然而,它们的治疗效果仍然受到被动扩散和有限的靶向特异性的限制。虽然配体修饰有可能增强脂质体的靶向能力,但一系列挑战,包括复杂的合成、高成本和潜在的免疫原性,往往会阻碍其更广泛的临床转化。在这里,我们提出了一种简单而有效的肿瘤靶向药物递送和多模式协同治疗策略,通过将磁驱动脂质体颗粒与外部磁场相结合。lipoo - ion系统通过将超顺磁性氧化铁纳米颗粒(SPIONs)包封在脂质体内而形成,可以在磁场的引导下在肿瘤部位实现靶向积累,显著提高递送效率。此外,SPIONs能够在近红外(NIR)照射下产生光热效应和活性氧(ROS),导致肿瘤细胞凋亡和巨噬细胞向促炎M1表型极化。这种免疫调节有效地重塑了肿瘤微环境,增强了抗肿瘤疗效。该方法绕过了复杂的脂质体修饰步骤和复杂的制造过程,实现了靶向积累和多模式协同作用,为精确、高效、低毒的抗肿瘤治疗提供了一种有前景的临床策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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