Journal of Polymers and the Environment最新文献

{"title":"Effect of Polyelectrolyte Properties of Fucoidans on Antimicrobial Activity","authors":"Olga Brovko,&nbsp;Irina Palamarchuk,&nbsp;Natalia Gorshkova,&nbsp;Dmitriy Chukhchin,&nbsp;Irina Eliseeva","doi":"10.1007/s10924-025-03506-7","DOIUrl":"10.1007/s10924-025-03506-7","url":null,"abstract":"<div><p>Over the years, brown algae have been highlighted as valuable natural sources of bioactive polysaccharides. They are known to consist of a number of bioactive polysaccharides, fucoidan being the principal polysaccharide. Fucoidans, a sulphated polysaccharide composed of a fucopyranose backbone and several monosaccharaides have been reported to possess numerous biological activities such as anticancer, antioxidant, antiviral, antithrombotic, and anti-inflammatory properties, thus may confer health benefits to humans. However, the main mechanisms bridging the structural complexity of fucoidans and their biological activity are mostly unexplored. This study aimed to compare the structural features and the antimicrobial properties of the fucoidan extracts isolated from the two brown macroalgae, <i>Fucus vesiculosus</i> and <i>Saccharina latissima</i>, sampled in the littoral zone of the Barents Sea. The physicochemical properties of fucoidans and their polyelectrolyte properties were investigated. The antibacterial activity of fucoidans was evaluated using the disc diffusion method against <i>Bacillus subtilis</i> (gram-positive bacteria), <i>Pseudomonas aeruginosa</i>, and <i>Proteus mirabilis</i> (gram-negative bacteria). It was shown that fucoidans inhibited the growth of both gram-positive and gram-negative microorganisms. At the concentration of 0.25–0.5%, the highest clear inhibition zones were observed for all the studied bacteria. The high antibacterial activity of fucoidans was due to the availability of functional groups and the particle sizes of fucoidan molecules that affect the cell membranes of the bacterial microflora. On the basis of obtaining results, fucoidans were suggested as potential natural and green bactericidal agents to be used by the pharmaceutical, medicine, and food industries.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2138 - 2148"},"PeriodicalIF":4.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Eco-friendly Approach for the Separation and Reusage of Pre-consumer Polycotton Textile Waste","authors":"Fábio Pedroso de Lima,&nbsp;Cátia Alves,&nbsp;Rita Gomes-Dias,&nbsp;Marta Fernandes,&nbsp;Bárbara Vieira,&nbsp;Rui Rodrigues,&nbsp;Jorge Padrão,&nbsp;Andrea Zille","doi":"10.1007/s10924-025-03500-z","DOIUrl":"10.1007/s10924-025-03500-z","url":null,"abstract":"<div><p>One of the most challenging features of textile recycling is the widespread use of mixed fibre blends, which hardens the task of effective separation. A mixture of aqueous sodium hydroxide and a cosolvent was applied to a polycotton pre-consumer fabric to promote the chemical separation of polyester (PES) and cotton (CO). The feasibility of reusing the hydrolytic solutions was tested, where dimethyl sulfoxide (DMSO) and 2-propanol allowed the reusage of the hydrolytic solution for up to 3 consecutive cycles when applied to pristine material. The recovery of pure terephthalic acid (TPA), after treatment at 50 °C followed by vacuum filtration, achieved yields ranging from 65 to 69%. No further purification was required in 75% of the tested conditions. Through this environmentally sustainable procedure, a method was proposed that could facilitate the development of a scalable process for the TPA recovery from polycotton textiles. This approach aims to reduce both textile waste production and the need for the <i>de novo</i> synthesis of TPA.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"1847 - 1863"},"PeriodicalIF":4.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03500-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Polyaminophenol/Glycerol–Silver Nanohybrids: Synthesis, Characterization, and Antimicrobial Activity","authors":"Ghadah M. Al-Senani,&nbsp;Amal Abdelfatah,&nbsp;Omayma F. Abdel-Gawad,&nbsp;Mashael N. Alshabanat,&nbsp;Mohamed Shaban,&nbsp;Azza Al-Ghamdi,&nbsp;Fatma Mohamed","doi":"10.1007/s10924-025-03498-4","DOIUrl":"10.1007/s10924-025-03498-4","url":null,"abstract":"","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 4","pages":"2123 - 2123"},"PeriodicalIF":4.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Hydrogel Dressing with Zinc Oxide-Copper Oxide Nanocomposite for Effective Wound Management: Mechanochemistry, Antibacterial Efficacy, Cytocompatibility and Wound Healing Potentials","authors":"Nasrin K. Ramtan Gadaime,&nbsp;Rabiatul Basria S. M. N. Mydin,&nbsp;G. Ambarasan Govindasamy,&nbsp;Yazmin Bustami,&nbsp;Srimala Sreekantan","doi":"10.1007/s10924-024-03468-2","DOIUrl":"10.1007/s10924-024-03468-2","url":null,"abstract":"<div><p>Managing open wounds is difficult because of the risk of bacterial infections and moisture loss, which can delay healing. Advanced wound care solutions are essential for healing. Hydrogel bandages provide a promising option because of the unique features of hydrogel such as high porosity and absorbency from its hydrophilic polymer composition. In addition, advanced hydrogel dressings infused with nanotechnology, especially zinc oxide–copper oxide (ZnO–CuO) nanocomposites, remarkably improve the effectiveness of wound care strategies. In the current study, the mechanochemistry, antibacterial efficacy, cytocompatibility and wound healing potential of ZnO–CuO nanocomposite-embedded polyethylene glycol hydrogel (CPZCH) were investigated. Antibacterial profiles were examined by disc diffusion, time-kill tests, and bacterial cell adherence against <i>S. aureus</i>, <i>MRSA</i>, <i>P. aeruginosa</i> and <i>E. coli</i>. Cytocompatibility and wound healing profiles were studied using the fibroblast cells. CPZCH exhibited favourable swelling‐shrinkable behaviours with a swelling, porosity and degradation ratio of approximately 1920.45%, 142.86% and 60.27%, respectively. These characteristics are crucial for maintaining a moist wound environment, facilitating nutrient distribution and making eco-friendly dressings. CPZCH exhibited antibacterial potential within 24h, which is crucial for managing infection and protecting wounds from bacterial infections. CPZCH exhibited high cytocompatibility (~ 110.177%) and remarkable <i>in vitro</i>wound healing properties within 48h, which are crucial for maintaining cell integrity from toxicity and rapid wound closure. Therefore, CPZCH showed great application potential in wound dressing with favourable swelling‐shrinkable behaviours, antibacterial efficacy, cytocompatibility and wound healing properties. Further studies especially involving hemocompatibility and molecular interaction are necessary to reach comprehensive knowledge about the behaviour of the dressing in wound management.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1601 - 1614"},"PeriodicalIF":4.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioplastic (Polyhydroxybutyrate) Synthesis Using Orange Wastes by the Marine Bacterium Bacillus sp. Caspian04","authors":"Salman Ahmady-Asbchin,&nbsp;Saba Amiri Kojuri","doi":"10.1007/s10924-025-03488-6","DOIUrl":"10.1007/s10924-025-03488-6","url":null,"abstract":"<div><p>The production and development of bioplastics are necessary to solve the crisis originating from the accumulation of non-biodegradable plastics in the environment. This study aimed to synthesize polyhydroxybutyrate (PHB) using orange wastes by the bacterium separated from the Caspian Sea. Seven PHB synthesizing bacterial isolate were isolated from Caspian Sea water. The initial screening for PHB synthesis was performed with a dye-based method. The most powerful marine bacterium with the synthesis of 1.73 g/L PHB was identified via 16S rRNA gene sequencing as <i>Bacillus</i> sp. Caspian04 and its nucleotide sequence was preserved with the accession number OR999904.1 in GeneBank. PHB synthesis increased in the presence of ammonium chloride, 4% orange wastes extract, and 3% NaCl, at temperature of 35 °C and pH 8.0. Using the orange wastes extract (4% w/v) led to the synthesis of 5.22 g/L PHB, which can help reduce the cost of PHB synthesis. FTIR, ¹H NMR, ¹³C NMR, XRD, and TGA were used to evaluate extracted PHB’s characterization. The present study is the first attempt to bioplastic synthesis by bacteria isolated from the Caspian Sea. Furthermore, with the biotechnological production of PHB from orange wastes by <i>Bacillus</i> sp. Caspian04, the way will be paved for the development of management strategy of solid wastes and highlights the role of marine bacteria in the production of polymers with commercial value.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1636 - 1650"},"PeriodicalIF":4.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Corn Starch Hydrogels for Effective Sorption of Potentially Toxic Metals: The Role of Amylose and Amylopectin Content","authors":"Talles B. da Costa,&nbsp;Paulo H. Camani,&nbsp;Rafaela R. Ferreira,&nbsp;Rennan F. S. Barbosa,&nbsp;Derval dos S. Rosa","doi":"10.1007/s10924-025-03495-7","DOIUrl":"10.1007/s10924-025-03495-7","url":null,"abstract":"<div><p>This study evaluated the effect of corn starch's amylose/amylopectin content on the development of crosslinked hydrogels with trisodium citrate for the sorption of potentially toxic metals (PTMs). The results, obtained through a robust methodology, indicated a clear relation between the amylose content and crosslinking degree, thereby impacting the properties of the hydrogels. The hydrogel with high amylose (70 wt.%) and low amylopectin (30 wt.%) content (Hylon VII®) demonstrated a high crosslinking degree (0.297) and good thermal stability and water absorption (72.71%), with a semicrystalline structure. The hydrogel with low amylose (1.8 wt.%) and high amylopectin (98.2 wt.%) content (Amisol 4000®), on the other hand, showed the lowest degree of crosslinking (0.109), water absorption (49.77%), and high solubility (46%), which makes its applicability difficult due to its low stability in aqueous media. The influence of amylose (28 wt.%) and amylopectin (72 wt.%) content indicated that the Amisol 3408® hydrogel showed valuable properties, presenting a higher potential for PTMs sorption with the following affinity order: Cu²⁺ (68.62%) &gt; Cd²⁺ (63.13%) &gt; Mn²⁺ (37.36%) &gt; Zn²⁺ (26.61%) &gt; Cr⁶⁺ (16.80%). Besides, the possible sorption mechanism was ion exchange between Cu²⁺/Cd²⁺/Mn²⁺/Zn²⁺ and H⁺ in the hydrogels. Thus, starch-based hydrogel is an alternative sorbent to remove and recover PTMs from wastewater.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1615 - 1635"},"PeriodicalIF":4.7,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Thermo-Mechanical Analysis of Bio-based Epoxy Resin/Cardanol Blends as Matrices for Green Composites Manufacturing","authors":"Lorena Saitta,&nbsp;Giuliana Rizzo,&nbsp;Claudio Tosto,&nbsp;Ignazio Blanco,&nbsp;Gianluca Cicala","doi":"10.1007/s10924-024-03486-0","DOIUrl":"10.1007/s10924-024-03486-0","url":null,"abstract":"<div><p>This study explores the development of recyclable and bio-based epoxy resin/cardanol blends with varying cardanol content (25, 50, and 75%<i>wt</i>) using a cleavable amine hardener to achieve full recyclability. This approach offers a significant advantage by addressing two critical aspects of the epoxy resin life cycle—feedstock selection and end-of-life recyclability. Blends with over 28% bio-based content were developed and their recyclability was demonstrated through chemical dissolution tests. The most performing formulations in terms of thermo-mechanical properties were identified through thermo-mechanical characterizations (such as TGA, DSC, DMA, and flexural tests). The obtained results showed that, by selecting the most suitable curing cycle and cardanol content, it was possible to achieve promising properties. In fact, glass transition temperatures (<span>(:{T}_{text{g}})</span>), ranging between 67 and 79 °C, were found enabling most of the common applications for these formulations. Flexural strength values reaching 77.3 ± 1.3 and 73.4 ± 1.5 MPa were found for formulations containing 25 and 50<i>%wt</i> cardanol, respectively. These formulations also exhibited good flexural modulus values (up to 2.50 ± 0.06 GPa) and stiffness, attributed to higher cross-linking densities. Generally, the findings of this study suggest the potential for developing eco-composites with good thermo-mechanical properties, high bio-based content, which are also fully-recyclable through a chemical approach, thus enhancing the overall sustainability of these materials. The latter class of materials is finding industrial applications in the automotive, sports and wind turbine fields, such as for the manufacturing of the first generation of fully-recyclable wind turbine blade.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1561 - 1584"},"PeriodicalIF":4.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Electrically Conductive Montmorillonite-Polypyrrole Composite Nanoparticles to Enhance the Antifouling, Cleaning Efficiency and Arsenic Separation in PLA Membranes","authors":"Elham Shokri,&nbsp;Elham Effati,&nbsp;Kosar Behmaram","doi":"10.1007/s10924-025-03489-5","DOIUrl":"10.1007/s10924-025-03489-5","url":null,"abstract":"<div><p>This study focuses on the synthesis of electrically conductive montmorillonite-polypyrrole (Mt-PPy) composite nanoparticles (NPs) to enhance antifouling properties and arsenate (As (V)) separation. Fourier transforms infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and scanning electron microscopy (SEM) confirmed the formation of Mt-PPy composite NPs. Results from porosity, mechanical property, and water uptake analysis of the fabricated membranes incorporating Mt-PPy demonstrated superior performance for the PLA-(Mt-PPy-0.5) membrane. The positive charge of PPy and Cl ions in its structure enhanced the As (V) removal efficiency, mainly in PLA-(Mt-PPy-0.5) membrane (~ 100%), where the concentration of Mt-PPy was higher and well-dispersed. An electro-conductive PLA-(Mt-PPy) membrane was employed as a cathode, and the impact of Mt-PPy concentration on the cleaning efficacy of the membranes examined. The findings highlight the potential of conductive membrane in improving antifouling performance. By applying an electric current, PLA-(Mt-PPy-0.5) membrane achieved highest flux recovery ratio (FRR) of approximately 91.3%, due to the stronger repulsive force between the membrane and humic acid (HA). This process also increased As (V) desorption, enabling effective use of the membrane in multiple As (V) adsorption-desorption cycles.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1528 - 1541"},"PeriodicalIF":4.7,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving rPET/PBT Bead Foam Structure via Chain Extender Modification and Blend Variance","authors":"Andreas Himmelsbach,&nbsp;Yavuz Akdevelioglu,&nbsp;Mohammadreza Nofar,&nbsp;Holger Ruckdäschel","doi":"10.1007/s10924-024-03360-z","DOIUrl":"10.1007/s10924-024-03360-z","url":null,"abstract":"<div><p>In this study, the influence of the chain extender (CE) and the blend ratio on the bead foam extrusion of rPET/PBT is investigated. The shape and density of the bead foams were analyzed during extrusion using a camera scanner while the morphology of the foam was investigated using scanning electron microscopy (SEM). Melt strength and thermal behavior were also investigated with Rheotens and differential scanning calorimetry (DSC), respectively. Both chain extender and blend ratio had pronounced effect on the foaming behavior. Significant improvements were observed up to 0.8 wt.-% CE in rPET50PBT50, which achieved an average cell size of 107 ± 17 μm and a density of 182 kg/m³, representing a weight reduction of 86.4% compared to the bulk material. In addition, rPET40PBT60 with 0.8 wt.-% CE gave an average cell size of 108 ± 23 μm and a foam density of 170 kg/m³, with a comparable cell size distribution. After CE modification, the melt strength of rPET-dominant blends obtained higher values but a strong decrease in elongation was observed. In contrast, the CE-modified rPET40PBT60 and rPET30PBT70 blends exhibited much higher elongation with a moderate increase in melt strength which resulted in better bead and foam morphologies. DSC analysis revealed lowest crystallization temperature in rPET50PBT50 with deviations shifting towards higher temperatures. All blends except rPET70PBT30 shows double melting peak formation, with higher rPET formulations also exhibiting cold crystallization. These findings provide crucial insight for development of rPET/PBT foams by controlling the blend and CE composition, which is critical for achieving temperature-resistant bead foams with improved structural integrity.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1517 - 1527"},"PeriodicalIF":4.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-024-03360-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Room-Temperature Synthesis of pH-Responsive MOF Nanocarriers for Targeted Drug Delivery in Cancer Therapy","authors":"Amir Kazemi,&nbsp;Mohammad Hossein Afshari,&nbsp;Hasan Baesmat,&nbsp;Saber Keshavarz,&nbsp;Fateme Zeinali,&nbsp;Shahla Zahiri,&nbsp;Elahe Torabi,&nbsp;Faranak Manteghi,&nbsp;Sohrab Rohani","doi":"10.1007/s10924-025-03496-6","DOIUrl":"10.1007/s10924-025-03496-6","url":null,"abstract":"<div><p>The synthesis of nanoscale metal-organic frameworks (MOFs) is emerging as a promising method for targeted drug delivery in cancer therapy. In this study, unlike conventional solvothermal methods that require high temperatures, room-temperature synthesis of two Zn-MOF-74 variants was achieved using zinc nitrate and zinc acetate with triethylamine (TEA). The use of different anions allows precise control over the morphology and particle size of the MOF, optimizing drug loading in nanocarriers. Drug loading and release were evaluated using 5-fluorouracil (5-FU) as a model drug in both aqueous and ethanolic environments. The results showed that Zn-MOF-74 prepared with zinc acetate (R_A-MOF-74) at a 1:1 drug-to-nanocarrier ratio in ethanol exhibited superior drug adsorption and release characteristics. To enhance biocompatibility and controlled release, R_A-MOF-74 nanocarriers were coated with two biodegradable polymers, sodium alginate (ALG) and polydopamine (PDA), to improve stability at low pH and enhance release control. The release profiles of 5-FU from R_A-MOF-74 and its coated samples (PDA and ALG) were evaluated at different pH levels. In uncoated R_A-MOF-74, drug release at pH 7.4 and 8 was 48.4% and 59.1%, respectively, reaching 100% at pH 1.5. For the coated samples, 5-FU@R_A-MOF-74/ALG released 19.8% and 45.9% at pH 1.5 and 8, respectively, while 5-FU@R_A-MOF-74/PDA showed 25.2% and 40.8% release at pH 7.4 and 5.5. These results clearly highlight pH-sensitive release and the role of biocompatible coatings in enhancing controlled drug release, demonstrating the potential of Zn-MOF-74 with controlled morphology for pH-responsive delivery of 5-FU in cancer therapy, paving the way for future in vivo applications.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 3","pages":"1505 - 1516"},"PeriodicalIF":4.7,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}