Journal of Polymers and the Environment最新文献

{"title":"A Quality by Design Approach for the Systematic Screening and Optimization of Glucose-Based Polyurethane Foams","authors":"Marta Santos,&nbsp;Beatriz Sampaio,&nbsp;Marco S. Reis,&nbsp;Susana Alarico,&nbsp;Paula Ferreira,&nbsp;Marcos Mariz","doi":"10.1007/s10924-025-03555-y","DOIUrl":"10.1007/s10924-025-03555-y","url":null,"abstract":"<div><p>Sugar-based polyurethane (PU) foams represent an important advancement in structured materials offering a more sustainable alternative to traditional PU foams derived from petro-based polyols. These PU foams can hold particular importance in fields such as construction, packaging, biomedical materials, and medical devices. Hitherto, the development relies on a trial-and-error basis or, at most, by changing one-factor-at-a-time (OFAT). Unfortunately, these methods are inefficient and prone to miss the intended goals. In this study, we apply a Quality by Design (QbD) strategy, integrating systematic experimental design and data-driven approaches, to optimize sugar-based PU foam formulations for integration into a pathogen-monitoring device and identify key factors affecting their properties. The effects of surfactant, water, catalyst, chain extender, and isocyanate concentrations were evaluated using statistical design of experiments (DoE), and the amount of water was identified as the most influential factor. An optimized formulation was obtained with 0.58% (w/w) water, 5.69% (w/w) surfactant, and 34.26% (w/w) toluene diisocyanate (TDI), with butanediol excluded due to its minor impact on foam’s performance and the water being the most impactful factor. This optimized formulation was synthesized and validated with the final material being able to absorb liquids, support capillary flow, and maintain physical integrity and glucose content. This approach enabled the tailored development of sugar-based PU foams to meet the specific application requirements.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2672 - 2683"},"PeriodicalIF":4.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03555-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elimination of Ofloxacin from Water Media by chitosan/kappa-carrageenan/polyvinyl alcohol/NiFe LDH Nanocomposite Hydrogel","authors":"Zahra Sayyar,&nbsp;Mahsa Khadem Sadigh,&nbsp;Parisa Mohammadzadeh Pakdel,&nbsp;Parisa Sadeghpour,&nbsp;Mohammad Reza Sayyar","doi":"10.1007/s10924-025-03541-4","DOIUrl":"10.1007/s10924-025-03541-4","url":null,"abstract":"<div><p>In this study, chitosan/kappa-carrageenan/polyvinyl alcohol-NiFe-layered double hydroxide (CS/KCa/PVA-NiFe LDH) as novel nanocomposite hydrogels were synthesized by freeze and thawing method to eliminate Ofloxacin (OFL) from water media in a batch mode. Solvothermal method was applied to synthesize NiFe LDH nanoparticles. The successful formation of NiFe LDH, CS/KCa/PVA and CS/KCa/PVA-NiFe LDH was confirmed by FTIR, XRD, SEM and TEM analysis. The optimum weight% of these nanoparticles in the hydrogel matrix was obtained 2 wt% and the removal efficiency of CS/KCa/PVA was enhanced from 68.86 to 91.94% by incorporating 2wt.% of NiFe LDH. The swelling study demonstrated that the highest swelling factor was obtained at a pH of 7.4. The highest removal efficiency of CS/KCa/PVA, CS/KCa/PVA-NiFe LDH (1 wt%), and CS/KCa/PVA-NiFe LDH (2 wt%) was obtained to be 68.86, 85.02, and 91.94%, respectively in optimum values of 7, 0.05 g/L, 30 mg/L, 100 min, and 298 K for pH, adsorbent dose, initial concentration, contact time, and temperature, respectively. Kinetic and isotherm data showed high accuracy fitting with pseudo-second-order and Langmuir models, respectively. Based on the outcomes of intraparticle diffusion model, penetration into adsorbents are more effective than film diffusion in OFL removal. The monolayer adsorption capacity of CS/KCa/PVA, CS/KCa/PVA-NiFe LDH (1 wt%), and CS/KCa/PVA-NiFe LDH (2 wt%) was computed to be 37.59, 41.49, and 52.63 mg/g, respectively. Thermodynamic study reveals that OFL removal process by adsorbents has negative variations in Gibbs free energy and enthalpy (-17.55 kJ/mol for CS/KCa/PVA, -35.88 kJ/mol for CS/KCa/PVA-NiFe LDH (1 wt%), and − 49.15 kJ/mol for CS/KCa/PVA-NiFe LDH (2 wt%)) showing spontaneous and exothermic nature of this process. The ad(de)sorption study showed that no significant changes in removal performance were seen up to 4 cycles. Antibacterial activity showed that CS/KCa/PVA-NiFe LDH has uppermost antibacterial activity towards S. <i>aureus</i> compared to <i>E.Coli</i>. Finally, synthesized adsorbents specially CS/KCa/PVA-NiFe LDH (2 wt%) could be applied as efficient adsorbents in wastewater treatment application.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2651 - 2671"},"PeriodicalIF":4.7,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Complex Dyeing of Bio-based Polyamide 11 Fibers in Ethanol","authors":"Kaijun He,&nbsp;Guanpeng Zhou,&nbsp;Yanyan Li,&nbsp;Jiajia Shen","doi":"10.1007/s10924-025-03554-z","DOIUrl":"10.1007/s10924-025-03554-z","url":null,"abstract":"<div><p>Polyamide 11 (PA11) is a novel type of 100% bio-based and renewable fiber which can not achieve good dyeing results for conventional water bath dyeing techniques due to its smooth surface and long carbon chain hydrophobic structure. Furthermore, conventional dyeing processes typically involve extensive use of water and chemical reagents, driving up production costs and exerting serious ecological damage. The development of a new dyeing method suitable for bio-based PA11 fibers is crucial for sustainable development in the textile industry. In this study, we present a novel method for achieving effective dyeing of bio-based PA11 fibers using only dyes, calcium chloride (CaCl₂), and recyclable ethanol (EtOH), eliminating the necessity for additional chemical reagents. The dyeing process operates at a reduced temperature (80 ℃) and bypasses the pre-treatment stage for PA11. Compared to the traditional aqueous dyeing, the novel method significantly enhances dye uptake (&gt; 98%) and color depth (K/S value) of PA11, while maintaining comparable color fastness ( ≧ grades 3–4), and acceptable mechanical properties. In addition, the new dyeing method has minimal impacts on the structure and performance of bio-based PA11 fibers. This is of great significance for the development and application of bio-based PA11 in the field of chemical fibers. </p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2619 - 2632"},"PeriodicalIF":4.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus acidophilus-Produced Polyhydroxybutyrate Nanoparticles: an Ideal Carrier for Multiple Sclerosis Treatment","authors":"Zahra Salarieh,&nbsp;Akbar Esmaeili","doi":"10.1007/s10924-025-03549-w","DOIUrl":"10.1007/s10924-025-03549-w","url":null,"abstract":"<div><p>Polyhydroxyalkanoates (PHAs), specifically polyhydroxybutyrate (PHB), are biodegradable polymers synthesized by various bacteria as energy. Unlike petrochemical-based plastics, PHAs are environmentally friendly and biocompatible. This study investigates a novel approach utilizing <i>Lactobacillus acidophilus</i> to produce PHB nanoparticles (PHB NPs), which holds promise for biomedical applications PHBs have advanced applications. The NPs exhibit small, uniform sizes and favorable zeta potential, making them ideal biotherapeutic carriers. The study focuses on optimizing PHB synthesis via microbial fermentation, where <i>L. acidophilus</i> cells were engineered to produce PHB NPs loaded with glatiramer acetate. In vitro and In vivo studies demonstrate the NPs’ efficacy in treating multiple sclerosis (MS). The findings suggest that these PHB NPs can potentially halt disease progression. Further pharmacodynamic and pharmacokinetic evaluations are crucial for advancing these NPs toward industrial applications in biomedicine. The goal is to utilize the produced PHB as a drug delivery system that is both biocompatible and capable of carrying active pharmaceutical ingredients.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2633 - 2650"},"PeriodicalIF":4.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Microencapsulation of Quercetin-Rich Onion (Allium cepa) Peel Extract in Ethyl Cellulose Using a W/O/W Double Emulsion: Optimised Production, Characterisation, and Controlled Release","authors":"Sara M. Ferreira,&nbsp;Loleny Tavares,&nbsp;Lúcia Santos","doi":"10.1007/s10924-025-03552-1","DOIUrl":"10.1007/s10924-025-03552-1","url":null,"abstract":"<div><p>Quercetin (QE) is an important phenolic that offers various health benefits. This compound can be extracted from onion (<i>Allium cepa</i>) peels, a common agro-industrial by-product, resulting in quercetin-rich extracts (QRE). However, incorporating QE and QRE into foods and other products remains limited due to their low stability and solubility. Thus, this study aimed to microencapsulate QE and QRE using ethyl cellulose as wall material and double-emulsion as encapsulation technology to enhance their stability and bioavailability. The effect of different formulation and production parameters was studied to optimise the final formulation and assess their influence on the final characteristics. The oil phase solvent was the most significant variable influencing the encapsulation efficiency (EE), actual loading content and particle size. The QRE was obtained from onion peels and characterised, exhibiting a total phenolic content of 362 mg_GAE∙g_extract^-1 and interesting antioxidant properties. The anti-diabetic potential was demonstrated by inhibiting 91 and 90% of α-amylase and β-glucosidase, respectively. The QRE was microencapsulated using the two most effective formulations and compared with the quercetin-loaded microparticles. Extract-loaded microparticles performed similarly to quercetin-loaded microparticles, with EEs between 90 and 97% and an average particle size of around 19 μm. In vitro release studies were conducted in ultrapure water and octanol. Results indicated that the primary release mechanism in both media was Fickian diffusion, and higher loading resulted in a faster release into the medium. This study provided new and innovative insights into the microencapsulation of bioactive QE, whether pure or from agro-industrial by-products, for incorporation into various value-added products.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2567 - 2586"},"PeriodicalIF":4.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03552-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Sustainable Smart Biodressing Using Chitosan, Albumin, and Green Propolis for Dermal Lesion Care: An In Vitro Study with Multivariate Analysis","authors":"Marcos Vinicius de Sousa Pereira,&nbsp;Gislaine Gonçalves Fonseca,&nbsp;Yugreidis Pianeta Cervantes,&nbsp;Jonnier Javier Fontalvo Martinez,&nbsp;Edileuza Marcelo Vieira,&nbsp;Tatianny de Araujo Andrade,&nbsp;Renê Chagas da Silva,&nbsp;Jemmyson Romário de Jesus","doi":"10.1007/s10924-025-03550-3","DOIUrl":"10.1007/s10924-025-03550-3","url":null,"abstract":"<div><p>Here, we report on the development and characterization of a smart chitosan-based biodressing for the treatment of dermal lesions, based on the controlled release of green propolis (GP). Smart biodressing refers to dressing that responds to wound environmental conditions, such as temperature, to release therapeutic substances. Smart biodressing was produced using multifactorial optimization. Three factors were evaluated: (i) chitosan mass (0.5–2.0 g), (ii) acetic acid concentration (1.0–5.0%, w/v) and (iii) glutaraldehyde concentration (0.0–5.0%). Fixed concentration of albumin (Alb) (6.7 mg mL⁻¹) was tested to increase the biocompatibility and biodegradability of the produced biodressing. Infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) analysis were used to characterize the prepared biodressing. Using the best conditions for preparation of the biodressing, the GP loading efficiency into the biodressing was 89.9 ± 1.1% (<i>n</i> = 3). Prepared biodressing showed high porosity (88.7 ± 1.3%) and high water vapor permeability, ranging between 74.3 and 98.3 × 10¹⁰ g ms⁻¹ Pa⁻¹. The release kinetics of green propolis followed a controlled pseudo-second order model (R² = 0.985), highlighting the material’s smart release capabilities. In vitro and ex-vivo skin penetration studies showed that the drug carried by the material penetrated the skin layers (stratum corneum, epidermis and dermis). In vitro study using <i>Artemia salina</i> indicate that the biodressing demonstrated low toxicity. The use of biodegradable and natural materials, such as chitosan and green propolis, reinforces the sustainable nature of the biodressing, offering an environmentally friendly alternative for wound treatment.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2587 - 2601"},"PeriodicalIF":4.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Catechin Loaded Bioactive Nanoparticulate Formulation to Improve Cellular Uptake and Gastrointestinal Digestion by In-Vitro Intestinal Co-culture Method","authors":"Chunmei Yin","doi":"10.1007/s10924-025-03548-x","DOIUrl":"10.1007/s10924-025-03548-x","url":null,"abstract":"<div><p>Nanoparticles, specifically polymeric nanoparticles, have been investigated to utilize as drug carriers in recent research. Oral ingestion has been considered a prominent exposure route to nano-based carriers. Hence, the uptake of bioactive NPs by epithelial cells and their interaction with digestive enzymes in the gastrointestinal tract (GIT) would be an effective therapeutic approach to many diseases. The present report aimed to investigate the catechins (CAT) and gelatin (GEL) were blended to fabricate self-assembled gelatin nanoparticles (CAT@GEL NPs) for their improved cellular uptake ability by cell co-culture method, which was developed by Caco-2/HT-29 co-cultured cell prototype. The prepared GEL NPs have a particle size of about ≈ 160 nm and a polydispersity index (PDI) is 0.258, which is suitable for effective cellular uptake. The prepared GEL NPs have prominently improved encapsulation efficiency (EE %) and in-vitro drug release ability about 90.40% and 89.62%, respectively. Importantly, the efficiency of the cellular intake and nanoparticle absorption activity in monoculture was determined by performing flow cytometry and fluorescence spectroscopic analyses on the in-vitro co-culture model. The outcome of the study demonstrated that prepared nanoformulation revealed an outstanding absorption ability, cellular uptake, and suitable cell compatibility (&gt; 90% survival rate). The flow cytometry analysis demonstrated that digested CAT@GEL NPs were significantly higher about 93.98%, confirming that particles are stable without disturbing cell survival rate (%). This study suggests that the developed CAT@GEL nanoformulation could be an effective nanocarrier for the bioactive substances to gastrointestinal oral digestion applications.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 6","pages":"2602 - 2618"},"PeriodicalIF":4.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valorization of Corn Bran-derived Carbohydrate Polymers for Developing Biodegradable Packaging Films","authors":"Syed Ammar Hussain,&nbsp;Phoebe X. Qi,&nbsp;Brajendra K. Sharma,&nbsp;Madhav P. Yadav,&nbsp;Kalidas Mainali,&nbsp;Tony Z. Jin","doi":"10.1007/s10924-025-03551-2","DOIUrl":"10.1007/s10924-025-03551-2","url":null,"abstract":"<div><p>This study aims to develop biobased composite films using hemicellulose (HB), methylcellulose (MC), and carboxymethyl cellulose (CMC) combined with natural additives, including high methoxy pectin (HMP), selected proteins (whey, casein, soy, and pea), and glycerol. Results showed that integrating these components significantly improved the physical qualities, peelability, foldability, and transparency, particularly in HB/CMC-based films. Mechanical properties of the films, i.e., elongation at break, tensile stress, elastic modulus, and toughness, were also enhanced by incorporating these additives. Among the combinations studied, the HB/CMC-based films with HMP, sodium caseinate (NaCas) or pea protein isolate (PPI), and glycerol (G) films exhibited the highest elongation at a break of 139%. Supplementing additives to HB, MC, or CMC-based films improved thermal stability, supported by thermogravimetry. Combining HMP/NaCas/G to HB/CMC resulted in films with the highest peak temperature (276° C). Additionally, integrating NaCas into the films also reduced oxygen and water vapor permeabilities by up to 25% and 11%, respectively, compared to their controls. Fourier Transform Infrared spectroscopy (FTIR) revealed an additive relationship between HB and MC or CMC composite films relative to their singular spectra. SEM showed a smooth compact structure, indicating a homogeneous blending amongst all components. This work demonstrated a viable solution for developing environmentally friendly bio-packaging materials based on HB extracted from corn bran, a plentiful low-value by-product of the biofuel industry’s corn kernel dry milling process combined with other agricultural-derived biomass, such as pectin, proteins, and glycerol.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2552 - 2566"},"PeriodicalIF":4.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-Arginine-Functionalized Chitosan/Poly(Vinylpyrrolidone) Composite as a Novel Adsorbent for Efficient Removal of Hg (II) and Amoxicillin from Aqueous Medium","authors":"Mojtaba Azizi,&nbsp;Mahdi Akhgari,&nbsp;Maryam Esmkhani,&nbsp;Hossein Ghafuri,&nbsp;Shahrzad Javanshir","doi":"10.1007/s10924-025-03529-0","DOIUrl":"10.1007/s10924-025-03529-0","url":null,"abstract":"<div><p>Biobased adsorbents such as chitosan due to nontoxic nature, biocompatibility, and accessibility can be used to blend with other polymers to develop their physical and chemical features. This study aims to fabricate a highly efficient adsorbent through the functionalization of Chitosan- Poly(Vinylpyrrolidone) (PVP) beads with l-arginine. The prepared nano-sorbent was well characterized via various analytical methods such as FTIR, BET, EDS, XRD, FESEM, and TGA and applied in the removal of amoxicillin and Hg (II). The optimal conditions for higher performance were assessed with the optimization of different factors including pH, dosage, time, and initial concentration for both pollutants. The prepared composite has demonstrated considerable adsorption capacity toward Hg(II) and amoxicillin with the highest adsorption capacities of 313.162 mg/g and 2800 mg/g, respectively, confirming the composite’s various adsorption mechanisms. Accordingly, the composite mostly follows the pseudo-second-order kinetics and the Langmuir adsorption isotherm model. The extraordinary adsorption capacity with the accompaniment of the porous structure of the prepared composite has a promising application for high-performance wastewater treatment.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2537 - 2551"},"PeriodicalIF":4.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable Shape Memory Nanocomposites Based on PCL/PPC/Graphene: As a Proposal Material for Cardiovascular Stent","authors":"Maryam Hashemi,&nbsp;Ismaeil Ghasemi,&nbsp;Abdollah Omrani,&nbsp;Abbasali Rostami,&nbsp;Carlos J. Durán-Valle,&nbsp;Mohammad Qandalee","doi":"10.1007/s10924-025-03546-z","DOIUrl":"10.1007/s10924-025-03546-z","url":null,"abstract":"<div><p>The limitations of metallic stents have led to the development of absorbable polymer stents in cardiovascular applications. This study focuses on the synthesis of biodegradable shape memory nanocomposites made of polycaprolactone (PCL), poly(propylene carbonate) (PPC) and functionalized graphene nanoparticles (FGNp), designed for medical devices that exhibit shape memory effects at human body temperature. The nanocomposites were synthesized using a solvent casting method. To enhance the performance of graphene nanoparticles (GNPs), chemical modification with polyethylene glycol (PEG) was performed, which was confirmed by energy dispersive X-ray spectroscopy (EDX) and Raman spectroscopy. The effect of modified graphene nanoparticles on the shape memory behavior was discussed in detail and the presence of graphene showed an increase in temporary shape stabilization in the samples. In the nanocomposite with 10 wt% PCL and 0.5 phr FGNp, the shape fixation ratio (Rf) and shape recovery ratio (Rr) of about 90% were achieved with a shape memory transition temperature (Ts) close to human body temperature. This sample was successfully fabricated into a stent by a 3D bioprinter, and the fabricated stent exhibited an improved shape memory effect. Furthermore, comprehensive blood compatibility evaluations including hemolysis, cytotoxicity, and complement activation along with in vitro degradation and drug release behavior evaluations confirmed the potential of the nanocomposite PCL10/PPC90/FGNP0.5 as a promising candidate for the fabrication of biomedical stents.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 5","pages":"2464 - 2479"},"PeriodicalIF":4.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}