Journal of Polymers and the Environment最新文献

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A Sustainable Artemisia Vulgaris Hydrogel-co-Acrylic Acid Polymer: A High-Performance Sorbent for Mitigating Heavy Metal Water Pollution 可持续发展的青蒿水凝胶-共丙烯酸聚合物:一种减轻重金属水污染的高性能吸附剂
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-29 DOI: 10.1007/s10924-026-03833-3
Mohammed G. M. Zeariya, Fahad Awwadh Almarshadi, Reda Abdel-Hameed, Haitham Elbir, Mariam Saeed Ibrahim Essa, Shagufta Zayan, Tauqeer Ahmad, Umar Nishan, Azhar Abbas, Sara Kh. M. El-Shennawy
{"title":"A Sustainable Artemisia Vulgaris Hydrogel-co-Acrylic Acid Polymer: A High-Performance Sorbent for Mitigating Heavy Metal Water Pollution","authors":"Mohammed G. M. Zeariya,&nbsp;Fahad Awwadh Almarshadi,&nbsp;Reda Abdel-Hameed,&nbsp;Haitham Elbir,&nbsp;Mariam Saeed Ibrahim Essa,&nbsp;Shagufta Zayan,&nbsp;Tauqeer Ahmad,&nbsp;Umar Nishan,&nbsp;Azhar Abbas,&nbsp;Sara Kh. M. El-Shennawy","doi":"10.1007/s10924-026-03833-3","DOIUrl":"10.1007/s10924-026-03833-3","url":null,"abstract":"<div><p> The pollution of water by heavy metals is a severe problem to the environment and human health, as these pollutants are toxic, persistent, and can be absorbed by living organisms throughout the food chain. This study involves the synthesis, characterization, and application of a new Artemisia Vulgaris Hydrogel—Acrylic Acid copolymer (AVH-co-AA) as an efficient and sustainable sorbent for Cu(II),and Co(II) ions removal from aqueous solutions. Hydrogel was synthesized by a simple green approach using Artemisia Vulgaris seed extract as natural precursor, acrylic acid (AA) as monomer, and N, N′-methylene bisacrylamide (MBA) as cross-linker. Fourier Transform Infrared Spectroscopy (FTIR), Thermo Gravimetric Analysis (TGA), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM) were used to characterize the chemical and structural nature of the copolymer, which suggested successful polymerization, functional groups responsible for binding metal cations, and a porous landscape suitable for adsorption applications. High dynamic adsorption capacity was demonstrated in fixed-bed column tests, where breakthrough behavior was influenced by influent concentration, bed height, and flow rate. The Thomas and Yoon-Nelson models accurately described column kinetics, demonstrating dependable and predictable performance. Copolymer maintained high removal efficiency over multiple adsorption–desorption cycles, confirming its reusability and stability. Hence, this AVH-co-AA copolymer is presented as a green, cost-effective, and highly active adsorbent for the effective removal of heavy metals and may thus provide a promising approach toward water purification and environmental protection.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Solvent-Assisted Coaxial Electrospinning of PVA/PLLA Nanofibers with Tailored Morphology and Diffusion-Controlled Transport 具有定制形态和扩散控制传输的PVA/PLLA纳米纤维的绿色溶剂辅助同轴静电纺丝
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-28 DOI: 10.1007/s10924-026-03840-4
Rubén Martín-Cabezuelo, María-Antonia Serrano, Enrique Barrajón-Catalán, Lara Peral Ballester, José Antonio Gómez-Tejedor
{"title":"Green Solvent-Assisted Coaxial Electrospinning of PVA/PLLA Nanofibers with Tailored Morphology and Diffusion-Controlled Transport","authors":"Rubén Martín-Cabezuelo,&nbsp;María-Antonia Serrano,&nbsp;Enrique Barrajón-Catalán,&nbsp;Lara Peral Ballester,&nbsp;José Antonio Gómez-Tejedor","doi":"10.1007/s10924-026-03840-4","DOIUrl":"10.1007/s10924-026-03840-4","url":null,"abstract":"<div><p>Green solvent strategies are increasingly important for advancing sustainable polymer processing and deepening the understanding of structure–property relationships. In this work, we report a coaxial electrospinning approach that employs dimethyl sulfoxide and ethyl acetate as environmentally benign solvents to fabricate nanofibers composed of polyvinyl alcohol (PVA) cores and poly(L-lactic acid) (PLLA) shells. Comprehensive morphological and physicochemical characterization confirmed the successful formation of uniform, defect-free core–shell architectures. Comparative transport studies revealed clear architecture-dependent behavior: uniaxial PVA fibers displayed rapid burst release, PLLA-only fibers acted as complete diffusion barriers, and coaxial PVA/PLLA fibers enabled finely tunable, diffusion-controlled transport over extended timescales. These findings establish direct links between solvent choice, processing architecture, and transport properties in biodegradable nanofiber systems. This study provides both a scalable eco-conscious electrospinning strategy and a fundamental framework for correlating processing, morphology, and mass transport in polymeric materials.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-026-03840-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Fabrication, Characterization and Biological Evaluation of 3D-Printed PCL–Lignin Copolymer Scaffold for Tissue Engineering 组织工程用3d打印聚氯乙烯-木质素共聚物支架的合成、制备、表征及生物学评价
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-27 DOI: 10.1007/s10924-026-03829-z
Shayan Hosseini, Mahdieh Ranjbar-jamalabadi, Tayebeh Behzad, Mohammad Dinari, Mohammad Mohammadalipour
{"title":"Synthesis, Fabrication, Characterization and Biological Evaluation of 3D-Printed PCL–Lignin Copolymer Scaffold for Tissue Engineering","authors":"Shayan Hosseini,&nbsp;Mahdieh Ranjbar-jamalabadi,&nbsp;Tayebeh Behzad,&nbsp;Mohammad Dinari,&nbsp;Mohammad Mohammadalipour","doi":"10.1007/s10924-026-03829-z","DOIUrl":"10.1007/s10924-026-03829-z","url":null,"abstract":"<div><p>Biopolymeric 3D-printed scaffolds promote cell adhesion, proliferation, and differentiation for tissue regeneration. This study addresses the mechanical limitations of natural polymers and enhances interfacial bonding and bioactivity by fabricating polycaprolactone-lignin (PCL-Lig) copolymer scaffolds via ring-opening copolymerization, achieving a 71% yield. FTIR spectroscopy confirmed ether bond formation (1070–1150 cm⁻¹), and ¹H NMR spectra exhibited peaks at 3.85 ppm and 6.85 ppm corresponding to lignin and caprolactone units. Thermal analysis revealed a melting temperature of 59 °C and a glass transition temperature of −20 °C, indicating suitability for printing. Scaffolds printed using a 0.3 mm nozzle at 57 °C and 0.1–0.15 MPa, optimized via the Taguchi design, exhibited a compressive modulus of 98.00 MPa and a compressive strength of 9.89 MPa at failure. These values correspond to an increase of 13.3% in modulus and 15.7% in strength compared with pure PCL scaffolds, meeting the mechanical requirements for bone scaffolds. SEM analysis revealed uniform fibrous morphology with pore sizes of 219–236 μm, favorable for cell infiltration. Fibroblast assays also demonstrated excellent biocompatibility with cell viability of 114% and 105% at 24 h and 72 h, respectively. Immunocytochemistry indicated 13.65% and 9.9% increases in ALP and RUNX2 expression, respectively, compared with pure PCL scaffolds. Quantitative RT-PCR further confirmed an 81.25% increase in RUNX2 expression and the highest observed increases in ALP (75.69%), OCN (42.38%), and COL1A1 (34.86%) in MG-63 cells. These findings establish PCL-Lig scaffolds as promising candidates for bone tissue engineering.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147796874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable Marine-Derived Protein based Nanocomposite Scaffolds for Bone Tissue Engineering: Fabrication, Characterization, and Osteogenic Potential 用于骨组织工程的可持续海洋蛋白质纳米复合材料支架:制造、表征和成骨潜能
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-20 DOI: 10.1007/s10924-026-03837-z
Veeruraj Anguchamy, Jianping Wu
{"title":"Sustainable Marine-Derived Protein based Nanocomposite Scaffolds for Bone Tissue Engineering: Fabrication, Characterization, and Osteogenic Potential","authors":"Veeruraj Anguchamy,&nbsp;Jianping Wu","doi":"10.1007/s10924-026-03837-z","DOIUrl":"10.1007/s10924-026-03837-z","url":null,"abstract":"<div><p>Natural bio-derived polymers such as collagen and chitosan are widely used in regenerative medicine due to their biocompatibility and ability to form extracellular matrix-like scaffolds. In this study, a three-dimensional nanocomposite scaffold was developed using collagen, chitosan, and nano-hydroxyapatite (nHAp) derived from marine fish and cephalopod processing waste, providing a sustainable alternative to mammalian-sourced biomaterials. nHAp was incorporated into the polymer matrix (Col/CS/CHS) solution to enhance both the mechanical and cell-attachment properties of the scaffolds. SEM and AFM analyses revealed a hierarchically porous, smooth and interconnected structure favorable for nutrient diffusion and cell infiltration. XRD and FTIR confirmed the structural stable incorporation, and crystalline nature of nHAp within the composite. Thermal properties were evaluated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) to determine the scaffold’s thermal stability. In vitro assays with MC3T3-E1 osteoblasts demonstrated non-cytotoxicity and enhanced bioactivity, including increased cell adhesion, proliferation, and alkaline phosphatase (ALP) activity, indicating promoted osteogenic differentiation. The scaffold also supported higher mineral deposition, increased cell density, DNA content, reflecting strong osteoconductive potential. By valorizing marine processing waste into high-value biomaterials, this work reduces environmental impact and supports circular bioeconomy practices. Moreover, the scaffold’s multifunctional properties suggest potential applications in stem cell proliferation, antibacterial activity, wound healing, and broader tissue regeneration, reinforcing its strong potential in bone tissue engineering. Overall, the marine-derived nanocomposite scaffold exhibits desirable physicochemical properties, biocompatibility, and osteogenic capacity, highlighting its promise for bone tissue engineering applications.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147738327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functionalizing Calendered PLA/PBAT Films with Natural Food Additives 用天然食品添加剂使压延PLA/PBAT薄膜功能化
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-025-03724-z
Ignacio Mena-Prado, Marta Fernández-García, Enrique Blázquez-Blázquez, Sara Limbo, Manuela Rollini, Daniele Maria Martins, Juan P. Fernández-Blázquez, Adolfo del Campo, Alexandra Muñoz-Bonilla
{"title":"Functionalizing Calendered PLA/PBAT Films with Natural Food Additives","authors":"Ignacio Mena-Prado,&nbsp;Marta Fernández-García,&nbsp;Enrique Blázquez-Blázquez,&nbsp;Sara Limbo,&nbsp;Manuela Rollini,&nbsp;Daniele Maria Martins,&nbsp;Juan P. Fernández-Blázquez,&nbsp;Adolfo del Campo,&nbsp;Alexandra Muñoz-Bonilla","doi":"10.1007/s10924-025-03724-z","DOIUrl":"10.1007/s10924-025-03724-z","url":null,"abstract":"<div><p>Herein, biodegradable and functional films based on PLA/PBAT (Ecovio<sup>®</sup>) blends were prepared by calandering processing that allows high-quality films and proper blend mixing. To provide functional properties such as antioxidant and antimicrobial activity, food additives were incorporated including sodium stearoyl lactylate (designated as E481) at 5 wt% and bioplasticizers derived from vegetable oils, namely CITREM (E472C) and ACETEM (E472A) at 10 wt%. Chitin nanocrystals were also added to enhance barrier and mechanical properties. The films of around 200 μm thick were produced resulting in uniform and high-quality materials. Scanning electron microscopy and confocal Raman microscopy demonstrated good mixing of PLA and PBAT biopolymers, as well as a homogeneous dispersion of the additives. This effective blending provides excellent mechanical performance, particularly elongation at break, with values approaching 500% for most of the prepared films. The additives had minimal effect on the crystallinity, thermal and barrier properties while imparting antioxidant and antimicrobial properties with negligible migration into food simulant media, bellow 0.08 mg/Kg in all the cases. Citroglycerides, mono-and diglycerides of fatty acids and sodium stearoyl lactylate provides Trolox equivalent antioxidant capacity (TEAC) values between 14 and 18 µmol Trolox/g, and were effective against Gram-positive <i>Staphylococcus aureus</i> and <i>Listeria innocua</i> achieving complete bacterial inhibition at the contact tested concentration (ΔLog CFU/mL: 4.54 and 3.71, respectively). Finally, the disintegration of the films under industrial composting condition was demonstrated; this issue is essential to evaluate the environmental impact of the packaging at the end of its life cycle.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10924-025-03724-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio-based Poly(butylene 2,5-furandicarboxylate-co-glutarate): The Effect of Glutaric Acid on the Properties of Poly(butylene 2,5-furandicarboxylate) 生物基聚丁烯2,5-呋喃二甲酸酯-共戊二酸酯:戊二酸对聚丁烯2,5-呋喃二甲酸酯性能的影响
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-026-03835-1
Chao Qi, Jun Jia, Ning Zhang, Yi Qin, Haiyang Li, Jingyuan Feng, Jing Hu
{"title":"Bio-based Poly(butylene 2,5-furandicarboxylate-co-glutarate): The Effect of Glutaric Acid on the Properties of Poly(butylene 2,5-furandicarboxylate)","authors":"Chao Qi,&nbsp;Jun Jia,&nbsp;Ning Zhang,&nbsp;Yi Qin,&nbsp;Haiyang Li,&nbsp;Jingyuan Feng,&nbsp;Jing Hu","doi":"10.1007/s10924-026-03835-1","DOIUrl":"10.1007/s10924-026-03835-1","url":null,"abstract":"<div><p>Bio-based poly(butylene 2,5-furandicarboxylate) (PBF) has high tensile strength, but low elongation at break. To improve the toughness, this study employed 1,5-glutaric acid (GA) to synthesize poly(butylene 2,5-furandicarboxylate-co-glutarate) (PBFG). The impact of GA on PBF’s composition and properties was investigated in detail. The thermal decomposition temperature exceeded 350 °C, and as the concentration of GA rose, the thermal decomposition behavior gradually grew closer to poly(butylene glutarate) (PBG). In accordance with DMA, GA enables PBF’s glass transition temperature to fall from 44.4 °C to -52.7 °C. The copolyester’s toughness is substantially improved by adding a portion of GA. PBFG25 with high tensile strength of 61.5 MPa and high elongation at break of 856% combines exceptional toughness and high tensile strength. After the tensile test, the transparency of PBFG25 and PBFG50 increased, the melting enthalpy of DSC decreased, and they rebounded after the fracture. The above results support the mesophase hypothesis of furan-based polyesters. This paper presents the theoretical foundations for the controlled structure and property enhancement of bio-based polyesters.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound Activated Biocomposite of Saccharomyces cerevisiae and Magnetic Nanoparticles with Cellulose Acetate Microfibers for Cadmium (II) Removal 超声活化酿酒酵母和磁性纳米颗粒与醋酸纤维素微纤维的生物复合去除镉(II)
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-026-03819-1
Maryam Nikkhoo, Mohsen Dalvi-Isfahan, Abdollah Hematian Sourki
{"title":"Ultrasound Activated Biocomposite of Saccharomyces cerevisiae and Magnetic Nanoparticles with Cellulose Acetate Microfibers for Cadmium (II) Removal","authors":"Maryam Nikkhoo,&nbsp;Mohsen Dalvi-Isfahan,&nbsp;Abdollah Hematian Sourki","doi":"10.1007/s10924-026-03819-1","DOIUrl":"10.1007/s10924-026-03819-1","url":null,"abstract":"<div>\u0000 \u0000 <p>Heavy metal contamination in aquatic environments has become a serious global concern due to its toxicity, persistence, and bioaccumulation in living organisms. Therefore, the development of efficient, low-cost, and environmentally friendly adsorbents for heavy metal removal is of great importance. Conventional adsorbents such as <i>Saccharomyces cerevisiae</i>, Fe₃O₄ nanoparticles, and electrospun cellulose acetate (CA) microfibers have inherent limitations that restrict their practical applications in this field. Yeast cells, despite possessing abundant functional groups, suffer from low mechanical stability, difficult recovery, and limited adsorption capacity. Fe₃O₄ nanoparticles tend to aggregate, leading to a decrease in active surface area and potential secondary contamination. Furthermore, pure CA microfiber mats often exhibit low adsorption efficiency and surface fouling. To overcome these limitations, a biocompatible composite adsorbent was synthesized by combining ultrasound-treated <i>Saccharomyces cerevisiae</i> yeast, Fe₃O₄ magnetic nanoparticles, and electrospun cellulose acetate (CA) pads. The synergistic combination of these components resulted in increased surface area, improved mechanical stability, reduced nanoparticle aggregation, and facile magnetic separation of the adsorbent after use. SEM images and FTIR spectra confirmed the successful loading of Fe₃O₄ nanoparticles onto the yeast cells and the formation of the composite adsorbent. The maximum adsorption capacity of 11.84 mg g⁻¹ was achieved under optimal conditions, including a pH of 5.19, a contact time of 3 h, and an Fe₃O₄-loaded yeast dosage of 0.2 g. Isotherm modeling demonstrated a better fit with the Freundlich model (R² = 0.97), indicating a heterogeneous surface and multilayer adsorption behavior. Kinetic analysis showed that the adsorption process followed the pseudo-first-order model (R² = 0.97, qₑ = 3.6 mg g⁻¹), suggesting that physical adsorption was the dominant mechanism. The combined effects of the porous CA structure, bioactive yeast, and Fe₃O₄ nanoparticles contributed to the enhanced adsorption performance.</p>\u0000 </div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication and Evaluation of a Bilayer Gelatin Nanofiber/Alginate Hydrogel Skin Substitute with Sustained Release of bFGF-Loaded Mesenchymal Stem Cell-Derived Exosomes at the Wound Site 双层明胶纳米纤维/海藻酸盐水凝胶皮肤替代品的制备和评价,并在伤口部位持续释放装载bfgf的间充质干细胞来源的外泌体
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-026-03831-5
Shaghayegh Shahsavan, Akram Alizadeh, Fazel Sahraneshin Samani, Vajihe Taghdiri Nooshabadi, Hamid Reza Sameni
{"title":"Fabrication and Evaluation of a Bilayer Gelatin Nanofiber/Alginate Hydrogel Skin Substitute with Sustained Release of bFGF-Loaded Mesenchymal Stem Cell-Derived Exosomes at the Wound Site","authors":"Shaghayegh Shahsavan,&nbsp;Akram Alizadeh,&nbsp;Fazel Sahraneshin Samani,&nbsp;Vajihe Taghdiri Nooshabadi,&nbsp;Hamid Reza Sameni","doi":"10.1007/s10924-026-03831-5","DOIUrl":"10.1007/s10924-026-03831-5","url":null,"abstract":"<div>\u0000 \u0000 <p>We developed a bilayer dermal–epidermal skin substitute that structurally and functionally mimics native skin and supports the treatment of full-thickness wounds. The construct was incorporated with bone marrow mesenchymal stem cell (BM-MSC)–derived exosomes loaded with basic fibroblast growth factor (bFGF) to enhance and expedite the wound healing process. The epidermal-mimicking upper layer consisted of electrospun gelatin nanofibers, while the dermal-mimicking lower layer comprised an alginate hydrogel. Both gelatin and alginate are biocompatible polymers routinely used in commercially available wound dressings. Fourier transform infrared spectroscopy (FTIR) confirmed stable integration of the two layers through intermolecular interactions, including hydrogen bonding and electrostatic forces. The bFGF-loaded exosome-encapsulating scaffold (bFGF-Exo@A4G20; 4% alginate and 20% gelatin) exhibited several favorable properties essential for effective wound healing, including excellent biocompatibility with negligible cytotoxicity; suitable porosity (90.8%); an optimal swelling ratio (666.3%); efficient moisture retention; and the ability to support cell adhesion, proliferation, and migration. In line with emerging wound healing strategies that emphasize temporally coordinated therapeutic interventions, the alginate hydrogel layer enabled controlled and sustained release of bFGF-loaded exosomes, and provided prolonged bioactive signaling during critical proliferative and remodeling phases of tissue repair. In vivo, wounds treated with the bilayer construct showed significantly accelerated closure compared with controls, accompanied by enhanced re-epithelialization, increased epidermal thickness, and improved regeneration of skin appendages such as hair follicles and sebaceous glands. The treated wounds exhibited higher collagen deposition and more robust angiogenesis, which highlights the effectiveness of sustained pro-angiogenic signaling in functional tissue regeneration.</p>\u0000 </div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimuli-Responsive Permeation of Niacin from Gelatin/Polyacrylamide Hybrid Hydrogels under Electric Field and Ultrasound Stimulation 明胶/聚丙烯酰胺杂化水凝胶中烟酸在电场和超声刺激下的刺激响应渗透
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-026-03821-7
Apichart Sonthisombat, Kanyanat Maengtap, Sopin Sirichat, Nophawan Paradee, Supanit Chungyampin, Sumonman Niamlang
{"title":"Stimuli-Responsive Permeation of Niacin from Gelatin/Polyacrylamide Hybrid Hydrogels under Electric Field and Ultrasound Stimulation","authors":"Apichart Sonthisombat,&nbsp;Kanyanat Maengtap,&nbsp;Sopin Sirichat,&nbsp;Nophawan Paradee,&nbsp;Supanit Chungyampin,&nbsp;Sumonman Niamlang","doi":"10.1007/s10924-026-03821-7","DOIUrl":"10.1007/s10924-026-03821-7","url":null,"abstract":"<div><p>To investigate the permeation efficiency of hybrid gelatin (GE)/polyacrylamide (PAM) hydrogel for transdermal drug delivery patch application, niacin (NA) was chosen as a hydrophilic model active pharmaceutical ingredient to evaluate permeation behavior. To investigate the effect of crosslinking ratio on the permeation characteristics, gelatin/polyacrylamide hydrogels were prepared at different crosslinking ratios (Mol<sub>MBAA</sub>/Mol<sub>AM</sub> at 0.001, 0.005, 0.01, 0.035 for GE_PAM_0.001, GE_PAM_0.005, GE_PAM_0.01 and GE_PAM_0.035). The permeation experiment was conducted at pH 7.4 and a temperature of 37 °C for 24 h with or without external stimuli (electrical potential, ultrasound, and a hybrid system). For passive permeation, the amount of NA permeation increased with time and reached a plateau value. The GE_PAM_0.01 showed the highest NA permeation due to its highest % swelling. To enhance the permeation efficiency, external electrical potential and ultrasound were applied. The amount of NA permeation increased with increasing electrical potential due to electro-repulsive forces. For the ultrasound-assisted system, the NA permeation increased with longer durations of ultrasound application due to thermal effects and micro-pathway generation within the skin membrane. In the hybrid system that combined the electrical potential with ultrasound, the amount of NA permeation reached 78.24%, which was higher than that of either the electrical potential or ultrasound alone. Thus, GE/PAM hydrogel, which was efficient in drug permeation under external stimulation, can be developed to become an NA transdermal patch when being controlled by external electrical potential and ultrasound.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pheromones Impregnated on Porous PLA Fibers for Integrated Pest Management 多孔聚乳酸纤维浸渍信息素用于害虫综合治理
IF 5 3区 工程技术
Journal of Polymers and the Environment Pub Date : 2026-04-17 DOI: 10.1007/s10924-026-03827-1
Darius Klassen, Catherine Pouchet, William Simon, Isabella Smith, Noémie Lemoine, Bruno Blais, Mikaël Larose, Gérald Chouinard, Adya Karthikeyan, Marie-Josée Dumont, Jason R. Tavares
{"title":"Pheromones Impregnated on Porous PLA Fibers for Integrated Pest Management","authors":"Darius Klassen,&nbsp;Catherine Pouchet,&nbsp;William Simon,&nbsp;Isabella Smith,&nbsp;Noémie Lemoine,&nbsp;Bruno Blais,&nbsp;Mikaël Larose,&nbsp;Gérald Chouinard,&nbsp;Adya Karthikeyan,&nbsp;Marie-Josée Dumont,&nbsp;Jason R. Tavares","doi":"10.1007/s10924-026-03827-1","DOIUrl":"10.1007/s10924-026-03827-1","url":null,"abstract":"<div><p>The harmful health impacts of insecticides on non-target organisms, including humans, are well known and since the advent of organic farming, there has been a continuous push to find alternative ways of protecting crops. This work proposes a device that integrates two existing insecticide alternatives, exclusion nets and pheromonal pest control, by turning the fibers of the nets into dispensers for pheromone. This is accomplished using a technique known as Dip-Dip-Dry and differs from other methods of storing pheromone on polymers by sequestering pheromone within a porous structure rather than integrating it directly into the polymer matrix. The major advantage of this is that the porous structure can be refilled with pheromone and the nets reused over multiple growing seasons. When testing with the alarm pheromone of the green apple aphid (<i>Myzus persicae</i>), (E)-β-farnesene, Dip-Dip-Dry modified nets exceeded the targeted pheromone release rate of 0.05–0.9 mg·m<sup>− 2</sup>·day<sup>− 1</sup>, which is as the minimum required dose to elicit a response in aphids, and release lasted for a 10–20 day period. Field tests conducted on McIntosh apple trees demonstrated the effectiveness of the pheromone impregnated nets with a 76% reduction in aphid populations compared to plants protected by conventional, pheromone-free exclusion nets.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"34 5","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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