Analytical Methods最新文献

{"title":"A bio-nano-engineered platform fabricated from cerium oxide-carbon nanoparticles stabilized with chitosan for label-free sensing of a lung cancer biomarker†","authors":"Upendra Kumar Mishra, Saurabh Srivastava, Kshitij RB Singh, Atul Kumar, Vivekanand Singh, Devendra P. Mishra, Vishal Singh Chandel, Jay Singh, Shyam S. Pandey and Saurabh Srivastava","doi":"10.1039/D4AY01535E","DOIUrl":"10.1039/D4AY01535E","url":null,"abstract":"<p >Herein, we report a label-free cancer biosensor designed for carcinoembryonic antigen (CEA) detection using a nanohybrid comprising CeO<small>₂</small> nanoparticles, carbon nanoparticles (CNPs), and chitosan (Ch). CeO<small>₂</small> nanoparticles were prepared using a simple green synthesis process. A thin film of the CeO<small>₂</small>-CNPs-Ch nanohybrid was formed on indium tin oxide (ITO)-coated glass plates that endowed a high surface area, excellent stability, and good adsorption for the efficient loading of CEA antibodies. Quantitative and selective determination of CEA antigen was achieved by immobilizing monoclonal CEA antibodies (anti-CEA) on the CeO<small>₂</small>-CNPs-Ch/ITO platform. The electrochemical response of the anti-CEA/CeO<small>₂</small>-CNPs-Ch/ITO immunoelectrode was evaluated in a label-free immunoassay format using differential pulse voltammetry (DPV). The response studies of immunoelectrodes indicated wider linearity with respect to the CEA concentration in the range of 0.05–100 ng mL<small>⁻¹</small>. The electrochemical cancer biosensor exhibited a higher sensitivity of 22.40 μA cm<small>⁻²</small> per decade change in concentration along with storage stability for up to 35 days. The limit of detection (LOD) was 0.037 ng mL<small>⁻¹</small>. Furthermore, this cancer biosensor exhibited good specificity and reproducibility. Thus, the proposed CeO<small>₂</small>-CNPs-Ch nanocomposite-based platform provides an efficient method for the analysis of other antigen–antibody interactions and biomolecule detection. The efficacy of the anti-CEA/CeO<small>₂</small>-CNPs-Ch/ITO immunoelectrode was further examined by measuring CEA levels in human serum.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 2","pages":" 349-359"},"PeriodicalIF":2.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new compact potentiometric electrode for pH monitoring built upon a glass substrate with a Ce-doped SnO2 layer","authors":"Ayman H. Kamel, Noor H. A. Al-Sabbagh, Ibrahim Moussa, M. Obaida, Hisham S. M. Abd-Rabboh and Waleed E. Boraie","doi":"10.1039/D4AY01161A","DOIUrl":"10.1039/D4AY01161A","url":null,"abstract":"<p >A novel compact potentiometric electrode specifically designed for pH monitoring, featuring a good construction on a glass substrate coated with a cerium-doped tin oxide (Ce-doped SnO<small>₂</small>) layer. The Ce-doped SnO<small>₂</small> thin film was created by spray-pyrolysis it on a glass substrate. Field emission scanning electron microscopy (FESEM) and X-ray diffraction (XRD) were used to characterize the deposited metal oxide coating. As a miniature potentiometric electrode, the synthesized Ce-doped SnO<small>₂</small>/glass substrate was utilized to measure a broad pH range (pH 2–12) in aqueous solutions. The electrode had a perfect near-Nernstian response (slope of −58.6 ± 0.7 mV per decade), high potential stability, mechanical durability, and great selectivity towards some common interfering cations and anions. These characteristics made it ideal for quality control and assurance purposes. The electrode's performance parameters and validation measurements were assessed using established procedures. The Ce-doped SnO<small>₂</small>-based electrode satisfactorily monitored the pH of several genuine water, drink, and fruit juice samples, and the data compared well with those obtained using a traditional pH glass electrode. The integration of Ce-doped SnO<small>₂</small> as the active material marks a significant advancement, providing enhanced electrochemical stability, improved sensitivity, and a wider pH detection range compared to conventional electrodes. The compact design not only reduces the sensor's footprint but also facilitates its application in miniaturized and portable pH monitoring devices, making it highly suitable for advanced analytical and environmental sensing applications.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 1","pages":" 92-103"},"PeriodicalIF":2.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PGI Chianina meat traceability by means of multivariate HRMAS-NMR data analysis†","authors":"Mena Ritota, Michela Contò, Sebastiana Failla, Claudio Beni, Alceo Macchioni and Massimiliano Valentini","doi":"10.1039/D4AY01585A","DOIUrl":"10.1039/D4AY01585A","url":null,"abstract":"<p >Food quality is a crucial issue for producers and consumers, either dealing with commodities according to basic standards or with top quality products. Among the parameters contributing to quality, the place of origin is considered to be one of the most relevant, especially for protected denomination of origin and protected geographical indication foods, PDO and PGI, respectively. These labels have been designed by the EU to protect and valorise high quality foodstuff produced in limited areas and to ensure higher incomes to farmers. Such economic interest has prompted the use of several analytical techniques for the traceability issue. Here we proposed the multivariate HRMAS-NMR (<em>i.e.</em> High-Resolution Magic Angle Spinning-Nuclear Magnetic Resonance) data analysis for the traceability of PGI Chianina meat, specifically for the semitendinosus muscle. The metabolic profile of Chianina meat assessed by HRMAS-NMR spectroscopy was analysed by means of PCA (Principal Component Analysis), PLS-DA (Partial Least Square-Discriminant Analysis) and OPLS-DA (Orthogonal Partial Least Square-Discriminant Analysis) in order to classify samples according to the geographical origin. The built models provided an excellent separation between PGI and non-PGI, and the use of the VIP (Valuable Influence on Projection) values allowed us to identify metabolites contributing significantly to classification. Specifically, we found molecules such as amino acids, carnosine, some nucleosides, and fatty acids to be responsible for the discrimination: the fatty acid profile of meat is affected by the different feeding systems, while the other metabolites are involved in the ageing process of meat (ATP degradation during <em>post mortem</em> and proteolysis).</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 2","pages":" 291-299"},"PeriodicalIF":2.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A colorimetric strategy and smartphone-based test strip for the detection of glucose based on the peroxidase activity of a hemin-derived nanozyme†","authors":"Ziqiang Yuan, Meizhen Fu, Xin Wang, Meng Wang, Yue Wei, Yanna Sun, Qingfeng Zhang, Yunyi Zhang and Bo Zhang","doi":"10.1039/D4AY01878H","DOIUrl":"10.1039/D4AY01878H","url":null,"abstract":"<p >Nanozymes are nanomaterials with catalytic properties similar to enzymes and offer advantages over natural enzymes such as lower cost, ease of storage, and convenience for large-scale preparation. Thus, they have received increasing attention and are extensively applied in fields such as chemistry, sensing, food, environment, and medicine. Herein, a hemin-derived nanozyme (Hemin-CDs) was prepared using hemin as the precursor and used to substitute the natural horseradish peroxidase (HRP) for colorimetric detection. The prepared Hemin-CDs exhibit excellent water dispersibility, stability and superior peroxidase-like activity. They catalyze the oxidative coupling of colorless 4-aminoantipyrine (4-AAP) with <em>N</em>-ethyl-<em>N</em>-(2-hydroxy-3-sulfopropyl)-3-methylaniline sodium salt (TOOS) in the presence of H<small>₂</small>O<small>₂</small>, forming a purple quinone diimine dye with an absorption peak at 554 nm, which enables the quantification of H<small>₂</small>O<small>₂</small> by measuring the absorbance. Quantitative detection of glucose was further demonstrated under physiological conditions. The detection of H<small>₂</small>O<small>₂</small> and glucose takes only 10 minutes, with linear ranges of 1–150 μM and 2.5–300 μM, and LODs of 0.867 μM and 1.026 μM, respectively. Glucose in human serum was successfully detected with satisfactory recoveries (87.5–104.0%). Furthermore, a test strip was developed, and a smartphone was utilized to recognize the color of the test position, enabling rapid and accurate quantification of glucose concentrations within 5 minutes, which promises to enhance the accessibility and convenience of glucose testing.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 2","pages":" 320-329"},"PeriodicalIF":2.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and fabrication of superhydrophobic microstructured grooved substrates to suppress the coffee-ring effect and enhance the stability of Sr element detection in liquids using LIBS","authors":"Hongbao Wang, Honglian Li, Xusheng Huang, Zhichao Yao, Huiming Zhang, Yu hang Yao, Xiaolin Yin, Ziying Chen and Lide Fang","doi":"10.1039/D4AY01582G","DOIUrl":"10.1039/D4AY01582G","url":null,"abstract":"<p >A new technique has been developed to enhance the stability of laser-induced breakdown spectroscopy (LIBS) in the analysis of dry droplets by mitigating the coffee ring effect (CRE) on substrates with superhydrophobic microstructured grooves. The substrate was prepared from a laser-etched pure copper base, resembling the surface of a lotus leaf, creating a biomimetic superhydrophobic substrate. The superhydrophobic microstructured grooved substrate contained an array of dome-shaped cones with heights of approximately 140 μm and 100 μm, arranged in a periodic pattern of high-low-high. The superhydrophobic properties of the substrate not only evaporation-induced thermal capillary action but also initiated the Marangoni flow, which moves from the periphery to the center of the droplet as it evaporates. This flow mechanism effectively mitigated the CRE by transporting the analyte from the bottom edge of the droplet across its surface to the central peak. To assess how these superhydrophobic microstructured grooved substrates impede the formation of coffee rings, LIBS was deployed to analyze samples from both structured and unstructured grooved substrates. The results indicated that the relative standard deviation (RSD) of the spectral intensity for Sr I at 407.67 nm in substrates with a superhydrophobic microstructured groove edge length of 0.8 mm was 3.6%. In contrast, for the unstructured grooved substrate and a side length of 0.9 mm, the RSD was significantly higher at 25.4%. This research demonstrates that substrates with superhydrophobic microstructured grooves are capable of effectively mitigating the CRE. Additionally, the study examined how the dimensions of these grooves impact the plasma characteristics across two distinct configurations. Based on these observations, calibration curves for Sr were developed using substrates with groove side lengths of 0.6 mm and 0.8 mm. The performance of the superhydrophobic microstructured grooved substrate was satisfactory, exhibiting determination coefficients (<em>R</em><small>²</small>) of 0.994 and 0.995 for the Sr element. The detection limits (LOD) were notably low at 0.16 μg mL<small>⁻¹</small> and 0.11 μg mL<small>⁻¹</small>. The average relative standard deviations (ARSD) were 7.2% and 4.9%, respectively. These results demonstrate that the superhydrophobic microstructured grooved substrate effectively mitigates the CRE, thereby enhancing the detection sensitivity and prediction accuracy for heavy metals. This provides a robust reference for selecting platforms using LIBS technology in the pre-treatment process.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 1","pages":" 64-76"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative extraction of antioxidant proteins from whole frogs (Rana ridibunda Pollas)","authors":"Naziermu Dongmulati, Ahmidin Wali, Zi Yang, Yusufujiang Aili, Rexili Kelaimu, Yanhua Gao, Abulimiti Yili and Haji Akber Aisa","doi":"10.1039/D4AY01636J","DOIUrl":"10.1039/D4AY01636J","url":null,"abstract":"<p >The forest frog (<em>Rana ridibunda</em> Pollas) is a traditional medicinal source rich in active protein compounds. In order to extract these compounds, six extraction methods were employed, including freeze–thaw and stirring techniques. Three different solvents were utilized in this process: 0.15 M sodium chloride (NaCl), 0.05 M phosphate buffer (PB), and 0.05 M phosphate-buffered saline (PBS). The objective was to identify the most effective extraction method. The extraction efficiencies, protein content, structure, and physicochemical properties of the extracts were compared. Additionally, antioxidant activity and free amino acid composition were analyzed. The highest-scoring extract, denoted as M1, obtained through freeze–thaw extraction using 0.15 M NaCl, exhibited an extraction rate of 7.79 ± 0.71% and a protein content of 60.36 ± 2.12%. M1 also showed antioxidant activity against DPPH˙, ABTS<small>⁺</small>˙, and ˙OH free radicals, with IC<small>₅₀</small> values of 0.41, 0.41, and 0.39 mg mL<small>⁻¹</small>, respectively. The freeze–thaw extraction method utilizing 0.15 M NaCl has been identified as effective for extracting proteins from dried forest frogs, confirming their potential as a source of antioxidant proteins for scientific research and application.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 1","pages":" 54-63"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Magnetic solid-phase extraction to preconcentrate ultra trace amounts of lead(ii) using modified-carbon nanotubes decorated with NiFe2O4 magnetic nanoparticles","authors":"Ali A. Ensafi, Sedigheh Rabiei, Behzad Rezaei and Ali R. Allafchian","doi":"10.1039/D4AY90151G","DOIUrl":"https://doi.org/10.1039/D4AY90151G","url":null,"abstract":"<p >Retraction of ‘Magnetic solid-phase extraction to preconcentrate ultra trace amounts of lead(<small>II</small>) using modified-carbon nanotubes decorated with NiFe<small>₂</small>O<small>₄</small> magnetic nanoparticles’ by Ali A. Ensafi <em>et al.</em>, <em>Anal. Methods</em>, 2013, <strong>5</strong>, 3903–3908, https://doi.org/10.1039/C3AY40246K.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 48","pages":" 8482-8482"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/ay/d4ay90151g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in electrochemical sensor technology for warfarin detection: a comprehensive review","authors":"Hassan Akbari, Mostafa Rahimnejad, Hossein Amani and Hoda Ezoji","doi":"10.1039/D4AY01450B","DOIUrl":"10.1039/D4AY01450B","url":null,"abstract":"<p >Warfarin (WA), the most prescribed oral anticoagulant in patients with atrial fibrillation, is widely utilized for the treatment of various diseases, such as vascular disorders, venous thrombosis, and atrial fibrillation. However, its abnormal concentration is linked to a variety of disorders and diseases, namely bleeding while brushing teeth, skin tissue issues, hair loss, and chest pain. Therefore, WA monitoring in blood serum is vital due to its narrow therapeutic window. Accordingly, WA determination has been conducted using various methods, such as high-performance liquid chromatography, fluorescent, surface-enhanced Raman scattering, and electrochemical methods. Electrochemical methods have received considerable attention due to their outstanding selectivity, remarkable sensitivity, great time efficiency, and cost-effectiveness. Herein, a comprehensive literature survey on electrochemical methods for determining WA is presented. This review discusses the development of various chemically modified electrodes (CMEs). These CMEs, such as multi-wall carbon nanotubes, molecularly imprinted polymers, metal oxide nanoparticles, and polymer nanocomposites, owing to their morphology and structure, high selectivity, high conductivity, and high volume/area ratio, are designed to overcome the limitations of bare electrodes, which include reduced electrocatalytic activity, slower electron transfer rates, and poor sensitivity. Also, this review presents the advantages and disadvantages of various modified electrodes applied in WA detection.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 47","pages":" 8103-8118"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An l-cysteine based sensor for Cu2+ detection applicable for both environmental water and human plasma†","authors":"Yanhong Chen, Li Lv, Xuanjiao Mao, Jun Chai, Jayne Wu, Yicheng Zhou, Jian Zhang and Haochen Qi","doi":"10.1039/D4AY01680G","DOIUrl":"10.1039/D4AY01680G","url":null,"abstract":"<p >A flexible electrochemical sensor with high sensitivity and specificity is developed using gold nanoparticles (AuNPs) and a reduced graphene oxide/molybdenum disulfide (rGo–MoS<small>₂</small>) composite modified screen printed carbon electrode (SPCE), with <small>L</small>-cysteine (<small>L</small>-Cys) as a probe for Cu<small>²⁺</small> target recognition. Owing to the AuNPs/rGo–MoS<small>₂</small>, the electron transference ability is improved by increasing the specific surface area of the working electrode, and a high sensitivity is achieved. Meanwhile, the bidentate chelation of <small>L</small>-Cys to Cu<small>²⁺</small> contributes to a good selectivity. Using differential pulse voltammetry (DPV) for spiked standard Cu<small>²⁺</small>, the test results show a dynamic range from 0.1 μM to 100 μM, a detection limit of 0.020 μM, and a high sensitivity of 1.190 μA μM<small>⁻¹</small>. Furthermore, detection in both environmental water and human plasma samples demonstrates a wide applicability of this sensor in various matrices, and an excellent feasibility for environmental and clinical applications.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 2","pages":" 214-222"},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation methods for precise pH detection in ocular chemical burns: a review of recent analytical advancements.","authors":"H H P Benuwan Sandaruwan, Danushika C Manatunga, Renuka N Liyanage, Narahenpitage Pabakara Costha, Rohan S Dassanayake, Ruchire Eranga Wijesinghe, Yang Zhou, Yuanyuan Liu","doi":"10.1039/d4ay01178c","DOIUrl":"10.1039/d4ay01178c","url":null,"abstract":"<p><p>Ocular burns due to accidental chemical spillage pose an immediate threat, representing over 20% of emergency ocular traumas. Early detection of the ocular pH is imperative in managing ocular chemical burns. Alkaline chemical burns are more detrimental than acidic chemical burns. Current practices utilize litmus, nitrazine strips, bromothymol blue, fluorescent dyes, and micro-combination glass probes to detect ocular pH. However, these methods have inherent drawbacks, leading to inaccurate pH measurements, less sensitivity, photodegradation, limited pH range, and longer response time. Hence, there is a tremendous necessity for developing relatively simple, accurate, precise ocular pH detection methods. The current review aims to provide comprehensive coverage of the conventional practices of ocular pH measurement during accidental chemical burns, highlighting their strengths and weaknesses. Besides, it delves into cutting-edge technologies, including pH-sensing contact lenses, microfluidic contact lenses, fluorescent scleral contact lenses, fiber optic pH technology, and pH-sensitive thin films. The study meticulously examines the reported work since 2000. The collected data have also helped propose future directions, and the research gap needs to be filled to provide a more rapid, sensitive, and accurate measurement of ocular pH in eye clinics. For the first time, this review consolidates current techniques and recent advancements in ocular pH detection, offering a strategic overview to propel ophthalmic-related research forward and enhance ocular burn management during a chemical spillage.</p>","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}