Analytical Methods最新文献_第9页

Tensile mechanical analysis in cultural heritage 文化遗产的拉伸力学分析。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-09-02 DOI: 10.1039/D4AY90097A

Analytical Methods Committee, AMCTB No. 115

引用次数: 0

Exploring Time-Dependent and Wavelength-Guided Tunable binary & Ternary Logic Behaviour of a Charge-Transfer Probe 探索电荷转移探针的时间依赖性和波长引导的可调二元和三元逻辑行为

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-02 DOI: 10.1039/d4ay01195c

Monaj Karar, Animesh Pal, Nilanjan Dey

{"title":"Exploring Time-Dependent and Wavelength-Guided Tunable binary & Ternary Logic Behaviour of a Charge-Transfer Probe","authors":"Monaj Karar, Animesh Pal, Nilanjan Dey","doi":"10.1039/d4ay01195c","DOIUrl":"https://doi.org/10.1039/d4ay01195c","url":null,"abstract":"This study presents the development of a novel time-dependent logic behavior system driven by basic chemical interactions. The absorption spectra of probe molecule underwent time-dependent changes upon the individual and simultaneous addition of two analytes, F– and CN–, leading to alterations in logic behavior observed at both the 295 nm (from AND to TRANSFER) and 400 nm bands (from OR to INHIBIT). Additionally, we explored the creation of wavelength-guided molecular logic systems that leverage reversible (F– and H2O) and irreversible (CN– and H2O) chemical interactions. By employing CN– and H2O as dual chemical inputs, we derived binary TRANSFER, 2-input PASS 0, and binary COMPLEMENT logic gates based on the optical responses at 295 nm, 400 nm, and 500 nm, respectively. Furthermore, utilizing F– and H2O as dual chemical inputs, we constructed dual complementary INHIBIT (at 400 nm) and IMPLICATION (at 500 nm) logic gates. Finally, we introduced an innovative inter-switchable ternary molecular logic system, comprising 3-input INHIBIT and 3-input TRANSFER logic gates, using F–, CN–, and H2O as ternary chemical inputs. This approach capitalizes on the probe's versatile and distinct absorption responses at varying wavelengths.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid chromatography and mass spectrometric studies of gilteritinib fumarate and characterization of its major degradation products by NMR 富马酸吉特替尼的液相色谱和质谱研究及其主要降解产物的核磁共振表征

IF 3.1 3区化学

Analytical Methods Pub Date : 2024-09-02 DOI: 10.1039/d4ay01094a

Bhuvaneshwari Vuyyala, Krishna Prasad Pisini, Debasish Swain

{"title":"Liquid chromatography and mass spectrometric studies of gilteritinib fumarate and characterization of its major degradation products by NMR","authors":"Bhuvaneshwari Vuyyala, Krishna Prasad Pisini, Debasish Swain","doi":"10.1039/d4ay01094a","DOIUrl":"https://doi.org/10.1039/d4ay01094a","url":null,"abstract":"Gilteritinib fumarate (GTB) is an anti-cancer drug belonging to the class of tyrosine kinase inhibitors used for the treatment of acute myeloid leukemia. It has been designated as an orphan drug by the US Food and Drug Administration (US FDA). The present research focused on carrying out the forced degradation studies of GTB and developing a UHPLC-PDA stability indicating method capable of separating GTB and its degradation products. The degradation studies were carried out under hydrolytic (acid, base, and neutral), oxidative, thermal, and light conditions. The drug degraded under hydrolytic and oxidative conditions whereas it was found to be stable under thermal and light exposure. The separation of the components was achieved on an Acquity BEH C18 column (2.1 × 100 mm; 1.7μ) and a mobile phase comprising ammonium acetate and acetonitrile eluting in gradient mode at a flow rate of 0.3 mL min−1. A total of five degradation products were obtained and were structurally characterized with the help of accurate mass and tandem mass experiments performed on LC-QTOF-MS equipment and DP-1 was isolated and characterized using 1D and 2D NMR experiments. The UHPLC-PDA method was validated as per the ICH Q2 (R1) guidelines for its accuracy, precision, linearity, and specificity. The method was found to be appropriate for its intended purpose and can be effectively used in the determination of GTB and its degradation products and/or impurities in bulk drugs as well as formulations.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142194683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and properties of temperature-responsive imprinted sensors based on fluorescently labeled yeast cells via MVL ATRP† 通过 MVL ATRP 制作基于荧光标记酵母细胞的温度响应印记传感器及其特性。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-09-02 DOI: 10.1039/D4AY00905C

Yue Chen, Shaokai Du, Ailu Cui, Shipeng Jiang, Yuxuan He, Shuhan Yang, Ruyi Ma and Yue Sun

{"title":"Fabrication and properties of temperature-responsive imprinted sensors based on fluorescently labeled yeast cells via MVL ATRP†","authors":"Yue Chen, Shaokai Du, Ailu Cui, Shipeng Jiang, Yuxuan He, Shuhan Yang, Ruyi Ma and Yue Sun","doi":"10.1039/D4AY00905C","DOIUrl":"10.1039/D4AY00905C","url":null,"abstract":"Temperature-responsive yeast cell-imprinted sensors (CIPs/AuNPs/Ti3C2Tx/AuNPs/Au) were prepared based on fluorescein isothiocyanate labeled yeast cells (FITC-yeast) via metal-free visible-light-induced atom transfer radical polymerization (MVL ATRP). Here, N-isopropyl acrylamide (NIPAM) was used as a temperature-responsive functional monomer, α-methacrylic acid (MAA) was chosen as an auxiliary functional monomer, N,N′-methylene bisacrylamide (MBA) was used as a cross-linker, and FITC-yeast was selected as both a template and photocatalyst. Under the optimal conditions, the detection range of the yeast cell-imprinted sensor toward yeast cells was 1.0 × 102 to 1.0 × 109 cells per mL, and the detection limit was 11 cells per mL (S/N = 3), with a linear equation of ΔI (μA) = 8.44 log[C (cells per mL)] + 7.62 (R2 = 0.993). The sensor showed good selective recognition in the presence of interfering substances such as autolyzed yeast cells (AY), dead yeast cells (DY), human mammary epithelial cells (MCF-10A), human breast cancer cells (MCF-7) and Escherichia coli (EC). The sensor also had good consistency and reproducibility. Finally, spiked recovery experiments were performed to investigate the recognition of yeast cells in the actual sample using the yeast cell-imprinted sensor. The spiked recoveries were all in the range of 98.5–108.0%, and the RSD values were all less than 4%, indicating that the sensor had good application prospects.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of fluoroquinolone-resistant Mycobacterium tuberculosis through high-level data fusion of Raman and laser-induced breakdown spectroscopy† 通过拉曼光谱和激光诱导击穿光谱的高级数据融合鉴定耐氟喹诺酮结核分枝杆菌。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-09-02 DOI: 10.1039/D4AY01331J

Gookseon Jeon, Soogeun Kim, Young Jin Kim, Seungmo Kim, Kyungmin Han, Kyunghwan Oh, Hee Joo Lee and Janghee Choi

引用次数: 0

Label-free ratiometric fluorescence detection of Pb2+via structure-specific fluorescent dyes and dual signal amplification 通过结构特异性荧光染料和双重信号放大技术对 Pb2+ 进行无标记比率荧光检测。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-08-29 DOI: 10.1039/D4AY01369G

Jinmin Zhang, Zhiguang Suo, Ruirui Liang, Min Wei, Wenjie Ren, Yiwei Xu, Baoshan He, Huali Jin and Renyong Zhao

{"title":"Label-free ratiometric fluorescence detection of Pb2+via structure-specific fluorescent dyes and dual signal amplification","authors":"Jinmin Zhang, Zhiguang Suo, Ruirui Liang, Min Wei, Wenjie Ren, Yiwei Xu, Baoshan He, Huali Jin and Renyong Zhao","doi":"10.1039/D4AY01369G","DOIUrl":"10.1039/D4AY01369G","url":null,"abstract":"Lead ions (Pb2+) are a widely distributed and highly toxic heavy metal pollutant, which seriously threatens the environment, economy and human safety. Here, a label-free ratiometric fluorescent biosensor was constructed for Pb2+ detection using DNAzyme-driven target cycling and exonuclease III (Exo III)-mediated DNA cycling as a dual signal amplification strategy. The SYBR Green I (SGI) and N-methyl mesoporphyrin IX (NMM) used in this study are characterized by low cost, storage resistance, and short preparation time compared with conventional signaling probes labeled with fluorescent groups. Unlike the single-emission fluorescence strategy, monitoring the fluorescence intensity ratio of SGI and NMM can effectively reduce external interference to achieve accurate detection of Pb2+. DNAzyme structures on the surface of magnetic beads (MBs) can recognize Pb2+ and activate the target circulatory system to cleave single-stranded DNA (ssDNA). The ssDNA further initiated the Exo III-assisted DNA circulatory system to digest double-stranded DNA (dsDNA) and release guanine-rich G1. Finally, the fluorescence signals of SGI and NMM were weakened and enhanced, respectively. The sensing strategy achieved a wide linear range from 0.5 to 500 nM and a low limit of detection (LOD) of 26.4 pM. Furthermore, its anti-interference ability and potential applicability for Pb2+ detection in actual samples were verified. This work ingeniously combines the dual signal amplification strategy with the ratiometric sensing strategy constructed by structure-specific fluorescent dyes, which provides a promising method for constructing sensitive and accurate fluorescent biosensors.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single reaction chamber microwave digestion coupled with ICP-MS for the determination of ultra-trace mercury in rocks 单反应室微波消解与 ICP-MS 联用测定岩石中的超痕量汞。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-08-27 DOI: 10.1039/D4AY00824C

Minsi Liang and Hongtao Liu

{"title":"Single reaction chamber microwave digestion coupled with ICP-MS for the determination of ultra-trace mercury in rocks","authors":"Minsi Liang and Hongtao Liu","doi":"10.1039/D4AY00824C","DOIUrl":"10.1039/D4AY00824C","url":null,"abstract":"In this study, a method for rock digestion using a single reaction chamber (SRC) microwave system was established. Nitric acid (HNO3) and hydrofluoric acid (HF) were used as digestion agents, and the determination of mercury (Hg) in rocks was performed by inductively coupled plasma mass spectrometry (ICP-MS). The optimal conditions for the SRC microwave system were achieved at 260 °C and 70 bar, with a mixture of 3 mL of 65–68 wt% HNO3 and 1 mL of 49 wt% HF when the sample weight is in the range of 0.025–0.05 g. The method quantitation limit (MQL) was determined to be 0.0016 mg kg−1. Measurement accuracy was evaluated using five Chinese nationally certified reference materials, demonstrating good consistency between measurement results and certified values. The method was applied to two rock samples, resulting in a recovery rate ranging from 105% to 109%. This method exhibits high sensitivity, stability, and low acid consumption. Importantly, it provides a reliable and efficient determination method for Hg in rocks, which is of great significance in geochemical analysis.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel point-of-care rapid detection of monkeypox virus 新型床旁猴痘病毒快速检测方法。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-08-27 DOI: 10.1039/D4AY01437E

Hui Chen, Yuhong Guan, Xinyu Zhang, Yuting Chen, Song Li, Yan Deng and Yanqi Wu

{"title":"Novel point-of-care rapid detection of monkeypox virus","authors":"Hui Chen, Yuhong Guan, Xinyu Zhang, Yuting Chen, Song Li, Yan Deng and Yanqi Wu","doi":"10.1039/D4AY01437E","DOIUrl":"10.1039/D4AY01437E","url":null,"abstract":"Monkeypox, a viral zoonotic disease caused by MPXV, has emerged as a significant global health concern since the first outbreak outside Africa in 2003. As of the current data, there have been 30 189 confirmed cases of monkeypox in 88 countries, with 29 844 cases reported in 81 countries. Given the absence of prior documented instances of the disease, swift and accurate testing is imperative to contain the spread of monkeypox. In this study, we developed a LAMP detection reagent for monkeypox and evaluated its performance in terms of sensitivity, specificity, repeatability, stability, linear range, and linearity, utilizing a commercial magnetic bead-based nucleic acid extraction system. This has led to the establishment of an integrated on-site detection platform for the monkeypox virus, utilizing a closed cartridge. The sensitivity was found to be 100 copies per μL, with no cross-reactivity observed with three other viruses, indicating robust performance. The parameters of repeatability, stability, linear range, and linearity were also assessed. For 28 simulated samples, the detection results obtained from the integrated system were consistent with those from conventional laboratory methods, specifically qPCR and LAMP detection following nucleic acid extraction. The entire process can be completed in approximately one hour, making it highly suitable for immediate rapid testing.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification and visual inspection of adipic dihydrazide in textile using a xanthylium-based ratiometric fluorescent probe† 使用基于黄原酸盐的比率荧光探针对纺织品中的己二酸二酰肼进行定量和目测。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-08-27 DOI: 10.1039/D4AY01164C

Sifan Wang, Weijie Wu, Jiaqi Lv, Zicheng Li and Wencai Huang

引用次数: 0

Highly sensitive voltammetric determination of hydrochlorothiazide using a glassy carbon electrode modified with Super P carbon black nanoparticles† 使用超 P 纳米炭黑修饰的玻璃碳电极高灵敏伏安法测定氢氯噻嗪。

IF 2.7 3区化学

Analytical Methods Pub Date : 2024-08-26 DOI: 10.1039/D4AY00900B

Domingos R. Santos-Neto, Carlos E. C. Lopes, Gabrielly P. Silva, Lizandra N. Castro, João Pedro C. Silva, Dianderson C. M. Ferreira, Luiz Ricardo G. Silva, Luiza M. F. Dantas and Iranaldo S. da Silva

{"title":"Highly sensitive voltammetric determination of hydrochlorothiazide using a glassy carbon electrode modified with Super P carbon black nanoparticles†","authors":"Domingos R. Santos-Neto, Carlos E. C. Lopes, Gabrielly P. Silva, Lizandra N. Castro, João Pedro C. Silva, Dianderson C. M. Ferreira, Luiz Ricardo G. Silva, Luiza M. F. Dantas and Iranaldo S. da Silva","doi":"10.1039/D4AY00900B","DOIUrl":"10.1039/D4AY00900B","url":null,"abstract":"Hydrochlorothiazide is an extremely important diuretic that regulates body functions, which can prevent several diseases. However, the abuse of this diuretic is concerning since it does not require a medical prescription, particularly for aesthetic purposes such as weight loss, which can lead to various health problems, including ventricular arrhythmia. The present work aims to use a glassy carbon electrode modified with Super P carbon black (SPCB/GCE) to quantify hydrochlorothiazide through Linear Sweep Adsorptive Stripping Voltammetry (LSAdSV). The modification of the GCE with SPCB significantly improved the response of hydrochlorothiazide. Furthermore, due to the adsorptive nature of charge transport, applying preconcentration time enhanced sensitivity. The optimized system provided a linear range of 0.5 to 30.0 μmol L−1 with a detection limit of 0.083 μmol L−1. Pharmaceutical tablet analyses indicated approximately 25 mg per tablet, which was confirmed by the UV-vis and in agreement with that indicated by the manufacturer. Furthermore, analyses of the tea, synthetic urine, tap water and lake water samples indicated recovery values close to 100%, demonstrating that there was no matrix effect. Therefore, it is possible to infer that the proposed method together with the sensor modified with carbon black nanoparticles presented excellent results, demonstrating that it can be an alternative method of monitoring this drug in different samples.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0