Analytical Methods最新文献_第9页

A portable and ecological paper-based device for glucose monitoring in peripheral blood mononuclear cell lysates†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-13 DOI: 10.1039/D5AY00057B

Grazia Nota, Wanda Cimmino, Sima Singh, Ibrahim A. Darwish, Claudia La Rocca, Fortunata Carbone, Giuseppe Matarese and Stefano Cinti

{"title":"A portable and ecological paper-based device for glucose monitoring in peripheral blood mononuclear cell lysates†","authors":"Grazia Nota, Wanda Cimmino, Sima Singh, Ibrahim A. Darwish, Claudia La Rocca, Fortunata Carbone, Giuseppe Matarese and Stefano Cinti","doi":"10.1039/D5AY00057B","DOIUrl":"10.1039/D5AY00057B","url":null,"abstract":"The increasing need for point-of-care (POC) testing has prompted a rise in the popularity of affordable biosensors that are eco-friendly, especially paper-based electrochemical sensors. This research introduces a biodegradable paper-based enzymatic biosensor for detecting glucose levels in intricate biological samples, such as cell lysates. This biosensor uses Prussian Blue (PB) as a mediator and glucose oxidase to detect glucose with excellent accuracy using direct electrochemical signals. Screen printing using Whatman filter paper produced a better biosensor than other substrates. The PB concentration of 12.5 mmol L−1 was found to be optimal and resulted in an operating potential of −0.1 V, which helped decrease interference from other active substances and improved its selectivity. Calibration was found to be linear up to a concentration of 2 mmol L−1 with a detection limit of 40 μmol L−1 and a limit of quantification of 120 μmol L−1. Moreover, experiments performed on cell lysates obtained from peripheral blood mononuclear cells (PBMCs) suggest the possible application of biosensors to measure glucose levels in vitro in both stimulated and unstimulated cells. This feature underscores its promise for use in monitoring metabolism and conducting diagnostic applications. The paper-based biosensor is an alternative to the current platform for the development of an eco-friendly, portable glucose-sensitive biosensor for point-of-care monitoring of glucose. Its flexibility and efficiency make it a strong candidate for use in the field of POC diagnostics, especially in areas of limited resources and in conditions where there is a problem with glucose dysregulation including diabetes and other related metabolic disorders.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 12","pages":" 2529-2535"},"PeriodicalIF":2.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ay/d5ay00057b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of volatile compounds among different types of Tieguanyin oolong tea using DHI-GC-MS†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-13 DOI: 10.1039/D4AY02042A

Desen Su, Yunyun Zheng, Minmin Huang, Ziqiang Chen, Lisong Chen, Meizhen Chen and Qinghua Yao

{"title":"Comparison of volatile compounds among different types of Tieguanyin oolong tea using DHI-GC-MS†","authors":"Desen Su, Yunyun Zheng, Minmin Huang, Ziqiang Chen, Lisong Chen, Meizhen Chen and Qinghua Yao","doi":"10.1039/D4AY02042A","DOIUrl":"10.1039/D4AY02042A","url":null,"abstract":"Depending on the manufacturing process, Tieguanyin tea (TGY) is classified into three main groups, light flavor type (LFT), heavy flavor type (HFT), and stale flavor type (SFT). However, the compositions and contents of volatile compounds among TGY types were still unclear. This study aimed to develop an efficient method for the nonselective determination of volatile compounds in teas via direct-headspace injection coupled with gas chromatography mass spectrometry (DHI-GC-MS), and to perform a comprehensive comparison among these teas. One hundred and twelve volatile compounds belonging to 9 classes were identified. Among them, 33 common volatiles from 4 categories (aldehydes, alcohols, ketones, and acids) were the dominant volatiles and accounted for 71.5%, 73.0%, and 71.8% of the total amount in LFT, HFT, and SFT, respectively. E-Nerolidol, ethanol, acetic acid, and some volatiles with five and six-carbon chains were the key chemicals to distinguish three different TGY teas. With PLS-DA analysis, distinct differences among different groups were observed. The results generated from this study may offer valuable insights for better grading of TGY teas.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 10","pages":" 2326-2334"},"PeriodicalIF":2.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A robust PET-based chiral Schiff base molecular probe for recognition of Hg2+ and Pb2+ and its application in live cell imaging†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-11 DOI: 10.1039/D5AY00098J

S. Benita Jeba Silviya, S. Michlin Ruphina Maragatham, S. G. Jebastin Andrews, Nattamai S. P. Bhuvanesh, J. Winfred Jebaraj and Chithiraivel Balakrishnan

{"title":"A robust PET-based chiral Schiff base molecular probe for recognition of Hg2+ and Pb2+ and its application in live cell imaging†","authors":"S. Benita Jeba Silviya, S. Michlin Ruphina Maragatham, S. G. Jebastin Andrews, Nattamai S. P. Bhuvanesh, J. Winfred Jebaraj and Chithiraivel Balakrishnan","doi":"10.1039/D5AY00098J","DOIUrl":"10.1039/D5AY00098J","url":null,"abstract":"A new salen-based chiral Schiff base, 6,6′-((1E,1′E)-((1R,2R)-cyclohexane-1,2-diylbis(azanylylidene))bis(methanylylidene))bis(2,4-dibromophenol) (H2L) has been designed and synthesized. H2L is a fluorescent chemical sensor that can rapidly and precisely detect harmful heavy metal ions such as Hg2+ and Pb2+ with well-separated excitation and emission wavelengths. Single-crystal X-ray diffraction analysis confirmed the structure of H2L. The binding of Hg2+/Pb2+ causes a change in the emission behavior of H2L from weakly fluorescent to highly fluorescent through the CHEF effect and inhibits the PET process. H2L exhibited immense selectivity and tremendous sensitivity, with LOD values of 8.29 nM and 7.65 nM for Hg2+ and Pb2+, respectively. The 1 : 1 binding mode of H2L·Hg2+ and H2L·Pb2+ is validated by using Job's plot, 1H NMR titration, and ESI-MS investigations. In addition, H2L has been used to detect Hg2+/Pb2+ ions in real water samples and paper strips, and intracellularly in HeLa cells.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 10","pages":" 2342-2354"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dispersive liquid–liquid microextraction with a deep eutectic solvent coupled with GC-MS for the determination of chiral carvone in herbaceous plants†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-11 DOI: 10.1039/D4AY02002B

Yuluan Wu, Ming Liang, Yanping Xian, Rongqiao Chen, Junpeng Hu, Hang Dai, Chenghao Liu and Xiangchang Hou

{"title":"Dispersive liquid–liquid microextraction with a deep eutectic solvent coupled with GC-MS for the determination of chiral carvone in herbaceous plants†","authors":"Yuluan Wu, Ming Liang, Yanping Xian, Rongqiao Chen, Junpeng Hu, Hang Dai, Chenghao Liu and Xiangchang Hou","doi":"10.1039/D4AY02002B","DOIUrl":"10.1039/D4AY02002B","url":null,"abstract":"Carvone is an important flavoring substance and widely used in the food and chemical industries. Carvone has two optical isomers (L-carvone and D-carvone), which have different aroma characteristics. However, the green extraction of natural carvone and isolation of chiral carvone present challenges, leading to its limited application. In this study, a deep eutectic solvent (DES) was prepared and used as a green extraction solvent for the extraction of carvone from herbaceous plants, and then a chiral chromatography column combined with GC-MS was used for the separation and detection of L-carvone and D-carvone. Response surface methodology was used to optimize the extraction conditions including the volume of DES, extraction time and extraction temperature. The results showed that the extraction recoveries and intra-day precision (n = 6) were 83.5–101.3% and 3.2–6.1% when the volume of DES was 5 mL, and the extraction time and temperature were 25 min and 51 °C, respectively. The MLOD and MLOQ of L-carvone and D-carvone were 8.0 mg kg−1 and 25.0 mg kg−1, respectively. The real sample detection results revealed that about 235.8–1600.0 mg kg−1 of L-carvone was detected in Mentha spicata L., and 6658.5–9788.6 mg kg−1 of D-carvone in Anethum graveolens L. seeds. The established method can be an effective method for the detection of chiral carvone in herbaceous plants.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 9","pages":" 2171-2180"},"PeriodicalIF":2.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging microfluidic technologies for CRISPR-based diagnostics: an overview

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-11 DOI: 10.1039/D5AY00063G

Fatemeh Nafian, Kimia Sadat Esfahani, Mina Hobabi Aghmiuni, Saloomeh Khoushab, Tina Illeslamllo, Simin Nafian, Negin Mohamadiyan, Narges Sadat Aleyasin and Babak Kamali Doust Azad

引用次数: 0

Detection of β-d-glucuronidase activity in environmental samples using 4-fluorophenyl β-d-glucuronide and 19F NMR†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-10 DOI: 10.1039/D4AY01723D

Aleksandra Teriosina, Igor L. Barsukov, Alan Cartmell, Andrew K. Powell, Andrew V. Stachulski and Edwin A. Yates

{"title":"Detection of β-d-glucuronidase activity in environmental samples using 4-fluorophenyl β-d-glucuronide and 19F NMR†","authors":"Aleksandra Teriosina, Igor L. Barsukov, Alan Cartmell, Andrew K. Powell, Andrew V. Stachulski and Edwin A. Yates","doi":"10.1039/D4AY01723D","DOIUrl":"10.1039/D4AY01723D","url":null,"abstract":"Common methods for establishing the presence of enteric bacteria polluting water supplies, or in other samples, rely on detecting the hydrolysis of model glucuronide substrates by glucuronidases to release a phenolic product quantifiable by absorbance or fluorescence. Substrates include the β-D-glucuronides of p-nitrophenol, and umbelliferyl or quercetin derivatives. One limitation is that it may be difficult or impossible to quantify the released phenolic moiety in samples that are strongly coloured or, that contain fluorescent compounds. Exploiting the sensitivity available from the 19F nucleus to changes in chemical environment which can be detected by 19F NMR spectroscopy, and the almost complete absence of 19F from naturally-occurring samples containing organic matter, which provides background-free signals, we propose a model substrate; 4-fluorophenyl β-D-glucuronide (4FP-glucuronide). The 19F NMR chemical shift position of 4FP-glucuronide changes from −121.0 ppm upon hydrolysis to release 4-fluorophenol, at −124.9 ppm (at pH 6.8), enabling detection of β-glucuronidase activity. We illustrate the use of this substrate with environmental samples from forest soil, standing water, and mud from cattle pasture. Each of these would challenge conventional methods, owing to their opacity or the presence of coloured organic material. The technique enables detection of glucuronidases, a widely-used proxy for enteric bacteria, extending the scope of testing beyond water to include environmental and other challenging samples.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 9","pages":" 2015-2020"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ay/d4ay01723d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid detection and quantitative analysis of thiram in fruits using a shape-adaptable flexible SERS substrate combined with deep learning†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-10 DOI: 10.1039/D4AY02098G

Hongjun Wang, Ziyang Bian, Yue Wang, Huijuan Niu, Zhenshan Yang and Hefu Li

{"title":"Rapid detection and quantitative analysis of thiram in fruits using a shape-adaptable flexible SERS substrate combined with deep learning†","authors":"Hongjun Wang, Ziyang Bian, Yue Wang, Huijuan Niu, Zhenshan Yang and Hefu Li","doi":"10.1039/D4AY02098G","DOIUrl":"10.1039/D4AY02098G","url":null,"abstract":"Ensuring food safety necessitates rapid identification of pesticide residues on fruits. Herein, we developed a shape-adaptable flexible surface-enhanced Raman scattering (SERS) substrate, combined with a deep learning algorithm, to quickly detect and quantitatively analyze thiram on fruit surfaces. This SERS substrate was fabricated by depositing silver nanoparticles (Ag NPs) onto a thin, corrugated polydimethylsiloxane (PDMS) film. This innovative design improves physical flexibility, ensuring conformal contact with curved surfaces while achieving high sensitivity, reproducibility, and mechanical robustness. The corrugated Ag NPs@PDMS thin film was able to directly detect thiram at concentrations as low as 10−7 M on tomato and blueberry peels, exhibiting consistent SERS activity with small interference from the fruit's shape. Furthermore, we developed a one-dimensional convolutional neural network (1D CNN) model, trained using a dataset of SERS signals from thiram, for quantitative analysis. The developed model achieved high prediction accuracy, with a coefficient of determination (R2) of 0.9905 and a root mean square error (RMSE) of 0.1364. The integration of our flexible SERS substrate, which adapts well to irregular surfaces, with the 1D CNN algorithm for quantitative analysis, holds great potential for rapid thiram detection in fruits.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 8","pages":" 1884-1891"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dispersive liquid–liquid microextraction for the determination of urinary 8-hydroxy 2′-deoxyguanosine in COVID-19 patients by gas chromatography-mass spectrometry†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-10 DOI: 10.1039/D4AY01937G

Sanaz Zare, Zohreh Zahraei, Mohammad Khodadadi, Maryam Zarean and Azam Salehi

{"title":"Dispersive liquid–liquid microextraction for the determination of urinary 8-hydroxy 2′-deoxyguanosine in COVID-19 patients by gas chromatography-mass spectrometry†","authors":"Sanaz Zare, Zohreh Zahraei, Mohammad Khodadadi, Maryam Zarean and Azam Salehi","doi":"10.1039/D4AY01937G","DOIUrl":"10.1039/D4AY01937G","url":null,"abstract":"COVID-19 disease has led to many deaths worldwide and early detection of people at a high risk of severe forms of this disease would greatly help physicians. The presence of oxidative stress biomarkers may help identify high-risk individuals early in the course of the disease. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) is a widely used biomarker for assessing endogenous oxidative DNA damage. In this study, the urinary 8-OHdG levels were determined in COVID-19 patients and COVID-19 patients with cancer by a dispersive liquid–liquid microextraction (DLLME) method using gas chromatography-mass spectrometry (GC-MS). The effects of essential parameters on the extraction method were investigated. The LOD and LOQ are equal to 1.7 nM and 5.1 nM, respectively. At varied concentrations of 8-OHdG (300, 400, and 600 nM), the relative standard deviation (RSD) ranged from 18.35% to 22.36%. The mean urinary 8-OHdG levels of cancer and COVID-19 patients were 13.20 ± 6.20 nmol mmol−1, while the mean levels in COVID-19 patients and healthy volunteers were 6.67 ± 5.80 nmol mmol−1 and 1.61 ± 1.72 nmol mmol−1, respectively. The results of this study showed that the level of 8-OHdG urine biomarkers in people with COVID-19 is significantly higher than in healthy people. In this study, the DLLME approach was used for the first time to determine the value of 8-OHdG using GC-MS. According to the results of this research, the DLLME method was successfully used as a biomarker of DNA oxidative stress for extracting 8-OHdG urine. Compared to other methods, this technique has advantages such as shorter extraction time and low cost.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 8","pages":" 1915-1922"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative and quantitative analysis of metronidazole formulations using a low-cost near infrared transmission spectrophotometer and chemometric tools†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-10 DOI: 10.1039/D4AY02251C

Moussa Yabré, Abdoul Karim Sakira, Moumouni Bandé, Kouka Luc Delma, Isaïe Nyamba, Loconon Y. Achille Yemoa, Souleymane Fofana and Touridomon Issa Somé

{"title":"Qualitative and quantitative analysis of metronidazole formulations using a low-cost near infrared transmission spectrophotometer and chemometric tools†","authors":"Moussa Yabré, Abdoul Karim Sakira, Moumouni Bandé, Kouka Luc Delma, Isaïe Nyamba, Loconon Y. Achille Yemoa, Souleymane Fofana and Touridomon Issa Somé","doi":"10.1039/D4AY02251C","DOIUrl":"10.1039/D4AY02251C","url":null,"abstract":"For effective drug quality control and detection of falsified and substandard medicines in developing countries, there is an urgent need to develop reliable, rapid, and inexpensive analytical methods. In this work, a methodology combining a low-cost near infrared transmission spectrophotometer with chemometrics and sample analysis in solution has been applied to develop qualitative and quantitative methods to analyze metronidazole in various formulations. To achieve this, calibration and validation solution samples of metronidazole at different concentrations were prepared. The qualitative method consisted of building a model based on a data driven soft independent modeling of class analogy using metronidazole samples at the concentration of 100 mg L−1 as the target class. The built model allowed a satisfactory identification of metronidazole at the target concentration and a clear discrimination of the excipient mixture and metronidazole samples at other concentration levels and related active pharmaceutical ingredients used to mimic falsified and substandard drugs. The quantitative method was based on a partial least squares regression model allowing the quantification of metronidazole in the concentration range of 50–125 mg L−1. The regression model was fully validated according to the accuracy profile methodology. Both qualitative and quantitative methods were successfully employed to analyze various metronidazole tablet samples collected in Burkina Faso. The obtained outcomes underline the feasibility of using these economically accessible portable spectrophotometers as a first line screening tool for drug quality control and detection of falsified and substandard drugs in developing countries.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 10","pages":" 2312-2320"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical-triggered ring-opening of aminocyclopropane for detection of hydroxyl radicals in living cells†

IF 2.7 3区化学

Analytical Methods Pub Date : 2025-02-10 DOI: 10.1039/D4AY02150A

Shiqi Jin, Wang Qian, Ruiyang Suo, Yi Li, Huan Ling, Shuqi Li, Kai Deng, Yongchang Wei, Bo Wu and Huaixia Chen

{"title":"Radical-triggered ring-opening of aminocyclopropane for detection of hydroxyl radicals in living cells†","authors":"Shiqi Jin, Wang Qian, Ruiyang Suo, Yi Li, Huan Ling, Shuqi Li, Kai Deng, Yongchang Wei, Bo Wu and Huaixia Chen","doi":"10.1039/D4AY02150A","DOIUrl":"10.1039/D4AY02150A","url":null,"abstract":"Hydroxyl radicals (˙OH), highly reactive oxygen species involved in oxidative stress and cancer therapy, are challenging to detect intracellularly due to their short lifetime, low concentration, and high reactivity. To address this, a novel ˙OH-specific fluorescent probe, CC-7, was developed by integrating an aminocyclopropane group into a coumarin derivative. This design was inspired by the radical-mediated ring-opening of aminocyclopropanes in synthetic chemistry. The ring-opening reaction triggered by ˙OH in CC-7 produces a significant “Fluorescence-ON” response with a 10-fold increase in intensity, demonstrating high selectivity for ˙OH over other reactive oxygen species. CC-7 effectively visualized intracellular ˙OH, distinguished between normal (HEK-293T) and cancer cells (4T1), and monitored ˙OH generated by chemotherapeutic agents like doxorubicin and cisplatin. This study highlights CC-7 as a powerful tool for selectively detecting ˙OH in living cells, with potential applications in investigating oxidative stress-related diseases and monitoring cancer therapy.","PeriodicalId":64,"journal":{"name":"Analytical Methods","volume":" 8","pages":" 1892-1899"},"PeriodicalIF":2.7,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0