临床护理研究最新文献

{"title":"The Clinical Value of Detecting the Level of Exfoliated Cells in Pleural Effusion by Flow Cytometry in the Differential Diagnosis of Non-Small Cell Lung Cancer and Benign Lung Diseases","authors":"Yang Yu, Yiyang Li, Chengbi Tong, Xiaomeng Zheng, Chaoqi Yang","doi":"10.26689/jcnr.v7i3.4849","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4849","url":null,"abstract":"Objective: To explore the value of flow cytometry (FCM) in detecting the level of exfoliated cells in pleural effusion in the differential diagnosis of non-small cell lung cancer and benign lung diseases. Methods: Clinical data of patients with non-small cell lung cancer who were hospitalized in Hebei hospital from June 2019 to March 2022 were collected. A total of 98 patients were included, and 63 patients with alveolar lung disease were screened during the same period, and the two groups of patients were analyzed. Results: Compared with alveolar lung disease group, FCM detection and analysis showed that the level of exfoliated cells in the pleural effusion of non-small cell lung cancer (NSCLC) patients was 99 (3-969)/100,000, and patients with alveolar lung disease was 4 (0 ~ 19)/100,000. Additionally, compared with the alveolar lung disease group, the level of exfoliated cells in the pleural effusion of patients with non-small cell lung cancer (NSCLC) was significantly increased (P<0.001). The diagnostic efficacy of FCM for detecting pleural fluid exfoliated cells in non-small cell lung cancer was assessed using ROC curves and using 95% CI (-11.1, -13.2) with a sensitivity of 0.75 and specificity of 0.94, and the diagnostic efficacy of FCM for detecting pleural fluid exfoliated cells in alveolar lung disease was assessed using 95% CI (-11.1, -13.2) with a sensitivity of 0.71 and specificity of 0.87. Conclusion: Flow cytometry has a wider range of clinical applications, simple operation, low cost, and high sensitivity, which makes it of great significance in disease diagnosis.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48235976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway","authors":"Peng Liu, Haizhe Chang, Xinyu Peng, Xiuqin Zhang, Jianjun Zhang, Jiusong Luan","doi":"10.26689/jcnr.v7i3.4862","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4862","url":null,"abstract":"Objective: To study the mechanism of lncRNA p21 inhibiting the growth and metastasis of human gastric cancer SGC7901/GES-1 cells by mediating the Wnt/β-catenin signaling pathway. Methods: Lentiviral overexpression of lncRNA-p21 in human gastric cancer SGC7901/GES-1 cell transfections was observed and analyzed for in vitro migration, invasion, cell morphology and proliferation. Besides. Wnt/β-catenin signaling pathway was tested for direct involvement in lncRNA-p21-mediated inhibition of gastric cancer cell growth and proliferation. Wnt/β-catenin signaling pathway was validated using Li-C1. Results: Gastric cancer SGC7901/GES-1 cells in the overexpression of lncRNA-p21 showed changes in stellate morphology, low invasion, or spindle-shaped morphology. LncRNA-p21 inhibited the growth and proliferation of gastric cancer SGC7901/GES-1 cells both in vivo and in vitro, and Wnt/β-catenin signaling pathway mediated the proliferation, invasion, and migration of lncRNA-p21 on gastric cancer SGC7901/GES-1 cells. Conclusion: LncRNA-p21 can inhibit the growth and metastasis of gastric cancer SGC7901/GES-1 cells in vitro and in vivo, and the inhibition of lncRNA p21 is mainly mediated by inhibiting the Wnt/β-catenin signaling pathway.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42435383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Neonatal Medical Adhesive-Related Skin Injury and Management of High-Risk Nodes","authors":"Sisi Hu, X. Huang, Dan Wang","doi":"10.26689/jcnr.v7i3.4959","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4959","url":null,"abstract":"Objective: To analyze the risk factors of neonatal medical adhesive-related skin injury and put forward targeted preventive measures, so as to provide reference for the care and prevention of neonatal medical adhesive-related skin injuries. Methods: Using the convenience sampling method, 262 neonates admitted to the neonatal intensive care unit (NICU) of a tertiary general hospital in Wenzhou from April 2021 to May 2022 were selected as the study subjects. The incidence of medical adhesive-related skin injuries in these neonates was retrospectively analyzed. Results: Among the 262 children, 43 cases had skin injuries, with an incidence rate of 16.4%. Single factor analysis showed that the occurrence of medical adhesive-related skin injury was related to gestational age, weight, electrocardiogram (ECG) monitoring, venous access, ambient temperature, and mechanical ventilation (P < 0.05). Multivariate logistic regression showed that gestational age, ECG monitoring, and ambient temperature were independent risk factors of medical adhesive-related skin injury (OR values were 0.700, 0.431, and 6.365, respectively). Conclusion: The high incidence of neonatal medical adhesive-related skin injury may be caused by one or more factors. Clinical measures should be taken, such as selecting the appropriate type of adhesive according to gestational age and using skin-protecting membrane, minimizing ECG monitoring, etc., to prevent the occurrence of neonatal medical adhesive-related skin injury.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43752023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Implementation of Integrated Healthcare Management in Preoperative Preparation","authors":"Huiling Liu, Xuling Li, Xinyi Liu, Yuhua Ma, Haomin Li, Cuiqing Liu","doi":"10.26689/jcnr.v7i3.4831","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4831","url":null,"abstract":"Objective: To strengthen preoperative preparation management and reduce preoperative preparation defects. Methods: We set up a special medical care management team to investigate the preoperative preparation in surgical departments, analyze the causes of the shortcomings in preoperative preparation, and propose countermeasures. The medical staff jointly formulated plans related to preoperative preparation management including clear outline of responsibilities, strengthening of training, integrated medical care, timely feedback, and continuous improvement. Besides, the preoperative preparation of patients before and after the improvement measures were compared using statistical analysis. Results: The rate of inadequate preoperative preparation was 11.14 per thousand before the integrated management model was implemented. After the implementation of the integrated management model, the rate of inadequate preoperative preparation decreased to 2.99 per thousand, and the difference was statistically (P < 0.05). Conclusion: The integrated management of preoperative preparation can help reduce the rate of preoperative complications and ensure the safety of surgery.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46426291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Sustained CO-Releasing Molecules Alleviates Cyclosporin-A-Induced Nephrotoxicity and Renal Fibrosis by Inhibiting NLRP3 Inflammasome-Mediated TGF-β/Smad Signaling Pathway","authors":"J. Ji, Zhao Bi, Ling Tian, Qian Zhang, Shuhua Hou, Song Li","doi":"10.26689/jcnr.v7i3.4806","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4806","url":null,"abstract":"Objective: To investigate the effect nano-sustained CO-releasing molecules on cyclosporin-A (CsA)-induced nephrotoxicity by inhibiting the NLRP3 inflammasome-mediated TGF-β/Smad signaling pathway. Methods: 3×105 cell/mL human renal tubular epithelial cells (HK-2) and mouse primary cultured renal tubular epithelial cells (RTECs) were cultured under an inverted microscope and incubated with 10% DMEM and 0.25% β2M in NaCl solution for 3 h. HK-2 and RTECs were divided into 5 complex numbers. MTT assay was used to detect the relative proliferation level of one of the HK-2 cells and calculate the multiplication ratio. Results: The nano-sustained CO-releasing molecules CS-CO had a strong protective effect on the kidney. HK-2 and RTECs cells were treated with siRNA, inhibitors, and NLRP3 knockout mice, and the changes in cell activity and expression of intracellular inflammatory factors were studied. The expression of TGF-β1/Smad signaling pathway related proteins in HK-2 and RTECs was detected by ELISA, western blot, immunofluorescence, and other techniques. Conclusion: SMA/CORM2 alleviates CsA-induced renal fibrosis by inhibiting NLRP3 inflammasome-mediated TGF-β/Smad signaling pathway.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43399894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Observation of Non-Staining Circular Capsulorhexis for Hypermature Cataract","authors":"Lizhao Wang, Rong Li","doi":"10.26689/jcnr.v7i3.4985","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4985","url":null,"abstract":"Objective: To explore the circular capsulorhexis method and its clinical effect in phacoemulsification of hypermature cataract without staining. Methods: In this prospective randomized case-control study, 22 patients (22 eyes) with hypermature cataract were randomly divided into a staining agent group (10 cases, 10 eyes) and a non-staining agent group (12 cases, 12 eyes). Both groups underwent phacoemulsification with foldable intraocular lens implantation under topical anesthesia. In the staining agent group, 0.5% indocyanine green was used to stain the anterior lens capsule to assist in circular capsulorhexis; in the non-staining agent group, after puncturing the anterior lens capsule and aspirating the liquefied cortical material, the capsular bag was filled with viscoelastic agent to increase the contrast prior to circular capsulorhexis. The operability of the anterior capsule without staining in capsulorhexis was observed, and the effect of capsulorhexis, diameter of capsulorhexis opening, and operative time were compared and analyzed between the two groups. Results: Both groups successfully underwent circular capsulorhexis, with a success rate of 100%. The diameters of capsulorhexis opening in the staining agent group and non-staining agent group were 5.68 ± 0.15 mm and 5.54 ± 0.16 mm, respectively, without any statistical difference between the groups (P > 0.05); the operative time of the staining agent group (40.40 ± 5.42 s) was shorter than that of the non-staining agent group (50.92 ± 3.97 s), and the difference was statistically significant (P < 0.001). In both groups, phacoemulsification was successful, and intraocular lens were implanted into the capsular bags; their visual acuity showed significant improvement during the 1-month follow-up period after surgery, without any surgical complications. Conclusion: In hypermature cataract, injecting viscoelastic agent into the capsular bag for volume replacement, given a lack of capsule staining agent, can increase the contrast for capsulorhexis and reduce the risk of large capsular bag collapse on the zonular ligament. Thus, it is considered safe and effective. Circular capsulorhexis is conducive to a smooth phacoemulsification procedure.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42044026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Heuristic Method to the Clinical Teaching of Internal Medicine","authors":"Y. Ni, Hongyuan Bai, Haitao Shi","doi":"10.26689/jcnr.v7i3.4974","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4974","url":null,"abstract":"There is an old saying, “Give a man a fish, and he will eat for a day. Teach a man to fish, and he will eat for the rest of his life.” In clinical teaching, students should not only be taught about diseases, but their intelligence should also be cultivated, along with their analytical, comprehension, and independent learning skills. The ability to solve problems enables students to think independently and acquire knowledge. This is known as the heuristic method of teaching. In this study, we mainly analyze the application value of the heuristic method in the clinical teaching of internal medicine.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46215738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience in Surgical Coordination of Type III Cesarean Scar Pregnancy Removal with Combined Assistance of Hysteroscopy and Laparoscopy","authors":"Fang Zhou, Jinfeng Tan, Y. Li, Qinfang Huang, Y. Teng","doi":"10.26689/jcnr.v7i3.4907","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4907","url":null,"abstract":": Objective: This paper aims to summarize the operative nursing coordination essentials of type III cesareans car pregnancy removal. Methods: Six patients were recruited for this study, and the patient’s condition was fully evaluated before the operation. In addition, the personnel, environment, and materials were well prepared before the operation, and the preparation of special intraoperative instruments and equipment was perfected. Results: The operation is successfully performed in all six patients. Each surgery lasted 70 to 120 minutes with an average duration of 90 minutes. Postoperative blood loss was about 100-500 ml. Postoperative recovery was good without complications in all the patients. Conclusion: In summary, laparoscopic removal of gestational tissue from type III cesareans car pregnancy in conjunction with hysteroscopy ensures compete removal of gestational tissue, while avoiding damaging the surrounding organs and tissues, thus greatly avoiding common complications which usually occur during the surgery. Effective surgical coordination is helpful to further improve the success rate of the operation.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":"10 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41243486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Safety Risks and Measures for Pediatric Neurosurgery Nursing","authors":"Lili Jiang, Weifang Yang, Song Zhang","doi":"10.26689/jcnr.v7i3.4961","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4961","url":null,"abstract":"The aim of this study was to determine the patient safety risks and measures for pediatric neurosurgery nursing. A total of 564 pediatric patients admitted to the hospital from June 2020 to June 2023 under the neurosurgery department were included in this study. We analyzed the safety incidents in pediatric neurosurgery nursing and their causes and proposed corresponding measures for pediatric neurosurgery nursing in hope to reduce the occurrence of patient safety incidents in pediatric neurosurgery nursing and establish harmonious nurse-patient relationships.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41411744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Traditional Chinese and Western Medicine Dressing Change on Wound Healing After Anal Fistula Surgery","authors":"Xiaona Miao, Jia-min Hang","doi":"10.26689/jcnr.v7i3.4877","DOIUrl":"https://doi.org/10.26689/jcnr.v7i3.4877","url":null,"abstract":"With the change of people’s lifestyle and diet, the incidence of anorectal diseases is increasing year by year. Anal fistula is a common anorectal disease. Because it cannot heal by itself, surgery has become the main treatment method. Due to the particularity of wound location and physiological structure, the wound is easily contaminated by bacteria, so dressing change after surgery plays a decisive role in wound healing. Modern western medicine and traditional Chinese medicine have different dressing changing methods respectively. In this paper, we reviewed commonly used dressing changing methods of traditional Chinese and western medicine after anal fistula surgery.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44869590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}