临床护理研究最新文献

{"title":"Study on the Risk Factors of Central Venous-Related Bloodstream Infection in Outpatients","authors":"Lu Yan, Cuiyu Han, Xuerun Du, Y. Gu, R. Gao","doi":"10.26689/jcnr.v7i4.5076","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5076","url":null,"abstract":"Objective: To analyze the risk factors of catheter-related bloodstream infection in outpatients and propose feasible prevention and control measures. Methods: The medical records of outpatients with peripherally inserted central catheter (PICC) from January 2020 to December 2021 were selected for retrospective analysis, and the factors that may be related to the occurrence of catheter-related bloodstream infection were analyzed by logistic multivariate analysis. Results: The incidence rate of catheter-related bloodstream infection among the enrolled patients was 4.78%. It was found that age, duration of catheterization, catheter site, number of punctures, and diabetes were all risk factors for catheter-associated bloodstream infection, and the differences were statistically significant. Conclusion: Age, duration of catheterization, catheterization site, and diabetes are all risk factors for catheter-related bloodstream infection, and medical personnel should fully understand and learn more about these risk factors and actively develop countermeasures to reduce the risk of catheter-related bloodstream infection.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47649801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of MMP-9 Inhibitors on the Biological Behavior of Human Oral Squamous Cell Carcinoma SCC15 Cell Line Through PI3K/Akt Signaling Pathway","authors":"Zhizheng Zhuang, Yan Hu, Hongyue Liu","doi":"10.26689/jcnr.v7i4.5085","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5085","url":null,"abstract":"Objective: To investigate the effect of MMP-9 inhibitor (Mki67) on the biology of human oral squamous cell carcinoma SCC15 cell line and to explore its mechanism of action through PI3K/Akt signaling pathway. Methods: SCC15 cells were extracted, and the supernatant was discarded. The cells were then rinsed twice with PBS, and 0, 2.5, 5, and 10 μL of Mki67 (50 mg/mL) were added to the culture respectively. The inhibition rate of cell proliferation was detected by 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) method, and the cell migration was measured by Transwell chamber test. The cell apoptosis rate was detected by cytometry, and the p-Akt protein content in the cells of each group was determined by a double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results: The cell proliferation rates of the 2.5 μL, 5 μL, and 10 μL dose groups were all lower than the 0 μL group (P < 0.05) before treatment, and the cell proliferation rates in the 2.5 μL, 5μL, and 10μL dose groups decreased overtime (P < 0.05). After 24 h, with the increase of Mki67 concentration, the number of migration and invasion gradually decreased (P < 0.05), and the number of apoptosis gradually increased (P < 0.05); besides, the relative expression of MMP-9, PI3K, and Akt mRNA decreased gradually (P < 0.05), and the expression level of Akt mRNA was not statistically significant (P > 0.05). Conclusion: MMP-9 inhibitor (Mki67) can inhibit the proliferation and migration of SCC15 cell line and induce apoptosis, and its mechanism of action may be related to the inhibition of PI3K/Akt signaling pathway.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46747909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Survey on Vitamin A, D, E Levels of Pregnant Women in Baoding","authors":"Bei Wang, Yakun Zhao, Hongli Wu, L. Liang, Wenli Kang, Yan-yan An, Jie Cui","doi":"10.26689/jcnr.v7i4.5128","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5128","url":null,"abstract":"Objective: To understand the vitamin levels in pregnant women and its influencing factors and provide a basis for formulating scientific and reasonable vitamin supplement plans for pregnant women. Methods: Pregnant women with a pregnancy period of 12 weeks to 36 weeks in Baoding area were selected as the research subjects using the random sampling method. The sample size is estimated to be 5,000 people, and the diversity of the research subjects, such as age, education level, pregnancy, etc., were recorded through a survey. The content of the survey included the personal information of the research subjects, pregnancy conditions, eating habits, vitamin supplements taken, etc. At the same time, blood tests were carried out on the research subjects to detect indicators such as vitamin levels. Results: The results of serum measurement showed that the vitamin A level of pregnant women was 0.38 ± 0.12 mg/L, the vitamin E level was 13.51 ± 3.17 mg/L, and the vitamin D level was 17.82 ± 4.18 ng/L; the level of vitamin A of pregnant women in the first trimester was significantly lower than those in the second and third trimesters, and the level of vitamin E of pregnant women in second trimester was significantly higher than those in the first and third trimesters, with statistically significant differences (P < 0.05). The rate of vitamin A deficiency in the early stage was significantly higher than that in the middle and late stages of pregnancy, (P < 0.05); vitamin D deficiency existed in all pregnant women. Conclusion: Pregnant women should maintain a reasonable diet and eat more vitamin-rich foods, such as vegetables, fruits, etc.; besides, pregnant women should take vitamin supplements under the guidance of doctors or professionals according to their own conditions; moreover, the publicity and education for pregnant women should be improved with more emphasis on vitamin supplementation.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47559585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Whole-Process Management in Day Surgery for Endometrial Polyp","authors":"Min Xia, Zhiqin Yin","doi":"10.26689/jcnr.v7i4.5135","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5135","url":null,"abstract":"Objective: To explore the effect of whole-process management model in nursing management of endometrial polyp day surgery. Methods: 266 patients that underwent endometrial polyp day surgery from January to December 2022 were selected for this study, and they were separated into an observation group (131 patients) and a control group (135 patients); the clinical data of the two groups were compared. Results: After intervention, the scores of Hamilton Anxiety Scale (HAM-A) of the patients in the observation group were lower than those in the control group (P < 0.05). The rate of postoperative complications in the observation group was lower than that in the control group (P < 0.05), and the satisfaction degree of the patients in the observation group was higher than that in the control group (P < 0.05). Conclusion: The application of the whole-course management model in endometrial polyp day surgery can alleviate patients’ anxiety, ensure the quality and safety of day surgery nursing, and improve patients’ satisfaction.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41398037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the Application Effect of Targeted Infusion Safety Nursing in Inpatients with Cancer","authors":"Xue Jin, Wenfeng Li","doi":"10.26689/jcnr.v7i4.5003","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5003","url":null,"abstract":"Objective: To study the clinical effect of targeted infusion safety nursing during infusion of inpatients with cancer. Methods: From January 1, 2020, to January 1, 2023, a total of 6,614 infusion patients were treated in The First Affiliated Hospital of Wenzhou Medical University, and 300 inpatients with cancer were selected as the research objects and randomly divided into the observation group and the control group, with 150 patients in each group. The control group received routine infusion nursing, and the observation group received targeted infusion safety nursing. The targeted infusion safety nursing was judged by comparing the nursing quality assessment, incidence of adverse events, patient compliance, and patients’ mastery of infusion knowledge between the two groups. clinical effect. Results: After the targeted infusion safety nursing was given to the patients in the observation group, the patients in this group recognized the nursing quality, and the statistical score was higher than that in the control group; the incidence of adverse events in the observation group was lower than that in the control group. The compliance of the observation group was higher than that of the control group. The mastery of health knowledge in the observation group was also higher than that in the control group and the difference was statistically significant (P < 0.02). Conclusion: After implementing targeted infusion safety nursing for inpatients with cancer, it can effectively prevent the occurrence of adverse events, improve patient compliance, and increase the mastery of relevant knowledge of patients.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45679808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect Analysis of WeChat Platform Combined with PBL Teaching Method for Standardized Training of Residents in Anesthesiology Department","authors":"Xiaoyan Sun, Jiang Shen","doi":"10.26689/jcnr.v7i4.5009","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5009","url":null,"abstract":"Objective: To explore and analyze the effect of the WeChat platform combined with the PBL teaching method in the standardized training of anesthesia residents. Methods: 120 anesthesiology residents from January 2018 to the end of December 2019 were selected, and divided into a control group and an observation group of 60 each according to the time sequence of admission. The control group adopted the conventional teaching mode, and the observation group adopted the WeChat platform combined PBL teaching method. The scores of theoretical knowledge and anesthesia skills operation after training, the scores of the teaching interest survey, and the satisfaction with the teaching mode between the two groups were compared. Results: The scores of theoretical knowledge and anesthesia skills operation in the observation group were significantly higher than those in the control group, and the indicators of teaching interest in the observation group were also higher than those in the control group. The differences were statistically significant (P < 0.05). The satisfaction degree of the observation group was significantly higher than that of the control group, and the difference was also statistically significant (P < 0.05). Conclusion: The WeChat platform combined with the PBL teaching method is beneficial to improve the training effect of anesthesiology residents, stimulating autonomous learning ability, ensuring the effective practice of theoretical knowledge, and promoting them to move towards a higher standard of anesthesia skills.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41939589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress of Perioperative Application of GLP-1 and Its Protective Effects on Organs","authors":"H. Xi, Zhigang Pang, Yifan Liu, Lixiong Xue, Jiandong He, Wenqu Yang","doi":"10.26689/jcnr.v7i4.5033","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5033","url":null,"abstract":"Glucagon-like peptide-1 (GLP-1) is a multifunctional hormone with broad pharmacological potential to control inflammation, protect cardiovascular, kidney, and liver functions. Moreover, GLP-1 can also cross the blood-brain barrier and bind with GLP-1R distributed in various parts of the brain, thereby reducing apoptosis caused by neuroinflammation and oxygen stress, and promoting learning, memory, cognitive function, neuroprotection, and nerve cell remodeling. However, the exact molecular pathway by which GLP-1 receptor agonists (GLP-1RAs) exerts protective effects on many organs is not fully understood, so it is a hot topic of research. In this article, the recent research on the multi-organ protection of GLP-1 is reviewed, with emphasis on the research progress in the field of nervous system and perioperative anesthesia.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42874843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a New Model of Contactless Medical Services for Outpatients Based on the Project-Achieving Quality Control Circle","authors":"Shuang Chen, Zhihong Guo, X. Huang, Zhiqin Yin","doi":"10.26689/jcnr.v7i4.4953","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.4953","url":null,"abstract":"Objective: To carry out empirical research on the role of project-achieving quality control circle (QCC) in constructing a new model of contactless medical service for outpatients. Methods: A QCC, consisting of information office members from a grade A tertiary hospital in Wenzhou, was established to conduct a research project with the theme “Constructing a new model of contactless medical service based on outpatients’ experience.” According to the ten steps and PDCA cycle, an analysis was carried out before and after the QCC activities, focusing on improving pre-consultation services, providing steward-like services, and facilitating post-consultation management. Results: After the QCC activities, the mobile appointment rate, missed appointment rate, the proportion of smart check-ins, and the average check-in time were 55.68%, 4.02%, 39.75%, and 8.24 ± 3.66 min, respectively; in contrast, before the activities, they were 32.00%, 7.88%, 0.00%, and 14.96 ± 4.98 min, respectively; the difference between the two groups was statistically significant (χ2 = 3480.112, 4994.496; Fisher’s exact probability = 963788.570; t = 5.323, P < 0.001). Many experts have also visited the hospital to learn about this system, thus rendering social and economic benefits. Conclusion: Project-achieving QCC activities are suitable for complex situations, such as constructing a new model of contactless medical service, and can significantly improve outpatient service quality, enhance patients’ experience, and improve the abilities of circle members.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43715480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction of clinical research progress, mechanism analysis and application prospect of acupuncture and moxibustion when treating diabetic constipation","authors":"Leyao Qin, Z. Lei","doi":"10.26689/jcnr.v7i4.5035","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.5035","url":null,"abstract":"Chronic diseases like diabetes, hypertension, and coronary heart disease are increasingly prevalent in Chinese ageing population due to its accelerated ageing process, which has been a serious threat to people's health. The prevention and treatment of these diseases have received increasing attention from the medical sector. Diabetes is a metabolic disease characterized by polydipsia, polyuria and emaciation, in which the incidence of type 2 diabetes is much higher compared to type 1 diabetes. Diabetes has a variety of complications that can occur after the progression of the disease. Diabetic constipation is one of the most common and harmful complications of diabetes, which can negatively impact the health of patients. Western medicine is limited when treating these diseases, and there are obvious side effects associated with some drugs. The tolerance of the middle-aged and elderly is poor. Therefore, more and more experts and scholars have advocated the introduction of Chinese medicine into the treatment of diabetic constipation, of which acupuncture is widely used and its efficacy is well recognized by doctors and patients. This study collated and analyzed the relevant literature reports and studies in the past three years. It was confirmed that the use of acupuncture for diabetic constipation can remarkably improve clinical symptoms, its efficacy and safety are good, and this treatment protocol has positive clinical application value.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48959448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Liposuction Combined with Subareolar Incision Adenectomy for Gynecomastia","authors":"Lu Sun, W. Shao, Xiao-Qi Weng","doi":"10.26689/jcnr.v7i4.4989","DOIUrl":"https://doi.org/10.26689/jcnr.v7i4.4989","url":null,"abstract":"Objective: To investigate the clinical effect of liposuction combined with subareolar incision glandectomy in the treatment of Simon Grade Ⅲ adipo-glandular gynecomastia (GYN). Methods: From March 2021 to March 2022, the data of patients with Simon Grade Ⅲ adipo-glandular GYN treated by liposuction combined with glandectomy in the Department of Plastic Surgery, Zhongshan Hospital Affiliated to Dalian University and Henan Plastic Surgery and Aesthetic Hospital were retrospectively analyzed. Based on the medical records, color ultrasound was performed on the patient’s breast before surgery, which was determined to be GYN (more than 50% glandular tissue). A 3 mm long incision was made at the lower boundary of the surgical range, through which the adipose tissue in the hypertrophic region of the breast was repeatedly aspirated until a satisfactory thickness was achieved. The residual glandular tissue was removed by a semicircular arc incision under the areola, and then the areola incision was sutured in position. The blood flow, sensation, and wound healing of bilateral nipples and areola were observed after surgery, and the morphology of bilateral thorax and scar of incision were followed up. Results: A total of 15 GYN patients aged 18 to 35 years with body mass index of 23.8 to 26.5 kg/m2 (mean = 24.8 kg/m2) were included in this study. The average intraoperative liposuction volume of unilateral breast was 170 mL (150–200 mL), the average glandectomy volume was 115 g (95–125 g), and the average blood loss was about 40 mL (15–75 mL). Postoperative hypertrophic breast volume decreased significantly, and no complications such as hematoma, infection, skin ischemic necrosis, or sensory disturbance occurred in the nipple and areola, during the healing process. The patients were followed up for 3 to 6 months, and the bilateral thorax was smooth, symmetrical, and natural in contour. The incision was concealed, and the scar was not obvious. Conclusion: Liposuction combined with subareolar incision glandectomy in the treatment of Simon Grade Ⅲ adipo-glandular GYN is safe. The postoperative chest contour is smooth and natural, and the scar is small and invisible, which achieves good aesthetics.","PeriodicalId":64151,"journal":{"name":"临床护理研究","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48896012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}