{"title":"Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles","authors":"Dadong Guo, Wenfeng Song, Xuemei Wang, Baoan Chen","doi":"10.1109/BMEI.2009.5305763","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305763","url":null,"abstract":"Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74996588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Approximate Analytical Solution for Tissue Temperature Distribution in High-Intensity Focused Ultrasound","authors":"Dehui Li, G. Shen, Jingfeng Bai, Yazhu Chen","doi":"10.1109/BMEI.2009.5304866","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5304866","url":null,"abstract":"An approximate analytical solution for tissue temperature distribution in high-intensity focused ultrasound (HIFU) is obtained in this work. Based on variable separation method (VSM), the solution is performed to solve the simplified bioheat transfer equation (BHTE). Lack of enough boundary conditions; the parameters in this analytic solution are estimated using the temperature data calculated by finite element method (FEM) with nonlinear least square algorithm. The absolute root mean square error (RMSE) of temperature is 0.21℃ and 0.22℃ for two strategies, respectively. Feasibility and accuracy of the analytical solution are verified by comparison with FEM for transient temperature response in a longer time domain. The average deviation of temperature is about 0.35℃. So this analytic solution is suitable to calculate spatiotemporal temperature distribution in HIFU treatment, and it is quite useful to the treatment planning.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75124840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Robust Medical Image Registration Algorithm Based on the SAM of Multi-Scale Harris Corners","authors":"Ying Ding, Jingtao Fan, Huamin Yang","doi":"10.1109/BMEI.2009.5302680","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5302680","url":null,"abstract":"To make up for the lack of concern on spatial information in conventional mutual information based image registration framework, this paper designs a novel registration algorithm based on the SAM information of multi-scale Harris corners (CSAM for short). First, the multi-scale contour is extracted, and multi-scale Harris corner detector is added to acquire the estimated transform parameters; and then CSAM is regarded as Similarity Measure function, several optimized match points are obtained, the finally registration parameters are resolved by using least squares method. This algorithm realizes registration of medical images with noise and multiresolutions, further more, it only matches corners and doesn’t need optimal searching, so it has reduced calculate time and avoided local extremum. Experimental results on clinical CT and T1-weighted MR images demonstrate that, as compared with the conventional mutual information based method, the proposed method consistently completes much higher precision, faster speed and better robustness. Keywords-image registration; square root arithmetic mean divergence(SAM); Harris corner; multi-scale","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75937848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wrist Pulse Analysis Based on RP and RQA","authors":"Chunming Xia, Rui Liu, Yiqin Wang, Haixia Yan, Helge Gewiss","doi":"10.1109/BMEI.2009.5305193","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305193","url":null,"abstract":"Wrist pulse waveform analysis is common in Traditional Chinese Medicine (TCM) engineering and diagnosis modernization. Nonlinear dynamics theory has been a tool in the analysis of physiological signals containing some nonlinear and chaotic information indispensable. The chaotic properties of wrist pulse containing a wealth of human physiological and pathological information were seldom studied. An application of nonlinear qualitative and quantitative analysis method, i.e., Recurrence Plots (RP) and Recurrence Quantification Analysis(RQA), to analyze the two kinds of wrist pulse time series is proposed in this paper. Both controls and patients with cardiovascular diseases, and the other kind of series of 4 common TCM pulses are analyzed by RP and RQA to extract nonlinear features, which are then used for classification and discrimination. The results from analyzing real data show the feasibility of the proposed RP and RQA method and indicate the potential of further applications to syndrome classification and diagnosis. Keywords-wrist pulse analysis, nonlinear features, syndrome classification, Recurrence Plots (RP), Recurrence Quantification Analysis(RQA)","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76272972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of Chitosan-Hyaluronic Acid Blended Membrane on the Growth of Keratocytes","authors":"Zi-Ang Yao, Hai-Ge Wu, Ying Bai, Wei Qu, Yan Pan","doi":"10.1109/BMEI.2009.5305837","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305837","url":null,"abstract":"In order to construct a suitable scaffold for corneal cells culture and transplantation in vitro, different chitosan- hyaluronic acid blended membranes were prepared and the compatibility of chitosan and hyaluronic acid in blended membranes was studied. Rabbit keratocytes were seeded onto the blended membranes surface and the effects of the blended membranes on cells attachment and metabolism were investigated. The results showed that chitosan and hyaluronic acid had good compatibility in blended membranes within a certain blended ratio. Within the blending ratio of 1:0.05, hyaluronic acid could reduce the damage of chitosan membrane to cells and improve the adhersion and proliferation of cells on blended membranes. So chitosan and hyaluronic acid had good compatibility within a certain blended ratio. Hyaluronic acid could improve the biocompatibility between cells and membranes. The blended membrane had potential to be used as a scaffold for corneal cells culture in vitro and a carrier for corneal cells transplantation. Keywords-chitosan; hyaluronic acid; blended membrane; keratocytes","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75750870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Design and Implementation of Computer Assisted Thoracic Surgery System","authors":"Yanmin Peng, Rong Liu","doi":"10.1109/BMEI.2009.5304944","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5304944","url":null,"abstract":"The system chose the Visualization Toolkit and Visual C++ as the development platform. The coronal section and the sagittal section were reconstructed through the crosssection of patients thoracic computed tomography (CT). Analyzing of these slices, the doctor can discover the position of tumors. And then the three-dimensional (3-D) reconstruction of the chest and the tumors can be reconstructed by the volume rendering Ray-Casting method. The position of incision surgery can be located by the position of tumors, which would help the doctor analysis and view tumors and 3-D reconstruction of the chest from any angle through graphical visual interfaces in the computer. The surgical injury could be minimized.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72983543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chaotic Synchronization of Coupled Hindmarsh-Rose Neurons Using Adaptive Control","authors":"Yu Shi, Jiang Wang, Bin Deng, Qiuxiang Liu","doi":"10.1109/BMEI.2009.5302804","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5302804","url":null,"abstract":"In this paper, we propose an approach for adaptive synchronization of two uncertain nonlinear chaotic neuron systems by using the coupled system of Hindmarsh-Rose [18]. An outline of this paper is given as follows: In Sec. 2, we study the dynamics of gap junction coupled neuronal system of two HR neurons without control. In Sec.3, we design the adaptive controller for chaos synchronization of the coupled HR neurons. Asymptotic synchronization can be obtained by proper choice of the control parameters. The simulation given in Sec. 4 demonstrated the effectiveness of the control. Conclusion of this paper is given in Sec. 5.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73267810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Novel Method for Computer Aided Plastic Surgery Prediction","authors":"Jie Liu, Xubo Yang, T. Xi, Lixu Gu, Zhe-yuan Yu","doi":"10.1109/BMEI.2009.5305021","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305021","url":null,"abstract":"In this paper, a novel method based on former cases for plastic surgery prediction is presented. This method takes a pre-operative frontal facial picture as an input. Landmarks of the face are then extracted and constitute a distance vector. As a set of facial parameters, such a vector is entered into either a sup- port vector regression (SVR) predictor or a k-nearest neighbor (KNN) predictor which is trained on a set of pre- and post- operative facial distance vectors of former cases. After the pre- dicted distance vector generated, new landmarks positions are updated and the final result is generated in terms of changes be- tween predicted landmarks and the original ones. Several expe- riments are carried out and the results show a great accuracy of prediction, which proves that this method is of high validity. Keywords-ASM; SVR; KNN; plastic surgery prediction","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74196260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficient Privacy of Message Encryption Algorithm for Anonymous Receivers in E-Commerce","authors":"Xiangyang Xu","doi":"10.1109/BMEI.2009.5305827","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305827","url":null,"abstract":"protecting the privacy of message receivers is an important issue in pay services of e-commerce and the distribution of digital contents on the Internet. This paper proposes an efficient privacy of message encryption algorithm called PMEA for pay services of e-commerce. In PMEA, each of the receivers only needs to perform constant times of pairing computation to decrypt the received message. PMEA adopts bilinear pairings on elliptic curves to protect the privacy of message receivers, to ensure that an attacker or any other message receiver can not derive the identity of a message receiver such that the privacy of every receiver can be guaranteed. Detailed theoretical analysis proves that PMEA is secure and anonymous for message receivers. Keywordsprivacy message; encryption algorithm; anonymous receivers; E-commerce","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74211047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sequence Analysis of rDNA ITS of Clinical Fusarium Species","authors":"He Li, G. Zhou, Junang Liu","doi":"10.1109/BMEI.2009.5305743","DOIUrl":"https://doi.org/10.1109/BMEI.2009.5305743","url":null,"abstract":"The study on molecular structure of Fusarium proliferatum clinically isolated can provide the basis for accurate diagnosis and treatment of F. proliferatum infection. The rDNA ITS gene of 6 strains that had been identified as Fusarium proliferatum based on morphological were cloned and sequenced. The molecule phylogenetic tree was constructed based on rDNA ITS sequences, and the 6 genus were divided into two groups. Group was F.proliferatum, including strains of CSUFT201, CSUFT204, CSUFT205. Group was F. moniliforme, including CSUFT202,CSUFT203,CSUFT206. The results of this study showed that 3 strains of F. moniliforme were confirmed out of the 6 strains with the molecular methods. Keywords-Fusarium; ITS gene; clone; phylogenetic; sequence analysis","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74636846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}