高强度聚焦超声中组织温度分布的近似解析解

Dehui Li, G. Shen, Jingfeng Bai, Yazhu Chen
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引用次数: 1

摘要

本文给出了高强度聚焦超声(HIFU)中组织温度分布的近似解析解。基于变量分离法(VSM),求解简化生物传热方程(BHTE)。缺乏足够的边界条件;利用非线性最小二乘有限元法计算的温度数据对解析解中的参数进行了估计。两种策略的温度绝对均方根误差(RMSE)分别为0.21℃和0.22℃。通过与有限元法在较长时域内瞬态温度响应的比较,验证了解析解的可行性和准确性。温度平均偏差约为0.35℃。因此,该解析解适用于HIFU治疗过程中温度的时空分布计算,对治疗方案的制定有一定的参考价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Approximate Analytical Solution for Tissue Temperature Distribution in High-Intensity Focused Ultrasound
An approximate analytical solution for tissue temperature distribution in high-intensity focused ultrasound (HIFU) is obtained in this work. Based on variable separation method (VSM), the solution is performed to solve the simplified bioheat transfer equation (BHTE). Lack of enough boundary conditions; the parameters in this analytic solution are estimated using the temperature data calculated by finite element method (FEM) with nonlinear least square algorithm. The absolute root mean square error (RMSE) of temperature is 0.21℃ and 0.22℃ for two strategies, respectively. Feasibility and accuracy of the analytical solution are verified by comparison with FEM for transient temperature response in a longer time domain. The average deviation of temperature is about 0.35℃. So this analytic solution is suitable to calculate spatiotemporal temperature distribution in HIFU treatment, and it is quite useful to the treatment planning.
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