Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles

Dadong Guo, Wenfeng Song, Xuemei Wang, Baoan Chen
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引用次数: 2

Abstract

Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.
磁性纳米颗粒增强三氧化二砷对白血病细胞的细胞毒性抑制作用
近年来,超顺磁性氧化铁纳米颗粒在磁共振成像对比度增强、药物传递、生物分离、组织修复、热疗等生物领域显示出巨大的应用潜力。在这项研究中,我们通过MTT实验探讨了三氧化二砷(As2O3)在没有和存在Fe3O4纳米粒子的情况下对敏感的K562细胞株和阿霉素抗性的K562/A02细胞株的增强细胞毒性作用。结果表明,Fe3O4纳米颗粒可以抑制p糖蛋白(P-gp)的功能,从而增加靶癌细胞中相关药物的积累,从而增强As2O3对细胞毒性的抑制作用。这为Fe3O4纳米颗粒在白血病肿瘤化疗中的临床应用提供了广阔的前景。
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