{"title":"磁性纳米颗粒增强三氧化二砷对白血病细胞的细胞毒性抑制作用","authors":"Dadong Guo, Wenfeng Song, Xuemei Wang, Baoan Chen","doi":"10.1109/BMEI.2009.5305763","DOIUrl":null,"url":null,"abstract":"Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.","PeriodicalId":6389,"journal":{"name":"2009 2nd International Conference on Biomedical Engineering and Informatics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles\",\"authors\":\"Dadong Guo, Wenfeng Song, Xuemei Wang, Baoan Chen\",\"doi\":\"10.1109/BMEI.2009.5305763\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.\",\"PeriodicalId\":6389,\"journal\":{\"name\":\"2009 2nd International Conference on Biomedical Engineering and Informatics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 2nd International Conference on Biomedical Engineering and Informatics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/BMEI.2009.5305763\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 2nd International Conference on Biomedical Engineering and Informatics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BMEI.2009.5305763","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Enhanced Cytotoxicity Suppression of Arsenic Trioxide to Leukemia Cancer Cells by Using Magnetic Nanoparticles
Recently, superparamagnetic nanoparticles of iron oxides have shown great potential in bio-applications, including magnetic resonance imaging contrast enhancement, drug delivery, bio-separation, tissue repair, hyperthermia, and others. In this study, we have explored the enhanced cytotoxicity effect of arsenic trioxide (As2O3) on both sensitive K562 cell line and adriamycin-resistance K562/A02 cell line in the absence and presence of Fe3O4 nanoparticles by MTT assay. The results demonstrate that Fe3O4 nanoparticles could inhibit the function of Pglycoprotein (P-gp) so as to increase the relevant drug accumulation in target cancer cells and thus enhance the cytotoxicity suppression of As2O3. This raises the promising possibility of the great potential application of Fe3O4 nanoparticles in the cancer chemotherapy of leukemia in clinical area.
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