世界病毒学杂志(英文版)最新文献

{"title":"Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated alcohol-related liver disease in human immunodeficiency virus.","authors":"Dinuka Bandara, Krishan Joshi, Carol Singh, Aalam Sohal, Mohanad Al-Qaisi, Nilofar Najafian","doi":"10.5501/wjv.v15.i2.120027","DOIUrl":"10.5501/wjv.v15.i2.120027","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated alcohol-related liver disease (MetALD) have emerged as increasingly important sources of morbidity among people living with human immunodeficiency virus (HIV). Advances in antiretroviral therapy have substantially improved life expectancy in people living with HIV (PLWH), but have also unmasked a growing burden of metabolic comorbidities which contribute to steatotic liver disease. Recent shifts in nomenclature and the introduction of MetALD emphasize metabolic dysfunction and graded alcohol exposure as central drivers of disease and are particularly relevant to PLWH, a population in whom overlapping metabolic and behavioral risk factors are common. Epidemiologic studies demonstrate that MASLD affects approximately one-third to one-half of PLWH worldwide, often occurring at younger ages and lower body mass index thresholds than in HIV-negative individuals. Emerging data further highlight the synergistic contribution of metabolic dysfunction and alcohol use to accelerated fibrosis progression in PLWH. Pathophysiologic mechanisms linking HIV infection to MASLD and MetALD include chronic immune activation and systemic inflammation, antiretroviral therapy-associated metabolic effects, altered adipose tissue distribution, gut-liver axis dysregulation, and alcohol-metabolic synergy. This review synthesizes contemporary evidence on the definitions, epidemiology, pathogenesis, clinical assessment, and management of MASLD and MetALD in PLWH.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"120027"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous quality improvement, linkage to peer supporters in prevention of mother-to-child human immunodeficiency virus transmission programs in Rwanda.","authors":"Jackson Sebeza, Peter Memiah, Mariam Salim Mbwana, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Upendo Kayeke Chenya, Beatrice Kelvin Mpimo, Haji Mbwana Ally, Basile Ikuzo, Habib Omari Ramadhani","doi":"10.5501/wjv.v15.i2.120310","DOIUrl":"10.5501/wjv.v15.i2.120310","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Peer supporters are instrumental for the successful navigation of prevention of mother-to-child human immunodeficiency virus (HIV) transmission services, including maternal viral load suppression and early infant HIV diagnosis. These outcomes are critical for the elimination of mother-to-child HIV transmission. We assessed the impact of continuous quality improvement (CQI) services on assignment to peer supporters and undetection of the viruses among pregnant women living with HIV (WLHIV) and mother-to-child transmission of HIV (MTCT) rates among HIV exposed babies in Rwanda.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To assess the impact of CQI services on assignment to peer supporters and undetection of the viruses among pregnant WLHIV and MTCT rates among HIV exposed babies in Rwanda.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between 2021 and 2022, CQI services were implemented in 18 of the 38 healthcare facilities included in this analysis. Healthcare workers in 18 facilities used CQI approaches to key predictors of, and contributors related to, the implementation of the prevention of MTCT (PMTCT) program to improve maternal and infant outcomes. This was a secondary data analysis that explored the association between CQI and assignment to peer supporters, undetection of the virus, and MTCT rates. To assess the impact of CQI on these outcomes, a multivariable logistic regression model was used to compute adjusted odds ratios (aOR) and corresponding 95% confidence intervals (CI).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 1145 mother-baby pairs were included, of whom 558 (48.7%) were from facilities that implemented CQI. At the end of evaluation, 1043 (91.0%) either completed 24-months of follow-up or remained in care in the same facilities. Of 102 not available at the evaluation, 84 were transferred out, and 18 were dead or lost to follow-up. Overall, 405 (35.4%) women were assigned to peer supporters, 1004 (87.7%) had undetectable viruses, and 8 (0.7%) infants were infected with HIV. Compared to women from non-CQI facilities, those from CQI implementing facilities had 32% higher odds of being assigned to peer supporters (aOR = 1.32; 95%CI: 1.02-1.71). Similarly, disclosing HIV status (aOR = 1.53; 95%CI: 1.10-2.14) and a higher number of health care workers per 1000 active patients (&gt; 4 &lt;i&gt;vs&lt;/i&gt; ≤ 4) (aOR = 1.34; 95%CI: 1.05-1.75) were associated with higher odds of being linked to peer supporters. Having a formal education was associated with reduced odds of being linked to peer supporters compared to those with no education. Compared to women from non-CQI facilities, those from CQI implementing facilities had 51% higher odds of having undetectable viruses (aOR = 1.51; 95%CI: 1.05-2.18). CQI was associated with fewer transferred out compared to non-CQI facilities (6.0% &lt;i&gt;vs&lt;/i&gt; 8.8%; &lt;i&gt;P&lt;/i&gt; = 0.07).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Nearly 3 in 10 pregnant WLHIV in Rwanda were linked to peer support to support the successful navig","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"120310"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Dengue virus as an underrecognized cause of encephalitis in tropical Asia - Bridging diagnostic and surveillance gaps.","authors":"Alok Kumar, Devlina Ghosh","doi":"10.5501/wjv.v15.i2.118082","DOIUrl":"10.5501/wjv.v15.i2.118082","url":null,"abstract":"<p><p>Arboviral encephalitis remains a major public health concern in tropical Asia, where the etiology of a substantial proportion of central nervous system infections remains undetermined despite endemic circulation of dengue virus (DENV) and Japanese encephalitis virus. Laboratory confirmation is frequently absent in clinically suspected encephalitis. Perera <i>et al</i> recently published a study in <i>World Journal of Virology</i>, highlight this diagnostic gap by identifying DENV infection in 6.06% of encephalitis cases, including molecular evidence of DENV-3 neuroinvasion. These findings add to the growing evidence that DENV can cause encephalitis and meningoencephalitis across age groups. However, encephalitis in endemic settings is etiologically heterogeneous, and dengue represents only one of several infectious and immune-mediated contributors. Neurological dengue is likely under-recognized due to overlapping clinical presentations and limited diagnostic capacity. The identification of DENV-3 is noteworthy given its recurrent association with neurological disease. Limited concordance between reverse transcription polymerase chain reaction and immunoglobulin M assays reflects challenges related to viral kinetics, timing of specimen collection, and flaviviral serological cross-reactivity. Strengthening surveillance through integrated molecular and serological diagnostic strategies, including multiplex polymerase chain reaction and metagenomic next-generation sequencing, is essential to reduce undiagnosed encephalitis and improve clinical management and public health preparedness in tropical Asia.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"118082"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral innate immunity and adaptive immune responses against monkeypox and viral immune evasion.","authors":"Zi-Hao Liang, Ping Huang, Jian-Jun Shen, Jie Wei, Wen-Xian Qian, Chang-Hua Yi","doi":"10.5501/wjv.v15.i2.116792","DOIUrl":"10.5501/wjv.v15.i2.116792","url":null,"abstract":"<p><p>The monkeypox virus (MPXV) belongs to the Poxviridae family and has emerged as a global problem for public health since May 2022. Both innate and adaptive immunity are crucial for preventing MPXV infections. Understanding the interaction between the innate and adaptive immune systems and MPXV could be critical in developing novel treatments. This review presents an update on the host antiviral innate and adaptive immune responses against four zoonosis poxvirus, including mouse kidney parvovirus, cowpox virus, variola virus, and vaccinia virus. The effect of APOBEC3 variants on viral immune escape and the underlying mechanisms were also explored. The possible mechanisms of the effects of human immunodeficiency virus and monkeypox co-infection in the clinical setting were also analysed in the hope of providing a basis for clinical drug development and treatment.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"116792"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency robotic-assisted repair in an elderly patient with strangulated hernia and active influenza A infection: A case report.","authors":"Kyriacos Evangelou, Andreas Polydorou, Thalia Petropoulou","doi":"10.5501/wjv.v15.i2.117106","DOIUrl":"10.5501/wjv.v15.i2.117106","url":null,"abstract":"<p><strong>Background: </strong>Emergency repair of strangulated hernias in elderly patients with active respiratory viral infections is high risk and poorly described. This case reports the first emergency robotic-assisted transabdominal preperitoneal (r-TAPP) repair performed in an elderly patient with active influenza A infection, highlighting surgical and infection-control adaptations enabling safe outcomes.</p><p><strong>Case summary: </strong>An 80-year-old male with significant comorbidities presented with a strangulated left inguinal hernia and confirmed influenza A (H3N2) infection, associated with abdominal pain, bowel obstruction, and mild hypoxaemia. Emergency robotic r-TAPP repair was performed using targeted modifications, including ultra-low-pressure pneumoperitoneum, ultra-low particulate air filtration, and lung-protective ventilation. Operative time was 85 minutes with minimal blood loss. The patient was extubated immediately postoperatively, experienced no complications, and was discharged on postoperative day two. Antiviral therapy was continued without respiratory deterioration or nosocomial transmission.</p><p><strong>Conclusion: </strong>Emergency robotic-assisted repair of strangulated hernia can be safely performed in selected elderly patients with active respiratory viral infection when appropriate surgical, anaesthetic, and infection-control strategies are applied.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"117106"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Physical functioning as a neglected determinant of antiviral adherence in chronic hepatitis B.","authors":"Xiao-Feng Huang, Jing-Qi Zeng","doi":"10.5501/wjv.v15.i2.117858","DOIUrl":"10.5501/wjv.v15.i2.117858","url":null,"abstract":"<p><p>As global strategies shift toward expanding treatment eligibility for chronic hepatitis B, ensuring long-term adherence is critical. Block <i>et al</i> recently published a study in <i>World Journal of Virology,</i> challenging the conventional focus on economic barriers and revealing that compromised physical functioning is a significantly more potent predictor of non-adherence than financial affordability. This finding exposes a profound \"clinical discordance\": Patients may achieve viral suppression yet suffer from residual fatigue and functional impairment, potentially driven by immune exhaustion or metabolic comorbidities. We argue that this symptom burden serves as a functional blockade to daily persistence. Therefore, clinical care must evolve from \"adherence policing\" to active symptom management. Integrating patient-reported outcomes and addressing physical deficits are essential strategies to safeguard the efficacy of antiviral regimens in the elimination era.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"117858"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding machupo virus: A neglected arenavirus with global health importance.","authors":"Praveen Kumar Uppala, Sita Kumari Karanam, Naga Vishnu Kandra, Sandhya Edhi","doi":"10.5501/wjv.v15.i2.119515","DOIUrl":"10.5501/wjv.v15.i2.119515","url":null,"abstract":"<p><p>Machupo virus (MACV), classified within the Mammarenavirus genus of the Arenaviridae family, serves as the causative agent of Bolivian hemorrhagic fever (BHF), a life-threatening zoonosis primarily confined to rural regions of Bolivia's Beni Department. First identified in 1959 during epidemics in San Joaquín, this bisegmented, ambisense, single-stranded RNA virus exhibits 20%-35% case-fatality rates, with highest lethality among children under 5 and adults over 55. The vesper mouse (<i>Calomys callosus</i>) acts as the principal reservoir, sustaining lifelong asymptomatic infections and shedding virus through excreta, facilitating human spillover <i>via</i> aerosol inhalation, contaminated food, or direct contact-predominant in agrarian settings. Clinically, BHF follows a 5-21 days incubation with initial nonspecific febrile prodrome (fever, myalgia, prostration) evolving into hemorrhagic diathesis (petechiae, mucosal bleeds), neurological signs (tremors, delirium), leukopenia/thrombocytopenia, and shock. Pathogenesis hinges on transferrin receptor 1-mediated endothelial tropism, type I interferon suppression (NP/Z), and cytokine storms, recapitulated in guinea pig/primate models. Designated Centers for Disease Control and Prevention Category A and biosafety level (BSL)-4, MACV constrains research; diagnostics demand reverse transcription polymerase chain reaction, enzyme-linked immunosorbent assay, or isolation in maximum containment. Supportive therapy prevails, augmented by off-label ribavirin (preclinical efficacy) and convalescent plasma; Candid 1 (Junín-attenuated) cross-protects informally. This review details MACV's genomic organization (L/S segments encoding L/Z, NP/GPC), epidemiology, etiology, and advances: Reverse genetics for antivirals, GP-specific mAbs (100% guinea pig survival), multi-epitope vaccines, and high-throughput screening entry inhibitors. One health imperatives-rodent control, artificial intelligence surveillance, and Bolivian BSL-3 expansion-counter ecological drivers like deforestation. Amid climate, prioritizing global collaborations will forge resilient countermeasures, leveraging MACV as a sentinel for new world arenavirus threats.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 2","pages":"119515"},"PeriodicalIF":0.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13324784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148378251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone health and chronic viral infections: A narrative literature review.","authors":"Jelena S Jadzic, Andreja B Baljozovic, Ljubica D Simic","doi":"10.5501/wjv.v15.i1.118225","DOIUrl":"10.5501/wjv.v15.i1.118225","url":null,"abstract":"<p><p>Chronic viral infections, such as human immunodeficiency virus (HIV), hepatitis B (HBV), and hepatitis C (HCV), negatively impact bone health leading to osteopenia/osteoporosis and increased bone fragility. This narrative review aims to provide a comprehensive overview of the contemporary literature on bone changes in patients with chronic viral infections (HIV, HBV, HCV mono-infection, and coinfections), focusing on their clinical implications and the importance of assessing multiscale bone properties to evaluate bone strength decline in these individuals. Previous studies suggest that skeletal alterations in these subjects may arise from direct viral effects on bone cells and from indirect mechanisms involving systemic inflammation, immune dysregulation, therapy-related effects, and distant organ failure (<i>e.g.</i>, liver disease). It has been reported that HBV/HCV co-infection in people living with HIV produces the most severe phenotype through additive inflammatory, hepatic, and metabolic insults. Further, an increased risk of developing osteonecrosis of multiple joints has also been reported among people living with HIV. Given the limited contemporary data, future studies should focus on investigating hierarchical alterations in bone structure to deepen our understanding of the complex skeletal changes in patients with chronic viral infections, thereby providing a solid foundation for advancing clinical management. As the population living with chronic viral infections ages, total joint arthroplasty will increasingly become a standard procedure, requiring a deeper understanding of how various hierarchical bone morpho-structural changes affect implant stability and longevity in these patients.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 1","pages":"118225"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of tracheostomy practices after the COVID-19 pandemic: The fast lane in the post-COVID era.","authors":"Stephens Griner, Sabrina Elliott, Dimitrios Giannis, Camille Mai-Phuong Tran Quang, Kellyann Inniss, Andrew Miele, Martine A Louis, Nageswara R Mandava","doi":"10.5501/wjv.v15.i1.118274","DOIUrl":"10.5501/wjv.v15.i1.118274","url":null,"abstract":"<p><strong>Background: </strong>The optimal timing of tracheostomy in critically ill patients remains controversial. While early tracheostomy has been associated with reduced ventilator days and intensive care unit length of stay (LOS), survival benefits remain inconsistent. The coronavirus disease 2019 (COVID-19) pandemic changed intensive care unit workflows, airway management strategies, and interdisciplinary decision-making, potentially affecting tracheostomy practices even beyond the pandemic.</p><p><strong>Aim: </strong>To evaluate differences in tracheostomy timing, interdisciplinary consultation patterns, and clinical outcomes before and after the COVID-19 pandemic in critically ill patients without active COVID-19.</p><p><strong>Methods: </strong>This is a single-center retrospective cohort study of adult patients undergoing tracheostomy at a community hospital in New York during two periods, pre-COVID (October 2012 to February 2020) and post-COVID (June 2022 to July 2024). Patients with active COVID-19 were excluded. Demographics, comorbidities, time-based outcomes (including time to palliative care and surgical consultation, intubation-to-tracheostomy interval, and hospital LOS), and mortality at 2 months and 6 months were analyzed. Multivariable logistic regression was used to identify factors associated with 6-month mortality.</p><p><strong>Results: </strong>A total of 314 patients were included (246 pre-COVID, 68 post-COVID). Compared with the pre-COVID cohort, post-COVID patients had a significantly shorter time to palliative care consultation (3 days <i>vs</i> 7 days, <i>P</i> = 0.001), surgical consultation (9.5 days <i>vs</i> 15.0 days, <i>P</i> < 0.001), intubation-to-tracheostomy interval (11.0 days <i>vs</i> 15.5 days, <i>P</i> < 0.001), and hospital LOS (29.5 days <i>vs</i> 34.0 days, <i>P</i> = 0.033). Mortality at 2 months and 6 months did not differ significantly between cohorts. In multivariable analyses, age was the only factor independently associated with mortality.</p><p><strong>Conclusion: </strong>The post-COVID era was associated with earlier interdisciplinary engagement and tracheostomy placement without improvement in short- or long-term mortality. These findings suggest a pandemic-driven change in airway management practices. The COVID-19 pandemic may have sensitized healthcare providers, leading to earlier involvement in tracheostomy decision-making, but long-term effects are yet to be determined.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 1","pages":"118274"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the correlation between molecular characteristics of SARS-CoV-2 and its epidemiology and clinical manifestations in Lu'an city.","authors":"Hong-Wei Chang, Wei Yang, Long Yu, Da-Wei Gao, Feng Zhang, Zhi-Chao Chen, Bei-Lei Chen, Li-Mei Zhang, Rui Zhu, Qin Zhang, Zhao-Yang Li, Jian-Guo Rao","doi":"10.5501/wjv.v15.i1.118988","DOIUrl":"10.5501/wjv.v15.i1.118988","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic remains a major global public health threat, and ongoing viral mutations continue to complicate control efforts. To inform local prevention strategies, this study investigated the epidemiological and molecular characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Lu'an city from 2020 to 2022, and analyzed their association with clinical outcomes.</p><p><strong>Aim: </strong>To analyze the molecular epidemiology and risk factors for severe COVID-19, and provide a scientific basis for guiding local epidemic prevention and control strategies.</p><p><strong>Methods: </strong>Biological samples were collected from confirmed COVID-19 patients in Lu'an city between 2020 and 2022. Complete SARS-CoV-2 genomic sequences were obtained through sequencing. Epidemiological and clinical data were collected concurrently for each patient. Statistical analyses were conducted using IBM SPSS 29.0 software to assess risk factors associated with severe COVID-19. Viral genomic sequences were analyzed using MEGA software to characterize the molecular features of circulating SARS-CoV-2 strains.</p><p><strong>Results: </strong>Sequencing identified the original SARS-CoV-2 strain in samples from 2020-2021, while the Omicron variant was detected in samples from 2022. The predominant clinical manifestations among patients were cough (67.03%) and fever (65.56%). Laboratory and imaging examinations revealed that 78.85% of infected patients exhibited abnormalities on chest computed tomography scans. Comprehensive analyses demonstrated that the temporal and spatial distribution of prevalent SARS-CoV-2 strains in Lu'an city was consistent with national trends in China. The presence of underlying comorbidities, including hypertension, diabetes, and liver injury, was significantly associated with progression to severe COVID-19. This risk showed little correlation with the specific SARS-CoV-2 variant type.</p><p><strong>Conclusion: </strong>The development of severe COVID-19 was predominantly associated with pre-existing comorbidities rather than with SARS-CoV-2 variant type. These findings provide evidence to inform targeted clinical management and public health planning for vulnerable populations.</p>","PeriodicalId":61903,"journal":{"name":"世界病毒学杂志(英文版)","volume":"15 1","pages":"118988"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13010956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}