Journal of Chemical Sciences最新文献

{"title":"Synthesis, type II diabetes inhibitory activity and docking studies of novel thiazole molecules","authors":"Jaysinh I Jadeja,&nbsp;Mahesh M Savant","doi":"10.1007/s12039-023-02225-7","DOIUrl":"10.1007/s12039-023-02225-7","url":null,"abstract":"<div><p>A series of novel ethyl (<i>E</i>)-2-cyano-3-((4-methyl-5-(arylcarbamoyl)thiazol-2-yl)amino)-3-(methylthio)acrylate have been synthesized starting from various 2-amino-<i>N</i>-aryl-4-methylthiazole-5-carboxamide. The reaction of 3-oxo-<i>N</i>-arylbutanamide <b>2a-i</b> with <i>N</i>-bromosuccinimide and cyclization with thiourea under reflux conditions yielded derivatives of 2-amino-<i>N</i>-aryl-4-methylthiazole-5-carboxamide <b>3a-i.</b> Further reaction of thiazoles <b>3a-i</b> with ethyl 2-cyano-3,3-bis(methylthio)acrylate in DMF and K₂CO₃ as a base under room temperature gave new thiazole molecule <b>4a-i</b> with excellent yields. The significant features of this reaction procedure are novel, modest, and short time. The spectral characterization of molecules was confirmed by ¹H NMR, ¹³C NMR, FTIR, and MS. Synthesized molecules were evaluated <i>in vitro</i> for their α-amylase inhibitory activity and displayed moderate to excellent inhibition with IC₅₀ values varying from 12.55 μg/mL to 69.47 μg/mL using acarbose (IC₅₀=23.62 μg/mL) as control. Moreover, a molecular docking study was carried out for synthesized molecules <b>4a-i</b> against human pancreatic α-amylase (2QV4) <i>via</i> utilizing the Autodock technique. The docking outcomes of molecules <b>4g</b> and <b>4h</b> showed good cytotoxic activity.</p><h3>Graphical abstract</h3><p>An efficient procedure for synthesizing highly functionalized thiazole molecules, type II diabetes inhibitory activity with molecular docking studies.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A facile, metal-free synthesis of aryl bromides using molecular bromine-an alternative to the Sandmeyer reaction","authors":"Satish Wakchaure,&nbsp;Kiran Nathe,&nbsp;Sharayu Deshmukh","doi":"10.1007/s12039-023-02228-4","DOIUrl":"10.1007/s12039-023-02228-4","url":null,"abstract":"<div><p>An efficient metal-free synthesis of aryl bromides from aniline derivatives using molecular bromine is described. This one-pot reaction affords aryl bromides from corresponding electron-rich anilines in moderate to excellent yields without isolation of diazonium salts. The transformation has short reaction times, an ambient temperature, a simple workup, and insensitivity to moisture and air. This synthetic strategy represents an alternative approach to the classic Sandmeyer reaction.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div><h3>Graphical abstract</h3><p>A Metal-free Sandmeyer reaction strategy has been used to synthesize various aryl bromides. An aryl amines have diazotized by using sodium nitrite and 48% HBr in water and subsequently reaction mass treated with liquid bromine to offord variety of aryl bromides. Around 12 different aryl amines have been studied. Excellent yield has been obtained from electron rich aryl amine.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134795811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atropinium dithiophosphates and dithiophosphonates on the basis of α-D-glucofuranose and α-D-galactopyranose diacetonide scaffolds","authors":"Ilyas S Nizamov,&nbsp;Georgiy G Shumatbaev,&nbsp;Ilnar D Nizamov,&nbsp;Varis R Urazbakhtin,&nbsp;Marina P Shulaeva,&nbsp;Oscar K Pozdeev,&nbsp;Elvira S Batyeva","doi":"10.1007/s12039-023-02224-8","DOIUrl":"10.1007/s12039-023-02224-8","url":null,"abstract":"<div><p>Optically active dithiophosphoric and dithiophosphonic acids bearing glucofuranose and galactopyranose diacetonide substituents reacted with racemic atropine to give atropinium dithiophosphates or dithiophosphonates as the mixture of diastereomers. Dithiophosphoric and dithiophosphonic acids and their atropinium salts possess antimicrobial activity.</p><h3>Graphical abstract</h3><p><b>SYNOPSIS:</b> Optically active dithiophosphoric and dithiophosphonic acids bearing α-D-glucofuranose and α-D-galactopyranose diacetonide substituents reacted with racemic atropine to give atropinium dithiophosphates or dithiophosphonates as the mixture of diastereomers. Dithiophosphoric and dithiophosphonic acids and their atropinium salts possess antimicrobial activity.</p>\u0000 <div><figure><div><div><picture><img></picture></div></div></figure></div>\u0000 </div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134795397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure and supramolecular organization of N-acylserinols: agonists of the G-protein coupled receptor, GPR-119","authors":"Suman K Choudhury,&nbsp;D Sivaramakrishna,&nbsp;Musti J Swamy","doi":"10.1007/s12039-023-02222-w","DOIUrl":"10.1007/s12039-023-02222-w","url":null,"abstract":"<div><p><i>N</i>-acyl serinols, the amphiphilic molecules produced by gastrointestinal bacteria regulate metabolic hormone production and glucose homeostasis in the host species, and also exhibit anti-cancer activity. In this study, molecular structure, supramolecular organization and intermolecular interactions of two <i>N</i>-acylserinols (NASOHs), <i>viz.</i>,<i> N</i>-nonanoylserinol (N9SOH) and <i>N</i>-pentadecanoylserinol (N15SOH), are determined by single-crystal X-ray diffraction. The molecular structure and packing are compared and discussed with the structurally related molecules, <i>N</i>-acylethanolamine (NAE) and <i>N</i>-acyl tris (NAT) as NASOHs and NATs are derived by substituting one/two α-hydrogen(s) (with respect to amide N-H) of NAE with hydroxymethyl group(s). Structures of N9SOH and N15SOH were solved in the triclinic system in the <i>P-1</i> space group and both molecules are organized in a tilted head-to-head (and tail-to-tail) manner, resembling a bilayer membrane. The acyl chains in N9SOH and N15SOH are tilted by 20.43° and 18.12°, respectively, with respect to the bilayer normal. Several N—H⋯O, O—H⋯O, and C—H⋯O hydrogen bonds between the hydroxyl and amide moieties of the head groups of NASOH molecules belonging to adjacent and opposite layers stabilize the overall supramolecular organization. These results suggest that the α-hydroxymethyl groups exhibit considerable influence on the crystal structure, molecular packing, and phase structure of these amphiphiles.</p><h3>Graphical abstract</h3><p>Removing one of the CH₂OH moieties of <i>N</i>-acylserinol gives <i>N</i>-acylethanolamine, whereas introducing one more CH₂OH moiety on the α-carbon gives <i>N</i>-acyltris. While both <i>N</i>-acylethanolamine and <i>N</i>-acylserinol adopt tilted bilayer structure, the larger head group of <i>N</i>-acyltris induces it to adopt an interdigitated bilayer structure.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12039-023-02222-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicomponent regioselective synthesis of 7-aryl-5-methyl- and 5-aryl-7-trifluoromethyl-2-amino-3-(4′-arylazo)-pyrazolo[1,5-a]pyrimidines and their cytotoxic evaluation","authors":"Ranjana Aggarwal,&nbsp;Suresh Kumar,&nbsp;Garima Sumran,&nbsp;Virender Kumar,&nbsp;Rachna Sadana","doi":"10.1007/s12039-023-02219-5","DOIUrl":"10.1007/s12039-023-02219-5","url":null,"abstract":"<div><p>The present study deals with a highly efficient and regioselective synthesis of 7-aryl-5-methyl- and 5-aryl-7-trifluoromethyl-2-amino-3-(4′-arylazo)-pyrazolo[1,5-<i>a</i>]pyrimidines <i>via</i> multicomponent reaction of hydrazine hydrate, 2-(arylhydrazono)malononitrile and <i>β</i>-diketones in presence of <i>p</i>-toluenesulphonic acid under solvent-free condition. The structure of the isolated products was established on the basis of NMR (¹H, ¹³C, and ¹⁹F) and IR spectral data. The scope of the reaction was studied using various <i>β</i>-diketones <i>viz.,</i> aliphatic, aromatic, heteroaromatic, and trifluoromethyl-<i>β</i>-diketones. The protocol has several advantages, such as mild conditions, atom economy, practical simplicity, shorter reaction times, and avoidance of multi-step procedures. Seventeen diversely substituted pyrazolo[1,5-<i>a</i>]pyrimidines were screened against two breast cancer cell lines, named MCF-7 and BT474, and two leukemia cell lines, named NALM-6 and SB-ALL, using the MTT cytotoxicity assay. Preliminary results reveal that compound 2-amino-5-(4-bromophenyl)-3-(4-methoxyphenylazo)-7-(trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidine was identified as the most effective compound against all the four cancer cell lines with 65-49% cell survival.</p><h3>Graphical abstract</h3><p>An efficient regioselective synthesis of 7-aryl-5-methyl- and 5-aryl-7-trifluoromethyl-2-amino-3-(4′-arylazo)-pyrazolo[1,5-<i>a</i>]pyrimidines is developed using solvent-free sequential multicomponent reaction of hydrazine hydrate, 2-(arylhydrazono)malononitrile with unsymmetrical <i>β</i>-diketones.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MnO2 and CuBi2O4 hybrid microstructures for efficient nonenzymatic hydroxylamine detection","authors":"Neeraja Sinha Gudipati,&nbsp;Asha Ramesh,&nbsp;Sivaramakrishna Vanjari,&nbsp;Suryakala Duvvuri,&nbsp;Subrahmanyam Challapalli","doi":"10.1007/s12039-023-02221-x","DOIUrl":"10.1007/s12039-023-02221-x","url":null,"abstract":"<div><p>In this report, CuBi₂O₄ and CuBi₂O₄/MnO₂ are synthesized using coprecipitation and hydrothermal methods, respectively. CuBi₂O₄/MnO₂ has been extensively used for the electrochemical detection of hydroxylamine. CuBi₂O₄ and CuBi₂O₄/MnO₂ are well characterized by XRD, XPS, and FESEM to reveal the structural and morphological features of the material. Electrochemical measurements like CV, chronoamperometry, and impedance are studied to reveal the electrochemical behavior of CuBi₂O₄/MnO₂ towards hydroxylamine. Stability, reproducibility, and interference studies are performed to reveal the suitability of CuBi₂O₄/MnO₂ as an electrode material for the electrochemical detection of hydroxylamine.</p><h3>Graphical abstract</h3><p>CuBi2O4 and CuBi2O4/MnO2 are synthesized using coprecipitation and hydrothermal methods, respectively, and tested for the electrochemical detection of hydroxylamine. CuBi2O4/MnO2 exhibited a high sensitivity of 488 μA mM⁻¹ cm⁻² with a limit of detection 0.86 μM, revealing its ability to display good electrochemical activity towards hydroxylamine.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies on syntheses and self-assembly behaviour of homoseleno-peptides","authors":"Ram P Gokula,&nbsp;Abhishek Tripathi,&nbsp;Selvakumar Karuthapandi,&nbsp;Harkesh B Singh","doi":"10.1007/s12039-023-02216-8","DOIUrl":"10.1007/s12039-023-02216-8","url":null,"abstract":"<div><p>The development of straightforward synthetic and characterization methods for selenopeptides is essential to discovering hierarchical structured functional materials. Here, the synthesis of a series of homo-selenopeptides <b>1-4,</b> having the benzyl (Bzl) group-protected selenocysteine [(Bzl)SeCH₂CH(NH₂)COOH] monomer units in the sequence, is reported. The homo-selenopeptides <b>1-4</b> are characterized by 1D (¹H, ¹³C, and ⁷⁷Se) and 2D (¹H-¹H COSY, ¹H-¹H NOESY, and ¹H-¹H TOCSY) NMR spectroscopy, and ESI-MS spectrometry. The triselenopeptide <b>1</b> shows a propensity for self-assembly into β-sheet amyloid-like fibril structure in acetonitrile (ACN) solution at room temperature. This has systematically been analyzed and established through the spectroscopic techniques; FT-IR, CD, and ThT-based fluorescence spectroscopy for secondary bonding analyses and microscopic techniques; SEM and TEM for the amyloid-like fibril structure in ACN solution. The amide I band vibrational stretching frequencies observed in the range 1600-1700 cm⁻¹ confirm that all peptides in the homologous series have a strong propensity to form amyloid-like fibril structures.</p><h3>Graphical abstract</h3><p>Synthesis of a series of homo-selenopeptides <b>1</b>-<b>4</b> through the solid-phase peptide synthesis (SPPS), using Fmoc protected Sec(Bzl)-OH as a source of amino acid, has been described. Spectroscopic and morphological imaging studies revealed that the homo-selenopeptides have a high propensity to get self-organized into amyloid-like fibrillar structures.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molybdate incorporated α-Ni(OH)2: potential catalyst for oxidation of Iso-eugenol and anisole hydrotreating","authors":"P Aswin,&nbsp;Soumya B Narendranath,&nbsp;Arya Unni,&nbsp;S Balamurugan,&nbsp;N J Venkatesha,&nbsp;A Sakthivel","doi":"10.1007/s12039-023-02218-6","DOIUrl":"10.1007/s12039-023-02218-6","url":null,"abstract":"<div><p>The molybdate-incorporated hydrotalcite-type α-Ni(OH)₂ catalysts were prepared by the post-synthesis method. The synthesized catalyst was thoroughly studied using several physicochemical characterization methods. The catalytic activity of the material was studied on biomass model compounds such as anisole hydrotreating and the oxidation of <i>iso</i>-eugenol. The catalyst shows a significant conversion for the anisole hydrotreating in vapour phase conditions, yielding a steady-state conversion of 30% even after 10 h of time-on-stream (TOS). The primary product was benzene, with other products, viz., methyl anisole, methylcyclohexane, and toluene, as minor components. The catalyst also has the potential for <i>iso-</i>eugenol oxidation and shows 76.1% conversion with 75.5% selectivity for vanillin at 100 °C, 5 h.</p><h3>Graphical abstract</h3><p>Molybdate-incorporated hydrotalcite-type α-Ni(OH)₂ catalysts have the potential for oxidation of iso-eugenol to vanillin in the presence of an oxidant in a liquid phase and hydro-deoxygenation in the vapour phase under a hydrogen atmosphere.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134796021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A coumarin-anthracene-based chemodosimeter for the selective detection of arginine","authors":"Devender Singh,&nbsp;Ibrahim Annan,&nbsp;Shivani Tyagi,&nbsp;Vedprakash Meena,&nbsp;Sweta Singh,&nbsp;Rajeev Gupta","doi":"10.1007/s12039-023-02215-9","DOIUrl":"10.1007/s12039-023-02215-9","url":null,"abstract":"<div><p>This work presents a coumarin-anthracene-based chemodosimeter <b>L</b> for the selective detection of Arginine (Arg) <i>via</i> hydrolysis of the imine bond of the Schiff base <b>L</b>. Significant changes in the emission and absorption spectra of <b>L</b> were observed during the detection of Arg. Chemodosimeter <b>L</b> displayed an impressive detection limit of 0.46 μM for Arg by the emission spectral titrations. A combination of UV-Vis, emission, and mass spectral studies, as well as excited-state lifetime measurements, and quantum yield calculations illustrated Arg-assisted dosimetry of <b>L</b>. The sensing of Arg by <b>L</b> was employed in cell imaging and for the colorimetric detection and paper test strip-based practical detection methods.</p><h3>Graphical abstract</h3><p>This work presents a chemodosimeter <b>L</b> based on a coumarin-anthracene platform for the selective detection of amino acid arginine.\u0000</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6551729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-promoted multi-component and green synthesis of thiadiazolo[3,2-a]pyrimidines under solvent-free conditions","authors":"Behjat Pouramiri,&nbsp;Mohsen Rashidi","doi":"10.1007/s12039-023-02217-7","DOIUrl":"10.1007/s12039-023-02217-7","url":null,"abstract":"<div><p>This research is aimed at synthesizing pyrimidine heterocycles that contain 1,3,4-thiadiazole ring moiety by microwave-assisted multi-component reactions. For this purpose, synthesizing of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate, and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in the presence of [Et₃NH]⁺[HSO₄]^- ionic liquid, under solvent-free conditions.</p><h3>Graphical abstract</h3><p>This research, synthesis of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1, respectively) in the presence of [Et₃NH]⁺[HSO₄]^- ionic liquid under solvent-free microwave irradiation.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85242430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}