Journal of Chemical Sciences最新文献

{"title":"Synthesis, characterization, and biological evaluation of a β-amino carbonyl and its metal complexes using guanine hydrochloride catalyst","authors":"Mohit Panwar,&nbsp;Shweta Chand Thakuri,&nbsp;Vijay Kumar Juyal,&nbsp;Virendra Kasana,&nbsp;Viveka Nand","doi":"10.1007/s12039-024-02342-x","DOIUrl":"10.1007/s12039-024-02342-x","url":null,"abstract":"<div><p>In this study, we synthesized 3-(4-chlorophenyl amino)-1,3-diphenyl propane-1-one and its Cu(II), Zn(II), and Ni(II) metal complexes using the novel catalyst, guanine hydrochloride. The synthesized compounds were characterized using UV–Vis, FT-IR, HRMS, elemental analysis, ¹HNMR, and ¹³CNMR techniques. Subsequently, the antioxidant and antibacterial potential (biological activity) of the compounds were evaluated. Antioxidant activity was assessed using DPPH radical scavenging, H₂O₂ hydroxyl scavenging, and FRAP assay methods, while antibacterial activity was determined via disc-diffusion method against gram-positive (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>) and gram-negative (<i>Erwinia amylovora</i> and <i>Escherichia coli</i>) bacteria. Ligand–protein interactions were examined using molecular docking studies. Guanine hydrochloride, the catalyst used, improved reaction time and operated under room temperature, and was easily removed. The ligand exhibited superior antioxidant potential (IC₅₀ = 470.916 ± 0.30 ppm) compared to its metal complexes in all three assays. Among the tested compounds, the Cu(II) metal complex showed the largest zone of inhibition (4–9.9 mm) against all bacteria. The metal complexes displayed better binding energy than the ligand, proving the compounds’ candidacy for future therapeutic applications.</p><h3>Graphical abstract</h3><p>Benzaldehyde, <i>p</i>-chloroanilines and acetophenone were allowed to react in this multi-component reaction to form <i>b</i>-amino carbonyl. Metal salts of Cu(II), Zn(II) and Ni(II) were mixed with the ligand to form metal-ligand complexes. The formed products were tested for their anti-oxidant and antibacterial activity, which showed appreciable results.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile synthesis of nanostructured Co3O4 using cobalt fumarate as the precursor and its catalytic exploration in the selective oxidation of benzyl alcohol","authors":"Ruhul Amin Bepari,&nbsp;Monsumi Gogoi,&nbsp;Nabajyoti Mochahari,&nbsp;Saurav Paul,&nbsp;Birinchi Kumar Das","doi":"10.1007/s12039-024-02344-9","DOIUrl":"10.1007/s12039-024-02344-9","url":null,"abstract":"<div><p>Nanoscale cobalt oxide with particle size of 12–17 nm was prepared via a facile calcination route using cobalt fumarate as the precursor. The one-step method involves the simple calcination of cobalt fumarate precursor at temperatures 400–600°C. The crystallographic phase purity and other microstructural characteristics are thoroughly investigated using several physical techniques, including, powder XRD, SEM, TEM, and UV-visible and IR spectroscopy. Among the prepared oxides, Ru-supported Co₃O₄ demonstrated remarkable catalytic activity in the oxidation of benzyl alcohol using TBHP as an oxidant. The Ru-supported catalyst gives 95% alcohol conversion with 97% selectivity for benzaldehyde and can be recycled for several consecutive runs without major loss of activity.</p><h3>Graphical abstract</h3><p>\u0000Cobalt fumarate precursor is calcined at four different temperatures <i>viz.</i> 400–600°C to synthesize nanoscale cobalt oxide. The trace of Ru is doped to enhance the catalytic performance of cobalt oxide in the oxidation of benzyl alcohol using TBHP. Ru@Co₃O₄ gives almost complete alcohol conversion with excellent selectivity for benzaldehyde and reusability.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of conjugation in photophysics of methoxycinnamate","authors":"Kartik Chandra Pal,&nbsp;Somsuta Ray,&nbsp;Debashree Ghosh","doi":"10.1007/s12039-025-02349-y","DOIUrl":"10.1007/s12039-025-02349-y","url":null,"abstract":"<div><p>Methoxycinnamates, especially octyl methoxycinnamate, are common active ingredients in sunscreens. Its photoprocesses have experimentally shown ultrafast quenching of UV-B light and photoproduct formation and eventual degradation. It is known to absorb intensely around 310 nm. However, the molecular origin and mechanism of these photoprocesses and excited state channels remain elusive. Due to these reasons, it is imperative to study the molecular mechanism of the excited state photoactivated reactions of octyl methoxycinnamate and compare it to several molecules with similar structural motifs. The excited state quenching mechanism and molecular pathways need to be elucidated along with the effect of different structural motifs on its excited states. Therefore, in this work, we have studied the photoprocesses of methoxycinnamates using state-of-the-art multireference methods. We find a crucial role played by the extended conjugation and the ester group on the excitation energies, and this is, therefore, expected to have a significant effect on the quenching pathways.</p><h3>Graphical Abstract</h3><p>Para methoxymethylcinnamate, an active ingredient in sunscreens, gets photoexcited at around 310 nm. In this work, we have investigated its photoprocesses. Energetically accessible conical intersections favour its non-radiative decay to the ground state. Comparing molecules sharing a similar structural motif, we find that extended conjugation plays a vital role.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diruthenium(II)diacetylide organometallic complexes with thienylethynyl bridging units: Synthesis, characterization and electrochemical properties","authors":"Sourav Saha Roy,&nbsp;Supriya Das,&nbsp;Sanjib K Patra","doi":"10.1007/s12039-025-02348-z","DOIUrl":"10.1007/s12039-025-02348-z","url":null,"abstract":"<div><p>A series of soluble diruthenium(II)diacetylide complexes (<b>M1</b>-<b>M3</b>) by varying thienlylethynyl bridging ligands have been achieved by treating the appropriate thienylethynyl spacers (<b>B1, B2</b> and <b>B3</b> with one, two and three units of thienylethynyl respectively) with [Ru(dppe)Cp*Cl] and KF in THF/MeOH medium. The synthesized diruthenium(II) organometallic complexes have been thoroughly characterized by multinuclear NMR spectroscopy, FTIR and mass spectrometry. The photophysical and electrochemical studies of these soluble <i>wire-</i>like Ru(II) organometallic complexes (<b>M1</b>-<b>M3)</b> with aromatic π-extended bridges have been carried out to comprehend the electronic and electrochemical properties. The electronic delocalization in Ru(II)–C≡C–Ar–C≡C–Ru(II) (Ar = aromatic bridging ligand) conjugate through the bridging backbone is dependent on the bridging spacers. Potential difference (Δ<i>E</i>_1/2) and comproportionation constant (<i>K</i>_c) decrease with increasing the length of the thienylethynyl unit. The mixed-valence species, generated by single-electron oxidation, exhibits absorption in the near-infrared (NIR) region. Moreover, FTIR studies also reveal a change in <span>(bar{upsilon })</span>(Ru-C≡C) stretching frequency of the mixed valence species, suggesting considerable participation of the bridging ligand in redox processes.</p><h3>Graphical abstract</h3><p>Electrochemical and electronic properties of the diruthenium(II)diacetylide organometallic conjugates have been modulated by varying the number of thienylethynyl bridging units.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium–silver nanoalloys: Digestive ripening-facilitated interatomic diffusion and hydrogen sorption behaviour upon alloying","authors":"Chirasmita Bhattacharya,&nbsp;Balaji R Jagirdar","doi":"10.1007/s12039-024-02346-7","DOIUrl":"10.1007/s12039-024-02346-7","url":null,"abstract":"<div><p>To facilitate and understand interatomic diffusion between pure Pd and Ag nanoparticles, which were prepared using solvated metal atom dispersion (SMAD) technique, herein we employed different capping agents and their combination. After subjecting to the digestive-ripening process, monodispersed spherical nanoparticles were obtained in the case of Ag, while ripening of Pd nanoparticles resulted in the formation of nanoflowers-like morphology. The judicious/tailored combination of tri-<i>n</i>-octylphosphine and tri-<i>n</i>-octylphosphine oxide, not merely allowed controlling of the nucleation and growth of the alloy nanoparticles, but also played a key role in attaining high phase purity and homogeneity of the resulting Pd–Ag alloy nanoparticles. Finally, we investigated hydrogen sorption properties of phase-pure Pd–Ag nanoalloys by measuring their pressure–composition isotherms at 25°C and 1 atm H₂ pressure. The hydrogen storage capacities of Pd and Pd–Ag alloy nanoparticles were found to be 0.4 and 0.25 wt%, respectively. This study revealed a reduction in the hydrogen sorption behaviour of Pd upon dilution of Pd content by alloying with Ag and a rationale for the observed behaviour has been discussed in detail.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143553896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible light-enhanced synergistic catalysis of AuCu nanostructures immobilized within porous support","authors":"Ajay,&nbsp;Heeralal Jaipal,&nbsp;Ryo Watanabe,&nbsp;Choji Fukuhara,&nbsp;Priyanka Verma","doi":"10.1007/s12039-025-02356-z","DOIUrl":"10.1007/s12039-025-02356-z","url":null,"abstract":"<div><p>In this study, 2.5 wt% of Au and Cu were uniformly immobilized within the pores of hierarchically porous zeotype materials to investigate the plasmonic catalysis under visible-light irradiation. Both monometallic and bimetallic catalysts of Au and Cu were prepared to investigate the catalytic performance due to the synergistic interaction between the two metal nanoparticles (NPs). All the prepared catalysts were characterized using PXRD, HAADF-STEM, DRS-UV and XAS to unveil the proximity and interaction between bimetallic NPs. The HAADF-STEM images revealed the proximity between Au and Cu NPs, and a significant difference in the NPs size was observed. Owing to the very small size of Cu NPs, exceptional behaviour of Cu-containing catalysts was observed. Plasmonic activity of the photocatalysts was investigated using <i>p</i>-nitrophenol (4-NP) reduction as a model reaction in the presence of ammonia borane as an <i>in situ</i> source of hydrogen. Interestingly, a 3.7-times enhancement in the rate of 4-NP reduction was achieved in the presence of bimetallic Cu/Au/HP-AlPO-5 (LSPR) under visible light irradiation compared to the dark conditions. We believe our findings will pave the way for advanced research to understand the unique plasmonic behaviour of AuCu NPs under light conditions.</p><h3>Graphical abstract</h3><p>In this report, the CuAu bimetallic nanostructures immobilized within the hierarchically porous zeotype material have been prepared via the LSPR-assisted synthesis method. The nanostructures displayed synergistic catalytic performance in reducing nitroaromatics. A 3.7 times enhancement in the reduction rate was achieved under visible light irradiation compared to the dark conditions.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyoxometalate-driven assembly of inorganic–organic hybrid materials: Proton conductivity studies","authors":"Parvathy M Unnikrishnan,&nbsp;Gopika Premanand,&nbsp;Samar K Das","doi":"10.1007/s12039-024-02339-6","DOIUrl":"10.1007/s12039-024-02339-6","url":null,"abstract":"<div><p>A zinc-containing, one-dimensional coordination polymer, [Zn(NH₂trz)₃](NO₃)₂ (1D-CP, NH₂-trz <span>(=)</span> 4-amino-4H-1,2,4-triazole) has been employed to synthesize two water-insoluble proton conductors, ZnL-PW₁₂ and ZnL-SiW₁₂ (L <span>(=)</span> 4-amino-4H-1,2,4-triazole), that are formulated as {[Zn(NH₂trz)₃](NO₃)}₂{HPW₁₂O₄₀}·4H₂O and [Zn(NH₂trz)₃][NH₃trz]₂[SiW₁₂O₄₀]·10H₂O, respectively. These proton conductors were prepared through simple room-temperature aqueous reactions involving [Zn(NH₂trz)₃](NO₃)₂ and phosphotungstic or silicotungstic acids, which proceed via aqueous disassembly of the CP, followed by recrystallization into a new phase driven by the addition of heteropolyanions. Here, the Keggin POMs, specifically H₃PW₁₂O₄₀ and H₄SiW₁₂O₄₀, impart enhanced stability to the overall structures of the resulting Zn-complex-POM adducts, ZnL-PW₁₂ and ZnL-SiW₁₂. Upon mixing the aqueous solutions of 1D-CP and POMs, immediate precipitations of the water-insoluble inorganic–organic hybrid products are obtained, the aqueous suspensions of which exhibit acidic pH. This observation prompted us to investigate proton conductivity behaviour of the resulting materials. As anticipated, the isolated products, ZnL-PW₁₂ and ZnL-SiW₁₂ exhibit significant proton conductivity values of 5.1 × 10⁻³ and 5.6 × 10⁻³ S cm⁻¹, respectively, at 80°C and 98% relative humidity, demonstrating excellent stability for about 30 h with decent cycling stability over four heating–cooling cycles.</p><h3>Graphical abstract</h3><p>A zinc-based one-dimensional coordination polymer, [Zn(NH₂-trz)₃](NO₃)₂ (1D-CP), was modified into two water-insoluble proton conductors by a process involving the disassembly and subsequent restructuring of the coordination polymer into more stable inorganic–organic hybrids by the addition of phosphotungstic and silicotungstic heteropolyanions. The resulting hybrid materials, ZnL-PW₁₂ and ZnL-SiW₁₂ (L = 4-amino-4H-1,2,4-triazole), exhibit significant proton conductivities of 5.1 × 10⁻³ and 5.6 × 10⁻³ S cm⁻¹, respectively, and demonstrate excellent stability for &gt;30 h under the operational conditions.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoacetylated bishydroperoxide-derived singlet molecular oxygen-mediated oxidative coupling of primary and secondary alcohols with phenylhydrazine: Synthesis of 1,3,5-trisubstituted pyrazoles","authors":"Z Najminejad,&nbsp;D Azarifar,&nbsp;S-M Khatami","doi":"10.1007/s12039-024-02341-y","DOIUrl":"10.1007/s12039-024-02341-y","url":null,"abstract":"<div><p>Oxidative synthesis of pyrazoles from aromatic alcohols and phenyl hydrazine has been achieved by using trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolan-3-yl ethaneperoxate and KOH. The reaction proceeds via oxidative coupling of primary and secondary alcohols with phenylhydrazines by singlet molecular oxygen produced from trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolane-3-yl ethaneperoxate at room temperature, and broad range of derivatives were obtained in good to excellent yields. Advantageous features of the present methodology include mild reaction conditions, transition metal-free, good functional-group tolerance, use of readily available primary and secondary alcohols and so on.</p><h3>Graphical abstract</h3><p>Oxidative synthesis of pyrazoles from aromatic alcohols and phenyl hydrazine has been achieved by using trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolan-3-yl ethaneperoxate/KOH. The reaction proceeds via oxidative coupling of primary and secondary alcohols with phenylhydrazines by singlet oxygen produced from trans-5-hydroperoxy-3,5-dimethyl-1,2-dioxolane-3-yl ethaneperoxate and a range of derivatives were obtained in good to excellent yields\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational study on non-covalent interactions in benzene–X complexes (X = He, Ne and Ar)","authors":"Achal S Bhoge,&nbsp;Sachin D Yeole","doi":"10.1007/s12039-024-02337-8","DOIUrl":"10.1007/s12039-024-02337-8","url":null,"abstract":"<div><p>Weakly bound complexes of inert gas atoms with aromatic rings have received the attention because these are important for understanding the several solution- and condensed-phase properties. Extrapolated complete basis set (CBS) limit interaction energies for van der Waal complexes of benzene with He, Ne and Ar were calculated by using MP2 level and B2PLYPD3 and M06-2X functionals, employing aug-cc-pVTZ basis set. It was observed that as the size of inert gas increases, the interaction energy becomes more negative suggesting more stabilizing interaction. In sandwich complexes, the magnitude of CBS interaction energies was found to be double when compared to benzene complexes. The calculated vibrational stretching frequencies of cationic benzene complexes show red-shift, whereas almost same frequencies are found in sandwich complexes, with respect to benzene–X (X = He, Ne and Ar) complexes. However, in deuterated benzene–X complexes, the C–D stretching frequencies show a decrease in frequency value compared to benzene–X complexes and this may due to the presence of deuterated atom. Apart from that, the complexes, (benzene)⁺⁺–X dication and X–(benzene)⁺–X sandwich cation were also studied using MP2/aug-cc-PVTZ level. It is observed that the charge is increased when moving from (benzene)⁺–X to (benzene)⁺⁺–X complexes, the strength of interaction is increasing. Further, the nature of interaction present in benzene–X complexes was investigated by energy decomposition analysis using SAPT analysis. The SAPT analysis revealed that the contribution from dispersion terms is increasing when moving from He to Ar complexes.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143361946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple and efficient synthesis of novel thiazolo[4,5-e]indole derivatives via three-component reaction","authors":"Bing-Wei Wang,&nbsp;Ming-Han Huang,&nbsp;Xue Wang,&nbsp;Dong-Sheng Chen","doi":"10.1007/s12039-024-02345-8","DOIUrl":"10.1007/s12039-024-02345-8","url":null,"abstract":"<div><p>A series of thiazolo[4,5-<i>e</i>]indole derivatives have been obtained by a three-component domino reaction of 2-methylbenzo[<i>d</i>]thiazol-5-amine, arylglyoxal monohydrates and cyclohexane-1,3-dione in ethanol medium at 80°C catalyzed by acetic acid. Notable features of this synthesis are mild reaction, high synthesis efficiency, simple post-treatment operation and only water is generated as a byproduct.</p><h3>Graphical abstract</h3><p>\u0000A new procedure for the synthesis of thiazolo[4,5-<i>e</i>]indole derivatives.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}