Journal of Chemical Sciences最新文献

Synthesis and cytotoxic studies of novel azo-Schiff base derivatives against Hela and MCF7 cell lines 新型偶氮席夫碱衍生物的合成及对Hela和MCF7细胞株的细胞毒性研究

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-05-24 DOI: 10.1007/s12039-025-02364-z

Ozge Kozgus Guldu, Seda Yuksekdanaci

{"title":"Synthesis and cytotoxic studies of novel azo-Schiff base derivatives against Hela and MCF7 cell lines","authors":"Ozge Kozgus Guldu, Seda Yuksekdanaci","doi":"10.1007/s12039-025-02364-z","DOIUrl":"10.1007/s12039-025-02364-z","url":null,"abstract":"<div><p>A new azo-Schiff base derivative compounds have been synthesized and characterized by FTIR, <sup>1</sup>HNMR, <sup>13</sup>CNMR and elemental analysis techniques. The azo-Schiff base compounds were evaluated for their cytotoxicity against human epithelial breast adenocarcinoma (MCF7) and human epithelial cervix adenocarcinoma (HeLa) cell lines using the MTT assay. Compound <b>4a</b> exhibited potent <i>in vitro</i> antiproliferative activity with IC<sub>50</sub> 120.0 and 140.8 <i>μ</i>M against HeLa and MCF7 cell lines, respectively. As a result of the cell migration study, compound <b>4a</b> achieved 38%, recovery in HeLa cells at 48 hours and 59% in MCF7 cells at 48 hours. Compound <b>4b</b> achieved 12% recovery in HeLa cells at 48 hours and 49% in MCF7 cells at 48 hours. Apoptosis analysis studies show that the synthesized compounds (<b>4a</b>-<b>b</b>) can induce apoptosis in the HeLa and MCF7 cells.</p><h3>Graphical Abstract</h3><p>The IC<sub>50</sub> dose of compound <b>4a</b> was found to be 120.0 <i>µ</i>L in the HeLa cell line and 140.8 <i>µ</i>L in the MCF7 cell line. Furthermore, it has also been observed that compounds <b>4a</b> and <b>4b</b> can increase the apoptotic effect in both cell lines significantly compared with control group.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic strategies to pyrido fused heterocycles 吡啶多杂环的合成策略

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-05-17 DOI: 10.1007/s12039-025-02369-8

Tamanna Khandelia, Bhisma K Patel

{"title":"Synthetic strategies to pyrido fused heterocycles","authors":"Tamanna Khandelia, Bhisma K Patel","doi":"10.1007/s12039-025-02369-8","DOIUrl":"10.1007/s12039-025-02369-8","url":null,"abstract":"<div><p>Pyridine fused heterocycles are vital in material sciences, medicinal chemistry, and organic synthesis due to their distinct structural feature. These compounds, consisting of two or more heterocyclic rings, share one or more hetero atoms. They exhibit enhanced stability, varied electronic properties, and improved biological activity compared to their non-fused counterparts. The fusion of heterocyclic rings often leads to a rigid, planar structure that can interact more efficiently with biological targets, making them valued in advancing pharmaceuticals, particularly for intricate diseases. Additionally, fused heterocycles are important in designing functional materials, such as organic semiconductors and catalysts, due to their ability to impart desired electronic and optical properties. Their broad pertinence and the ability to fine-tune their characteristics through synthetic modifications continue to drive advancements in basic and applied chemistry. The fused heterocycles discussed in this review are furo-pyridine, pyrrolo-pyridine, and other assorted fused heterocycles. Their biological importance and synthetic procedures have been discussed.</p><h3>Graphical abstract</h3><p>The fused heterocycles discussed are furo-pyridine, pyrrolo-pyridine, and other assorted fused heterocycles. The biological importance and synthetic procedures of these fused heterocycles have been discussed. Pyridine fused heterocycles are vital in material sciences, medicinal chemistry, and organic synthesis due to their distinct structural feature.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ceria-coated cordierite monolith: A recyclable catalyst for palladium and ligand-free Suzuki–Miyaura coupling in water 铈包覆堇青石单体：水中钯与无配体Suzuki-Miyaura偶联的可回收催化剂

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-05-08 DOI: 10.1007/s12039-025-02366-x

Prasanna

{"title":"Ceria-coated cordierite monolith: A recyclable catalyst for palladium and ligand-free Suzuki–Miyaura coupling in water","authors":"Prasanna","doi":"10.1007/s12039-025-02366-x","DOIUrl":"10.1007/s12039-025-02366-x","url":null,"abstract":"<div><p>Phase-pure CeO<sub>2</sub> was synthesized by the solution combustion method, which crystallized in its cubic fluorite structure. The synthesized catalyst was characterized by SEM, EDX analysis, powder XRD, H<sub>2</sub>-TPR and FTIR to confirm its structure. This precious metal-free catalyst shows excellent activity towards the ligand-free Suzuki–Miyaura coupling reaction in aqueous media. Various biaryls, such as symmetrical, asymmetrical and heterocyclic moieties were obtained from corresponding aryl halides and arylboronic acid with good yields. The ceria can be coated on cordierite monolith, which acts as a catalyst cartridge, employed with ease in recycling experiments. An attempt for scale-up reaction is also carried out with a good yield.</p><h3>Graphical abstract</h3><p>The phase pure CeO<sub>2</sub> was synthesized by the solution combustion method which crystallized in its cubic fluorite structure. This precious metal-free catalyst shows excellent activity towards the ligand-free Suzuki-Miyaura coupling reaction in aqueous media. Recycling and scale-up reactions are carried out by employing catalyst coated cordierite monolith with ease.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensification of n-octyl acetate synthesis over H5PW10V2O40/FAC catalyst using ultrasound-assisted reactor 超声辅助反应器强化H5PW10V2O40/FAC催化剂合成乙酸正辛酯

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-05-05 DOI: 10.1007/s12039-025-02355-0

Vishnu A Gite, Virendra K Rathod

{"title":"Intensification of n-octyl acetate synthesis over H5PW10V2O40/FAC catalyst using ultrasound-assisted reactor","authors":"Vishnu A Gite, Virendra K Rathod","doi":"10.1007/s12039-025-02355-0","DOIUrl":"10.1007/s12039-025-02355-0","url":null,"abstract":"<div><p>The orange flavour, <i>n</i>-octyl acetate, was synthesized in the presence of ultrasound (US) over an H<sub>5</sub>PW<sub>10</sub>V<sub>2</sub>O<sub>40</sub> /FAC catalyst. The effect of parameters such as temperature (A), alcohol to acid ratio (B), duty cycle (C) and ultrasound power (D) on the conversion was optimised using response surface methodology. Various experiments were designed as per the central composite design method using the design of expert software. The relation between operating variables and conversion was established by a quadratic mathematical model equation. The relation of independent variables and their effect on conversion was explained by executing the statistical analysis and analysis of variance. The optimum solution of the maximum conversion of 78.2% in 180 minutes was obtained in the presence of US horn at parameters viz temperature (373 K), mole ratio (<i>n</i>-octyl alcohol to acetic acid) (2), duty cycle (80%) and ultrasound power (100 W). The intensification by US horn was compared to conventional processes.</p><h3>Graphical abstract</h3><p>The <i>n</i>-octyl acetate was synthesized over an H<sub>5</sub>PW<sub>10</sub>V<sub>2</sub>O<sub>40</sub>/FAC catalyst in the presence of ultrasound irradiation. It has many applications in cosmetics, hair products, and skin locations. The synthesis of <i>n</i>-octyl acetate in the ultrasound process was compared with the conventional synthesis. There was a considerable reduction in reaction time in ultrasound-assisted synthesis.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iodine and acid catalyzed efficient synthesis of anthracenyl porphyrin with different spectroscopic studies 碘和酸催化高效合成蒽基卟啉的不同光谱研究

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-05-02 DOI: 10.1007/s12039-025-02354-1

Anshu Dandia

{"title":"Iodine and acid catalyzed efficient synthesis of anthracenyl porphyrin with different spectroscopic studies","authors":"Anshu Dandia","doi":"10.1007/s12039-025-02354-1","DOIUrl":"10.1007/s12039-025-02354-1","url":null,"abstract":"<div><p>Meso tetra-anthracenyl porphyrin (TAP) was synthesized by pyrrole and 9-anthraldehyde (9-anthracene carboxaldehyde) in different yields. In the current synthetic methods, meso tetra-anthracenyl porphyrin (TAP) was synthesized with 8% yields. The first method involved iodine (I<sub>2</sub>) as Lewis acid, and in the second method, hydroxyl ammonium chloride (NH<sub>2</sub>OH·HCl) was used as a Lewis acid and proceeded in the presence of nitrobenzene. The formation of the product was confirmed with the help of various characterizations i.e., UV-visible, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectrometry.</p><h3>Graphical abstract</h3><p> The 5,10,15,20-tetra(9-anthracenyl) porphyrin (TAP) was synthesized by two newer methods in high yield (8% yield). The first method involved iodine (I<sub>2</sub>) as a catalyst which proceeded at room temperature, and in the second method, hydroxyl ammonium chloride (NH<sub>2</sub>OH·HCl) was used as a Lewis acid and proceeded in the presence of nitrobenzene. The various UV-vis studies of TAP were studies with different salts and acids.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiamine hydrochloride catalyzed environmentally benign synthesis of benzodiazepines in water 盐酸硫胺素催化水中无害合成苯二氮卓类药物

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-04-29 DOI: 10.1007/s12039-025-02367-w

Rajesh D Shanbhag, Yatin U Gadkari, Angad B Barkule, Savita B Lomte, Vikas N Telvekar

{"title":"Thiamine hydrochloride catalyzed environmentally benign synthesis of benzodiazepines in water","authors":"Rajesh D Shanbhag, Yatin U Gadkari, Angad B Barkule, Savita B Lomte, Vikas N Telvekar","doi":"10.1007/s12039-025-02367-w","DOIUrl":"10.1007/s12039-025-02367-w","url":null,"abstract":"<div><p>A rapid and environmentally friendly method was developed for synthesizing 1,5-benzodiazepine derivatives, utilizing catalytic quantities of thiamine hydrochloride in an aqueous media. The desired compounds were acquired with notable yields by amalgamating variously substituted aryl aldehydes with dimedone and o-phenylene diamine using thiamine hydrochloride as a catalyst. This approach presents several benefits, including swift reaction kinetics, utilization of eco-friendly solvents, straightforward workup procedures and a facile purification process, ensuring energy conservation and extensive compatibility with diverse substrates.</p><h3>Graphical Abstract</h3><p><b>Synopsis</b>. A green, rapid, and efficient method for synthesizing 1,5-benzodiazepine derivatives was developed using thiamine hydrochloride as a catalyst in water. This environmentally benign approach achieved excellent yields, compatibility with diverse substrates, and minimal reaction times, highlighting its potential as a sustainable alternative in heterocyclic compound synthesis.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfonic acid group modified ZSM-5 zeolite as a highly active catalyst for the hydration of cyclohexene to cyclohexanol 磺酸基改性ZSM-5沸石作为环己烯水化制环己醇的高活性催化剂

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-04-29 DOI: 10.1007/s12039-025-02350-5

Yi Chen, Heman Qin, Qian Zhang, Yatao Wang, Yunkai Lv, Libo Niu

{"title":"Sulfonic acid group modified ZSM-5 zeolite as a highly active catalyst for the hydration of cyclohexene to cyclohexanol","authors":"Yi Chen, Heman Qin, Qian Zhang, Yatao Wang, Yunkai Lv, Libo Niu","doi":"10.1007/s12039-025-02350-5","DOIUrl":"10.1007/s12039-025-02350-5","url":null,"abstract":"<div><p>In this work, sulfonic acid group modified ZSM-5 (SFZ-<i>x</i>, <i>x</i> presents the weight percentage of mercaptopropyltrimethoxysilane during preparation) has been prepared by introducing sulfydryl on ZSM-5 and then oxidizing them into the sulfonic acid group. The obtained samples were characterized by XRD, N<sub>2</sub> adsorption/desorption, FTIR, and SEM and studied the catalytic performance in the hydration of cyclohexene to produce cyclohexanol. The characterization results showed that with the introduction of -SO<sub>3</sub>H, the crystallinity of SFZ-15 decreased slightly, and the Brønsted acid sites obviously increased, while the pore structure was almost unchanged inside the ZSM-5 zeolites. Therefore, SFZ-15 exhibits better catalytic performance in the hydration of cyclohexene to produce cyclohexanol compared to commercial ZSM-5. Furthermore, this SFZ-15 catalyst kept the conversion of cyclohexene over 12% and the selectivity of cyclohexanol over 99% even after five runs, demonstrating the benefit of –SO<sub>3</sub>H functionalization on the activity improvement of traditional ZSM-5 catalyst.</p><h3>Graphical abstract</h3><p> The sulfonic acid group modified ZSM-5 zeolite has been prepared by introducing sulfydryl on ZSM-5 and then oxidizing them into the sulfonic acid group. The prepared catalyst exhibits excellent catalytic performance in the hydration of cyclohexene to produce cyclohexanol.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological analysis of non-conjugated ethylene oxide cored dendrimers decorated with tetraphenylethylene: Insights from degree-based descriptors using the polynomial approach 用四苯基乙烯装饰的非共轭环氧乙烷核树状大分子的拓扑分析：使用多项式方法从基于度的描述符的见解

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-04-29 DOI: 10.1007/s12039-025-02353-2

A Theertha Nair, D Antony Xavier, Annmaria Baby, S Akhila

{"title":"Topological analysis of non-conjugated ethylene oxide cored dendrimers decorated with tetraphenylethylene: Insights from degree-based descriptors using the polynomial approach","authors":"A Theertha Nair, D Antony Xavier, Annmaria Baby, S Akhila","doi":"10.1007/s12039-025-02353-2","DOIUrl":"10.1007/s12039-025-02353-2","url":null,"abstract":"<div><p>Topological descriptors are quantitative parameters that correlate the attributes of molecular structures, providing insights into their chemical properties and behavior. With the increasing significance of dendrimers in drug design, driven by advancements in technology, our study focuses on the topological analysis of non-conjugated ethylene oxide cored dendrimer decorated with tetraphenylethylene. We derive key degree-based descriptors, including degree, neighborhood degree, and reverse degree, using the novel M-polynomial approach. This innovative method not only facilitates the calculation of these descriptors but also has the potential to generate additional descriptors. Our results demonstrate the applicability of these descriptors in Quantitative Structure-Property Relationship (QSPR) and Quantitative Structure-Activity Relationship (QSAR) models, predicting properties across different generations of the dendrimer. Furthermore, a graphical comparison is provided to enhance the understanding and analysis of the derived descriptors. This work represents a significant step forward in the mathematical modeling of dendritic structures, offering new tools for researchers in the field of chemical graph theory and molecular chemistry.</p><h3>Graphical abstract</h3><p>This study presents a computational framework for predicting molecular properties without experimental research. Molecular descriptors, including degree based and entropy measures, are utilized in QSPR analysis. Statistical tools and regression models facilitate property prediction, offering valuable insights into molecular structures and their characteristics through topological descriptors.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lewis acid-catalyzed diazo insertion into electron-deficient C–H bonds 路易斯酸催化重氮插入到缺电子的碳氢键

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-04-29 DOI: 10.1007/s12039-025-02371-0

Jalaj Kumar Pathak, Namrata Rastogi

引用次数: 0

Formal [4+2] annulation of β-aminoacrylamides and malononitrile: a synthetic route to substituted pyridin-2(1H)-ones β-氨基丙烯酰胺和丙二腈的正式[4+2]环化：取代吡啶-2(1H)- 1的合成路线

IF 1.7 4区化学

Journal of Chemical Sciences Pub Date : 2025-04-17 DOI: 10.1007/s12039-025-02360-3

Xin Liu, Jiawang Li, Rui Zhang, Dewen Dong

引用次数: 0