Journal of Chemical Sciences最新文献

{"title":"First-principles insights into biphenylene-based graphynes: promising novel two-dimensional carbon allotropes for thermoelectric applications","authors":"Esackraj Karthikraja,&nbsp;Naga Venkateswara Rao Nulakani,&nbsp;Pandiarajan Devi,&nbsp;Palanichamy Murugan,&nbsp;Kothandaraman Ramanujam,&nbsp;V G Vaidyanathan,&nbsp;Venkatesan Subramanian","doi":"10.1007/s12039-025-02361-2","DOIUrl":"10.1007/s12039-025-02361-2","url":null,"abstract":"<div><p>Graphene is not an ideal candidate for thermoelectric applications due to its inherent high electrical and thermal conductivity. Graphynes are another class of carbon-based materials that exhibit a unique combination of sp² and sp hybridization in the carbon network. Certain graphynes are promising candidates for thermoelectric applications owing to their semiconducting nature and the presence of acetylenic linkers, i.e. <i>γ</i>-graphyne. In this work, we designed novel forms of biphenylene-based graphynes (BPNYnes) for potential use in thermoelectric applications. Density functional theory (DFT) has been employed to examine the electronic, structural and mechanical properties of various BPNYne nanosheets. The incorporation of the acetylenic <i>π</i>-conjugations altered the metallic nature of the pristine biphenylene monolayer. Boltzmann transport theory-based calculations reveal that the induced band gap in the carbon nanosheets significantly enhances the thermoelectric performance. Notably, 6,8,16-BPNYne nanosheet exhibits promising thermoelectric efficiency, with a figure of merit (<i>ZT</i>) significantly surpassing that of conventional carbon materials such as graphene and graphynes. This study suggests that these novel carbon allotropes could be viable candidates for future thermoelectric devices, offering a combination of high electrical conductivity and optimized Seebeck coefficients.</p><h3>Graphical abstract</h3><p>The BPNYne nanosheets resemble graphyne-like carbon networks with excellent dynamic and thermal stability. Notably, 6,8,16-BPNYne nanosheet shows promising thermoelectric efficiency, making it a potential candidate for thermoelectric applications.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for predicting enantioselectivity in chiral phosphoric acid-catalyzed naphthyl-indole synthesis","authors":"R A Oshiya,&nbsp;Ayan Datta","doi":"10.1007/s12039-025-02347-0","DOIUrl":"10.1007/s12039-025-02347-0","url":null,"abstract":"<div><p>The design of enantioselective axially chiral compounds is of great importance in modern synthetic chemistry, biochemistry, and material science due to their potential applications in the pharmaceutical and chemical industries. Traditional approaches to predicting enantioselectivity involve repetitive trial-and-error routines driven by chemical intuition. However, the fast-paced advancements in machine learning offer an alternate way to predict selectivity by leveraging data from laboratory experiments and computational analyses. In our study, we explore various machine learning (ML) techniques to predict the enantioselectivity of reactions using metal-free chiral phosphoric acid (CPA) catalysts in the synthesis of the naphthyl-indole scaffolds. We developed regression-based ML models using molecular descriptors of the reactants, catalysts and key intermediate complexes involved. Despite the limited dataset size, the random forest regression model performed remarkably well, achieving an R² score of 0.88 and RMSE of 0.32 on the test set. This demonstrates the effectiveness of integrating computational and machine learning methodologies in predicting enantioselectivity, marking a significant step forward in the pursuit of efficient, selective, and sustainable asymmetric catalysis.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assay of biotin in pharmaceuticals utilizing its inhibitory effect on Pd(II) catalyzed ligand substitution reaction","authors":"Abhishek Srivastava,&nbsp;Rashmi Nayak,&nbsp;Neetu Srivastava","doi":"10.1007/s12039-025-02351-4","DOIUrl":"10.1007/s12039-025-02351-4","url":null,"abstract":"<div><p>A spectrophotometric approach that is straightforward, efficient, highly sensitive, and precise has been devised for quantifying biotin (BTN) in both its pure state and pharmaceutical samples. Therapeutic assessment and patient bioavailability require biotin analysis in biological and pharmacological samples. Some drug detection methods require sophisticated equipment that many quality control laboratories and universities in developing nations lack. The methodology relies on the inhibitory approach of BTN on the Pd(II) promoted ligand substitution (LS) reaction involving 2,2′ bipyridine (BiPy) and hexacyanoferrate(II). The process entails replacing cyanide in [Fe(CN)₆]^4– with BiPy in ammonium dodecyl sulfate (ADS) micellar medium, triggering the development of a complex [Fe(CN)₄ BiPy]^2-. The complex demonstrates a significant level of absorption at a specific wavelength of 440 nm. The established limit of detection for BTN is 0.089 μg mL⁻¹. Experiments on recovery were conducted to confirm the precision and accuracy of BTN quantification. The suggested approach has been effectively utilized for the examination of BTN in pristine samples and various medications, demonstrating remarkable levels of precision and accuracy. The outcomes showed good agreement when compared to the findings of the official analytical method. The excipients typically employed in medicines do not exhibit any interference with the suggested methodology. This methodology effectively determines trace levels of various drugs and biological molecules that can significantly hinder the catalytic efficiency of Pd(II).</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, in silico study and antimalarial activity of 2-thioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives","authors":"Arvind N Prajapati,&nbsp;Shaffiqali Y Saiyad,&nbsp;Tarosh S Patel,&nbsp;Vipul B Kataria,&nbsp;Bharat C Dixit,&nbsp;Ritu B Dixit","doi":"10.1007/s12039-025-02358-x","DOIUrl":"10.1007/s12039-025-02358-x","url":null,"abstract":"<div><p>The present study mainly focused on synthesizing novel 2-thioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives using multicomponent reaction. Further, the potential of the synthesized compounds against <i>Plasmodium falciparum</i> dihydrofolate reductase (<i>Pf</i>-DHFR) inhibitors was evaluated by <i>in vitro</i> antimalarial activity, and the results of the study showed moderate to good antimalarial profile of synthesized entities. <i>In-silico</i> research of all the synthesized compounds was conducted using Schrödinger LLC-2020-3 software to explain the binding mode and interactions between molecules and the <i>Pf</i>-DHFR enzyme. To study the drug likeliness of molecules, 3D QSAR and pharmacokinetic studies have been carried out, and the results obtained showed good pharmacokinetics profile of two compounds, namely AMPS-26 and AMPS-28, having good IC₅₀ values concerning standard drugs. Further, the <i>in vitro</i> enzyme inhibition assay results suggested that the synthesized compound interacts nicely with the enzyme and might be used as a potent antimalarial agent.</p><h3>Graphical abstract</h3><p>The current study presents a synthesis of the novel 2-thioxo-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives using multicomponent reaction. A series of 30 compounds is synthesized. Amongst them, AMPS-28 (IC₅₀ value 0.028 <i>µ</i>g/mL) is found to be the most potent against <i>Pf</i>-DHFR enzyme, which is based on its molecular docking studies and IC₅₀ values, comparable to pyrimethamine having IC₅₀ value 0.035 <i>µ</i>g/mL.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143793195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin films of azobenzene dicarboxylate-based Cu-MOF: Generating electronic heterostructure by molecular doping","authors":"Sauvik Saha,&nbsp;Therese Mariya Jose,&nbsp;Mini Kalyani,&nbsp;Nahid Hassan,&nbsp;Umashis Bhoi,&nbsp;Ajay Ugale,&nbsp;Nirmalya Ballav","doi":"10.1007/s12039-025-02365-y","DOIUrl":"10.1007/s12039-025-02365-y","url":null,"abstract":"<div><p>Circumventing the limitations of lattice-mismatch factors in usual heterostructured thin films of metal-organic frameworks (MOFs), recent studies have achieved exotic electronic heterostructures for possible next-generation thin film device applications. This study reports a robust strategy to significantly enhance the conductivity in thin films of 4,4′-azobenzene dicarboxylate (ADA) linker-based 1D Cu-MOF while also creating an electronic heterostructure system in the process and explores how photoexcitation might perturb its electrical transport behaviour.</p><h3>Graphical abstract</h3><p>Fabrication of highly-uniform and crystalline thin films of 4,4′-azobenzene dicarboxylate (ADA) linker-based Cu-MOF, referred to as Cu-ADA thin films, through a layer-by-layer (LbL) method is reported. Molecular doping of TCNQ (tetracyanoquinodimethane) in Cu-ADA thin films led to the formation of an electronic heterostructure exhibiting rectification of current and enhancement of electrical conductance in the cross-plane and in-plane configurations, respectively.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of novel quinoline derivatives: Anticancer potential revealed through design, synthesis and biological evaluation","authors":"Janaiah Chevula,&nbsp;Saikrishna Balabadra,&nbsp;Ramakrishna Munnaluri,&nbsp;Vijjulatha Manga","doi":"10.1007/s12039-025-02362-1","DOIUrl":"10.1007/s12039-025-02362-1","url":null,"abstract":"<p>A novel series of quinoline derivatives were designed and synthesized for anticancer activity targeting epidermal growth factor receptor (EGFR) tyrosine kinase. The structures of all synthesized derivatives were confirmed by ¹H-NMR, ¹³C-NMR, FTIR and mass spectrometry. Most of the compounds showed good activity against MCF-7 and HeLa cancer cell lines. Compound <b>4a</b> showed good antiproliferative activity against MCF-7 (IC₅₀ <span>(=)</span> 36.07 μM) and HeLa (IC₅₀ <span>(=)</span> 17.06 μM) cancer cell lines. Moreover, molecular docking and Prime/MM-GBSA results showed that compound <b>4a</b> formed hydrogen bonds with Met 769 and Asp 831 residues of EGFR tyrosine kinase (PDB ID: 1M17).\u0000</p>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 6-amino-5-cyano [2,2′/2,3′/2,4′-bipyridin]-4-yl-triphenylamine dyes anchored on cadmium sulphide nanowires: Optical, electrochemical and photovoltaic applications","authors":"Ahmedraza Mavazzan,&nbsp;Avinash C Mendhe,&nbsp;Praveen K Bayannavar,&nbsp;Babasaheb R Sankapal,&nbsp;Vishwa B Nadoni,&nbsp;Suresh F Madar,&nbsp;Ravindra R Kamble,&nbsp;K M Mussuvir Pasha,&nbsp;Barnabas Kodasi","doi":"10.1007/s12039-025-02357-y","DOIUrl":"10.1007/s12039-025-02357-y","url":null,"abstract":"<div><p>This article explores the green synthesis methodology for a novel class of electron-rich 6-amino-5-cyano [2,2′/2,3′/2,4′-bipyridin]-4-yl-triphenylamine compounds. Employing microwave-assisted techniques and environmentally benign solvents, we have significantly reduced the environmental footprint of the synthetic process. The synthesized compounds exhibit promising optical and electrochemical properties, making them potential candidates as sensitizers for dye-sensitized solar cells (DSSCs). The density functional theory (DFT) calculations and EQE measurements corroborate the experimental findings, suggesting the potential of these compounds for DSSC application by anchoring on one-dimensional CdS nanowires. This study underscores the importance of green chemistry principles in developing sustainable and environmentally friendly materials for energy applications.</p><h3>Graphical abstract</h3><p>This work enhances the use of microwaves in green chemistry to synthesize novel substances while reducing the use of dangerous solvents and energy consumption. These compounds exhibit promising qualities as dye-sensitized solar cell (DSSC) sensitizers due to their remarkable optical and electrochemical characteristics. The outcomes support DFT and EQE studies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and synthesis of C-α-D-mannopyranoside linked mesoporous silica nanoparticles","authors":"Hemanth K Nechooli,&nbsp;Vilas Ramtenki,&nbsp;Chepuri V Suneel Kumar,&nbsp;B L V Prasad,&nbsp;Chepuri V Ramana","doi":"10.1007/s12039-024-02338-7","DOIUrl":"10.1007/s12039-024-02338-7","url":null,"abstract":"<div><p>Mannose functionalized mesoporous silica nanoparticles (MSNs) offer a promising approach for developing more targeted, effective, and safer cancer therapies. For many of the applications, immobilization of carbohydrates like mannose onto MSNs is a crucial aspect, and in most cases, mannose moieties are connected through <i>O</i>-glycosidic linkages that are susceptible to acidic/enzymatic hydrolysis. To generate a stable mannose-functionalized MSN, we designed a novel <i>C</i>(14)-<i>α</i>-mannosylated tetradeca-1-yne. The key steps involved in the synthesis of <i>C</i>-mannosylated alkyne are C1-alkynylation of tri-<i>O</i>-acetyl-D-glucal with 1-trimethylsilyl-tetradec-1-yne, followed by stereoselective dihydroxylation and the isomerization of the internal triple bond to a terminal position. This mannose ligand was then immobilized onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. Various physical techniques such as low-angle powder XRD, N₂ adsorption isotherms (BET), Fourier transform infrared (FTIR), high-resolution transmission electron microscopy (HRTEM), field emission scanning electron microscopy (FE-SEM), and thermogravimetric analysis (TGA) have been employed to characterize this <i>C</i>-mannosyl SBA-15 silica matrix. We evaluated the binding ability of <i>C</i>-mannosyl SBA-15 nanoparticles by using fluorescein-labelled Con-A as a target protein.</p><h3>Graphical abstract</h3><p>We document the synthesis of a novel novel <i>C</i>(14)-<i>α</i>-mannosylated tetradeca-1-yne from tri-<i>O</i>-acetyl-D-glucal its immobilization onto azidopropyl-functionalized SBA-15 through the Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction. The successfully immobilization of mannosyl units on SBA-15 and retention of the pore structure of SBA-15 after the incorporation of the organic molecules has been established with the help of various physical techniques and the binding ability of <i>C</i>-mannosyl SBA-15 nanoparticles by using fluorescein-labeled Con-A as a target protein.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of 4-propyl phenol from bio-based eugenol via hydrogenation and demethoxylation using novel Ni–Co/Al-SBA-15 catalysts","authors":"Harsha M Dhanwani,&nbsp;Ganapati D Yadav","doi":"10.1007/s12039-024-02321-2","DOIUrl":"10.1007/s12039-024-02321-2","url":null,"abstract":"<div><p>Fuels and energy produced from biomass are viable options for cutting carbon footprints and lessening environmental effects. One important phenolic molecule that may be extracted from lignocellulosic biomass is eugenol, which has a variety of industrial uses and can be used as a precursor to bio-based Industrial important compounds. This work investigates the utilization of a unique Ni–Co/Al-SBA-15 heterogeneous catalyst to convert eugenol into 4-propylphenol, a multifunctional chemical with use as an antioxidant, flavouring agent, and disinfectant. With 93% yield of 4-propylphenol, the catalyst demonstrated an astounding 100% conversion rate in an isopropanol medium when operated at optimal conditions of 230°C and 30 bar of pressure. Using a variety of characterization techniques, the catalyst activity, selectivity and stability were carefully evaluated, and reaction conditions were adjusted for the best outcomes. The activation energy was ascertained using a kinetic model and the reaction mechanism proposed. The catalyst durability and reusability emphasize its economic viability and fits into the principles of green chemistry that emphasize its environmental sustainability. The results of this study address the need for renewable energy sources with low environmental impact worldwide and progress in the development of cleaner, more effective methods of utilizing biomass as feedstock for chemicals, fuels and materials.</p><h3>Graphical abstract</h3><p>Selective conversion of eugenol to 4-propyl phenol using 5 wt% Ni–Co/Al-SBA-15 catalyst is reported here. Derived from non-edible biomass lignin, this green process yields fragrance and flavoring agents. It is a clean and green process, utilizing a robust reusable catalyst achieving high selectivity and yield.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruthenium catalyzed deaminative coupling of primary amines to secondary amines","authors":"Deepsagar Manikpuri,&nbsp;Jugal Kishore,&nbsp;Chidambaram Gunanathan","doi":"10.1007/s12039-024-02343-w","DOIUrl":"10.1007/s12039-024-02343-w","url":null,"abstract":"<div><p>A mono-hydrido bridged dinuclear ruthenium complex, [{(<i>η</i>6-<i>p</i>-cymene)RuCl₂(<i>μ</i>-H-<i>μ</i>-Cl)] catalyzed deaminative coupling of primary amines to secondary amines is reported. Both benzylic and aliphatic primary amines are amenable in the catalysis, which delivers the symmetrical secondary amines. Catalytic synthesis of unsymmetrical secondary amines is attained upon employing anilines and different primary amines in which the anilines are alkylated by the primary amines. Notably, the catalysis does not require any additives or base. Reaction pathway involving N–H activation of primary amines leading to the formation of cationic ruthenium hydride intermediate in which the <i>β</i>-hydride elimination generates the imine ligand followed by intermolecular nucleophilic addition by primary amines that produces the secondary amines is proposed as a possible reaction mechanism. Ammonia is the only by-product in this transformation.</p><h3>Graphical abstract</h3><p>\u0000A bridged dinuclear ruthenium complex, [{(<i>η</i>6-<i>p</i>-cymene)RuCl₂(<i>μ</i>-H-<i>μ</i>-Cl)] catalyzed deaminative coupling of primary amines to secondary amines is reported. The mechanism involves N–H activation of primary amines leading the formation of cationic ruthenium hydride intermediate where the β-hydride elimination generates the imine ligand followed by intermolecular nucleophilic addition by primary amines. </p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"137 2","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}