Journal of Chemical Sciences最新文献

{"title":"Redox catalysis with environmental benign and abundant aluminium towards cyclotrimerization of alkynes","authors":"Lokesh Rai,&nbsp;Sujoy Rana","doi":"10.1007/s12039-026-02508-9","DOIUrl":"10.1007/s12039-026-02508-9","url":null,"abstract":"<div><p>Low-valent aluminium catalyst can promote alkyne cyclotrimerization to form substituted benzene derivatives through an Al(III)/Al(I) redox catalytic cycle. The redox activity of aluminium resembles with the transition-metal behaviour in the Reppe Reaction. This work, recently reported by Zhang and Liu, highlights the potential of aluminium, an earth-abundant main-group element to mediate complex catalytic transformations, offering a more sustainable alternative to traditional transition-metal systems. Furthermore, it provides an important outline for the design and development of redox-active aluminium complexes for future catalytic applications.</p><h3>Graphical abstract</h3><p><i>Synopsis</i>: A carbazolyl-ligand based molecular Al(I)-complex has been developed which undergoes oxidative addition and triggers insertion, reductive elimination in presence with terminal alkynes to provide cyclotrimerization product. This news story highlights the essence of Al-catalysts in redox-catalysis due to its abundance, low toxicity, and cost-effectivity.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, crystal structure, spectral characterization of new pyrazole derivatives and their α-amylase inhibitory potential","authors":"Dinesh Kumar Govindappa,&nbsp;Karthik Kumara,&nbsp;Swati Mylarappa,&nbsp;Neratur Krishnappagowda Lokanath,&nbsp;Kariyappa Ajay Kumar,&nbsp;Hanasavadi Parameshwarappa Jayadevappa","doi":"10.1007/s12039-026-02496-w","DOIUrl":"10.1007/s12039-026-02496-w","url":null,"abstract":"<div><p>In search for novel α-amylase inhibitors, the present study reports an efficient protocol for the synthesis of 2-pyrazoline derivatives, which involves an Amberlyst-15-catalyzed (3 + 2) annulation reaction of chalcones with phenylhydrazine or semicarbazide at room temperature. The structures were confirmed by spectroscopic analysis, and among the series, the compound 5-(4-(dimethylamino)phenyl)-3-(4-methylphenyl)-4,5-dihydro-1<i>H</i>-pyrazole-1-carboxamide <b>5c</b>, was confirmed through single crystal X-ray diffraction studies. The analysis revealed the presence of intermolecular C–H...O and N–H...O hydrogen bond interactions. The molecular structure was stabilized by C–H...π and π...π molecular interactions. The intermolecular N–H...O interaction leads to the formation of an R₂²(8) supramolecular synthon. The preliminary <i>in vitro</i> α-amylase inhibition assay studies of compounds <b>4</b>(<b>a</b>–<b>d</b>) and <b>5</b>(<b>a</b>–<b>d</b>) indicated the promising inhibitory effects. The compounds demonstrated good α-amylase inhibition with IC₅₀ values ranging from 2.23 to 9.16 µM, with the most potent inhibitors being <b>5b</b> (IC₅₀ = 2.23 µM) and <b>4b</b> (IC₅₀ = 3.86 µM), in comparison to the control drug acarbose (IC₅₀ = 2.56 µM).</p><h3>Graphical abstract</h3><p>In search of potent anti-diabetic agents, a series of pyrazoles <b>4</b>(<b>a</b>–<b>d</b>) and pyrazole carboxamides <b>5</b>(<b>a</b>–<b>d</b>) were synthesised through Amberlyst-15 catalysed reaction of chalcones <b>3</b>(<b>a</b>–<b>d</b>) with phenylhydrazine/semicarbazide hydrochloride in acetonitrile medium at room temperature. The crystallographic studies confirm the structure of <b>5c</b>. The newly synthesised compounds were evaluated for α-amylase activity, and the results revealed that <b>4b</b> and <b>5b</b> exhibit the most potent activities.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystal engineering of 3-aminopyridinium incorporated Strandberg-type cluster-based solids: Synthesis, structure and optical properties","authors":"Annie Thomas Thattil,&nbsp;Jisha Joseph,&nbsp;Anupam Kumar Chakravarty,&nbsp;Jency Thomas","doi":"10.1007/s12039-026-02494-y","DOIUrl":"10.1007/s12039-026-02494-y","url":null,"abstract":"<div><p>Crystallization of Strandberg-type cluster (STC) based solids using 3-aminopyridine (3-<i>ampy</i>) viz<i>.</i> {3-H<i>ampy</i>}₄[{PO₃(OH)}₂Mo₅O₁₅]·H₂O (<b>1</b>) and {3-H<i>ampy</i>}₁₀[{PO₃(OH)}{PO₄}Mo₅O₁₅]₂·4H₂O (<b>2</b>) was achieved in aqueous solution under acidic conditions. While, strong hydrogen bonding interactions between protonated 3-aminopyridine moieties and STC dictated the crystal packing of the solids, non-bonding interactions such as C–H···π and π···π interactions strengthened the crystal structure. Detailed crystal structure analysis of <b>1</b> and<b> 2</b> demonstrated that both form 2-D supramolecular assemblies having voids occupied by protonated 3-aminopyridine moieties and lattice water molecules. Interestingly, pH and temperature influenced the occurrence of different ligand: cluster ratio in the solids. The results also suggested that solids <b>1</b> and<b> 2</b> were stable over a wide range of temperature indicating the formation of thermodynamically stable phases. Optical band gap energy calculations indicated that <b>1</b> showed lower band gap energy than <b>2</b> owing to greater extent of protonation of the Strandberg-type cluster.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div><div><p>Crystallization of Strandberg-type cluster-based solids using 3-aminopyridine (3-ampy) resulted in {3-Hampy}₄[{PO3(OH)}²M_o5O₁₅]∙H₂O (1) and {3-Hampy}₁₀[{PO₃(OH)}{PO₄}M_o5O₁₅]₂∙4H₂O (<b>2</b>) under aqueous acidic conditions. The crystal structure of both the solids was analyzed and their chemistry of formation was envisaged. In addition, optical band gap energy caluclations were also perfomed. </p></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147561307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation of interstellar molecules inside fullerenes: A molecular capture perspective","authors":"Muthupandi Senthilkumar,&nbsp;Mahesh Kumar Ravva,&nbsp;Elumalai Varathan,&nbsp;Ravinder Pawar,&nbsp;Muthuramalingam Prakash,&nbsp;Venkatesan Subramanian","doi":"10.1007/s12039-026-02486-y","DOIUrl":"10.1007/s12039-026-02486-y","url":null,"abstract":"<div><p>The encapsulation of small molecules such as formaldehyde (HCHO), formamide (HCONH2), and isocyanic acid (HNCO) inside fullerene cages (C₆₀ and C₈₀) has been investigated using density functional theory (DFT)-based calculations. The calculated interaction energy and energy decomposition analyses confirmed the thermodynamic stability of the endohedral complexes (Mol@C₈₀; here, Mol = HCHO, HCONH₂ and HNCO and HCHO@C₆₀). Furthermore, to assess the dynamic stability of the encapsulated complexes, <i>ab initio</i> molecular dynamics (AIMD) simulations were carried out at 213 K and 1 bar pressure. The results obtained from these simulations revealed that the encapsulated molecules remained stable inside the cage. The effect of confinement was further evaluated using vibrational frequency and frontier orbital analyses of the guest molecules. The findings show that confinement influences the vibrational modes and electronic properties. The results obtained from atoms in molecules (AIM) analysis reinforce the presence of non-covalent interactions between the guest and host cages. Energy decomposition analysis (EDA) quantifies and substantiates these results, indicating more effective charge transfer or polarization between the fullerene and the encapsulated molecule. Overall, this study demonstrates that HCHO, HCONH₂ and HNCO can be encapsulated within C₈₀, whereas only HCHO retains favorable encapsulation inside C₆₀, which is consistent with recent experimental observations.</p><h3>Graphical abstract</h3><p>The feasibility of encapsulating small polar molecules such as HCHO, HCONH₂, and HNCO was established through DFT calculations. This observation was further confirmed using topological (AIM) analysis, energy decomposition (EDA), ab initio molecular dynamics (AIMD), and frontier molecular orbital (FMO) studies.</p>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147560479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raw halloysite catalyzed an efficient one-pot three-component synthesis of 9-aryl-hexahydroacridine-1,8-diones","authors":"Sakshi Panhotra,&nbsp;Rashima Mehta,&nbsp;Wani Inam Ul Haq,&nbsp;Aakriti Mahajan,&nbsp;Manvi Mahajan,&nbsp;Princy Gupta","doi":"10.1007/s12039-026-02495-x","DOIUrl":"10.1007/s12039-026-02495-x","url":null,"abstract":"<div><p>Green chemistry promotes sustainable practices to minimize environmental impact, where heterogeneous catalysis serves as a key strategy for enhancing efficiency and eco-friendliness in chemical processes. Halloysite, a natural clay mineral with a tubular, hollow structure, large surface area and tunable surface chemistry has emerged as a sustainable, recyclable and highly efficient heterogeneous catalyst for the multicomponent reaction between dimedone, aromatic aldehydes, and a nitrogen source, specifically ammonium acetate in greener solvent leading to the efficient production of 1,8-dioxodecahydroacridines in good to excellent yields. The proposed method provides a straightforward procedure, featuring a simple setup, easy work-up, reduced reaction times, high product yields and no hazardous solvents, aligning with green chemistry principles of reducing waste and using safer materials.</p><h3>Graphical abstract</h3><p>Halloysite, a natural and reusable clay catalyst, enables an eco-friendly multicomponent synthesis of 1,8-dioxodecahydroacridines from dimedone, aromatic aldehydes, and ammonium acetate. This green approach delivers high yields in shorter reaction times while minimizing waste and aligning with the core principles of sustainable chemistry.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147560476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choline chloride-oxalic acid based deep eutectic solvent: A versatile catalyst for one-pot multicomponent synthesis of highly functionalised tetrahydropyridine","authors":"Roopali T Biradar,&nbsp;Vrushabh D Pare,&nbsp;Rahul S Hire,&nbsp;Yatin U Gadkari","doi":"10.1007/s12039-026-02490-2","DOIUrl":"10.1007/s12039-026-02490-2","url":null,"abstract":"<div><p>A novel and efficient protocol has been established for the synthesis of piperidine-containing tetrahydropyridines via a multicomponent reaction involving aromatic amines, aromatic aldehydes and methyl acetoacetate as starting materials. The reaction, catalysed by a reusable deep eutectic solvent (choline chloride-oxalic acid) under ultrasonic irradiation, proceeds under ambient conditions, yielding substituted tetrahydropyridines with high efficiency. The protocol offers several advantages, including excellent functional group tolerance, high yields, short reaction times, and eco-friendly solvent-free conditions, making it a cost-effective and sustainable approach.</p><h3>Graphical abstract</h3><p><i>Synopsis.</i> A mild and eco-friendly procedure has been established for the synthesis of piperidine-containing tetrahydropyridines using deep eutectic solvent (ChCl-OA) under ultrasonic irradiation. The method offers several advantages, including rapid kinetics, high yields, short reaction times, simple work-up, broad substrate scope tolerance, and product isolation without column chromatography, etc.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147560066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel coumarin-oxadiazole azo dyes for enhanced latent fingerprint detection","authors":"Kishan Balehalli Shivananda,&nbsp;Pradeep Kumar Badiya","doi":"10.1007/s12039-026-02482-2","DOIUrl":"10.1007/s12039-026-02482-2","url":null,"abstract":"<div><p>Organic azo dye molecules exhibit strong luminescent properties, which are useful for forensic experts to find and visualize invisible fingerprints in crime investigations. This study describes the newly developed heterocyclic azo dye, specifically (<i>E</i>)-4-hydroxy-3-((5-phenyl-1,3,4-oxadiazol-2-yl)diazenyl)-2H-chromen-2-one (coumarin-oxadiazole). The synthesis of coumarin-oxadiazole was achieved through a standard diazo-coupling reaction, employing 2-Amino-5-phenyl-1,3,4-Oxadiazole as a diazonium salt and 4-hydroxycoumarin as the coupling agent. The structural elucidation of the synthesized compound was carried out using spectroscopic techniques such as Infrared spectroscopy (IR), Proton nuclear magnetic resonance spectroscopy (¹H NMR), Carbon-13 nuclear magnetic resonance spectroscopy (¹³C NMR), Mass spectroscopy (MS) and Ultraviolet-visible (UV-Vis) spectroscopy were employed to confirm the structural characterization of the resultant molecule. Density functional theory analysis confirmed a donor–<i>π</i>–acceptor structure in the coumarin–oxadiazole dye, with a 3.65 eV HOMO-LUMO gap, supporting efficient charge transfer and strong fluorescence. The synthesized molecule was then successfully evaluated for its application in latent fingerprint (LFP) detection. Fingerprint pattern level I, level II and level III are clearly visible on both porous/non-porous surface with clear visibility under normal daylight and 365 nm UV light and ImageJ used to distinguish   ridges and furrows characteristics in fingerprint patterns, demonstrates its potential in forensic science.</p><h3>Graphical abstract</h3><p>Novel coumarin-oxadiazole azo dye via diazotization of 2-amino-5-phenyl-1,3,4-oxadiazole followed by a coupling reaction with 4-hydroxycoumarin. The resulting compound was characterized and evaluated for its applicability in latent fingerprint detection. The developed LFPs of all three levels were viewed under normal daylight and 365 nm UV light.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147560124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of pH, crude oil content and surfactant dosage on interfacial tension of crude oil nanoemulsions against diesel: A combined experimental and machine learning investigation","authors":"Andaç Batur Çolak,&nbsp;Sagheer A Onaizi","doi":"10.1007/s12039-026-02491-1","DOIUrl":"10.1007/s12039-026-02491-1","url":null,"abstract":"<p>Nanoemulsions are increasingly recognised for their superior interfacial properties and stability, making them highly valuable in various industrial sectors, including oilfield applications. This study presents a novel machine learning approach for predicting the interfacial tension (IFT) of crude oil-in-water nanoemulsions in contact with diesel, incorporating key formulation parameters such as pH, surfactant dosage and crude oil content. Unlike prior research that primarily focuses on IFT measurements between pure crude oil and aqueous phases, this work investigates more realistic multiphase systems involving pre-formulated nanoemulsions. A series of nanoemulsions were prepared under systematically varied conditions and their dynamic IFT behaviour was experimentally measured. To model this behaviour, three artificial neural network (ANN) models based on multilayer perceptron architecture were developed, each trained using different input combinations: (i) sodium dodecylbenzenesulfonate surfactant concentration and time, (ii) crude oil volume percentage and time, and (iii) pH and time. The models were trained and validated using the Levenberg–Marquardt algorithm and evaluated using coefficient of determination (<i>R</i>), mean squared error and margin of deviation metrics. All models demonstrated excellent predictive performance, with <i>R</i> values exceeding 0.9 and minimal deviation from experimental data. The results establish ANN as a powerful tool for accurately predicting interfacial properties of complex emulsion systems. This data-driven machine learning framework has the potential to reduce the need for extensive experimentation and to provide a robust platform for rapid formulation screening and optimisation in oilfield applications and beyond.</p><p>Crude oil–in–water nanoemulsions were prepared across diff erent pH, surfactant, and oil fraction. Pendant-drop tensiometry recorded dynamic interfacial tension (IFT) of the nanoemulsions against diesel. Multilayer-perceptronmodels using time and formulation variables accurately predicted IFT (R0.9), enabling rapid screening and guidelinesfor optimization while reducing experimental workload.</p>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147441496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the synergy between technique and timescale in simulations: From biomolecules to biomaterials","authors":"Apramita Chand","doi":"10.1007/s12039-026-02481-3","DOIUrl":"10.1007/s12039-026-02481-3","url":null,"abstract":"<div><p>The evolution of simulation techniques in biomolecules and biomaterials has led to a plethora of simulation times that are increasingly achieving timescales observed in biological events. This review addresses the challenges of conventional molecular dynamics simulations in such systems and explains how enhanced sampling techniques (like umbrella sampling, accelerated molecular dynamics, replica exchange molecular dynamics, metadynamics, Markov state models, milestoning) coupled with upgraded computing resources, can accelerate sampling of configurational space in various biomolecular systems like peptides, proteins, nucleic acids, and lipid membranes. A comparative analysis of such techniques with respect to timescales is also carried out for diverse biomaterial interfaces (such as biomolecular conjugates with graphene, carbon nanotubes, biopolymers and fullerenes) where it is seen that such advanced techniques can yield additional insights into free energies, binding affinities, orientations and interactions. A futuristic glimpse into recent techniques employing supercomputing, optimised workflows, and deep learning approaches for high throughput simulations is also presented in this review. It is expected that the evolution of multi-scale and hybrid approaches can pave the way towards exploring the balance of technique and timescale in biological system simulations in a synergistic manner.</p><h3>Graphical abstract</h3><p>The interplay between diverse simulation techniques and timescales in deciding the course of biological simulations involving proteins, nucleic acids, membranes as well as biomaterial interfaces has been reviewed in this work. Challenges and future prospects of enhanced sampling approaches are balanced in this amalgamate of simulation stories.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147441505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate determination of trace levels of sulphur in silicate minerals by ion-chromatography","authors":"Lori Rastogi,&nbsp;A Durga Prasad,&nbsp;K Dash","doi":"10.1007/s12039-026-02487-x","DOIUrl":"10.1007/s12039-026-02487-x","url":null,"abstract":"<div><p>A method has been developed for the trace level quantitation of sulphur as sulphate in silicate minerals using ion chromatography. The success of the method is based on the (i) drastic reduction (~900 times) of sulphate blank in HF used for the digestion of samples and (ii) release of sulphate from insoluble alkaline earth metal sulphates using potassium oxalate solution. Linear range of ion chromatography for the sulphate was established between 1.0 and 10.0 mgL^–1 (<i>R</i>² = 0.9994) for the analysis of sulphur as sulphate in quartz and other silicate minerals. Limit of quantification at 10 σ was calculated to be 6 mg kg^–1 (as sulphur). Analysis of Silicon 57A-CRM using the developed method resulted in 0.0031 ± 0.0003% m/m of sulphur which is in close agreement with the certified value of 0.003 ± 0.002% m/m, establishing the trueness of the developed method. The method has shown good repeatability (RSD = 1.7%) and reproducibility (RSD = 9.6%). The developed method was successfully applied for the analysis of sulphur in quartz powders where concentration of sulphur varied from 10 to 60 mg kg^–1. The method was further utilised to analyse sulphur in other geological silicate materials like basalt (BHVO-1, BIR-1) and granite (G2) where, the values of sulphur obtained by the developed method were found to be in close agreement with those published in the literature as suggested by Student’s <i>t</i>-test. The results obtained by the developed method were cross validated with C-S analyser.</p><h3>Graphical abstract</h3><p>The study reports a sensitive ion chromatography–based method for the trace-level quantification of sulphur as SO₄^2– in silicate minerals. The method involves minimising sulphur blanks in HF and liberating sulphate from samples\u0000using K₂C₂O₄. The limit of quantification (LOQ) is 6 mg kg^–1 (as sulphur). The developed method demonstrates high accuracy, repeatability and reproducibility.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":"138 2","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147441416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}