A convenient TBHP/Cu(NO3)2·2.5H2O-mediated oxidation of secondary and benzyl alcohols under microwave irradiation

IF 2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Sciences Pub Date : 2025-07-10 DOI:10.1007/s12039-025-02370-1

Luís M T Frija

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引用次数: 0

Abstract

A microwave-assisted and solvent-free protocol for secondary and benzyl alcohols oxidation to the corresponding ketones and aldehydes, using the inexpensive and widely available Cu(NO₃)₂·2.5H₂O salt as catalyst and aqueous tert-butyl hydroperoxide (TBHP) as oxidant, has been developed. The present strategy allows the isolation of the oxidation products with yields up to 80% for the majority of the tested substrates. Extremely short reaction times and the usage of low-power microwave irradiation are factors that contribute to the smoothness of the process and are shown as an asset of the described experiment. Remarkably, the approach features a one-pot procedure, an earth-abundant copper catalyst, a wide substrate scope (22 alcohols) and a high compatibility with several functional groups.

Graphical abstract

As an ecological, widely available and economical material, the copper salt Cu(NO3)2∙2.5H2O show a high performance as catalyst in the oxidation of a series of secondary and benzyl alcohols. The developed protocol, using TBHP as oxidant and assisted by microwave radiation, proceeds without the use of an organic solvent and is very chemoselective tolerating the presence of several functional groups.

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微波辐照下thbhp /Cu(NO3)2·2.5 h2o介导的仲醇和苄基醇的便捷氧化

研究了一种微波辅助、无溶剂的仲醇和苄基醇氧化制酮和醛的方法，该方法以廉价且广泛使用的Cu(NO3)2·2.5H2O盐为催化剂，水基过氧化叔丁基（TBHP）为氧化剂。目前的策略允许分离氧化产物的产量高达80%的大多数测试底物。极短的反应时间和低功率微波辐射的使用是有助于过程顺利进行的因素，并被视为所描述的实验的资产。值得注意的是，该方法的特点是一锅程序，地球上丰富的铜催化剂，广泛的底物范围（22个醇）以及与几个官能团的高相容性。铜盐Cu(NO3)2∙2.5H2O作为一种生态、广泛、经济的材料，在一系列仲醇和苯甲醇的氧化反应中表现出优异的催化剂性能。该方案使用三必和必拓作为氧化剂，在微波辐射的辅助下进行，不使用有机溶剂，并且具有很强的化学选择性，可以容忍几个官能团的存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Sciences CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

3.10

自引率

5.90%

发文量

107

审稿时长

1 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.