{"title":"抗病毒药物盐酸金刚烷胺的高效一步法合成工艺","authors":"Vilas Sudrik, Dnyaneshwar Karpe, Manohar Suryawanshi, Dattatraya Ukale, Arjun Bodkhe, Shamrao Lawande","doi":"10.1007/s12039-024-02275-5","DOIUrl":null,"url":null,"abstract":"<div><p>The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process by optimizing reaction conditions. This method employs a phase transfer catalyst, TBAI, and <i>in situ</i> salt formation with HCl, resulting in the desired product with enhanced yield and purity.</p><h3>Graphical Abstract</h3><p>The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process through the optimization of reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":616,"journal":{"name":"Journal of Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient one-pot process for synthesis of antiviral drug amantadine hydrochloride\",\"authors\":\"Vilas Sudrik, Dnyaneshwar Karpe, Manohar Suryawanshi, Dattatraya Ukale, Arjun Bodkhe, Shamrao Lawande\",\"doi\":\"10.1007/s12039-024-02275-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process by optimizing reaction conditions. This method employs a phase transfer catalyst, TBAI, and <i>in situ</i> salt formation with HCl, resulting in the desired product with enhanced yield and purity.</p><h3>Graphical Abstract</h3><p>The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process through the optimization of reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.\\n</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":616,\"journal\":{\"name\":\"Journal of Chemical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Chemical Sciences\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12039-024-02275-5\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Sciences","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s12039-024-02275-5","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Efficient one-pot process for synthesis of antiviral drug amantadine hydrochloride
The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process by optimizing reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.
Graphical Abstract
The synthesis of amantadine hydrochloride from 1-bromoadamantane utilizing urea and methanol is described as a one-pot, efficient, and sustainable process through the optimization of reaction conditions. This method employs a phase transfer catalyst, TBAI, and in situ salt formation with HCl, resulting in the desired product with enhanced yield and purity.
期刊介绍：
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.
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