Iranian Journal of Science and Technology, Transactions A: Science最新文献

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Effects of Epigenetic Inhibitors on Somatic Embryogenesis in Wheat (Triticum aestivum L.) 表观遗传抑制剂对小麦体细胞胚胎发生的影响
IF 1.7 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-29 DOI: 10.1007/s40995-024-01679-9
Sumeyra UCAR, Murat AYDIN
{"title":"Effects of Epigenetic Inhibitors on Somatic Embryogenesis in Wheat (Triticum aestivum L.)","authors":"Sumeyra UCAR, Murat AYDIN","doi":"10.1007/s40995-024-01679-9","DOIUrl":"https://doi.org/10.1007/s40995-024-01679-9","url":null,"abstract":"<p>Wheat (<i>Triticum aestivum L</i>.) is a global staple cereal known for its nutritional value and economic significance. Somatic embryogenesis (SE) is a powerful biotechnological tool for plant genetic improvement, driven by intricate epigenetic mechanisms as well as controlled by key genes such as <i>Wuschel-related HOMEOBOX</i> (<i>WOX4</i>), <i>Leafy cotyledon</i> (<i>LEC1</i>), <i>Baby Boom 1</i> (<i>BBM1</i>), and <i>Somatic embryogenesis receptor kinase</i> (<i>TaSERK</i>). This study investigates the impact of different concentrations (0.1, 0.5, 1, and 2 µM) of Trichostatin A (TSA) and 5-Azacytidine (5-Azac), recognized epigenetic inhibitors, on mature embryos of Kırık bread wheat variety cultured in a callus formation medium. In vitro parameters including Callus formation frequency (CFF) (mg), callus fresh weight (CFW) (%), embryogenic callus formation frequency (ECFF) (%), embryogenic callus frequency (RECF) (%), and regeneration efficiency (RE) (number) as well as expression levels of <i>WOX4</i>, <i>LEC1</i>, <i>BBM1</i>, and <i>TaSERK</i> genes, were evaluated at 14, 28, and 42 days after initiation of tissue culture (DAI). The results show that TSA and 5-Azac treatments had a considerable influence on the in vitro parameters tested. Furthermore, these compounds had a significant effect on the mRNA expression levels of the WOX4, LEC1, BBM1, and TaSERK genes, which are important in SE. Specifically, LEC1 expression peaked at 42 DAI across all treatments, while WOX4 and BBM1 peaked at 14 DAI. TaSERK expression decreased by 42 DAI, with variations depending on treatment at previous time points. As a result of this study, 0.5 µM TSA and 5 µM 5-Azac treatments resulted in optimal plant regeneration, emphasizing the importance of epigenetic regulators in promoting somatic embryogenesis via endosperm-supported mature embryo in wheat. This study suggests addressing epigenetic systems to improve SE protocols and inform wheat genetic engineering and breeding initiatives for sustainable agriculture and food security.</p>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"75 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141870607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quaternary Fission of Various Z = 120 Isotopes Accompanied by Two α Particles as Light Charge Particles 各种 Z = 120 同位素的四次裂变,伴有两个作为轻电荷粒子的 α 粒子
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-29 DOI: 10.1007/s40995-024-01686-w
Amaya Pavithran, M. K. Preethi Rajan, R. K. Biju
{"title":"Quaternary Fission of Various Z = 120 Isotopes Accompanied by Two α Particles as Light Charge Particles","authors":"Amaya Pavithran,&nbsp;M. K. Preethi Rajan,&nbsp;R. K. Biju","doi":"10.1007/s40995-024-01686-w","DOIUrl":"10.1007/s40995-024-01686-w","url":null,"abstract":"<div><p>Spontaneous quaternary fission accompanied by two α particles for isotopes <sup>304</sup>120 in both equatorial and collinear configurations, and for <sup>298,302</sup>120 in the equatorial configuration has been studied using Coulomb and proximity potential model with the inclusion of deformation and orientation of fragments. The most favourable quaternary fission channel is determined using cold reaction valley and relative yield plots. In the case of <sup>304</sup>120, the equatorial emission of light charge particles displays distinct peaks, reaching a peak relative yield of approximately 33.65%. In contrast, collinear emission shows continuous peaks with a maximum relative yield around 1.27%. The peak relative is attributed to the presence of nuclei <sup>121</sup>In for equatorial emission, and <sup>122</sup>I, <sup>192</sup>Au, <sup>97</sup>Ru and <sup>42</sup>Cl for collinear emission. For the parent isotopes <sup>302</sup>120 a peak relative yield around 19.44% is obtained for combination containing nuclei <sup>122</sup>Ag, whereas in the case of <sup>298</sup>120, fission channels result in a maximum relative yield of approximately 22.08% with one fragment as <sup>122</sup>Ag. The mentioned nuclei are found to possess either a magic number of protons or neutrons leading to shell closure. In addition to closed shell effect, the inclusion of deformation factors β<sub>2,</sub> β<sub>4</sub> and orientation of fragments have a prominent role in determining the relative yield of a particular fission channel.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1373 - 1381"},"PeriodicalIF":1.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141870608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Theoretical Validation and Comparative Analysis of Higher Order Modified Bernstein Operators 高阶修正伯恩斯坦算子的理论验证与比较分析
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-29 DOI: 10.1007/s40995-024-01667-z
Mahima Tomar, Naokant Deo
{"title":"Theoretical Validation and Comparative Analysis of Higher Order Modified Bernstein Operators","authors":"Mahima Tomar,&nbsp;Naokant Deo","doi":"10.1007/s40995-024-01667-z","DOIUrl":"10.1007/s40995-024-01667-z","url":null,"abstract":"<div><p>In this study, we present a technique for enhancing the order of approximation of the modified form of the Bernstein operators that Usta F. achieved. Moreover, two novel operators with degrees of approximation one and two are obtained. Furthermore, we validate a few theoretical findings such as the Korovkin theorem, Voronovskaja theorem, modulus of continuity, etc. about the rate of convergence of these operators. In the end, we operate graphs and tables to illustrate the comparison between the constructed operators and compute the numerical verification of the theoretical conclusions.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1313 - 1327"},"PeriodicalIF":1.4,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141873370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Short Note on Generalized Variation Diminishing Wavelets 广义变异递减小波简述
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-27 DOI: 10.1007/s40995-024-01689-7
A. M. Jarrah, Nikhil Khanna, A. Zothansanga, Dilip Kumar
{"title":"A Short Note on Generalized Variation Diminishing Wavelets","authors":"A. M. Jarrah,&nbsp;Nikhil Khanna,&nbsp;A. Zothansanga,&nbsp;Dilip Kumar","doi":"10.1007/s40995-024-01689-7","DOIUrl":"10.1007/s40995-024-01689-7","url":null,"abstract":"<div><p>Pathak (2011) introduced variation diminishing wavelets and wavelets of specified changes in sign by utilising Schoenberg’s notion of variation-diminishing integral operators of convolution type. In this paper, we introduce some generalized variation diminishing wavelets based on the Hartley kernel and the Boas transforms. In particular, we introduce wavelets with specific changes of sign and wavelets based on Tanno’s form of convolution kernels.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1299 - 1305"},"PeriodicalIF":1.4,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dislocation Induced Thermal Diffusivity Tuning of ZnO Hybrid Nanofluids: A Mode Mismatched Dual Beam Thermal Lens Study 氧化锌混合纳米流体的位错诱导热扩散率调谐:模式错配双光束热透镜研究
IF 1.7 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-27 DOI: 10.1007/s40995-024-01680-2
V. Gokul, M. S. Swapna, S. Sankararaman
{"title":"Dislocation Induced Thermal Diffusivity Tuning of ZnO Hybrid Nanofluids: A Mode Mismatched Dual Beam Thermal Lens Study","authors":"V. Gokul, M. S. Swapna, S. Sankararaman","doi":"10.1007/s40995-024-01680-2","DOIUrl":"https://doi.org/10.1007/s40995-024-01680-2","url":null,"abstract":"<p>The paper delineates the synthesis and development of zinc oxide (ZnO) hybrid nanofluids (HNFs) with different carbon sources (diesel soot (DS) and acetylene black (AB)) to address heat transfer (HT) limitations in thermal systems. Using a highly sensitive mode-mismatched dual beam thermal lens (MDTL) technique, the concentration-dependent thermal diffusivity modifications of the synthesized HNFs are monitored. The method of solution combustion is utilized for the synthesis of ZnO powder. The ZnO-hybrid composites are prepared by solid-state mixing and annealing of ZnO with DS and AB. The structure characteristics of the synthesized hybrid composites are understood through X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. The XRD and Raman analyses revealed the structural dislocations and the degree of disorder within the synthesized composites. The optical properties of the samples are revealed through ultraviolet-visible analysis. The MDTL investigation is carried out by preparing HNFs of the samples in ethylene glycol as the base fluid, thus elucidating the effect of lattice dislocations on the thermal behavior of the synthesized HNFs. Thus, the study suggests the potential of lattice dislocations-induced thermal diffusivity tuning ZnO-DS and ZnO-AB hybrid composites for various HT applications.</p>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"62 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prunus Species Diversity, Structure and Phylogenetic Studies Assessed by Chloroplastic Microsatellite Markers 利用叶绿体微卫星标记评估梅花物种多样性、结构和系统发育研究
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-27 DOI: 10.1007/s40995-024-01681-1
Sana Ben Mustapha, Donia Abdallah, Sahar Haffar, Amel Salhi Hannachi, Ghada Baraket
{"title":"Prunus Species Diversity, Structure and Phylogenetic Studies Assessed by Chloroplastic Microsatellite Markers","authors":"Sana Ben Mustapha,&nbsp;Donia Abdallah,&nbsp;Sahar Haffar,&nbsp;Amel Salhi Hannachi,&nbsp;Ghada Baraket","doi":"10.1007/s40995-024-01681-1","DOIUrl":"10.1007/s40995-024-01681-1","url":null,"abstract":"<div><p>The genus <i>Prunus</i> is among the main species cultivated in Tunisia, due to its economic importance. In this study, genetic diversity and relationships among Tunisian <i>Prunus</i> species was explored using six specific SSR chloroplastic primers (cpSSR) of Rosaceae. The parameters of polymorphism were estimated and showed 5.831 alleles per locus, among them, 1.315 were effective alleles, giving a Shannon’s information index of 0.323. Twelve haplotypes were shared by more than one accession, while 55 haplotypes were accession-specific, confirming the effectiveness of cpSSR as good markers for molecular characterization and identification of <i>Prunus</i> species. Furthermore, the important haplotype diversity proved the allelic singularity of the Tunisian genotypes, considered as a valuable gene pool repository for future breeding programs. Moreover, the results obtained highlighted the ancient origin of the Tunisian <i>Prunus</i> genotypes. The UPGMA dendrogram, the model based Bayesian clustering, PCA analysis and Nm values are clearly consistent with a genetic structuring and showed a high level of differentiation within the genus. Although, the classification of <i>Prunus</i> genus has been controversial issue, our results showed that chloroplastic genome may supply information regarding the evolutionary history of members of <i>Prunus</i> genus. To conclude, this work joins to other studies to demonstrate the effective power of single- parent organelle markers for molecular characterization and population genetic studies.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1175 - 1186"},"PeriodicalIF":1.4,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acantholimon brevispicum (Plumbaginaceae) a New Species from Southeastern Iran Based on Morphological and Molecular Data 基于形态学和分子数据的伊朗东南部新物种 Acantholimon brevispicum (Plumbaginaceae)
IF 1.7 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-27 DOI: 10.1007/s40995-024-01688-8
Hossein Bibak, Shahrokh Kazempour-Osaloo, Mostafa Assadi
{"title":"Acantholimon brevispicum (Plumbaginaceae) a New Species from Southeastern Iran Based on Morphological and Molecular Data","authors":"Hossein Bibak, Shahrokh Kazempour-Osaloo, Mostafa Assadi","doi":"10.1007/s40995-024-01688-8","DOIUrl":"https://doi.org/10.1007/s40995-024-01688-8","url":null,"abstract":"<p><i>Acantholimon brevispicum</i> Bibak, Kaz.Osaloo &amp; Assadi (Plumbaginaceae) is described and illustrated as a new species from the Palvar Mountains, Kerman province, SE Iran. In this paper, we discuss morphological characteristics and molecular data that differentiate the species from closely related taxa. According to morphological characters, the new species belongs to the <i>A</i>. sect. <i>Acantholimon</i> (= <i>Staticopsis</i>) and closely related to <i>A. hormozganense</i> and <i>A. zaeifii</i>, but is easily recognized by its leaves, flowering stem length, inflorescence, bracteole shape, and petal. Morphological comparisons and taxonomic relationships of <i>A. brevispicum</i> with closely related taxa are discussed. Phylogenetic analysis was performed using maximum likelihood and Bayesian inference methods based on nrDNA ITS and plastid <i>rpl</i>32-<i>trn</i>L<sub>(UAG)</sub> markers. According to molecular and morphological evidence, the new species is distinct from its close relatives. The molecular phylogeny analyses support the placement of <i>A. brevispicum</i> based on morphology. The information provided includes a species description, plant images, a diagnostic key, a distribution map, and a molecular phylogenetic tree.</p>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"62 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Numerical Simulation of Kink Collisions, Analytical Solutions and Conservation Laws of the Potential Korteweg–de Vries Equation Kink 碰撞的数值模拟、潜在 Korteweg-de Vries 方程的解析解和守恒定律
IF 1.7 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-27 DOI: 10.1007/s40995-024-01670-4
Chaudry Masood Khalique, Carel Olivier, Boikanyo Pretty Sebogodi
{"title":"Numerical Simulation of Kink Collisions, Analytical Solutions and Conservation Laws of the Potential Korteweg–de Vries Equation","authors":"Chaudry Masood Khalique, Carel Olivier, Boikanyo Pretty Sebogodi","doi":"10.1007/s40995-024-01670-4","DOIUrl":"https://doi.org/10.1007/s40995-024-01670-4","url":null,"abstract":"<p>In this study, we investigate the nonlinear potential Korteweg–de Vries equation (pKdVe) by making use of the Lie group analysis. We start by constructing Lie symmetries and thereafter utilize them to execute symmetry reductions of pKdVe. We then obtain solutions of the pKdVe by using the direct integration method. The obtained solutions are demonstrated in respect of Jacobi elliptic functions. Some of the obtained solutions are illustrated graphically. Moreover, we obtain four conserved vectors of the pKdVe by making use of the multiplier method and five conserved vectors by using the theorem owing to Ibragimov. Finally, we simulate collisions between kinks for the pKdVe.</p>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"69 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moire Structures in Graphene on Cu (111) Substrate: Computer Simulation 铜(111)基板上石墨烯的摩尔结构:计算机模拟
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-25 DOI: 10.1007/s40995-024-01674-0
Sergey V. Belim, Ilya V. Tikhomirov
{"title":"Moire Structures in Graphene on Cu (111) Substrate: Computer Simulation","authors":"Sergey V. Belim,&nbsp;Ilya V. Tikhomirov","doi":"10.1007/s40995-024-01674-0","DOIUrl":"10.1007/s40995-024-01674-0","url":null,"abstract":"<div><p>The article focuses on computer simulations of moire patterns in graphene film on a copper substrate. The surface potential simulates the influence of the substrate on the graphene film. The substrate potential is calculated from the Lennard-Jones paired potential. The interaction between carbon atoms is also determined by the Lennard-Jones potential. It is shown that for two-dimensional structures the parameters of the pair potential differ from the three-dimensional analogue. The simulation results in moire structures in the graphene film. We perform calculations for different orientation angles of graphene relative to the crystal lattice Cu(111). The moire superlattice period decreases with increasing angle between the bond directions of the graphene atoms and the main crystal lattice directions of the substrate. The results of the calculations are in good agreement with the experimental data.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 5","pages":"1365 - 1372"},"PeriodicalIF":1.4,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141870609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, Synthesis, and Toxicity Evaluation of the Green Synthesized Oxaliplatin Nanoparticles Using Ginger Extract against Colorectal Cancer Cells 利用生姜提取物设计、合成绿色合成的奥沙利铂纳米粒子并评估其对结直肠癌细胞的毒性
IF 1.4 4区 综合性期刊
Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-07-25 DOI: 10.1007/s40995-024-01678-w
Ilnaz Tork Cherik, Adeleh Divsalar, Seyed Abdolhamid Angaji
{"title":"Design, Synthesis, and Toxicity Evaluation of the Green Synthesized Oxaliplatin Nanoparticles Using Ginger Extract against Colorectal Cancer Cells","authors":"Ilnaz Tork Cherik,&nbsp;Adeleh Divsalar,&nbsp;Seyed Abdolhamid Angaji","doi":"10.1007/s40995-024-01678-w","DOIUrl":"10.1007/s40995-024-01678-w","url":null,"abstract":"<div><p>Colorectal cancer (CRC) ranks third in malignant tumor mortality worldwide. Oxaliplatin, a third-generation chemotherapeutic drug, treats several malignancies, including colorectal cancer, after cisplatin and carboplatin. However, reducing side effects and optimizing efficacy is challenging. The utilization of plant-assisted green synthesis for the production of nanoparticles is a cost-effective and environmentally sustainable approach. This method could be at the forefront of chemotherapy due to its simplicity and efficiency. The ginger extract has been well-introduced with anti-cancer and antioxidant properties. The present study involved the green synthesis and characterization of oxaliplatin nanoparticles (OxPt NPs) through dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), inductively coupled plasma spectroscopy (ICP), field emission scanning electron microscopy (FESEM), and atomic force microscopy (AFM). This study investigated the effectiveness of OxPt NPs, ginger extract, and conventional oxaliplatin (first-line drug of CRC) on the HCT116 colorectal cancer cell line through MTT assay comparatively. The findings exhibited an outstanding efficiency of 72% in the synthesis process of OxPt nanoparticles and their subsequent encapsulation utilizing ginger extract. The nanoparticles demonstrated a size distribution within the 50–110 nm range and exhibited remarkable stability in colloidal form. The MTT assay results indicate that the OxPt NPs showed a favorable cytotoxic effect on colorectal cancer cells, as evidenced by an IC<sub>50</sub> value of 7.08 µM. Furthermore, flow cytometry data show that the nanoparticles primarily induced apoptosis as the mechanism of cell death rather than necrosis. The findings indicate that the synthesized OxPt NPs can be a new and efficient medication for addressing CRC. Overall, the present investigation showcases the efficacious amalgamation and delineation of OxPt nanoparticles, exhibiting their potential cytotoxic impacts on colorectal cancer cells.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1411 - 1423"},"PeriodicalIF":1.4,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141778846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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