Iranian Journal of Science and Technology, Transactions A: Science最新文献

DNAzyme Loaded Nano-Niosomes Confer Anti-Cancer Effects in the Human Breast Cancer MCF-7 Cells by Inhibiting Apoptosis, Inflammation, and c-Myc/cyclin D1 DNAzyme 负载纳米生物诺姆通过抑制细胞凋亡、炎症和 c-Myc/cyclin D1 在人类乳腺癌 MCF-7 细胞中发挥抗癌作用

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-08 DOI: 10.1007/s40995-024-01731-8

Leila Aghamohseni, Kavian Barzegarian, Mohammadreza Ferdowsinia, Neda Mousavi-Niri, Maryam Naseroleslami

{"title":"DNAzyme Loaded Nano-Niosomes Confer Anti-Cancer Effects in the Human Breast Cancer MCF-7 Cells by Inhibiting Apoptosis, Inflammation, and c-Myc/cyclin D1","authors":"Leila Aghamohseni, Kavian Barzegarian, Mohammadreza Ferdowsinia, Neda Mousavi-Niri, Maryam Naseroleslami","doi":"10.1007/s40995-024-01731-8","DOIUrl":"10.1007/s40995-024-01731-8","url":null,"abstract":"<div><p>One of the promising strategies for destroying cancer cells is using small-molecule gene-silencing strategies such as DNAzyme. In the current study, we used niosomes as carriers to promote drug residence and stability in the human breast cancer MCF-7 cells and explore possible molecular mechanisms. Preparing the niosomes was performed using thin-layer hydration method. Shape and size of the niosomes were assessed using transmission electron microscopy (TEM). Cell cytotoxicity, invasion and migration, apoptosis, inflammation and apoptosis related genes were evaluated by MTT assay, wound healing assay, flow cytometry, and Real-time PCR. Our results showed that DNAzyme loaded niosomes had more powerful effects against proliferation and migration of the human breast cancer MCF-7 cells compared to free DNAzyme. Effects of DNAzyme loaded niosomes is attributed to elevation of apoptosis, suppressing pro-inflammatory cytokines, and down-regulation of c-Myc/cyclin D1. In conclusion, our study declares that DNAzyme loaded niosomes possess stronger effects on destroying the human breast cancer MCF-7 cells than free DNAzyme by targeting apoptosis, inflammation, and c-Myc/cyclin D1.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1397 - 1410"},"PeriodicalIF":1.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cylindrical Gravastar Structure in Energy–momentum Squared Gravity 能动平方引力中的圆柱引力星结构

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-08 DOI: 10.1007/s40995-024-01715-8

M. Sharif, Saba Naz

{"title":"Cylindrical Gravastar Structure in Energy–momentum Squared Gravity","authors":"M. Sharif, Saba Naz","doi":"10.1007/s40995-024-01715-8","DOIUrl":"10.1007/s40995-024-01715-8","url":null,"abstract":"<div><p>We discuss the gravastar structure referred to as Mazur and Mottola model by taking into account the cylindrically symmetric line element. Gravastar configuration is completely characterized by three regions including inner and outer sectors where a very thin layer of ultra-relativistic matter namely shell domain separates these both regions. The interior sector occupying dark energy (cause of repulsive force) is specified by de-Sitter spacetime. Moreover, the exterior is fully vacuum where state parameters (density and pressure) are zero. The classical de-Sitter and Schwarzschild event horizons are replaced by an intermediate shell of small thickness, which is thought to be the critical surface for the quantum phase transition. For each of these three regions, we use different values of the equation of state parameter. We build a gravastar structure by adopting a particular model of the theory under consideration. For an isotropic static cylindrical matter configuration, we develop the equations of motion. Over hypersurface, matching of the interior as well as exterior regions yields surface energy density and surface pressure. The crucial feature of the newly obtained solution is that it is singularity free. Along with the estimation for the total gravastar mass, the energy density, total energy, proper length, mass and entropy of the shell domain are investigated in correspondence with this model. The developed gravastar model is physically viable and stable.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1669 - 1677"},"PeriodicalIF":1.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplication Operators on Generalized Orlicz Spaces Associated to Banach Function Spaces 与巴拿赫函数空间相关的广义奥立兹空间上的乘法算子

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-05 DOI: 10.1007/s40995-024-01723-8

Büsra Aris, Serap Öztop, Seyyed Mohammad Tabatabaie, Badik Hüseyin Uysal, Rüya Üster

引用次数: 0

Impact of Alginate Nanogel with Epigallocatechin and 5-azacytidine on ex vivo Studies Against Copper Ischemic Injury 含有表没食子儿茶素和 5-氮杂胞苷的海藻酸纳米凝胶对铜缺血性损伤体内外研究的影响

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-05 DOI: 10.1007/s40995-024-01725-6

R. Nikitha Shalom, Shoba Narayan

{"title":"Impact of Alginate Nanogel with Epigallocatechin and 5-azacytidine on ex vivo Studies Against Copper Ischemic Injury","authors":"R. Nikitha Shalom, Shoba Narayan","doi":"10.1007/s40995-024-01725-6","DOIUrl":"10.1007/s40995-024-01725-6","url":null,"abstract":"<div><p>Naturally derived biopolymers like alginate are widely used for tissue engineering as hydrogels, and their angiogenic properties have led to their use in clinical trials. Myocardial ischemia is a significant concern in the treatment of cardiovascular diseases. In this context, multi-target therapeutic strategies are gaining significant importance, and the present study is designed to prepare alginate nanogels (ANGs) entrapped with bioactive molecules epigallocatechin gallate (EGCG) and 5-azacytidine (5-A). The nanogels were characterized using various physiochemical techniques, including UV-visible spectroscopy, DLS and zeta, FTIR, XRD, HR-SEM, and AFM analysis, indicating the entrapment of both bioactive molecules in ANGs. The antioxidant ability of the nanogels was evaluated using DPPH and superoxide scavenging activity to evaluate their protective effect, and it was indicated that the nanogels have superior antioxidant activity due to the presence of EGCG. To understand the hemocompatibility of the nanogels with bioactive molecules, a hemolysis test was carried out, and the nanogels did not cause any significant hemolysis for the concentrations tested. An ex-vivo copper ascorbate system was used to induce cardiac injury in chicken hearts, and the antioxidant status of heart tissue revealed that nanogels ANGs/EGCG/5-A could maintain an antioxidant status comparable to that of the control group. Histopathological analysis further revealed that nanogels containing EGCG and 5-A could preserve the structural integrity via an antioxidant defence mechanism, thereby protecting the cardiac function. Further in-vivo studies can establish alginate-based nanogels as a therapeutic agent for myocardial injury.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1425 - 1441"},"PeriodicalIF":1.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piecewise Differential Equations for Prey-Predator Interactions: From Dyadic to Triadic 猎物与捕食者相互作用的片断微分方程：从二元到三元

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-05 DOI: 10.1007/s40995-024-01722-9

Seda Igret Araz, Maroua Amel Boubekeur

{"title":"Piecewise Differential Equations for Prey-Predator Interactions: From Dyadic to Triadic","authors":"Seda Igret Araz, Maroua Amel Boubekeur","doi":"10.1007/s40995-024-01722-9","DOIUrl":"10.1007/s40995-024-01722-9","url":null,"abstract":"<div><p>In this study, the applications of the concept of piecewise differential equations, a powerful mathematical tool for addressing different processes occurring at different time intervals, on prey-predator models were discussed. Thanks to this new concept, we aimed to provide a new perspective for prey-predator models in which ecological processes that start with dyadic interactions can also include triadic interactions after a while. More specifically, two prey-predator models were proposed, one dealing with the different scenarios where a second predator was introduced into an environment with a prey and a predator, and the other where an infected prey was introduced into an environment with a prey and a predator. Numerical simulations were carried out in order to have a graphical representation of the different behavior of these two new models under different scenarios. We strongly believe that this study provides a comprehensive overview of piecewise differential equations and contributions to the field of mathematical biology, especially in modeling prey-predator dynamics.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1613 - 1624"},"PeriodicalIF":1.4,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact and Spatial Pattern of Diffusion of Nutrient from Cage Culture by Using CORMIX Modeling in the Coastal Ecosystem of the Caspian Sea 利用 CORMIX 模型评估里海沿海生态系统中网箱养殖营养物质扩散的影响和空间模式

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-10-01 DOI: 10.1007/s40995-024-01687-9

Omidreza Touni, Nooshin Sajjadi, Farhad Moosakhani, Rooholah Mahmoudkhani

{"title":"Assessing the Impact and Spatial Pattern of Diffusion of Nutrient from Cage Culture by Using CORMIX Modeling in the Coastal Ecosystem of the Caspian Sea","authors":"Omidreza Touni, Nooshin Sajjadi, Farhad Moosakhani, Rooholah Mahmoudkhani","doi":"10.1007/s40995-024-01687-9","DOIUrl":"10.1007/s40995-024-01687-9","url":null,"abstract":"<div><p>Aquaculture contributes to elevated levels of phosphates and nitrates in both water and sediment, leading to reduced biodiversity and a proliferation of pollution-resistant organisms. One significant challenge in developing effective management strategies is the lack of accurate predictions regarding the dispersion and distribution of pollutants. Consequently, modeling water quality and pollutant distribution is crucial for evaluating these impacts. This study aims to spatially model nutrient release from fish breeding cages in the Sisangan region and assess its impact on water quality using the CORMIX numerical model. Conducted in November 2019 in the Caspian Sea, Mazandaran province, the research involved nine sampling stations. Physicochemical parameters were measured using a Conductivity-Temperature-Depth (CTD) device. Nutrient samples, including nitrogen and phosphorus compounds, were collected with a Niskin bottle and analyzed in the laboratory. Field sampling revealed an average TRIX index of 2.3, indicating oligotrophic water conditions but an elevated trophic state. Modeling results demonstrated that nitrogen and phosphorus concentrations decrease with increasing distance from the fish cages. The findings suggest a potential shift from oligotrophic to mesotrophic conditions due to the increased nutrient load from fish farming activities. This underscores the importance of understanding and managing the environmental impacts of marine aquaculture on water quality and ecosystem health. Effective management strategies must be developed to mitigate these impacts and ensure sustainable aquaculture practices.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1443 - 1452"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of Fluid System at the Chahfirouzeh Porphyry Cu Deposit, Kerman Cenozoic Magmatic arc, Iran 伊朗克尔曼新生代岩浆弧 Chahfirouzeh 斑岩铜矿床流体系统的演变

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-09-26 DOI: 10.1007/s40995-024-01699-5

Tayebeh Ramezani, Sina Asadi, Johar Ali

{"title":"Evolution of Fluid System at the Chahfirouzeh Porphyry Cu Deposit, Kerman Cenozoic Magmatic arc, Iran","authors":"Tayebeh Ramezani, Sina Asadi, Johar Ali","doi":"10.1007/s40995-024-01699-5","DOIUrl":"10.1007/s40995-024-01699-5","url":null,"abstract":"<div><p>The Chahfirouzeh porphyry copper deposit is situated within the Kerman Cenozoic magmatic arc and forms part of the Urumieh–Dokhtar magmatic belt in southern Iran. Copper mineralization in the deposit is associated to a Miocene diorite/granodiorite stock. The ore–forming process can be categorized into early, main, and late stages. Based on the microthermometry results, the salinities of the fluid system evolved from 5.86 to 16.15 wt% NaCl equivalent in the early stage, through bimodal ranges of 2.4–12.2 and 30.39–42.56 wt% NaCl equivalent in the main stage, and to 8.14–23 wt% NaCl equivalent in the late stage, strongly suggesting that fluid boiling and CO<sub>2</sub> escape occurred during the main stage of the Chahfirouzeh porphyry system. Furthermore, the total homogenization temperatures of fluid inclusions decrease from 327 to 492 °C during the early, to 313–458 °C during the main, and finally to 250–377 °C during the late events. Laser Raman results also show the presence of CO<sub>2</sub> and CH<sub>4</sub> in the main stage fluid inclusion, which may be due to an equilibrium between them linked to the transition from potassic to phyllic alteration. We propose that the phase separation and release of CO<sub>2</sub> could be crucial for enhancing the activities of NaCl and S<sup>2−</sup> in the fluids, reducing the oxidation of the fluids, and leading to the deposition of metal sulfides and the entrapment of halite–bearing inclusions in the Chahfirouzeh hydrothermal system.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1453 - 1461"},"PeriodicalIF":1.4,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dielectric, Ferroelectric, and Energy Storage Properties of Solvent Casted P(VDF-TrFE) Film 溶剂浇铸 P（VDF-TrFE）薄膜的介电、铁电和储能特性

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-09-24 DOI: 10.1007/s40995-024-01711-y

S. Parthasarathy, S. Behera, Srikanta Moharana

引用次数: 0

Regarding a Novel Subclass of Harmonic Multivalent Functions Defined by Higher-Order Differential Inequality 关于由高阶微分不等式定义的谐波多价函数的一个新子类

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-09-24 DOI: 10.1007/s40995-024-01697-7

Serkan Çakmak

引用次数: 0

Analysis of Bulk Arrival Recurrent Queue with Active and Passive Breakdowns 带主动和被动故障的批量到达循环队列分析

IF 1.4 4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2024-09-24 DOI: 10.1007/s40995-024-01673-1

Shweta Upadhyaya, Radhika Agarwal, Divya Agarwal

{"title":"Analysis of Bulk Arrival Recurrent Queue with Active and Passive Breakdowns","authors":"Shweta Upadhyaya, Radhika Agarwal, Divya Agarwal","doi":"10.1007/s40995-024-01673-1","DOIUrl":"10.1007/s40995-024-01673-1","url":null,"abstract":"<div><p>This study investigates the <span>(M^X/G/1)</span> queue with retrials and an optional service facility for the one who opts for it. Here the service provider may follow Bernoulli vacation schedule. If the server is occupied, the clients are forced to join the virtual orbit from where they retry for their primary essential service or secondary optional service . The service provider is subjected to either active breakdown when occupied or passive breakdown when unoccupied. Depending on their types of breakdown, they are subjected to either immediate or delayed repair, respectively. After each service, depending on the server’s choice, it may either go on a Bernoulli vacation or may serve the next client. Implementing the embedded Markov chain technique, the system’s ergodic condition is established. Also, the steady state solution for various queueing parameters is obtained using the generating functions defined for the queue length distribution. The consequences of different parameters on the performance measures have been illustrated numerically. Further to develop a low cost model, formulation of the cost function is done and the impact of sensitive parameters on the overall cost of the system is studied. The optimization of the cost function using a soft computing technique, Artificial Bee Colony is also discussed which makes the system cost effective.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"48 6","pages":"1473 - 1487"},"PeriodicalIF":1.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0