Iranian Journal of Science and Technology, Transactions A: Science最新文献_第3页

Imidazole–Thiazole Hybrid: Synthesis, Brain Penetration, Cytochrome P450 Enzyme and Gastrointestinal Absorption Study 咪唑-噻唑杂合物:合成、脑渗透、细胞色素P450酶及胃肠道吸收研究

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-17 DOI: 10.1007/s40995-023-01496-6

Shital M. Dekate, Kishor M. Hatzade, Ajay M. Ghatole

{"title":"Imidazole–Thiazole Hybrid: Synthesis, Brain Penetration, Cytochrome P450 Enzyme and Gastrointestinal Absorption Study","authors":"Shital M. Dekate, Kishor M. Hatzade, Ajay M. Ghatole","doi":"10.1007/s40995-023-01496-6","DOIUrl":"10.1007/s40995-023-01496-6","url":null,"abstract":"<div><p>Thiazoles, imidazoles, and related derivatives are prominent heterocyclic molecules. Even though the chemistry of imidazole compounds with thiazole moiety has an ancient legacy, the rigorous search for biologically active substances in the imidazole series barely emerged in the last few cascades. The purpose of this communication is to highlight medicinally active substances, while also recent syntheses, which have been reported to still have antimicrobial activities. The present investigation identifies the synthesis and spectroscopic characterization of new 2-amino-4-aryl-1, 3-thiazole-5-carboxaldehydes, their imidazole derivatives, and Schiff bases with various substituted benzaldehydes, including the antimicrobial and antifungal activities among these compounds. The majority of the synthesized compounds are Pgp substrates and CYP3A4 inhibitors, according to the analysis of their pharmacokinetic properties. The overall findings of this study indicated that the molecular to physiologically intriguing imidazole scaffold with varied aromatic substituents was an intriguing methodology for the creation of antibacterial medicines.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1081 - 1096"},"PeriodicalIF":0.0,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4975893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benzofuran Substituted Chalcone Derivatives Trigger Apoptotic Cell Death Through Extrinsic Pathway in Human Lung and Breast Cancer Cells 苯并呋喃取代查尔酮衍生物通过外源性途径触发人肺癌和乳腺癌细胞凋亡细胞死亡

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-12 DOI: 10.1007/s40995-023-01494-8

Imren Alioglu, Sibel Cinar-Asa, Demet Coskun, Ferda Ari

{"title":"Benzofuran Substituted Chalcone Derivatives Trigger Apoptotic Cell Death Through Extrinsic Pathway in Human Lung and Breast Cancer Cells","authors":"Imren Alioglu, Sibel Cinar-Asa, Demet Coskun, Ferda Ari","doi":"10.1007/s40995-023-01494-8","DOIUrl":"10.1007/s40995-023-01494-8","url":null,"abstract":"<div><p>In this study, the anticancer potential of benzofuran-substituted chalcone derivatives Compound 1 [(3-(Benzofuran-2-yl) -5-(4-N, N-dimethylaminophenyl)-2-pyrazoline)], Compound 2 [(4) -((1E)-3-(1)-benzofuran-2-yl)-3-oxoprop-1-en-1-yl]-2-methoxyphenylchloroacetate), Compound 3 [(3-(Benzofuran-2-yl)) -5-(thiophen-2-yl)-2-pyrazoline)] and Compound 4 [3-[(1E)-3-(1-benzofuran-2-yl)-3-oxoprop-1-en-1-yl)] phenyl chloroacetate) was investigated. Their cytotoxic and apoptotic effects were explored on the human breast (MCF-7 and MDA-MB-231) and lung (A549 and H1299) cancer cells by SRB and ATP cell viability assays and Hoechst 33342/Propidium Iodide dual staining. Expressions of proteins were examined by Western blot, and cell migration test was performed for metastatic effect. In conclusion, it has been shown that Compounds 2 and 4 have high cytotoxic activity on both human breast MCF-7 (IC<sub>50</sub>:9.37–2.71) and MDA-MB-231 (IC<sub>50</sub>:5.36–2.12) and lung A549 (IC<sub>50</sub>:3.23–2.21) and H1299 (IC<sub>50</sub>:6.07–2.92) cancer cell lines respectively. In addition, it has been found that Compounds 2 and 4 induce apoptosis via extrinsic pathway in the cells. Besides, they inhibited the migration of the cells showing antimetastatic potential.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1057 - 1069"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4798245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cell-Free Supernatant of L. buchneri Probiotic Bacteria Enhancing Apoptosis Activity in AGS Gastric Cancer Cells 布氏乳杆菌益生菌上清液增强AGS胃癌细胞凋亡活性

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-12 DOI: 10.1007/s40995-023-01495-7

Adel Abedi, Farzaneh Tafvizi, Neda Akbari, Parvaneh Jafari

{"title":"Cell-Free Supernatant of L. buchneri Probiotic Bacteria Enhancing Apoptosis Activity in AGS Gastric Cancer Cells","authors":"Adel Abedi, Farzaneh Tafvizi, Neda Akbari, Parvaneh Jafari","doi":"10.1007/s40995-023-01495-7","DOIUrl":"10.1007/s40995-023-01495-7","url":null,"abstract":"<div><p>The current study aimed to evaluate the cytotoxic activity and apoptosis induction of cell-free supernatants (CFS) from <i>Lactobacillus buchneri</i> of traditional dairy products on the AGS gastric cancer cell line. Molecular identification of probiotic <i>L. buchneri</i> was carried out using <i>16S rRNA</i> PCR and sequencing. MTT assay, Annexin V-FITC, qRT-PCR, and cell cycle analysis were conducted to evaluate the induction of apoptosis in AGS-treated cells. The <i>L. buchneri</i> CFS inhibited the proliferation of AGS cancer cells in a dose- and time-dependent manner, which had great anticancer activity at 200 µg/mL after 72 h. Flow cytometry results confirmed the highest rate of apoptosis in cancer cells treated with IC<sub>50</sub> concentration of CFS after 72 h. <i>L. buchneri</i> supernatant also triggered the up-regulation of pro-apoptotic genes including BCL2-associated X<i>,</i> caspase 9, and caspase 3 genes. Treatment of cancer cells with CFS at IC<sub>50</sub> concentration caused the cell cycle arrest in the sub-G1 phase in a time-dependent manner. This study revealed that <i>L. buchneri</i> obtained from Iranian traditional yogurt may protect the host from gastric cancer by triggering apoptosis in cancer cells. Therefore, <i>L. buchneri</i> supernatant can be employed as a biological anticancer agent in the management and treatment of gastric cancer.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1071 - 1079"},"PeriodicalIF":0.0,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4496849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Properties of Stability and Local Hopf Bifurcation for an HBV Model with Two Delays 双时滞HBV模型的稳定性和局部Hopf分岔性质

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-10 DOI: 10.1007/s40995-023-01482-y

Hongzheng Quan, Xiao Yan, Xueyong Zhou

引用次数: 0

In Vivo Evaluation of Recombinantly Expressing M-Cell-Targeting Co1 Peptide Fused with VP1 of Enterovirus A71 Capsid 肠病毒A71衣壳重组表达靶向m细胞的Co1肽与VP1融合的体内评价

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-08 DOI: 10.1007/s40995-023-01489-5

Tien Ngo-My, Duy Nguyen-Le, Truong-Thang Le, Quoc-Gia Mai, Hai-Vy Vo-Nguyen, Anh-Huy Ngoc Nguyen, Khanh-Linh Thi Dao, Kiep Thi Quang, Huyen-Trang Thi Vu, Thanh-Thao Thi Nguyen, Hieu Tran-Van

{"title":"In Vivo Evaluation of Recombinantly Expressing M-Cell-Targeting Co1 Peptide Fused with VP1 of Enterovirus A71 Capsid","authors":"Tien Ngo-My, Duy Nguyen-Le, Truong-Thang Le, Quoc-Gia Mai, Hai-Vy Vo-Nguyen, Anh-Huy Ngoc Nguyen, Khanh-Linh Thi Dao, Kiep Thi Quang, Huyen-Trang Thi Vu, Thanh-Thao Thi Nguyen, Hieu Tran-Van","doi":"10.1007/s40995-023-01489-5","DOIUrl":"10.1007/s40995-023-01489-5","url":null,"abstract":"<div><p>Hand Foot Mouth disease, infected via the epithelium penetration of Enterovirus A71 (EVA71), causes neurological complications in children under five years old. VP1 is the most revealed protein capsid, gastric acid endurance, and immunogenic epitope expression of the EVA71. Co1 peptide is the ligand of the M cell, the main gate of the intestinal immune barrier, helping to transport antigens to the Gut-Associated Lymphoid Tissue in order to provoke mucosal immunity to secrete IgA. However, the present injectable vaccine of EVA71 only triggers IgG secretion but not IgA, which is ineffective for the prevention of mucosal-infected virus. Here we showed that the fusion of M-cell targeting Co1 peptide and VP1 protein, when orally gavaged, enhanced both IgA and IgG secretions. CO1-VP1 group’s antibody titer of fecal IgA had commenced on day three, the titer continued to increase doubly during the second week and fluctuated statically until the end of the experiment and were significantly higher than those of PBS and VP1 groups. Both types of antibody of the CO1-VP1 group had higher titer binding to VP1 antigen and EVA71 capsid than those of the VP1 group. The results provided the foundation for M cell-targeting oral vaccine development against EVA71 and for its clinical treatment of blood or neurological post-infection.</p><h3>Graphical Abstract</h3>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1049 - 1056"},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40995-023-01489-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4345035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Production of Cellulase Enzymes by Rhizomucor miehei Isolates in the Submerged Culture Containing Wheat Bran 麦麸深层培养中米黑根霉分离株生产纤维素酶的研究

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-08 DOI: 10.1007/s40995-023-01485-9

Athar Sadat Javanmard, Maryam M. Matin, Ahmad Reza Bahrami

{"title":"Production of Cellulase Enzymes by Rhizomucor miehei Isolates in the Submerged Culture Containing Wheat Bran","authors":"Athar Sadat Javanmard, Maryam M. Matin, Ahmad Reza Bahrami","doi":"10.1007/s40995-023-01485-9","DOIUrl":"10.1007/s40995-023-01485-9","url":null,"abstract":"<div><p>Large amounts of inedible materials including agricultural and forest residues are discarded or burnt annually. Bioconversion of these abundant, cheap and renewable materials to valuable biofuels is a significant issue in biotechnology. Enzymatic degradation of lignocellulosic biomass is the most expensive phase in biofuel production process, and cellulases play important roles in this phase. In this study, we aimed to find thermophilic cellulase-producing filamentous fungi which are compatible with the properties of this critical stage (acidic pH and high temperature). Four cellulase producing isolates (from cow manure samples) and <i>Rhizomucor miehei</i> PTCC 5155 (as a reference fungus) were grown in a simple medium containing salt solution, peptone and wheat bran in the submerged culture and investigated for their cellulase activities (at acidic condition (pH 5.5) and 50 °C temperature) during a 12-day period. FUM 4-6 isolate showed the highest levels of endoglucanase (70.95 U/g) and Filter Paperase (17.61 U/g) activities at day 8. Endoglucanase activity of FUM 4-6 isolate was measured approximately twofold levels of reference fungus enzyme activity. FUM 4-14 isolate exhibited the highest activity of exoglucanase (4.64 U/g) at day 8, which statistically was higher than reference fungus enzyme activity (3.32 U/g). Respecting our findings, it seems that <i>Rhizomucor miehei</i> FUM 4-6 isolate could be a suitable candidate for further studies in the field of cellulase enzymes production with the purpose of utilizing in biofuel production.\u0000</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1039 - 1048"},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40995-023-01485-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4341648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Reduced-Order Finite Difference Scheme Based on POD for Fractional Stochastic Advection–Diffusion Equation 基于POD的分数阶随机平流扩散方程降阶有限差分格式

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-06 DOI: 10.1007/s40995-023-01490-y

Z. Soori, A. Aminataei, D. Baleanu

引用次数: 0

On Sequence Spaces Due to lth Order q-Difference Operator and its Spectrum 关于第l阶q差算子的序列空间及其谱

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-07-04 DOI: 10.1007/s40995-023-01487-7

Taja Yaying, Bipan Hazarika, Syed Abdul Mohiuddine, Mikail Et

引用次数: 0

An Integrated Model of Maintenance Policies and Economic Design of X-bar Control Chart Under Burr XII Shock Model Burr 12冲击模型下x柱控制图维护策略与经济性设计的集成模型

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-06-20 DOI: 10.1007/s40995-023-01486-8

Ali Akbar Heydari, Masoud Tavakoli, Abdur Rahim

{"title":"An Integrated Model of Maintenance Policies and Economic Design of X-bar Control Chart Under Burr XII Shock Model","authors":"Ali Akbar Heydari, Masoud Tavakoli, Abdur Rahim","doi":"10.1007/s40995-023-01486-8","DOIUrl":"10.1007/s40995-023-01486-8","url":null,"abstract":"<div><p>The combination of different methods of maintenance and economic design of control charts has received much attention from researchers in recent years. These maintenance policies increase the reliability of a system. So far, only a small number of failure distributions, with fixed or increasing hazard rates, have been used as a shock model in the integrated model of maintenance and economic design of X-bar control chart. A proper alternative for this situation may be the Burr distribution, in which the hazard rate has general form. In this paper, for the economic design of the X-bar control chart under the Burr XII shock model, we have presented an integrated model using preventive maintenance and incomplete maintenance. The obtained integrated model has been implemented using a numerical example and its sensitivity analysis has been performed. The results show that, the use of higher maintenance levels causes further reduction of the average cost per unit time of the quality cycle. The results of sensitivity analysis also show that our proposed model is not sensitive to the misspecification of the Burr XII distribution parameters.\u0000</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1261 - 1269"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40995-023-01486-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4795023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Crystal Structural, Optical and Morphological Studies of Transition Metal Oxide Nanoparticles and their Photocatalytic Activity 过渡金属氧化物纳米颗粒的快速晶体结构、光学和形态学研究及其光催化活性

4区综合性期刊

Iranian Journal of Science and Technology, Transactions A: Science Pub Date : 2023-06-20 DOI: 10.1007/s40995-023-01483-x

S. Arul Vathana, K. Amudhavalli, T. Daniel

{"title":"Rapid Crystal Structural, Optical and Morphological Studies of Transition Metal Oxide Nanoparticles and their Photocatalytic Activity","authors":"S. Arul Vathana, K. Amudhavalli, T. Daniel","doi":"10.1007/s40995-023-01483-x","DOIUrl":"10.1007/s40995-023-01483-x","url":null,"abstract":"<div><p>In the present work, we report a green synthesis of cobalt oxide (Co<sub>3</sub>O<sub>4</sub>), bismuth oxide (Bi<sub>2</sub>O<sub>3</sub>) and cobalt-doped bismuth oxide (Co-doped BiO) nanoparticles using Bambusa seed extract. The green synthesized nanoparticles are characterized using various techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV–visible spectroscopy and field emission scanning electron microscopy (FESEM). The phase purity of the synthesized nanoparticles is confirmed with the aid of XRD analysis, and the crystallite sizes are found to be 10.42 nm, 18.85 nm and 61.23 nm for Co<sub>3</sub>O<sub>4,</sub> Bi<sub>2</sub>O<sub>3</sub> and Co-doped BiO nanoparticles, respectively. Bond length calculations and functional group analysis are done by FTIR technique. The UV–visible analysis depicts higher optical absorption and band gaps varying from 1.81, 2.65 and 1.87 eV for Co<sub>3</sub>O<sub>4,</sub> Bi<sub>2</sub>O<sub>3</sub> and Co-doped BiO nanoparticles, respectively. Changes in the surface morphology are observed from FESEM analysis. In addition, the samples' catalytic efficiency in the breakdown of methylene blue (MB) dye was studied and the effects of various process parameters on the extent of dye removals such as photocatalyst amount, irradiation period, the concentration of dye and pH of the solution were also studied. The pseudo-first-order MB photocatalytic decomposition kinetic model has a high correlation coefficient value (<i>R</i><sup>2</sup> > 0.95). The findings support the use of a Co-doped BiO in the field of photocatalytic applications under natural sunlight.</p></div>","PeriodicalId":600,"journal":{"name":"Iranian Journal of Science and Technology, Transactions A: Science","volume":"47 4","pages":"1407 - 1420"},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4794102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0