中华医学科研管理杂志最新文献

{"title":"Study on the relationship between the 2019 Novel Coronavirus Disease epidemic in China and population migration from Wuhan/ 中华医学科研管理杂志","authors":"Hong‐tian Li, Zhi-hao Cheng, Yong-ying Huang, Jian-meng Liu","doi":"10.3760/CMA.J.CN113565-20200213-00006","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200213-00006","url":null,"abstract":"Objective@#To investigate the relationship between the epidemic of Coronavirus Disease in 2019 (COVID-19) in China and population migration from Wuhan before the city implemented strict migration restrictions.@*Methods@#We collected the cumulative number of confirmed cases with COVID-19 up to January 31, 2020 from the official website of the health administrative departments, and information on population migration out of Wuhan during January 10, 2020 and January 24, 2020, approximately half months prior to the implementation of strict migration restrictions by the city, from Baidu population-migration big data platform. Population migration data were provided for the top 100 cities in the form of percentage values, calculated as the number of migrants from Wuhan into these cities divided by the total number of migrants out of Wuhan during the same period multiplied by 100%. The two-independent sample non-parametric Wilcoxon rank-sum test was used to compare the distribution of cumulative number of cases between the top 100 cities and the remaining 205 non-top 100 cities of China. The relationship between the cumulative number of cases and the percentage of migrants from Wuhan into the top 100 cities were further assessed by Pearson correlation and by multiple linear regression with adjustment for population size, population density, and GDP per capita.@*Results@#The top 100 cities accounted for 91.6% of total migrants out of Wuhan, and the top 14 cities were all in Hubei province. There were a total of 5,869 cases in the top 100 cities, with a median (interquartile range) of 21.5 (12~55) cases, whereas in the 205 non-top 100 cities there were a total of 1,063 cases, with a median (interquartile range) of 4 (2~7) cases. The median cumulative number of cases differed significantly between the two types of cities (P<0.001). Among the top 100 cities, there was a strong correlation between the percentage of migrants from Wuhan and the cumulated number of cases (Pearson correlation coefficient=0.92), and for every 1 percentage point increase in migrants from Wuhan the cumulative number of cases increased by approximately 42 (95%CI, 39 to 45). The number of cumulative number of cases in Wenzhou and Chongqing was detected as potential outliers in regression diagnosis (P<0.001, corresponding standardized residuals were 5.2 and 3.5, respectively), suggesting that the number of cases in these two cities was substantially higher than others with similar amount of migrants from Wuhan.@*Conclusions@#There is a strong positive association between the percentage of migrants from Wuhan and the epidemic status of COVID-19 infections in cities in China.","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45643473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on the design of special CT room for epidemic prevention in fever clinic to deal with COVID-19/ 中华医学科研管理杂志","authors":"Xiaoqi Xue, Jiabin Lu, Jincai Pi, Jin Tian, Feng Xu","doi":"10.3760/CMA.J.CN113565-20200214-00016","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200214-00016","url":null,"abstract":"Objective \u0000New infectious diseases have become a global problem that seriously threatens human life and health and social development, which greatly increases the demand of CT examination for outpatients with fever. Through the discussion of the examination room design of the special CT for epidemic prevention, it can provide reference for medical institutions and reduce cross infection. \u0000 \u0000 \u0000Methods \u0000Based on the requirements of CT equipment installation and environment, combined with the special requirements of epidemic prevention in fever clinic, the paper analyzed the location of examination room, room layout, site construction method, air purification and disinfection, intelligent image aided diagnosis of special CT for epidemic prevention, and put forward the design scheme. \u0000 \u0000 \u0000Results \u0000Through the detailed analysis of the key points of engineering technology and the requirements of infection prevention and control of CT examination room, the design scheme of the examination room was given. \u0000 \u0000 \u0000Conclusions \u0000The establishment of special CT for epidemic prevention can meet the needs of clinical examination and effectively reduce cross infection. The design scheme given in this paper has certain reference value and can provide effective help for medical institution. \u0000 \u0000 \u0000Key words: \u0000COVID-19; Computerised tomography; Design of examination room","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46708980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the layout of China’s emergency research projects during the public health emergency of COVID-19/ 中华医学科研管理杂志","authors":"Bi Zhang, Huifang Zhang, Hanlu Li, Lingling Yu, Miao Miao, Wei Liu, Pengjun Zhang","doi":"10.3760/CMA.J.CN113565-20200214-00003","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200214-00003","url":null,"abstract":"Objective \u0000To explore the main layout and countermeasures of Scientific research projects during the public health emergency of COVID-19. \u0000 \u0000 \u0000Methods \u0000Literature investigation method is applied to collect information of scientific research and emergency research projects of COVID-19 funded since January 20th by different entities including national, provincial and municipal administrative departments, public health agencies, research institutes, universities and industries. \u0000 \u0000 \u0000Results \u0000Along with priorities identified for the emergency response and key research agendas, the national science and technology authorities at all levels and scientific research institutions have deployed a series of new science and technology projects, as well as a number of supporting policies and measures. \u0000 \u0000 \u0000Conclusions \u0000In the campaign of science and technology to deal with COVID-19, the leadership of Chinese government and their coordination with local agencies facilitated quick response in both R&D investment and supporting policies. Periodical achievement is recognized so far, and with the continuous development and in-depth research, the related scientific research results will be gathered into the core force of epidemic prevention. Moreover, it will improve China's capacity to deal with health emergencies and the level of medical health innovation, and better protect the health of the people. \u0000 \u0000 \u0000Key words: \u0000COVID-19; Project layout; Research support","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47108174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective on computer aided drug discovery for anti-SARS-CoV-2","authors":"Qinghua Cui, Chuanbo Huang","doi":"10.3760/CMA.J.CN113565-20200213-00010","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200213-00010","url":null,"abstract":"Objective \u0000To explore theresearch progress of the computer aided drug discovery for SARS-CoV-2 drugs. \u0000 \u0000 \u0000Methods \u0000Comprehensively searching internetresour-ces including news report,research papers in scientific journals and academic preprint websites. \u0000 \u0000 \u0000Results \u0000Since the outbreak of COVID-19, researchers in China and all over the world rapidly start to search drugs for anti-SARS-CoV-2and some progresses were made. This paper reviewed the progress of computer aided discovery of SARS-CoV-2 drugs. \u0000 \u0000 \u0000Conclusions \u0000Both docking and bioinformatics based methods had achievements and a number of candidate drugs have been identified, but more novel targets should be considered in the future. \u0000 \u0000 \u0000Key words: \u0000Novel coronavirus; SARS-CoV-2; Drug discovery","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epitranscriptome analysis of COVID-19 prevention and control/ 中华医学科研管理杂志","authors":"Meiling Zhang, Kun Wang, Xiao Liu, Jinying Peng, C. Yi","doi":"10.3760/CMA.J.CN113565-20200212-00009","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200212-00009","url":null,"abstract":"Objective@#The purpose of this review of COVID-19 related research is to deepen our understanding of SARS-CoV-2, which would be inspire new ideas for targeted drug development and vaccine design, and further empower the prevention and control COVID-19.@*Methods@#Through literature research and data analysis, we explored the process and mechanism of epitranscriptomics modification to regulate the replication and infectivity of COVID-19.@*Results@#Provide important ideas and technical support for the prevention and control of SARS-CoV-2 infections and emerging epidemic diseases.@*Conclusions@#Taking the new research direction of epitranscriptomics as the starting point, it is expected to open up new scientific research concepts and paradigms.","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44897283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the ethical review criteria and management of COVID-19 Emergency Research/ 中华医学科研管理杂志","authors":"Haihong Zhang, Jie Li, Yu Xiao, Guowei Liang, Liyan Zhao, N. Zhang","doi":"10.3760/CMA.J.CN113565-20200213-00005","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200213-00005","url":null,"abstract":"Objective@#Conduct comprehensive analysis of the regulatory requirement of ethical review regarding to the response of public health emergency, illustrate particular ethical review and ethical administration strategies for COVID-19 Emergency Research.@*Methods@#Theoretical discussion, case study and interpretation of international guidelines were adopted to explore challenges and possible best practices for ethical review of such research.@*Results@#The ethical review of COVID-19 emergency research should comply with regulatory requirement in general, combined with contextual background.@*Conclusions@#The ethical review approval criteria of COVID-19 emergency research should take into full consideration of its urgency to make sure efficient and high quality initial review, meanwhile, more attention should be paid on continuing ethical review and ethical consultation during the whole life-circle of COVID-19 Emergency Research.","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70010847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problem exploration and measures on the investigator initiated trial from the perspective of scientific research supervision","authors":"lian Xue, Xiaoliang Zhu, Xingyuan Hu, Wentao Tang, Liling Lin, Tao Cen, Zhigang Liu, P. Peng, Hong Lu","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.005","url":null,"abstract":"Objective \u0000By analyzing the problems existed in the Investigator Initiated Trial(IIT), this article put forward the corresponding countermeasures and therefore provides reference for the standardization of clinical research project management. \u0000 \u0000 \u0000Methods \u0000Four types of problems identified in the supervision of hospital IIT projects are analyzed according to literature review, data analysis of clinical research project, comparative study and summary. Identified problems are existed in the following aspects: scientific research supervision function, research method guidelines, technical specification of the diagnosis and treatment, scientific research design and project approval review, research funds, medical ethics committee, construction of Biobank and Regulation Conflicts. \u0000 \u0000 \u0000Results \u0000This article put forward 6 countermeasures for improvement: establishing and perfect IIT project scientific research supervision entity, bring in the IIT project steering group to strengthen the scientific review; Strengthen risk management to ensure medical safety, carry out IIT training, establish IIT management database information system, build a comprehensive integrated development multi-point application model of hospital BioBank. \u0000 \u0000 \u0000Conclusions \u0000The establishment of the hospital's IIT scientific research supervision system, management mode and technical standard system is of great importance to standardize clinical research, ensure research quality and guide the clinical research work of the hospital effectively. \u0000 \u0000 \u0000Key words: \u0000Scientific research supervision; Investigator initiated trial(IIT); Problem; Countermeasures","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44860180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent information analysis of 77 medical and health institutions in Zhejiang Province","authors":"Congcong Yan, Y. Ma, Qifeng Zhang, Renzhi Lin, Zaifeng Yang, F. Zhu, Hanjie Ding, H. Gu","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.008","url":null,"abstract":"Objective \u0000To grasp the general situation of patent application and authorization of 77 medical and health institutions in Zhejaing, to provide reference and basis for promoting the patent application and conversion. \u0000 \u0000 \u0000Methods \u0000Patent data were searched through Bai Teng net patent database, and SPSS 19.0 was used for statistical analysis. \u0000 \u0000 \u0000Results \u0000The total number of patent application showed a trend of generally rise. There were 1430 valid invention patents in total, among which 264 were invention patents and 1166 utility model patents. The total number of patens as well as invention patents were positive correlated to province's GDP and doctors per thousand population(r=0.824, 0.812, 0.784, 0.771 respectively, P<0.001). The rate of collaborative patent application was 6.28%, and there was a significant difference (α=0.05/3, P<0.001) in the collaborative patent applications around Hangzhou, provincial and other cities medical and health institutions. \u0000 \u0000 \u0000Conclusions \u0000The total number of patents in 77 medical and health institutions in Zhejaing has reached a certain scale, and the number of patents increase with the economic development and the number of doctors per thousand population. The effective patents present in concentrating in regions, and the proportion of invention patents was low. \u0000 \u0000 \u0000Key words: \u0000Patent; Intellectual property; Medical hygiene","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"353-357"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42811920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and application of intelligent evaluation system for scientific research performance","authors":"Li Dan, Bai Songtao, Chu Danqi, W. Xiaoyun, Yao Yan, Cao Ye-ding","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.012","url":null,"abstract":"Objective \u0000The study built a scientific performance assessing model by using information technology to construct an intelligent reviewing system, in order to provide intelligent and normalized evaluation services for scientific research performance. \u0000 \u0000 \u0000Methods \u0000A comprehensive and novel practical scientific performance reviewing system was established to provide objective evaluation of scientific output, which was based on accumulated experience in Fuwai Hospital and ample discussion by the experts of academic committee. \u0000 \u0000 \u0000Results \u0000Scientific performance assessment service, which carried out by the collaboration of scientific research management department and informational technology center, were including senior professional title self-assessing system, annual scientific research performance assessing system on both the department basis and individual basis. All the service received satisfactory effect making the assessing service from manual to intelligent. It helps the assessment result turn into openness, fairness and justice. The establishment of the intelligent scientific performance assessing system broaden the mind and provide the basis for the further scientific reward self-evaluation, scientific project application conditions filtering, technology professionals intelligent screening, supervising qualification self-evaluation and scientific project self-reviewing etc. \u0000 \u0000 \u0000Conclusions \u0000The establishment of scientific performance reviewing system effectively avoided the subjective influence, provided timely, highly efficient and accurate evaluating service and comparative analysis, enabling the assessment result much more objective and fair. It merits the promotional value. \u0000 \u0000 \u0000Key words: \u0000Evaluation of scientific research performance; Intelligent evaluation; Information system","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"376-380"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46112372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and analysis on the status quo of education and management on research integrity: Taking hospitals, medical colleges and medical research institutes for example","authors":"Pengjun Zhang, B. Peng, Qiang Gao, Lingling Yu, Miao Miao, Yuantai Du","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.001","url":null,"abstract":"Objective \u0000To understand the current situation of education and management of research integrity in hospitals, medical colleges and medical research institutes. \u0000 \u0000 \u0000Methods \u0000A questionnaire survey and data analysis were conducted among 115 management personnel of scientific research and education management departments in 40 hospitals, medical colleges and medical research institutes. \u0000 \u0000 \u0000Results \u000069.57% of the management personnel showed their institutions were able to offer courses related to academic norms or research integrity, 71.30% of the management personnel showed their institutions have formulated punishment regulations related to violating academic integrity or ethics, and 59.13% of the management personnel showed their institutions were able to take the initiative to impose punishment measures after identification research misconduct, more than50% of the management personnel agree it is very necessary to promulgate corresponding rules and regulations, establish research integrity files, implement the one-vote veto system for those who seriously violate research integrity, and carry out research integrity education/academic ethics training/normative education among researchers, more than 70% of the management personnel believe that system constraints, integrity education, increasing penalties, clear responsibilities, supervision and whistleblowing can reasonably and effectively prevent violations of research integrity. \u0000 \u0000 \u0000Conclusions \u0000The education and management of research integrity in hospitals, medical colleges and medical research institutes need to be improved. We should further strengthen the education, training and dissemination of research integrity, improve the cognitive level and self-discipline awareness of research integrity, formulate and improve relevant management systems, supervisory and disciplinary mechanisms. Then, we should purify academic atmosphere and create a good academic atmosphere. \u0000 \u0000 \u0000Key words: \u0000Medicine; Scientific research management; Research integrity; Integrity education; Integrity management","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"321-324"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43850286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}