中华医学科研管理杂志最新文献

{"title":"Perspective on computer aided drug discovery for anti-SARS-CoV-2","authors":"Qinghua Cui, Chuanbo Huang","doi":"10.3760/CMA.J.CN113565-20200213-00010","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200213-00010","url":null,"abstract":"Objective \u0000To explore theresearch progress of the computer aided drug discovery for SARS-CoV-2 drugs. \u0000 \u0000 \u0000Methods \u0000Comprehensively searching internetresour-ces including news report,research papers in scientific journals and academic preprint websites. \u0000 \u0000 \u0000Results \u0000Since the outbreak of COVID-19, researchers in China and all over the world rapidly start to search drugs for anti-SARS-CoV-2and some progresses were made. This paper reviewed the progress of computer aided discovery of SARS-CoV-2 drugs. \u0000 \u0000 \u0000Conclusions \u0000Both docking and bioinformatics based methods had achievements and a number of candidate drugs have been identified, but more novel targets should be considered in the future. \u0000 \u0000 \u0000Key words: \u0000Novel coronavirus; SARS-CoV-2; Drug discovery","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epitranscriptome analysis of COVID-19 prevention and control/ 中华医学科研管理杂志","authors":"Meiling Zhang, Kun Wang, Xiao Liu, Jinying Peng, C. Yi","doi":"10.3760/CMA.J.CN113565-20200212-00009","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200212-00009","url":null,"abstract":"Objective@#The purpose of this review of COVID-19 related research is to deepen our understanding of SARS-CoV-2, which would be inspire new ideas for targeted drug development and vaccine design, and further empower the prevention and control COVID-19.@*Methods@#Through literature research and data analysis, we explored the process and mechanism of epitranscriptomics modification to regulate the replication and infectivity of COVID-19.@*Results@#Provide important ideas and technical support for the prevention and control of SARS-CoV-2 infections and emerging epidemic diseases.@*Conclusions@#Taking the new research direction of epitranscriptomics as the starting point, it is expected to open up new scientific research concepts and paradigms.","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44897283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the ethical review criteria and management of COVID-19 Emergency Research/ 中华医学科研管理杂志","authors":"Haihong Zhang, Jie Li, Yu Xiao, Guowei Liang, Liyan Zhao, N. Zhang","doi":"10.3760/CMA.J.CN113565-20200213-00005","DOIUrl":"https://doi.org/10.3760/CMA.J.CN113565-20200213-00005","url":null,"abstract":"Objective@#Conduct comprehensive analysis of the regulatory requirement of ethical review regarding to the response of public health emergency, illustrate particular ethical review and ethical administration strategies for COVID-19 Emergency Research.@*Methods@#Theoretical discussion, case study and interpretation of international guidelines were adopted to explore challenges and possible best practices for ethical review of such research.@*Results@#The ethical review of COVID-19 emergency research should comply with regulatory requirement in general, combined with contextual background.@*Conclusions@#The ethical review approval criteria of COVID-19 emergency research should take into full consideration of its urgency to make sure efficient and high quality initial review, meanwhile, more attention should be paid on continuing ethical review and ethical consultation during the whole life-circle of COVID-19 Emergency Research.","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70010847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problem exploration and measures on the investigator initiated trial from the perspective of scientific research supervision","authors":"lian Xue, Xiaoliang Zhu, Xingyuan Hu, Wentao Tang, Liling Lin, Tao Cen, Zhigang Liu, P. Peng, Hong Lu","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.005","url":null,"abstract":"Objective \u0000By analyzing the problems existed in the Investigator Initiated Trial(IIT), this article put forward the corresponding countermeasures and therefore provides reference for the standardization of clinical research project management. \u0000 \u0000 \u0000Methods \u0000Four types of problems identified in the supervision of hospital IIT projects are analyzed according to literature review, data analysis of clinical research project, comparative study and summary. Identified problems are existed in the following aspects: scientific research supervision function, research method guidelines, technical specification of the diagnosis and treatment, scientific research design and project approval review, research funds, medical ethics committee, construction of Biobank and Regulation Conflicts. \u0000 \u0000 \u0000Results \u0000This article put forward 6 countermeasures for improvement: establishing and perfect IIT project scientific research supervision entity, bring in the IIT project steering group to strengthen the scientific review; Strengthen risk management to ensure medical safety, carry out IIT training, establish IIT management database information system, build a comprehensive integrated development multi-point application model of hospital BioBank. \u0000 \u0000 \u0000Conclusions \u0000The establishment of the hospital's IIT scientific research supervision system, management mode and technical standard system is of great importance to standardize clinical research, ensure research quality and guide the clinical research work of the hospital effectively. \u0000 \u0000 \u0000Key words: \u0000Scientific research supervision; Investigator initiated trial(IIT); Problem; Countermeasures","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44860180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development strategy of medicine discipline in comprehensive university under the background of \" Double First-Class\" construction","authors":"Yuan Cao, Chunhui Zhao, Yu-rong Zheng, Tongtong Li, Jie Zheng, Hongbin Han","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.010","url":null,"abstract":"Objective \u0000To explore what kind of strategies should be adopted by the medical disciplines of comprehensive universities in China, taking into account and respect the particularity nature of medical science, inspiring innovative creation to build the First-Class disciplines. \u0000 \u0000 \u0000Methods \u0000Literature review and quantitative research were adopted in this paper. By reviewing published articles to better understand the special laws of medical disciplines and identify current development problems. Furthermore, the data from ESI, QS Ranking, and the Ministry of Education were collected to reveal problems and to propose strategies. \u0000 \u0000 \u0000Results \u0000The future development of Medicine disciplines possesses the characteristics of integration, technology dependence, heterogeneity, etc. In the new era of building world-class disciplines and first-class universities, compared with international first-class disciplines, peaks of medical disciplines in Chinese universities are still relatively scarce. The comprehensive university medical discipline should adhere to the principle of ′connotative development′. In the process of construction, medical discipline should pay full attention to cross-integration, promote cross-disciplinary, adjust and optimize the former system. Strengthen the construction of new disciplines development to build medical disciplines with distinctive features. Optimize top-level design to foster disciplines peaks. Attach great importance to the construction of talents to build up high-level talent team with sustainable development ability. Emphasize on medical education to improve the quality of personnel training. Promote institutional innovation to activate the vitality of integration. Build an effective evaluation system to promote construction. \u0000 \u0000 \u0000Conclusions \u0000With the premise of fully respecting the special laws and characteristics, the medical discipline constructions of comprehensive universities should be guided by the future development model of medicine and clinical needs, and adhered to the ′connotative development′. With the development of medical disciplines, the level of clinical diagnosis and treatment will be improved, the original innovation will be enhanced, as well as the social service capabilities of comprehensive universities, furthermore, the frontiers of scientific development and national strategic development needs will be effectively supported. \u0000 \u0000 \u0000Key words: \u0000Double First Class construction; Medical discipline; Medical development; Strategy","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"364-370"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42610717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of regional research competitiveness of medical subjects in China","authors":"Peng Liao, G. Qiao, Jinzhong Jia, Zhifeng Wang","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.011","url":null,"abstract":"Objective \u0000To analyze the current status of research competitiveness of medical subjects in China. \u0000 \u0000 \u0000Methods \u0000Analyzing the fund of Natural Science Foundation of China (NSFC) in 2017 and using the Range ratio and Theil Index to describe the dispersion and source of difference. Regional research competitiveness of Chinese medical subjects is measured by the attraction and accumulation capacity of NSFC. \u0000 \u0000 \u0000Results \u0000The research competitiveness of medical subjects in East China and South China are stronger, and those in the Northwest are weaker. The distribution of medical funds mainly originated from the interior (88.88%), among which the East China and North China are the two regions with the largest contribution rate. In terms of provinces, Shanghai and Beijing have a much higher concentration of medical funds than other provinces. \u0000 \u0000 \u0000Conclusions \u0000The Research competitiveness in inter-regional medical subjects in China is quite different, and the differences mainly stem from the competition of internal provinces; the degree of advantages of medical subjects in regions is different, and there are medical research centers in ever regions. \u0000 \u0000 \u0000Key words: \u0000Medical subjects; Research competitiveness; NFSC","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"371-375"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42008516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of scientific research management based on bibliometric analysis of SCI research papers published by Beijing Anzhen Hospital, Capital Medical University from 2008 to 2017","authors":"Tao Wu, Yu Zhang, Wei Li, Xiao-Li Li, Yang Yu","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.013","url":null,"abstract":"Objective \u0000By analyzing the SCI research papers published from 2008 to 2017 by Beijing Anzhen Hospital, to evaluate the development and trend of scientific research and provide quantified evidence for policy making of scientific research management department. \u0000 \u0000 \u0000Methods \u0000Based on Science Citation Index Expanded (SCIE) database, SCI papers that published by Beijing Anzhen Hospital as first author and corresponding author were searched, statistic analysis was conducted by quantities, citations, periodical impact factors, subjects and fund support. \u0000 \u0000 \u0000Results \u0000Totally, 1 731 papers were published among which 1 156 were reviews and articles. The number of the papers published was increased year by year from 2008 to 2017. All these papers were published in 375 periodicals, and each periodical recorded 4.61 papers. Periodical that impact factor is higher than 3.0 included 315 reviews and articles accounted for 27.2%. All papers were cited 8064 times in total and the average citation was decreased from 2008 to 2017. 829 papers, accounted for 47.9% were authored by cardiovascular subjects that rank the first among all subjects. 57.9% of reviews and articles were supported by funds. \u0000 \u0000 \u0000Conclusions \u0000The quantity of SCI research papers was dramatically increased while the quality was not well matched yet. The development of science research relies not only on effective scientific research management policies but also the optimal subject platform and strong talent pool. \u0000 \u0000 \u0000Key words: \u0000Bibliometrics; SCI research papers; Scientific research management","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"381-385"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48414184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of human genetic resources management","authors":"Liyan Zhao, Yu Xiao, Qiuyue Zhang, Yanshuang Song","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.002","url":null,"abstract":"Objective \u0000To explore the management of human genetic resources in our university, propose relevant suggestions for promoting the appropriate protection and scientific management of human genetic resources. \u0000 \u0000 \u0000Methods \u0000Based on the existing regulations and policies, discuss the potential problems relevant to how to strengthen management of human genetic resources in China at institute level. \u0000 \u0000 \u0000Results \u0000Main problems identified including the management scope of human genetic resources is not clear, the inconsistence of application materials, the informed consent and its process involved in biobank and lack of the management of whole process of human genetic resources exploration. \u0000 \u0000 \u0000Conclusions \u0000With the rapid development of biotechnology, the economic value and strategic significance of human genetic resources have become increasingly prominent. Enhancement of training and whole process management, as well as the improvement of informed consent for biobank play important roles in effectively improve the protection of human genetic resources. \u0000 \u0000 \u0000Key words: \u0000Human genetic resources; Management; Protection","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"325-328"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41524004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice of improving the efficiency of scientific and technological innovation in hospital from the perspective of modern hospital management","authors":"Luojing Zhou, Bin Cai","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.004","url":null,"abstract":"Objective \u0000To explore the importance of establishing and improving modern hospital science and technology management system in public hospitals, as well as the ways of establishing such system, analyze the key points that need consideration in order to provide reference for establishing modern hospital science and technology management system in public hospitals. \u0000 \u0000 \u0000Methods \u0000Starting from the reform requirements and perspectives of the construction of modern hospital management system, and based on the theory of innovative governance, this paper probes into the innovative practice and achievements of our hospital in implementing the internal scientific and technological management system of modern hospitals from three aspects: the incentive mechanism, the restraint mechanism and the coordination mechanism of innovative governance of scientific and technological management system. \u0000 \u0000 \u0000Results \u0000Through the establishment and improvement of internal scientific and technological management system, such as reward policies for scientific research work, reward and punishment for papers, layout fee management guidelines, management methods for scientific research funds, project evaluation policies, selection and training of subject leaders, temporary management methods for medical research institutes, and implementation methods for scientific research integrity construction, the effect of talent aggregation is gradually presented, and the discipline, team and technology are stable. Step by step development; innovative achievements are increasingly fruitful, and the quality of connotation is constantly improving. \u0000 \u0000 \u0000Conclusions \u0000The key to the establishment of modern hospital science and technology management system is to continuing innovative exploration of the system of science and technology management and to build a good operation mechanism of science and technology innovation. \u0000 \u0000 \u0000Key words: \u0000Modern hospital management; Science and technology management; System; Innovative governance","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"333-336"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43599886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on the construction of research integrity in medical science under new circumstances","authors":"Xuejia Li, Cheng Jiang, Feizhe Xiao, Weiwei Zhang, Haifeng Lin, Zhanyong Chen","doi":"10.3760/CMA.J.ISSN.1006-1924.2019.05.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1006-1924.2019.05.003","url":null,"abstract":"Objective \u0000This paper aimed to discuss the construction strategy to promote research integrity in medical science from the perspective of hospital research administrators, and to provide theoretical basis for fulfilling the national strategic requirement of implementing \" Scientific research integrity construction\" . \u0000 \u0000 \u0000Methods \u0000Analyze and summarize the connotation, manifestations, causes and countermeasures of research integrity and research misconduct. \u0000 \u0000 \u0000Results \u0000The misconduct in medical scientific research occurred in various aspects, including scientific research projects, research papers, scientific achievements and other different stages. Behind reasons include weak sense of research integrity, lack of moral integrity education and training, improper academic evaluation system, lack of sound supervision, reward and punishment mechanism, etc. \u0000 \u0000 \u0000Conclusions \u0000A lot of strategies could adopted to promote the construction of research integrity and development of medical scientific research, for instance, strengthening scientific research integrity education, establishing a multi-dimensional evaluation system, improving the supervision, reward and punishment mechanism of scientific research integrity, as well as promote a better scientific research atmosphere. \u0000 \u0000 \u0000Key words: \u0000Medicine; Research misconduct; Research integrity","PeriodicalId":59555,"journal":{"name":"中华医学科研管理杂志","volume":"32 1","pages":"329-332"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46428146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}