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[Application of Bioinformatics in Long Non-coding RNAs]. [生物信息学在长链非编码rna中的应用]。
生理科学进展 Pub Date : 2016-06-01
Jun-Hao Li, Jian-Hua Yang, Liang-Hu Qu
{"title":"[Application of Bioinformatics in Long Non-coding RNAs].","authors":"Jun-Hao Li,&nbsp;Jian-Hua Yang,&nbsp;Liang-Hu Qu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Long non-coding RNAs (lncRNAs)are non-coding RNA molecules larger than 200 nt.They play a key regulatory role in crucial biological processes.Recently,lncRNA researches have been devel-oped rapidly and a set of bioinformatic tools and databases about lncRNA identification,quantification, structural analysis and function prediction have been emerged.This review introduces the resources for lncRNA studies.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The progress of Long Noncoding RNAs in Cardiovascular Diseases]. [长链非编码rna在心血管疾病中的研究进展]。
生理科学进展 Pub Date : 2016-06-01
Ling Jin, Bin Geng
{"title":"[The progress of Long Noncoding RNAs in Cardiovascular Diseases].","authors":"Ling Jin,&nbsp;Bin Geng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiovascular disease is a common disease that threatens the health of human beings,espe-cially elders.The number of people dying from cardiovascular diseases annually ranks top one in the world-wide.Long noncoding RNAs (LncRNAs)is a big group of ncRNAs with nucleotides length >200 nt,and its numbers is most in the body.More and more study found that LcRNAs play critical roles in the pathogenesis and development of cardiovascular disease.This review will describe the latest research progress of long noncoding RNA in cardiovascular diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of long noncoding RNAs in head and neck diseases]. [长链非编码rna在头颈部疾病中的研究进展]。
生理科学进展 Pub Date : 2016-06-01
Yu-Zhu Guo, Sai-Nan Min, Xiang-Ting Wang
{"title":"[Research progress of long noncoding RNAs in head and neck diseases].","authors":"Yu-Zhu Guo,&nbsp;Sai-Nan Min,&nbsp;Xiang-Ting Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in protective effect of neuregulin-1 on myocardial ischemia reperfusion injury]. 神经调节蛋白-1对心肌缺血再灌注损伤保护作用的研究进展。
生理科学进展 Pub Date : 2016-06-01
Fu-Hua Wang, Xue-Jing Liu, Huan Wang, Bo Zuo, Zhu Song, Zuo Huang, Guisong Wang
{"title":"[Progress in protective effect of neuregulin-1 on myocardial ischemia reperfusion injury].","authors":"Fu-Hua Wang,&nbsp;Xue-Jing Liu,&nbsp;Huan Wang,&nbsp;Bo Zuo,&nbsp;Zhu Song,&nbsp;Zuo Huang,&nbsp;Guisong Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Exosome-Mediated Small RNA Delivery For Gene Therapy]. 外泌体介导的小RNA递送用于基因治疗。
生理科学进展 Pub Date : 2016-06-01
Wu Sun, Feng-Juan Cao, Nan Wang, Yu Zhou, Yi Ba, Chen-Yu Zhang
{"title":"[Exosome-Mediated Small RNA Delivery For Gene Therapy].","authors":"Wu Sun,&nbsp;Feng-Juan Cao,&nbsp;Nan Wang,&nbsp;Yu Zhou,&nbsp;Yi Ba,&nbsp;Chen-Yu Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Small RNAs,including small interfering RNAand microRNA,are emerging as promising ther-apeutic drugs against a wide array of diseases.Current techniques for small RNA transfer use viruses or synthetic agents as delivery vehicles,however,these kinds of vehicles have a high toxicity and low target-specific.Exosomes ,natural nanocarriers derived from endogenous cells ,have the intrinsic ability to trav-erse biological barriers and to naturally transport functional small RNAs between cells.Exosome-based de-livery of small RNAs may provide an untapped source of effective delivery strategy to overcome impedi-ments such as inefficiency,unspecificity and immunogenic reactions,and exosomes potentially represent a novel and exciting delivery vehicle.In this review,we provide an update and overview of the new find-ings that reveal the potential applications of exosome-based small RNA delivery as therapeutics in clinical settings.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitophagy and myocardial protection]. [线粒体自噬和心肌保护]。
生理科学进展 Pub Date : 2016-06-01
Jian-Li Wang, Xiu-Hua Liu
{"title":"[Mitophagy and myocardial protection].","authors":"Jian-Li Wang,&nbsp;Xiu-Hua Liu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of the effects of unloading muscle atrophy by KAATSU]. [KAATSU对卸荷性肌肉萎缩影响的研究进展]。
生理科学进展 Pub Date : 2016-06-01
Liang Yu, Rui-Yuan Wang, Xiao-Ping Chen
{"title":"[Research progress of the effects of unloading muscle atrophy by KAATSU].","authors":"Liang Yu,&nbsp;Rui-Yuan Wang,&nbsp;Xiao-Ping Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases]. [microRNAs与人类疾病关系研究的生物信息学方法与资源]。
生理科学进展 Pub Date : 2016-06-01
Fan Zhang, Qing-Fua Cui
{"title":"[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases].","authors":"Fan Zhang,&nbsp;Qing-Fua Cui","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>microRNAs (miRNAs)are one class of gene regulators whose mature sequences are ~22 nt in length. Normally miRNAs resulted in the cleavage and translation repression by specifically binding the 3'UTR of their target mRNAs in a base pairing form.Accumulating evidence has shown that miRNAs have important molecular functions and play critical roles in almost all biological processes. Therefore, miR-NA-related dysfunctions could be associated with the formation and development of human disease. Bioinformatics aims to provide tools for the research in life sciences. Currently, a number of bioinformatics methods and internet resources have been presented and developed for the investigations of miRNA-disease associations. In the review, we will describe the current status of the above topic and then discuss its future perspectives.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The relationship between obstructive sleep apnea and tumor]. [阻塞性睡眠呼吸暂停与肿瘤的关系]。
生理科学进展 Pub Date : 2016-06-01
Si-Yan Li, Yan Pan, Xue-Jun Li
{"title":"[The relationship between obstructive sleep apnea and tumor].","authors":"Si-Yan Li,&nbsp;Yan Pan,&nbsp;Xue-Jun Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of parathyroid hormone gene expression]. [甲状旁腺激素基因表达调控]。
生理科学进展 Pub Date : 2016-06-01
Ting-Ting Zhang, Tian-Tian Pang, You-Shan Li, Zuo Bai
{"title":"[Regulation of parathyroid hormone gene expression].","authors":"Ting-Ting Zhang,&nbsp;Tian-Tian Pang,&nbsp;You-Shan Li,&nbsp;Zuo Bai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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