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[Exosome-Mediated Small RNA Delivery For Gene Therapy]. 外泌体介导的小RNA递送用于基因治疗。
生理科学进展 Pub Date : 2016-06-01
Wu Sun, Feng-Juan Cao, Nan Wang, Yu Zhou, Yi Ba, Chen-Yu Zhang
{"title":"[Exosome-Mediated Small RNA Delivery For Gene Therapy].","authors":"Wu Sun,&nbsp;Feng-Juan Cao,&nbsp;Nan Wang,&nbsp;Yu Zhou,&nbsp;Yi Ba,&nbsp;Chen-Yu Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Small RNAs,including small interfering RNAand microRNA,are emerging as promising ther-apeutic drugs against a wide array of diseases.Current techniques for small RNA transfer use viruses or synthetic agents as delivery vehicles,however,these kinds of vehicles have a high toxicity and low target-specific.Exosomes ,natural nanocarriers derived from endogenous cells ,have the intrinsic ability to trav-erse biological barriers and to naturally transport functional small RNAs between cells.Exosome-based de-livery of small RNAs may provide an untapped source of effective delivery strategy to overcome impedi-ments such as inefficiency,unspecificity and immunogenic reactions,and exosomes potentially represent a novel and exciting delivery vehicle.In this review,we provide an update and overview of the new find-ings that reveal the potential applications of exosome-based small RNA delivery as therapeutics in clinical settings.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"162-7"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitophagy and myocardial protection]. [线粒体自噬和心肌保护]。
生理科学进展 Pub Date : 2016-06-01
Jian-Li Wang, Xiu-Hua Liu
{"title":"[Mitophagy and myocardial protection].","authors":"Jian-Li Wang,&nbsp;Xiu-Hua Liu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"215-8"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of the effects of unloading muscle atrophy by KAATSU]. [KAATSU对卸荷性肌肉萎缩影响的研究进展]。
生理科学进展 Pub Date : 2016-06-01
Liang Yu, Rui-Yuan Wang, Xiao-Ping Chen
{"title":"[Research progress of the effects of unloading muscle atrophy by KAATSU].","authors":"Liang Yu,&nbsp;Rui-Yuan Wang,&nbsp;Xiao-Ping Chen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"227-30"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases]. [microRNAs与人类疾病关系研究的生物信息学方法与资源]。
生理科学进展 Pub Date : 2016-06-01
Fan Zhang, Qing-Fua Cui
{"title":"[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases].","authors":"Fan Zhang,&nbsp;Qing-Fua Cui","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>microRNAs (miRNAs)are one class of gene regulators whose mature sequences are ~22 nt in length. Normally miRNAs resulted in the cleavage and translation repression by specifically binding the 3'UTR of their target mRNAs in a base pairing form.Accumulating evidence has shown that miRNAs have important molecular functions and play critical roles in almost all biological processes. Therefore, miR-NA-related dysfunctions could be associated with the formation and development of human disease. Bioinformatics aims to provide tools for the research in life sciences. Currently, a number of bioinformatics methods and internet resources have been presented and developed for the investigations of miRNA-disease associations. In the review, we will describe the current status of the above topic and then discuss its future perspectives.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"203-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The relationship between obstructive sleep apnea and tumor]. [阻塞性睡眠呼吸暂停与肿瘤的关系]。
生理科学进展 Pub Date : 2016-06-01
Si-Yan Li, Yan Pan, Xue-Jun Li
{"title":"[The relationship between obstructive sleep apnea and tumor].","authors":"Si-Yan Li,&nbsp;Yan Pan,&nbsp;Xue-Jun Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"211-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulation of parathyroid hormone gene expression]. [甲状旁腺激素基因表达调控]。
生理科学进展 Pub Date : 2016-06-01
Ting-Ting Zhang, Tian-Tian Pang, You-Shan Li, Zuo Bai
{"title":"[Regulation of parathyroid hormone gene expression].","authors":"Ting-Ting Zhang,&nbsp;Tian-Tian Pang,&nbsp;You-Shan Li,&nbsp;Zuo Bai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"231-4"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Noncoding RNA in the Regulation of Hepatic Glucose and Lipid Metabolism]. [非编码RNA在调节肝脏糖脂代谢中的作用]。
生理科学进展 Pub Date : 2016-06-01
Wei-Li Yang, Jun-Pei Wang, Qing-Hua Cui, Ji-Chun Yang
{"title":"[Noncoding RNA in the Regulation of Hepatic Glucose and Lipid Metabolism].","authors":"Wei-Li Yang,&nbsp;Jun-Pei Wang,&nbsp;Qing-Hua Cui,&nbsp;Ji-Chun Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the past decades, diabetes, in particular type 2 diabetes (T2D)mainly characterized by global insulin resistance and pancreatic beta cell failure, had become epidemic and a severe public health threat worldwide with the development of economy and change of lifestyle.The interactions between environment factors and genetic background play vital roles in the development and progression of T2D.More recently, it had been revealed that non-coding RNA including microRNA (miRNA)and long noncoding RNA (LncRNA)are widely involved inthe regulation of glucose and lipid metabolism. So far, it had been established that deregulated miRNA and LncRNA profile in main metabolic tissues is tightly associated with T2D,and intensive studies on non-coding RNAs had shed light on understanding the pathogen-esis of T2D.The current review aimed to briefly summarize and discuss the latest findings regarding the role and mechanism of miRNAs and LncRNAs in the regulation hepatic glucose and lipid metabolism.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"194-202"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanism of noncanonical Wnt signaling pathway in cardiac development and differentiation of stem cells into cardiomyocytes]. [非典型Wnt信号通路在心脏发育和干细胞向心肌细胞分化中的作用机制]。
生理科学进展 Pub Date : 2016-06-01
Xiao-Jing Han, Zhi-Rong Luo, Hai-Dong Guo
{"title":"[Mechanism of noncanonical Wnt signaling pathway in cardiac development and differentiation of stem cells into cardiomyocytes].","authors":"Xiao-Jing Han,&nbsp;Zhi-Rong Luo,&nbsp;Hai-Dong Guo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"235-9"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Overview of Circular RNA Research]. [环状RNA研究综述]。
生理科学进展 Pub Date : 2016-06-01
Shu-Hui Chang, Ge Shan
{"title":"[Overview of Circular RNA Research].","authors":"Shu-Hui Chang,&nbsp;Ge Shan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The fact that RNA could take circular form was discovered as early as 1 976.For a long peri-od,circular RNAs (circRNAs)had been viewed as outliners of transcripts.With the development of sec-ond generation RNA sequencing and bioinformatics,recent studies have revealed that circRNAs are prev-alent,with high degree of conservation,and with cell specificity in eukaryotes.Increasing lines of evi-dence indicate that circRNAs,rather than being noise of splicing,have essential biological functions in a seriers of regulatory events,and may even be related to the etiology of some human diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Research Advance of the piRNA Function]. 【piRNA功能研究进展】。
生理科学进展 Pub Date : 2016-06-01
Dong-Ya Cui, Jia-Jia Wang, Shun-Min He
{"title":"[The Research Advance of the piRNA Function].","authors":"Dong-Ya Cui,&nbsp;Jia-Jia Wang,&nbsp;Shun-Min He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Piwi-interacting RNA (piRNA)is the largest class of small non-coding RNA,which usually expressed in germline cells.piRNA has a role in transposon silencing,and contributes to maintain ge-nome integrity.The C.elegans piRNA has a special role in a memory of previous gene expression.The discovery of piRNA in somatic cells and cancers showed the functional diversity of piRNA.In this article, we reviewed the piRNA's role in transposon,mRNA,lncRNA,DNA methylation and epigenetic regula-tion,and discussed the function of piRNA in cancers.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"182-6"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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