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[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. [ppar介导长链脂肪酸调节能量代谢]。
生理科学进展 Pub Date : 2016-02-01
Yao Yan, Zong-Bao Wang, Chao-Ke Tang
{"title":"[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].","authors":"Yao Yan,&nbsp;Zong-Bao Wang,&nbsp;Chao-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances of the Role of Ezrin in Migration and Invasion of Breast Cancer Cells]. Ezrin在乳腺癌细胞迁移和侵袭中的作用研究进展
生理科学进展 Pub Date : 2016-02-01
Zhi-Yuan Long, Ting-Huai Wang
{"title":"[Advances of the Role of Ezrin in Migration and Invasion of Breast Cancer Cells].","authors":"Zhi-Yuan Long,&nbsp;Ting-Huai Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ezrin, also known as cytovillin or vilin 2, is one of the members of ERM (Ezrin/Radixin/Moesin) protein family. Ezrin, which is a tyrosine kinase substrate, functions to bridge membrane proteins and the actin cytoskeleton. Recent studies have demonstrated that Ezrin regulates the proliferation, apoptosis, adhesion, invasion, metastasis and angiogenesis of breast cancer cells. These processes are not only associated with changes in expression level and subcellular localization of Ezrin itself, but also influenced by alteration in microenvironment of primary breast cancer cells. The regulation of Ezrin in mammary carcinoma cells involves interactions among signaling pathways mediated by adhesion molecules (CD44, ICAM, E-cadherin) and the tyrosine kinase growth factors, Epidermal Growth Factor (EGF), and Platelet-derived Growth Factor (PDGF) and their receptors. The determination of the functions and mechanism(s) of action of Ezrin in the migration and invasion of breast cancer cells will provide new information on the basic mechanisms of metastasis of breast cancer cells and has the potential to identify a novel drug target for the prevention and treatment of breast cancer. This article addresses the role of Ezrin in the migration and invasion of breast cancer cells.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in vascular dementia in the endoplasmic reticulum stress pathway by homocysteine]. [同型半胱氨酸在内质网应激途径中血管性痴呆的研究进展]。
生理科学进展 Pub Date : 2016-02-01
Tian-Jiao Meng, Ling Qi, Wei-Yao Wang
{"title":"[Advances in vascular dementia in the endoplasmic reticulum stress pathway by homocysteine].","authors":"Tian-Jiao Meng,&nbsp;Ling Qi,&nbsp;Wei-Yao Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological Function of The Small G Protein Rap]. [小G蛋白Rap的生物学功能]。
生理科学进展 Pub Date : 2016-02-01
Shan-Shan Li, Xiao-Xi Guo, Shu An, Yang Yang, Ying Liu, Tian-Rui Xu
{"title":"[Biological Function of The Small G Protein Rap].","authors":"Shan-Shan Li,&nbsp;Xiao-Xi Guo,&nbsp;Shu An,&nbsp;Yang Yang,&nbsp;Ying Liu,&nbsp;Tian-Rui Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms]. [降糖药物GLP-1对阿尔茨海默病的神经保护作用及其分子机制]。
生理科学进展 Pub Date : 2016-02-01
Yu-Feng Li, Sheng-Xiao Zhang, Jin-Shun Qi
{"title":"[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms].","authors":"Yu-Feng Li,&nbsp;Sheng-Xiao Zhang,&nbsp;Jin-Shun Qi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The relationship between estrogen receptor (ER) and inflammatory bowel disease (IBD)]. [雌激素受体(ER)与炎症性肠病(IBD)的关系]。
生理科学进展 Pub Date : 2016-02-01
Wen-Xin Li, Bei Ma
{"title":"[The relationship between estrogen receptor (ER) and inflammatory bowel disease (IBD)].","authors":"Wen-Xin Li,&nbsp;Bei Ma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances of Epigenetic Studies on Mechanisms of Paramutation]. [参数化机制的表观遗传学研究进展]。
生理科学进展 Pub Date : 2016-02-01
Shan Cheng, Xiao-Rong Wang, Wei Ding
{"title":"[Advances of Epigenetic Studies on Mechanisms of Paramutation].","authors":"Shan Cheng,&nbsp;Xiao-Rong Wang,&nbsp;Wei Ding","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies in traditional genetics have revealed the molecular causes of many genetic diseases and provided direct clues for their prevention, diagnosis and treatments, as well as for various disorders with genetic background. However, the genetic profiles of most human diseases could not be fully explained with the canonical laws of genetics. Paramutation is one of non-Mendelian inheritance phenomenon, which was found in maize first in 1950s. The absence of alteration in nucleotide sequences in the gene-coding alleles suggested that paramutations might involve epigenetic mechanisms to transmit heritable changes in gene expression and determination of phenotypes. Recently, a novel epigenetic mechanism has been found in paramutation researches, emphasized the importance of DNA methyltransferase II mediated RNA (primarily non-coding RNAs) methylation in the occurrence and maintenance of paramutations. Researches on paramutations and their epigenetic mechnisms will not only expand our understanding in the genetic principles of life, but also help to develop new ideas for bioengineer and disease treatments. The present article reviewed the research highlights on molecular mechanisms of paramutation and discussed the prospects in disease study and therapy.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Central and peripheral mechanisms of Amyloid-β peptide clearance]. [淀粉样蛋白-β肽清除的中枢和外周机制]。
生理科学进展 Pub Date : 2016-02-01
Chun-Lan Fan, Min-Ke Tang
{"title":"[Central and peripheral mechanisms of Amyloid-β peptide clearance].","authors":"Chun-Lan Fan,&nbsp;Min-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in development and regulatory of brown adipose tissue]. [褐色脂肪组织的发育和调控进展]。
生理科学进展 Pub Date : 2016-02-01
Ran Chen, Xiao-Nan Li
{"title":"[Progress in development and regulatory of brown adipose tissue].","authors":"Ran Chen,&nbsp;Xiao-Nan Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease]. 【富含甘油三酯的脂蛋白与冠状动脉疾病关系的遗传学进展】。
生理科学进展 Pub Date : 2016-02-01
Wei Xie, Liang Li, Wei-Dong Yin
{"title":"[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease].","authors":"Wei Xie,&nbsp;Liang Li,&nbsp;Wei-Dong Yin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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