发布求助
文献互助 智能选刊 最新文献

生理科学进展最新文献

筛选
英文 中文
[Biological Function of The Small G Protein Rap]. [小G蛋白Rap的生物学功能]。
生理科学进展 Pub Date : 2016-02-01
Shan-Shan Li, Xiao-Xi Guo, Shu An, Yang Yang, Ying Liu, Tian-Rui Xu
{"title":"[Biological Function of The Small G Protein Rap].","authors":"Shan-Shan Li,&nbsp;Xiao-Xi Guo,&nbsp;Shu An,&nbsp;Yang Yang,&nbsp;Ying Liu,&nbsp;Tian-Rui Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms]. [降糖药物GLP-1对阿尔茨海默病的神经保护作用及其分子机制]。
生理科学进展 Pub Date : 2016-02-01
Yu-Feng Li, Sheng-Xiao Zhang, Jin-Shun Qi
{"title":"[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms].","authors":"Yu-Feng Li,&nbsp;Sheng-Xiao Zhang,&nbsp;Jin-Shun Qi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances of Epigenetic Studies on Mechanisms of Paramutation]. [参数化机制的表观遗传学研究进展]。
生理科学进展 Pub Date : 2016-02-01
Shan Cheng, Xiao-Rong Wang, Wei Ding
{"title":"[Advances of Epigenetic Studies on Mechanisms of Paramutation].","authors":"Shan Cheng,&nbsp;Xiao-Rong Wang,&nbsp;Wei Ding","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies in traditional genetics have revealed the molecular causes of many genetic diseases and provided direct clues for their prevention, diagnosis and treatments, as well as for various disorders with genetic background. However, the genetic profiles of most human diseases could not be fully explained with the canonical laws of genetics. Paramutation is one of non-Mendelian inheritance phenomenon, which was found in maize first in 1950s. The absence of alteration in nucleotide sequences in the gene-coding alleles suggested that paramutations might involve epigenetic mechanisms to transmit heritable changes in gene expression and determination of phenotypes. Recently, a novel epigenetic mechanism has been found in paramutation researches, emphasized the importance of DNA methyltransferase II mediated RNA (primarily non-coding RNAs) methylation in the occurrence and maintenance of paramutations. Researches on paramutations and their epigenetic mechnisms will not only expand our understanding in the genetic principles of life, but also help to develop new ideas for bioengineer and disease treatments. The present article reviewed the research highlights on molecular mechanisms of paramutation and discussed the prospects in disease study and therapy.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Central and peripheral mechanisms of Amyloid-β peptide clearance]. [淀粉样蛋白-β肽清除的中枢和外周机制]。
生理科学进展 Pub Date : 2016-02-01
Chun-Lan Fan, Min-Ke Tang
{"title":"[Central and peripheral mechanisms of Amyloid-β peptide clearance].","authors":"Chun-Lan Fan,&nbsp;Min-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"139-43"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in development and regulatory of brown adipose tissue]. [褐色脂肪组织的发育和调控进展]。
生理科学进展 Pub Date : 2016-02-01
Ran Chen, Xiao-Nan Li
{"title":"[Progress in development and regulatory of brown adipose tissue].","authors":"Ran Chen,&nbsp;Xiao-Nan Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease]. 【富含甘油三酯的脂蛋白与冠状动脉疾病关系的遗传学进展】。
生理科学进展 Pub Date : 2016-02-01
Wei Xie, Liang Li, Wei-Dong Yin
{"title":"[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease].","authors":"Wei Xie,&nbsp;Liang Li,&nbsp;Wei-Dong Yin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"33-7"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress in clock gene function]. [时钟基因功能研究进展]。
生理科学进展 Pub Date : 2016-02-01
Qian Gao, Ji-Min Cao
{"title":"[Research progress in clock gene function].","authors":"Qian Gao,&nbsp;Ji-Min Cao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitochondria-associated endoplasmic reticulum membrane and cell immunodysfunction]. [线粒体相关内质网膜与细胞免疫功能障碍]。
生理科学进展 Pub Date : 2016-02-01
Bi-Lei Xu, Xiao-Mei Zhu, Ning Dong
{"title":"[Mitochondria-associated endoplasmic reticulum membrane and cell immunodysfunction].","authors":"Bi-Lei Xu,&nbsp;Xiao-Mei Zhu,&nbsp;Ning Dong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The progress about CHL1 gene in cancer and other diseases]. 【CHL1基因在癌症及其他疾病中的研究进展】。
生理科学进展 Pub Date : 2016-02-01
Li-Hong He, Ye-Hui Shi, Yong-Sheng Jia
{"title":"[The progress about CHL1 gene in cancer and other diseases].","authors":"Li-Hong He,&nbsp;Ye-Hui Shi,&nbsp;Yong-Sheng Jia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"74-6"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research advance in the origin and immunological function of kupffer cells]. 【库普弗细胞起源及免疫功能研究进展】。
生理科学进展 Pub Date : 2016-02-01
Shi-Peng Guo, Wen-Feng Zhang, Jian-Ping Gong
{"title":"[Research advance in the origin and immunological function of kupffer cells].","authors":"Shi-Peng Guo,&nbsp;Wen-Feng Zhang,&nbsp;Jian-Ping Gong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信