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[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms]. [降糖药物GLP-1对阿尔茨海默病的神经保护作用及其分子机制]。
生理科学进展 Pub Date : 2016-02-01
Yu-Feng Li, Sheng-Xiao Zhang, Jin-Shun Qi
{"title":"[The neuroprotection of anti-diabetic medicine GLP-1 in Alzheimer's disease and its molecular mechanisms].","authors":"Yu-Feng Li, Sheng-Xiao Zhang, Jin-Shun Qi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The relationship between estrogen receptor (ER) and inflammatory bowel disease (IBD)]. [雌激素受体(ER)与炎症性肠病(IBD)的关系]。
生理科学进展 Pub Date : 2016-02-01
Wen-Xin Li, Bei Ma
{"title":"[The relationship between estrogen receptor (ER) and inflammatory bowel disease (IBD)].","authors":"Wen-Xin Li, Bei Ma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"65-8"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances of Epigenetic Studies on Mechanisms of Paramutation]. [参数化机制的表观遗传学研究进展]。
生理科学进展 Pub Date : 2016-02-01
Shan Cheng, Xiao-Rong Wang, Wei Ding
{"title":"[Advances of Epigenetic Studies on Mechanisms of Paramutation].","authors":"Shan Cheng,&nbsp;Xiao-Rong Wang,&nbsp;Wei Ding","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Studies in traditional genetics have revealed the molecular causes of many genetic diseases and provided direct clues for their prevention, diagnosis and treatments, as well as for various disorders with genetic background. However, the genetic profiles of most human diseases could not be fully explained with the canonical laws of genetics. Paramutation is one of non-Mendelian inheritance phenomenon, which was found in maize first in 1950s. The absence of alteration in nucleotide sequences in the gene-coding alleles suggested that paramutations might involve epigenetic mechanisms to transmit heritable changes in gene expression and determination of phenotypes. Recently, a novel epigenetic mechanism has been found in paramutation researches, emphasized the importance of DNA methyltransferase II mediated RNA (primarily non-coding RNAs) methylation in the occurrence and maintenance of paramutations. Researches on paramutations and their epigenetic mechnisms will not only expand our understanding in the genetic principles of life, but also help to develop new ideas for bioengineer and disease treatments. The present article reviewed the research highlights on molecular mechanisms of paramutation and discussed the prospects in disease study and therapy.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Central and peripheral mechanisms of Amyloid-β peptide clearance]. [淀粉样蛋白-β肽清除的中枢和外周机制]。
生理科学进展 Pub Date : 2016-02-01
Chun-Lan Fan, Min-Ke Tang
{"title":"[Central and peripheral mechanisms of Amyloid-β peptide clearance].","authors":"Chun-Lan Fan,&nbsp;Min-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"139-43"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in development and regulatory of brown adipose tissue]. [褐色脂肪组织的发育和调控进展]。
生理科学进展 Pub Date : 2016-02-01
Ran Chen, Xiao-Nan Li
{"title":"[Progress in development and regulatory of brown adipose tissue].","authors":"Ran Chen,&nbsp;Xiao-Nan Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease]. 【富含甘油三酯的脂蛋白与冠状动脉疾病关系的遗传学进展】。
生理科学进展 Pub Date : 2016-02-01
Wei Xie, Liang Li, Wei-Dong Yin
{"title":"[Genetic advances in the relationship between triglyceride-rich lipoproteins and coronary artery disease].","authors":"Wei Xie,&nbsp;Liang Li,&nbsp;Wei-Dong Yin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"33-7"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress in clock gene function]. [时钟基因功能研究进展]。
生理科学进展 Pub Date : 2016-02-01
Qian Gao, Ji-Min Cao
{"title":"[Research progress in clock gene function].","authors":"Qian Gao,&nbsp;Ji-Min Cao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"77-80"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mitochondria-associated endoplasmic reticulum membrane and cell immunodysfunction]. [线粒体相关内质网膜与细胞免疫功能障碍]。
生理科学进展 Pub Date : 2016-02-01
Bi-Lei Xu, Xiao-Mei Zhu, Ning Dong
{"title":"[Mitochondria-associated endoplasmic reticulum membrane and cell immunodysfunction].","authors":"Bi-Lei Xu,&nbsp;Xiao-Mei Zhu,&nbsp;Ning Dong","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The progress about CHL1 gene in cancer and other diseases]. 【CHL1基因在癌症及其他疾病中的研究进展】。
生理科学进展 Pub Date : 2016-02-01
Li-Hong He, Ye-Hui Shi, Yong-Sheng Jia
{"title":"[The progress about CHL1 gene in cancer and other diseases].","authors":"Li-Hong He,&nbsp;Ye-Hui Shi,&nbsp;Yong-Sheng Jia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"74-6"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The functions of nuclear receptors in acetaminophen induced hepatotoxicity]. [核受体在对乙酰氨基酚肝毒性中的作用]。
生理科学进展 Pub Date : 2016-02-01
Lin Ren, Jiang-Ying Kuang, Shi-Yun Pu
{"title":"[The functions of nuclear receptors in acetaminophen induced hepatotoxicity].","authors":"Lin Ren,&nbsp;Jiang-Ying Kuang,&nbsp;Shi-Yun Pu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"53-6"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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