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[Copper regulation of hypoxia-inducible factor 1]. [铜对缺氧诱导因子1的调控]。
生理科学进展 Pub Date : 2016-04-01
Wen-Jing Zhang, Tao Wang, Ying Xiao, Zuo Yin, Yujian Kang
{"title":"[Copper regulation of hypoxia-inducible factor 1].","authors":"Wen-Jing Zhang, Tao Wang, Ying Xiao, Zuo Yin, Yujian Kang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The glucose catabolism of M1 macrophage]. [M1巨噬细胞葡萄糖分解代谢]。
生理科学进展 Pub Date : 2016-04-01
Jing-Jie Pang, Min Liu, Wei-Guo Li
{"title":"[The glucose catabolism of M1 macrophage].","authors":"Jing-Jie Pang, Min Liu, Wei-Guo Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"149-52"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role and biological functions of ubiquitin-proteasome system in production and metabolism of amyloid-beta]. 泛素-蛋白酶体系统在淀粉样蛋白生成和代谢中的作用和生物学功能。
生理科学进展 Pub Date : 2016-04-01
Li-Li Sun, Hao Wang, Shu-Cun Qin, Ji-Guo Zhang
{"title":"[The role and biological functions of ubiquitin-proteasome system in production and metabolism of amyloid-beta].","authors":"Li-Li Sun, Hao Wang, Shu-Cun Qin, Ji-Guo Zhang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"153-6"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The lipid droplets and atherosclerosis]. 脂滴和动脉粥样硬化。
生理科学进展 Pub Date : 2016-04-01
Wei-Yi Wang, Bin Zhang, Han-Hua Ji, Guo-Heng Zu
{"title":"[The lipid droplets and atherosclerosis].","authors":"Wei-Yi Wang, Bin Zhang, Han-Hua Ji, Guo-Heng Zu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"144-8"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The roles of nuclear receptors in cholesterol gallstone diseases]. [核受体在胆固醇胆结石疾病中的作用]。
生理科学进展 Pub Date : 2016-04-01
Shi-Hai Cheng, Jin-Han He
{"title":"[The roles of nuclear receptors in cholesterol gallstone diseases].","authors":"Shi-Hai Cheng, Jin-Han He","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress in research of osteopontin (OPN) in hypertension and its target organ damage]. 骨桥蛋白(OPN)在高血压及其靶器官损伤中的研究进展
生理科学进展 Pub Date : 2016-04-01
Su-Jing Fan, Xiu-Hong Yang
{"title":"[Progress in research of osteopontin (OPN) in hypertension and its target organ damage].","authors":"Su-Jing Fan, Xiu-Hong Yang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 2","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids]. [ppar介导长链脂肪酸调节能量代谢]。
生理科学进展 Pub Date : 2016-02-01
Yao Yan, Zong-Bao Wang, Chao-Ke Tang
{"title":"[PPARs Mediate the Regulation of Energy Metabolism By Long-Chain Fatty Acids].","authors":"Yao Yan,&nbsp;Zong-Bao Wang,&nbsp;Chao-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>PPAR-alpha expressed primarily in liver is essential for metabolic adaptation to starvation by inducing genes for beta-oxidation and ketogenesis to increase the utility of LCFAs and fibroblast growth factor 21. PPAR-delta induces genes for LCFA oxidation during fasting and endurance exercise in skeletal muscle. PPAR-delta also regulates glucose metabolism and mitochondrial biogenesis by inducing FOXO1 and PGC1-alpha. PPAR-gamma can induces the pathways to store LCFAs as triglycerides in adipocytes. Adiponectin, another important target of PPAR-gamma may maintain insulin sensitivity between adipocytes. The present review summarize that PPARs mediate the regulation of energy metabolism by long-chain fatty acids.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances of the Role of Ezrin in Migration and Invasion of Breast Cancer Cells]. Ezrin在乳腺癌细胞迁移和侵袭中的作用研究进展
生理科学进展 Pub Date : 2016-02-01
Zhi-Yuan Long, Ting-Huai Wang
{"title":"[Advances of the Role of Ezrin in Migration and Invasion of Breast Cancer Cells].","authors":"Zhi-Yuan Long,&nbsp;Ting-Huai Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ezrin, also known as cytovillin or vilin 2, is one of the members of ERM (Ezrin/Radixin/Moesin) protein family. Ezrin, which is a tyrosine kinase substrate, functions to bridge membrane proteins and the actin cytoskeleton. Recent studies have demonstrated that Ezrin regulates the proliferation, apoptosis, adhesion, invasion, metastasis and angiogenesis of breast cancer cells. These processes are not only associated with changes in expression level and subcellular localization of Ezrin itself, but also influenced by alteration in microenvironment of primary breast cancer cells. The regulation of Ezrin in mammary carcinoma cells involves interactions among signaling pathways mediated by adhesion molecules (CD44, ICAM, E-cadherin) and the tyrosine kinase growth factors, Epidermal Growth Factor (EGF), and Platelet-derived Growth Factor (PDGF) and their receptors. The determination of the functions and mechanism(s) of action of Ezrin in the migration and invasion of breast cancer cells will provide new information on the basic mechanisms of metastasis of breast cancer cells and has the potential to identify a novel drug target for the prevention and treatment of breast cancer. This article addresses the role of Ezrin in the migration and invasion of breast cancer cells.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in vascular dementia in the endoplasmic reticulum stress pathway by homocysteine]. [同型半胱氨酸在内质网应激途径中血管性痴呆的研究进展]。
生理科学进展 Pub Date : 2016-02-01
Tian-Jiao Meng, Ling Qi, Wei-Yao Wang
{"title":"[Advances in vascular dementia in the endoplasmic reticulum stress pathway by homocysteine].","authors":"Tian-Jiao Meng,&nbsp;Ling Qi,&nbsp;Wei-Yao Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"61-4"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological Function of The Small G Protein Rap]. [小G蛋白Rap的生物学功能]。
生理科学进展 Pub Date : 2016-02-01
Shan-Shan Li, Xiao-Xi Guo, Shu An, Yang Yang, Ying Liu, Tian-Rui Xu
{"title":"[Biological Function of The Small G Protein Rap].","authors":"Shan-Shan Li,&nbsp;Xiao-Xi Guo,&nbsp;Shu An,&nbsp;Yang Yang,&nbsp;Ying Liu,&nbsp;Tian-Rui Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rap has different biological functions on intracellular signaling pathways, such as regulating cell polarity, cell proliferation, cell differentiation, cell adhesion and cell movement. Furthermore, at tissue and organ level, Rap controls the establishment of neural polarity, synaptic growth, synaptic plasticity, neuronal migration and so on. Rap belongs to Ras family which contains two subtypes, Rap1 and Rap2. By binding GTP or GDP Rap transform between active or inactive state, and plays an important role as a molecular switch. Moreover, in the signal pathway of tumor, Rap inhibits cell transformation induced by the oncogene Ras, therefore inhibits the proliferation, invasion and migration of certain cancer cells by interacting with its downstream target molecules. In this review, we summarized the biological functions of Rap and discussed It's significance in cancer therapy and drug treatment of neurological diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34675188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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