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[Noncoding RNA in the Regulation of Hepatic Glucose and Lipid Metabolism]. [非编码RNA在调节肝脏糖脂代谢中的作用]。
生理科学进展 Pub Date : 2016-06-01
Wei-Li Yang, Jun-Pei Wang, Qing-Hua Cui, Ji-Chun Yang
{"title":"[Noncoding RNA in the Regulation of Hepatic Glucose and Lipid Metabolism].","authors":"Wei-Li Yang,&nbsp;Jun-Pei Wang,&nbsp;Qing-Hua Cui,&nbsp;Ji-Chun Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the past decades, diabetes, in particular type 2 diabetes (T2D)mainly characterized by global insulin resistance and pancreatic beta cell failure, had become epidemic and a severe public health threat worldwide with the development of economy and change of lifestyle.The interactions between environment factors and genetic background play vital roles in the development and progression of T2D.More recently, it had been revealed that non-coding RNA including microRNA (miRNA)and long noncoding RNA (LncRNA)are widely involved inthe regulation of glucose and lipid metabolism. So far, it had been established that deregulated miRNA and LncRNA profile in main metabolic tissues is tightly associated with T2D,and intensive studies on non-coding RNAs had shed light on understanding the pathogen-esis of T2D.The current review aimed to briefly summarize and discuss the latest findings regarding the role and mechanism of miRNAs and LncRNAs in the regulation hepatic glucose and lipid metabolism.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanism of noncanonical Wnt signaling pathway in cardiac development and differentiation of stem cells into cardiomyocytes]. [非典型Wnt信号通路在心脏发育和干细胞向心肌细胞分化中的作用机制]。
生理科学进展 Pub Date : 2016-06-01
Xiao-Jing Han, Zhi-Rong Luo, Hai-Dong Guo
{"title":"[Mechanism of noncanonical Wnt signaling pathway in cardiac development and differentiation of stem cells into cardiomyocytes].","authors":"Xiao-Jing Han,&nbsp;Zhi-Rong Luo,&nbsp;Hai-Dong Guo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Overview of Circular RNA Research]. [环状RNA研究综述]。
生理科学进展 Pub Date : 2016-06-01
Shu-Hui Chang, Ge Shan
{"title":"[Overview of Circular RNA Research].","authors":"Shu-Hui Chang,&nbsp;Ge Shan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The fact that RNA could take circular form was discovered as early as 1 976.For a long peri-od,circular RNAs (circRNAs)had been viewed as outliners of transcripts.With the development of sec-ond generation RNA sequencing and bioinformatics,recent studies have revealed that circRNAs are prev-alent,with high degree of conservation,and with cell specificity in eukaryotes.Increasing lines of evi-dence indicate that circRNAs,rather than being noise of splicing,have essential biological functions in a seriers of regulatory events,and may even be related to the etiology of some human diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Research Advance of the piRNA Function]. 【piRNA功能研究进展】。
生理科学进展 Pub Date : 2016-06-01
Dong-Ya Cui, Jia-Jia Wang, Shun-Min He
{"title":"[The Research Advance of the piRNA Function].","authors":"Dong-Ya Cui,&nbsp;Jia-Jia Wang,&nbsp;Shun-Min He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Piwi-interacting RNA (piRNA)is the largest class of small non-coding RNA,which usually expressed in germline cells.piRNA has a role in transposon silencing,and contributes to maintain ge-nome integrity.The C.elegans piRNA has a special role in a memory of previous gene expression.The discovery of piRNA in somatic cells and cancers showed the functional diversity of piRNA.In this article, we reviewed the piRNA's role in transposon,mRNA,lncRNA,DNA methylation and epigenetic regula-tion,and discussed the function of piRNA in cancers.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The function of noncoding RNAs and their relationships with diseases]. [非编码rna的功能及其与疾病的关系]。
生理科学进展 Pub Date : 2016-06-01
Qinghua Cui
{"title":"[The function of noncoding RNAs and their relationships with diseases].","authors":"Qinghua Cui","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of c-kit+ Cardiac Stem Cells in Cardiac Regeneration and Repair]. c-kit+心脏干细胞在心脏再生与修复中的应用
生理科学进展 Pub Date : 2016-04-01
Mei Yang, Li Zhang
{"title":"[Application of c-kit+ Cardiac Stem Cells in Cardiac Regeneration and Repair].","authors":"Mei Yang,&nbsp;Li Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The epidemic of cardiovascular disease (CVD)is a global phenomenon,and the morbidity is increasing rapidly in China.The loss of cardiomyocytes has not been solved yet ,which is the critical issue of CVD.And stem cell transplantation may be a new potential therapy.The therapeutic potential of c-kit + CSCs in cardiac diseases has been proved by plentiful preclinical and clinical studies.But ,for the absence of direct and sufficient evidence that either endogenous or exogenous adult c-kit + CSCs differenti-ate into a relevant number of mature functional myocytes,the therapeutic mechanism is still controversial. Meanwhile,the clinical application of c-kit + CSCs is still facing a number of issues,such as the optimal delivery and source of cells,the proper number of cells and the regulation of cell defferentiation.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A research update on the physiological roles of amyloid precursor protein]. [淀粉样蛋白前体蛋白生理作用的研究进展]。
生理科学进展 Pub Date : 2016-04-01
Qiong Wu, Zuozuo Wen, Na Li, Chunyan Jiang, Shao Li
{"title":"[A research update on the physiological roles of amyloid precursor protein].","authors":"Qiong Wu,&nbsp;Zuozuo Wen,&nbsp;Na Li,&nbsp;Chunyan Jiang,&nbsp;Shao Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in structure and function of mitofusin 2]. [丝裂丝蛋白2的结构与功能研究进展]。
生理科学进展 Pub Date : 2016-04-01
Zuo Ying, Zhongqiu Lu, Yongming Yao
{"title":"[Advances in structure and function of mitofusin 2].","authors":"Zuo Ying,&nbsp;Zhongqiu Lu,&nbsp;Yongming Yao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of urinary protein in renal tubular epithelial cell injury]. 【尿蛋白在肾小管上皮细胞损伤中的作用】。
生理科学进展 Pub Date : 2016-04-01
Dan Xu, Wei Zhang
{"title":"[The role of urinary protein in renal tubular epithelial cell injury].","authors":"Dan Xu,&nbsp;Wei Zhang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Protective Effect of Hydrogen Sulfide in the Secondary Renal Disease and Renal Transplantation]. [硫化氢在继发性肾脏疾病和肾移植中的保护作用]。
生理科学进展 Pub Date : 2016-04-01
Yan-Ting Yu, Jun-Wei Yang
{"title":"[Protective Effect of Hydrogen Sulfide in the Secondary Renal Disease and Renal Transplantation].","authors":"Yan-Ting Yu,&nbsp;Jun-Wei Yang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The prevalence of kidney disease was increasing,which has become an important threaten to the health of the population.Hydrogen sulfide is the third gas signaling molecules after CO and NO.It has toxic effect at high concentration,but plays an important role in relaxing blood vessel ,antioxidation anti -inflammation and anti-apoptosis at physiological concentration.Kidney disease,especially seconda-ry kidney disease such as obstructive nephropathy,renal transplantation,diabetic nephropathy and hyper-tensive kidney lesion are closely related to vascular leision,oxidative stress and inflammation.Then what's the relationship between hydrogen sulfide and kidney disease?This article will review the relationship between hydrogen sulfide and kidney disease.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36023530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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