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[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications]. 【硫化氢与糖尿病及糖尿病并发症的研究进展】。
生理科学进展 Pub Date : 2018-06-21
Yue Gu, Li-Ping Xie, Guo-Liang Meng, Yong Ji
{"title":"[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications].","authors":"Yue Gu,&nbsp;Li-Ping Xie,&nbsp;Guo-Liang Meng,&nbsp;Yong Ji","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diabetes and its complications continue to be an increasing global health problem. Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology. Recent work has suggested important roles for H2S in the regulation of pancreatic β-cell function, as well as development of insulin resistance and diabetic complications. Targeting H2S represents a novel therapeutic approach in diabetes and its associated complications. This review article summarizes the current body of evidence regarding the role of H2S in diabetes mellitus, and especially in its associated vascular complications, as well as the underlying signaling mechanisms.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"22-9"},"PeriodicalIF":0.0,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Regulation Effects of Carbon Monoxide in Cardiovascular Systems]. 一氧化碳在心血管系统中的调节作用。
生理科学进展 Pub Date : 2017-02-01
Han-Min Liu, Liang Xie
{"title":"[The Regulation Effects of Carbon Monoxide in Cardiovascular Systems].","authors":"Han-Min Liu,&nbsp;Liang Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As a famous toxic gas, the toxicological mechanism of carbon monoxide has been elucidated. However, carbon monoxide can be synthesized endogenously in human body and play important roles in cardiovascular systems. The results from previous researches of carbon monoxide suggested that carbon monoxide could be an intervention target of many cardiovascular diseases. Future studies are deserved in this area.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"52-7"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanical regulation mechanism on vascular remodeling induced by hypertension]. 高血压血管重构的机械调控机制。
生理科学进展 Pub Date : 2017-02-01
Zhi-Yan Chen, Ming Xu, Wei Gao
{"title":"[Mechanical regulation mechanism on vascular remodeling induced by hypertension].","authors":"Zhi-Yan Chen,&nbsp;Ming Xu,&nbsp;Wei Gao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"73-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The protective effects and mechanisms of PPARγ in ischemia-reperfusion injury of tissues]. [PPARγ对组织缺血再灌注损伤的保护作用及机制]。
生理科学进展 Pub Date : 2017-02-01
Zhen-Zhen Chen, Qing-Hua Cui, Ji-Chun Yang
{"title":"[The protective effects and mechanisms of PPARγ in ischemia-reperfusion injury of tissues].","authors":"Zhen-Zhen Chen,&nbsp;Qing-Hua Cui,&nbsp;Ji-Chun Yang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress on research methods of transcription factors]. [转录因子研究方法进展]。
生理科学进展 Pub Date : 2017-02-01
Xiang-Lian Liu, Fang Qiao, De-Yu Huang, Zong-Hui Yuan, Xu Wang
{"title":"[Progress on research methods of transcription factors].","authors":"Xiang-Lian Liu,&nbsp;Fang Qiao,&nbsp;De-Yu Huang,&nbsp;Zong-Hui Yuan,&nbsp;Xu Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"73-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Molecular Switches and Atomic Biological Mechanisms Underlying the Physiological and Pathophysio-logical Effects of Hydrogen Sulfide to Regulate Its "Receptors"]. [硫化氢调节其“受体”的生理和病理生理作用的分子开关和原子生物学机制]。
生理科学进展 Pub Date : 2017-02-01
Weng-Long Xue, Wen-Jie Cai, Bei-Bei Tao, Min-Jie Wang, Xing-Hui Li, Yi-Chun Zhu
{"title":"[The Molecular Switches and Atomic Biological Mechanisms Underlying the Physiological and Pathophysio-logical Effects of Hydrogen Sulfide to Regulate Its \"Receptors\"].","authors":"Weng-Long Xue,&nbsp;Wen-Jie Cai,&nbsp;Bei-Bei Tao,&nbsp;Min-Jie Wang,&nbsp;Xing-Hui Li,&nbsp;Yi-Chun Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S)has emerged as pivotal signaling molecules since it is recognized as the third gasotransmitter together with nitric oxide and carbon monoxide. The development of detecting technologies contributed to the research in H2S biology.H2S plays significant roles in human body systems, such as the cardiovascular system, nervous system, respiratory system etc.. Alterations of H2S concentrations have been connected with many diseases. Hypertension, atherosclerosis, neurodegenerative disorder, asthma and many other diseases are found to be related with abnormal H2S metabolism. It has become a potential drug for therapeutic purposes. Understanding the mechanism of H2S biology, including a molecular switch contained in its \"receptor\", has deepened the research on how small molecules regulate big molecules, as well as providing new strategy for the therapeutic approaches for varies of diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"12-21"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adipocytic Endogenous Hydrogen Sulfide-Function,Regulation and Diseases]. [脂肪细胞内源性硫化氢-功能、调节和疾病]
生理科学进展 Pub Date : 2017-02-01
Bin Geng
{"title":"[Adipocytic Endogenous Hydrogen Sulfide-Function,Regulation and Diseases].","authors":"Bin Geng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S)is a novel gastrotransmitter, and plays a protective role in many diseases. Adipocyte endogenously produces H2S by cystathionine β synthase (CBS), cystathionine γ lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor γ (PPARγ) or potassium channel. H2S acts as an \"energy switch\" in regulation of metabolic diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiovascular Regulation by Sulfur-containing Gaseous Signaling Molecules and the Underlying Mechanisms:Updated Research Evidence]. [含硫气体信号分子的心血管调节及其潜在机制:最新研究证据]。
生理科学进展 Pub Date : 2017-02-01
Ya-Qian Huang, Chao-Shu Tang, Jun-Bao Du, Hong-Fang Jin
{"title":"[Cardiovascular Regulation by Sulfur-containing Gaseous Signaling Molecules and the Underlying Mechanisms:Updated Research Evidence].","authors":"Ya-Qian Huang,&nbsp;Chao-Shu Tang,&nbsp;Jun-Bao Du,&nbsp;Hong-Fang Jin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sulfur-containing gases hydrogen sulfide (H2S)and sulfur dioxide (SO2 )were previously considered to be waste gases. Recent studies showed that they could be endogenously generated from metabolism of the sulfur-containing amino acids in mammals. Endogenous H2S and SO2 generation pathways also existed in the cardiovascular system.H2S and SO2 had important physiological effects in the cardio-vascular system including vasorelaxation and myocardial negative inotropic effect. The pathophysiological effects of H2S and SO2 in the cardiovascular system have been recognized, such as alleviating hypertension and pulmonary hypertension, inhibiting the development of atherosclerosis, and protecting against myocardial ischemia-reperfusion (I /R)injury and isoproterenol-induced myocardial injury. Adenosine triphosphate-sensitive potassium (KATP )channel, L-type calcium (L-Ca2 +) channel, cGMP, NF-κB signaling pathway and MAPK signaling pathway and so on participated in the biological effects of H2S and SO2 .The above findings suggested that H2S and SO2 were important endogenous gaseous signaling molecules in the cardiovascular system, which provided a new way to elucidate the pathogenesis and therapeutic targets of cardiovascular diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36242700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research Progress in the Neurobiological Effects of Hydrogen Sulfide]. [硫化氢神经生物学效应的研究进展]。
生理科学进展 Pub Date : 2017-02-01
Yi-Yun Tang, Xiao-Qing Tang
{"title":"[Research Progress in the Neurobiological Effects of Hydrogen Sulfide].","authors":"Yi-Yun Tang,&nbsp;Xiao-Qing Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S),the third gaseous signal molecule after carbon monoxide (NO)and nitric oxide (CO),has been widely studied by many researchers.H2S plays important roles in neurobiology. This article overviews the roles of H2S in neuroprotection and neuromodulator and summarizes the progress of its role in central nervous disease.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"42-51"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulatory effect of miR-21 on peripheral nerve injury and regulation function]. [miR-21对周围神经损伤的调控作用及调控功能]。
生理科学进展 Pub Date : 2017-02-01
Yu-Pu Liu, Hai-Dong Guo, Zhi-Rong Luo, Xiao-Jing Han, Chang Wang, Shui-Jin Shao
{"title":"[Regulatory effect of miR-21 on peripheral nerve injury and regulation function].","authors":"Yu-Pu Liu,&nbsp;Hai-Dong Guo,&nbsp;Zhi-Rong Luo,&nbsp;Xiao-Jing Han,&nbsp;Chang Wang,&nbsp;Shui-Jin Shao","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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