{"title":"[Research Advances in Hydrogen Sulfide and Diabetes Mellitus as Well as Diabetic Complications].","authors":"Yue Gu, Li-Ping Xie, Guo-Liang Meng, Yong Ji","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetes and its complications continue to be an increasing global health problem. Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology. Recent work has suggested important roles for H2S in the regulation of pancreatic β-cell function, as well as development of insulin resistance and diabetic complications. Targeting H2S represents a novel therapeutic approach in diabetes and its associated complications. This review article summarizes the current body of evidence regarding the role of H2S in diabetes mellitus, and especially in its associated vascular complications, as well as the underlying signaling mechanisms.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"22-9"},"PeriodicalIF":0.0000,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生理科学进展","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Diabetes and its complications continue to be an increasing global health problem. Hydrogen sulfide (H2S)has emerged as the third gasotransmitter following the nitric oxide and carbon monoxide in the body, and plays an important role in both physiology and pathophysiology. Recent work has suggested important roles for H2S in the regulation of pancreatic β-cell function, as well as development of insulin resistance and diabetic complications. Targeting H2S represents a novel therapeutic approach in diabetes and its associated complications. This review article summarizes the current body of evidence regarding the role of H2S in diabetes mellitus, and especially in its associated vascular complications, as well as the underlying signaling mechanisms.
期刊介绍:
Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc.
Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.