Ya-Qian Huang, Chao-Shu Tang, Jun-Bao Du, Hong-Fang Jin
{"title":"[Cardiovascular Regulation by Sulfur-containing Gaseous Signaling Molecules and the Underlying Mechanisms:Updated Research Evidence].","authors":"Ya-Qian Huang, Chao-Shu Tang, Jun-Bao Du, Hong-Fang Jin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The sulfur-containing gases hydrogen sulfide (H2S)and sulfur dioxide (SO2 )were previously considered to be waste gases. Recent studies showed that they could be endogenously generated from metabolism of the sulfur-containing amino acids in mammals. Endogenous H2S and SO2 generation pathways also existed in the cardiovascular system.H2S and SO2 had important physiological effects in the cardio-vascular system including vasorelaxation and myocardial negative inotropic effect. The pathophysiological effects of H2S and SO2 in the cardiovascular system have been recognized, such as alleviating hypertension and pulmonary hypertension, inhibiting the development of atherosclerosis, and protecting against myocardial ischemia-reperfusion (I /R)injury and isoproterenol-induced myocardial injury. Adenosine triphosphate-sensitive potassium (KATP )channel, L-type calcium (L-Ca2 +) channel, cGMP, NF-κB signaling pathway and MAPK signaling pathway and so on participated in the biological effects of H2S and SO2 .The above findings suggested that H2S and SO2 were important endogenous gaseous signaling molecules in the cardiovascular system, which provided a new way to elucidate the pathogenesis and therapeutic targets of cardiovascular diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36242700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Research Progress in the Neurobiological Effects of Hydrogen Sulfide].","authors":"Yi-Yun Tang, Xiao-Qing Tang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S),the third gaseous signal molecule after carbon monoxide (NO)and nitric oxide (CO),has been widely studied by many researchers.H2S plays important roles in neurobiology. This article overviews the roles of H2S in neuroprotection and neuromodulator and summarizes the progress of its role in central nervous disease.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Nitric Oxide Signaling Pathway and Vascular Activity].","authors":"Yuan-Sheng Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitric oxide-cyclic guanosine 3',5'-monophosphate (cGMP)-cGMP dependent protein kinase signaling pathway is a key mechanism for the modulation of vascular function. The progress in this area of recent years was briefly summarized in this article, in particular, regarding the redox-dependent dimerization of the relevant signaling molecules and their physiological significance as well as the role of soluble guanylyl cyclase-derived cyclic inosine 3',5'-monophosphate as a new messenger for vasoconstriction.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ya-Qian Huang, Hong-Fang Jin, Jun-Bao Du, Chaos Tang
{"title":"[Gasses from wastes to stars].","authors":"Ya-Qian Huang, Hong-Fang Jin, Jun-Bao Du, Chaos Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Role Ofhydrogen Sulfide on Inflammatory Immune Disorders in Cardiovascular Diseases].","authors":"Li-Long Pan, Xin-Hua Liu, Yi-Zhun Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S),a colorless gas with a characteristic rotten-egg odor, has traditionally been considered to be a toxic environmental pollutant. Recently, a multitude of works have demonstrated that H2S was identified as the third gaseous signaling molecule alongside nitric oxide and carbon monoxide. Similar to other gaseous signaling molecules,H2S playeda pivotal role in the pathophysiological processes of cardiovascular disease due to its various biological activities, including anti-oxidative, antiapoptotic, proangiogenic, vasodilating capacities, modulating endothelial nitric oxide synthase activity, and so on. However, the mechanisms of H2S underlying the process remained unclear. In the present review, we summarized the current knowledge on the regulatory effects of H2S on disorders of immune inflammation in cardiovascular disease and underlying molecular mechanisms. A better understanding of the biochemical function of H2S might provide a new therapeutic strategy for cardiovascular diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Wu, Ze-Mei Zhu, Si-Si Yang, Shui-Dong Feng, Hong-Yan Ling
{"title":"[Notch signaling: A new regulator of metabolism].","authors":"Di Wu, Ze-Mei Zhu, Si-Si Yang, Shui-Dong Feng, Hong-Yan Ling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36215445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Regulative Role For Noncoding RNAs During Skeletal Muscle Development and Disease].","authors":"Sheng-Ju Chen, Fei Wang, Yue Zhou, Xiao-Ping Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Noncoding RNAs, including long noncoding RNAs (IncRNAs) and microRNAs (miRNAs), are close to myogenesis, regulating of muscle fiber type and muscle diseases. Recently, circulating ncRNAs have become research focus for they could as potential biomarkers for the screening and early diagnosis of some diseases. We are confident that the role of nccoding RNAs during skeletal muscle development will bring potential target for treatment of muscle diseases in the future.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Exercises participate in dialogues between gut microbiota and the immune system].","authors":"Chun-Yan Li, Su-Jie Zhang, Rui Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36215443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Research advances on effect of high density lipoprotein to the part of microbial infections].","authors":"Zhen-Wang Zhao, Chao-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}