[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases].

生理科学进展 Pub Date : 2016-06-01
Fan Zhang, Qing-Fua Cui
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引用次数: 0

Abstract

microRNAs (miRNAs)are one class of gene regulators whose mature sequences are ~22 nt in length. Normally miRNAs resulted in the cleavage and translation repression by specifically binding the 3'UTR of their target mRNAs in a base pairing form.Accumulating evidence has shown that miRNAs have important molecular functions and play critical roles in almost all biological processes. Therefore, miR-NA-related dysfunctions could be associated with the formation and development of human disease. Bioinformatics aims to provide tools for the research in life sciences. Currently, a number of bioinformatics methods and internet resources have been presented and developed for the investigations of miRNA-disease associations. In the review, we will describe the current status of the above topic and then discuss its future perspectives.

[microRNAs与人类疾病关系研究的生物信息学方法与资源]。
microRNAs (miRNAs)是一类成熟序列长度约为22 nt的基因调控因子。正常情况下,miRNAs通过以碱基配对形式特异性结合其靶mrna的3'UTR,从而导致切割和翻译抑制。越来越多的证据表明,mirna具有重要的分子功能,并在几乎所有的生物过程中发挥关键作用。因此,mir - na相关功能障碍可能与人类疾病的形成和发展有关。生物信息学旨在为生命科学的研究提供工具。目前,许多生物信息学方法和互联网资源已经被提出并开发用于研究mirna与疾病的关联。在回顾中,我们将描述上述主题的现状,然后讨论其未来的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
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期刊介绍: Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.
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