{"title":"[Bioinformatics Methods and Resources for the Research on the Relationship Between microRNAs and Human Diseases].","authors":"Fan Zhang, Qing-Fua Cui","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>microRNAs (miRNAs)are one class of gene regulators whose mature sequences are ~22 nt in length. Normally miRNAs resulted in the cleavage and translation repression by specifically binding the 3'UTR of their target mRNAs in a base pairing form.Accumulating evidence has shown that miRNAs have important molecular functions and play critical roles in almost all biological processes. Therefore, miR-NA-related dysfunctions could be associated with the formation and development of human disease. Bioinformatics aims to provide tools for the research in life sciences. Currently, a number of bioinformatics methods and internet resources have been presented and developed for the investigations of miRNA-disease associations. In the review, we will describe the current status of the above topic and then discuss its future perspectives.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 3","pages":"203-9"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"生理科学进展","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
microRNAs (miRNAs)are one class of gene regulators whose mature sequences are ~22 nt in length. Normally miRNAs resulted in the cleavage and translation repression by specifically binding the 3'UTR of their target mRNAs in a base pairing form.Accumulating evidence has shown that miRNAs have important molecular functions and play critical roles in almost all biological processes. Therefore, miR-NA-related dysfunctions could be associated with the formation and development of human disease. Bioinformatics aims to provide tools for the research in life sciences. Currently, a number of bioinformatics methods and internet resources have been presented and developed for the investigations of miRNA-disease associations. In the review, we will describe the current status of the above topic and then discuss its future perspectives.
期刊介绍：
Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc.
Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.
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