[Overview of Circular RNA Research].

生理科学进展 Pub Date : 2016-06-01

Shu-Hui Chang, Ge Shan

引用次数: 0

Abstract

The fact that RNA could take circular form was discovered as early as 1 976.For a long peri-od,circular RNAs (circRNAs)had been viewed as outliners of transcripts.With the development of sec-ond generation RNA sequencing and bioinformatics,recent studies have revealed that circRNAs are prev-alent,with high degree of conservation,and with cell specificity in eukaryotes.Increasing lines of evi-dence indicate that circRNAs,rather than being noise of splicing,have essential biological functions in a seriers of regulatory events,and may even be related to the etiology of some human diseases.

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[环状RNA研究综述]。

RNA可以呈环状的事实早在1976年就被发现了。长期以来，环状rna (circRNAs)一直被视为转录本的大纲。随着第二代RNA测序和生物信息学的发展，近年来的研究表明，环状RNA在真核生物中普遍存在，具有高度的保守性和细胞特异性。越来越多的证据表明，circrna不是剪接的噪音，而是在一系列调节事件中具有基本的生物学功能，甚至可能与某些人类疾病的病因有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

生理科学进展

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5953

期刊介绍： Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.