【piRNA功能研究进展】。

生理科学进展 Pub Date : 2016-06-01

Dong-Ya Cui, Jia-Jia Wang, Shun-Min He

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引用次数: 0

摘要

piwi相互作用RNA (piRNA)是一类最大的非编码小RNA，通常在种系细胞中表达。piRNA在转座子沉默中起作用，并有助于维持基因名的完整性。秀丽隐杆线虫的piRNA在先前基因表达的记忆中具有特殊的作用。piRNA在体细胞和肿瘤中的发现显示了piRNA功能的多样性。本文综述了piRNA在转座子、mRNA、lncRNA、DNA甲基化和表观遗传调控中的作用，并讨论了piRNA在癌症中的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[The Research Advance of the piRNA Function].

Piwi-interacting RNA (piRNA)is the largest class of small non-coding RNA,which usually expressed in germline cells.piRNA has a role in transposon silencing,and contributes to maintain ge-nome integrity.The C.elegans piRNA has a special role in a memory of previous gene expression.The discovery of piRNA in somatic cells and cancers showed the functional diversity of piRNA.In this article, we reviewed the piRNA's role in transposon,mRNA,lncRNA,DNA methylation and epigenetic regula-tion,and discussed the function of piRNA in cancers.

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来源期刊

生理科学进展

自引率

0.00%

发文量

5953

期刊介绍： Progress in Physiological Sciences is a bimonthly academic journal co-sponsored by Chinese Association for Science and Technology, Chinese Physiological Society and Peking University. It was founded in March 1957. China Core Journal of Science and Technology, China Core Journal of Medicine and Health, Statistical source journal of Chinese Academic Journal Impact Factor Annual Report, China Science Citation Database CSCD (1996-2018); Overview of Key Chinese Core Journals of Peking University (1992-2020, 2023-), It has been reported by China Journal Network, China Academic Journals (Optical Disc Edition), China Biomedical Citation Database CMCI, Science and Technology Journals World Impact Index (WJCI) (2022), Wanfang Data Resource System digital Journal Group (China Core Journal Database); American Medical Index (IM), American Chemical Abstracts (CA), etc. Progress in Physiological Sciences is published at home and abroad. The journal comprehensively reports the new progress in physiological sciences at home and abroad, and publishes review papers related to physiological sciences, namely physiology, biochemistry and molecular biology, pharmacology, pathophysiology, biophysics, nutrition, etc.