Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Effect of long-term carbamazepine therapy on bone metabolism in women with epilepsy].","authors":"G S Rakhimbaeva, F H Muratov, D Y Yusupova","doi":"10.17116/jnevro202612606194","DOIUrl":"https://doi.org/10.17116/jnevro202612606194","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of long-term carbamazepine monotherapy on bone metabolism and bone mineral density in women with epilepsy.</p><p><strong>Material and methods: </strong>The study included 60 women with epilepsy alongside a control group of 55 healthy women. Serum levels of interleukin-7 (IL-7), estradiol, transforming growth factor-beta4 (TGF-<i>β</i>4), alkaline phosphatase, calcium, and phosphorus were measured in all participants. Bone mineral density and structure were assessed using dual-energy X-ray absorptiometry (DEXA).</p><p><strong>Results: </strong>The findings from the early osteoporosis diagnosis examination revealed that the levels of estradiol, IL-7, and TGF-<i>β</i>4 were outside the normal range. In contrast, calcium, phosphorus, and alkaline phosphatase levels remained within reference ranges. Bone mineral density and T-score measurements obtained via DEXA in the lumbar spine, right radius, and right hip exhibited positive correlations with serum levels of estradiol, IL-7, and TGF-<i>β</i>4. Conversely, significant negative correlations were observed with serum calcium, phosphorus, and alkaline phosphatase.</p><p><strong>Conclusions: </strong>Prolonged carbamazepine treatment considerably increases the risk of osteoporosis in women by disrupting hormonal and cytokine regulation, underscoring the critical need to monitor biomarkers such as estradiol, TGF-<i>β</i>4, and IL-7 to facilitate early diagnosis and prevention of osteoporosis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 6","pages":"94-98"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of post-stroke speech disorders and the prospects of mirror therapy in the recovery of patients].","authors":"E V Isakova, S V Kotov, E S Guts","doi":"10.17116/jnevro202612601131","DOIUrl":"10.17116/jnevro202612601131","url":null,"abstract":"<p><p>The review describes the features of post-stroke speech disorders, including epidemiological data on their prevalence, spectrum, and characteristics of their various types. The prospects of using mirror therapy for stroke patients as an affordable, simple, safe, inexpensive method are discussed, which is a relatively new direction in the treatment of aphasia. Also, the literature review focuses on various mechanisms underlying a positive therapeutic effect, including the activation of mirror neurons during the performance of specific actions or the observation of hand and facial movements, and the activation of the tongue. Based on the neuroimaging results, we assessed the effectiveness of simultaneous recovery of hand motor function and speech through mirror therapy with visual biofeedback in the rehabilitation of patients with post-stroke speech disorders. The results of numerous clinical studies, meta-analyses, and case reports confirming the effectiveness of mirror therapy for speech disorders after a stroke are presented.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effectiveness of breathing exercises compared to audio signals to improve sleep].","authors":"D E Shumov, D S Sveshnikov, A E Khuurak, E B Yakunina, Z V Bakaeva, O V Mankaeva, V I Torshin, V B Dorokhov, A N Puchkova","doi":"10.17116/jnevro202612605223","DOIUrl":"10.17116/jnevro202612605223","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of three non-pharmacological interventions - binaural beats (BB) combined with suggestive instructions (SI), diaphragmatic breathing (DB), and BB combined with DB - for improving sleep, with consideration of sex differences among participants.</p><p><strong>Material and methods: </strong>The study included 217 healthy participants. Each participant completed four tasks in randomized order on separate nights before bedtime: (1) BB+SI, (2) DB, (3) BB+DB, and (4) monotonous sound without beats as a control (imitation, IM). Sleep latency (SL) was measured using a smartphone screen-touch test. Statistical analyses of SL values were conducted by task and sex factors.</p><p><strong>Results: </strong>Analysis revealed a statistically significant effect of the task factor on sleep latency (SL) (<i>p</i><0.05). Post-hoc comparisons showed that the DB task significantly reduced mean SL compared to IM for the overall group (<i>p</i><0.05). Additionally, a significant decrease in mean SL following the BB+SI intervention was observed in females compared to IM (<i>p</i><0.05). No statistically significant changes were found in males.</p><p><strong>Conclusions: </strong>The findings confirm the effectiveness of deep diaphragmatic breathing (DB) and suggestive instructions (SI) combined with binaural beats (BB) as non-pharmacological interventions for improving sleep in a large sample. The SI combined with BB demonstrated efficacy exclusively in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5. Vyp. 2","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of vitamin D levels on tension headache characteristics: a systematic review].","authors":"O V Vorobyeva, T E Morozova, A A Gertsog, M V Gurjar, M A Kiriakova, S V Sobenina","doi":"10.17116/jnevro20261260417","DOIUrl":"10.17116/jnevro20261260417","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between vitamin D levels and the frequency and intensity of tension headaches, as well as the therapeutic effectiveness of vitamin D.</p><p><strong>Material and methods: </strong>A systematic review of the literature was conducted, including observational and interventional studies on the relationship between vitamin D levels and tension headache characteristics. The review included 8 studies selected from PubMed, ScienceDirect, Google Scholar, eLibrary, and Europe PMC databases that met the inclusion criteria. The study design, clinical parameters of pain, vitamin D levels, and the effect of therapy were assessed.</p><p><strong>Results: </strong>Vitamin D deficiency is associated with a higher incidence and longer duration of headache episodes, but not with increased intensity. Several studies found a significant negative correlation between vitamin D levels and headache frequency or duration. Interventional studies confirmed the clinical benefit of vitamin D therapy in patients with hypovitaminosis.</p><p><strong>Conclusion: </strong>There is strong evidence linking vitamin D deficiency to a more severe course of tension headaches. Assessing and correcting vitamin D levels may be important in comprehensive treatment. However, further randomized controlled trials are needed to confirm causality and establish standardized therapeutic strategies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Informative value of instrumental methods in assessing the anatomical and functional state of the corticospinal tract in children with severe traumatic brain injury].","authors":"D S Kanshina, I A Melnikov, M V Ublinsky, S B Ivanov, T A Akhadov, V P Zykov, S S Nikitin","doi":"10.17116/jnevro202612607192","DOIUrl":"https://doi.org/10.17116/jnevro202612607192","url":null,"abstract":"<p><strong>Objective: </strong>To compare motor recovery in children with severe traumatic brain injury (TBI) with findings from functional and imaging diagnostic techniques based on the age-dependent theory of motor development.</p><p><strong>Material and methods: </strong>The study included 43 children (26 boys and 17 girls), aged 5 to 17 years, with severe TBI who underwent rehabilitation at the Department of Rehabilitation of the Research Institute of Emergency Pediatric Surgery and Traumatology (Dr. Roshal Clinic) from 2023 to 2024. The clinical evaluation used the Muscle Strength Scale, the Modified Ashworth Scale, and a classification system for gross motor function. Instrumental assessments of the anatomical and functional state of the corticospinal tract (CST) included diagnostic single-pulse transcranial magnetic stimulation (sTMS) and magnetic resonance (MR) tractography, which analyzed corticomotor neuronal pathways originating from the primary motor cortex (PMC) and supplementary motor area.</p><p><strong>Results: </strong>Improvement in motor deficits during both intermediate and long-term phases post-injury was associated with a reduction in the threshold for motor evoked responses (MER) (AUCs of 0.583 and 0.548, respectively) and an increase in MER amplitude (AUCs of 0.5 and 0.508, respectively). A significant correlation was noted between the deviation of the MER threshold from reference values and the patient's age at the time of injury, with deviations of 9.27% for ages 6-12 years and 26.1% for ages 12-18 years (<i>p</i><0.05). Additionally, an increase in the fractional anisotropy coefficient of CST was observed in children with various degrees of motor impairment following severe TBI within the first-year post-trauma.</p><p><strong>Conclusions: </strong>The findings suggest that instrumental diagnostic methods can effectively assess the severity of motor deficits in children with severe TBI and diminished consciousness. The interpretation of these results should incorporate the age-dependent theory of locomotor behavior development.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Guidelines for clinical electroencephalography: Russian professional community development and consensus building].","authors":"M V Sinkin, T A Aleksandrova, E A Baranova, A I Belyakova-Bodina, E P Bogdanova, Z K Gorchkhanova, O V Grebennikova, D V Drozdov, O D Elshina, I D Lemeshko, A J Smirnova, A S Smychkov, T R Tomenko, A A Troitskiy, I V Okuneva, A A Sharkov","doi":"10.17116/jnevro20261260225","DOIUrl":"10.17116/jnevro20261260225","url":null,"abstract":"<p><p>Clinical guidelines based on scientific data are mandatory for clinical practice. However, they only indicate the necessity of diagnostic tests and do not describe how to perform them. Additional methodological documents are therefore necessary to standardize diagnostic and therapeutic processes. The Association of Clinical Neurophysiology Specialists (ASCLIN), in collaboration with the Russian Association of Functional Diagnostics Physicians (RASFD), the All-Russian Society of Neurologists, and the Russian Anti-Epilepsy League (RAEL), has developed methodological guidelines for EEG and EEG with stress tests. Since this term, used in the nomenclature of medical services, is not used in practice, the recommendations use the synonym «functional tests» as the most common and understandable for personnel conducting EEG, corresponding to the English terms 'activating' and «modulating procedures.» The level of evidence was assessed using the GRADE system; more than 6000 functional diagnostics physicians and neurologists participated in the public discussion. Twenty-two recommendations were formulated, three of which are level B2 and eight of which are level C5. The document includes practical appendices with examples of standard operating procedures, a protocol for examinations during attacks, and illustrations of typical artifacts. The developed methodological guidelines align with the Ministry of Health of the Russian Federation's clinical recommendations ecosystem. They aim to standardize EEG procedures and improve diagnosis and treatment quality.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2. Vyp. 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence of mental disorders and syndromic mental distress in patients with chronic dermatoses: A cross-sectional epidemiological study].","authors":"I Yu Dorozhenok, O Yu Olisova, E P Melnik, D A Larionov, D A Koriakin, B A Volel","doi":"10.17116/jnevro2026126071107","DOIUrl":"https://doi.org/10.17116/jnevro2026126071107","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prevalence and clinical structure of comorbid mental disorders among patients with chronic dermatoses, to identify associations with specific nosological forms of skin diseases, and to perform a differential analysis of subsyndromal mental distress.</p><p><strong>Material and methods: </strong>A single-center, cross-sectional epidemiological study was conducted, including 500 patients diagnosed with chronic dermatoses at the Clinic for Skin and Venereal Diseases named after V.A. Rakhmanov of the Sechenov First Moscow State Medical University from March 2025 to March 2026. Dermatological and psychiatric diagnoses were validated according to ICD-10 criteria. To assess participants' mental status, a battery of validated assessment scales was used, along with a consultation with a psychiatrist. Participants were stratified into three groups: patients with psychiatric comorbidity, patients with subsyndromal mental distress, and a comparison group.</p><p><strong>Results: </strong>Psychiatric diagnoses conforming to ICD-10 criteria were confirmed in 46.4% of the overall population (<i>n=</i>232). The structure of comorbidity was primarily characterized by a prevalence of adaptation disorders (F43), which accounted for 61.2% of the group diagnosed with mental disorders. The highest risk of comorbid conditions was associated with psoriasis (odds ratio [OR]=2.34; <i>p<</i>0.001), atopic dermatitis (OR=2.18; <i>p</i>=0.002), and vitiligo (OR=2.13; <i>p</i>=0.044). Subsyndromal mental distress was identified in 39.6% of patients (<i>n=</i>198). Quality of life, as measured by the Dermatology Life Quality Index, was significantly reduced in the group with subsyndromal mental distress (median score of 14.0), which was comparable to that of the group with verified psychiatric diagnoses (18.4±6.3). Notably, psychogenic exacerbations of dermatosis were reported in 37.6% of patients, with those receiving psychotropic therapy experiencing significantly fewer exacerbations (median 2.0 vs. 4.0; <i>p</i>=0.018).</p><p><strong>Conclusions: </strong>The prevalence of psychiatric comorbidity among patients with chronic dermatoses is substantial, encompassing 86.0% of the population when considering subsyndromal conditions. The data obtained underscore the necessity for the introduction of systematic screening for psychosomatic status within dermatological protocols and advocate for a transition towards a multidisciplinary care model that integrates both dermatological and psychiatric management.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Current perspectives on non-pharmacological approaches to cognitive impairment].","authors":"E A Gileva, E A Kovalenko, E V Makhnovich, N A Osinovskaya, A N Bogolepova","doi":"10.17116/jnevro202612608159","DOIUrl":"https://doi.org/10.17116/jnevro202612608159","url":null,"abstract":"<p><p>Cognitive impairment (CI) is increasingly recognized as a significant public health issue. Despite extensive research into its causes, mechanisms, and risk factors, along with advancements in pharmacological treatments for associated conditions, preventing or slowing the progression of cognitive decline often cannot be achieved through medication alone. Consequently, non-pharmacological strategies are also employed to support cognitive health in patients with cognitive disorders. This literature review explores the most effective non-drug therapies for cognitive impairment, as well as potential combinations of these approaches.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 8","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Herpes infection and primary cerebral vasculitis].","authors":"L A Kalashnikova, A A Shabalina, M V Dreval, S A Zacharchuk, L A Dobrynina","doi":"10.17116/jnevro202612602139","DOIUrl":"10.17116/jnevro202612602139","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the presence of antibodies to herpes viruses (<i>Varicella zoster virus</i> [VZV], herpes simplex virus types I and II, Epstein-Barr virus, and cytomegalovirus) and their DNA in the cerebrospinal fluid (CSF) of patients with a history of ischemic stroke (IS) and/or transient cerebrovascular accident (TIA) caused by primary cerebral vasculitis (PCV); to evaluate their clinical significance.</p><p><strong>Material and methods: </strong>Thirty-one patients (mean age 41.2±8.7 years, 18 males, 58%) with PCV and a history of IS and/or transient cerebrovascular accidents (TIA), which in 94% occurred in the internal carotid artery (ICA) system, were examined. Antibodies were tested by enzyme-linked immunosorbent assay (ELISA) or immunochemiluminescence, and herpesvirus DNA was tested by polymerase chain reaction (PCR).</p><p><strong>Results: </strong>An increase in immunoglobulin (Ig) G antibodies to the VZV virus (anti-VZV IgG antibodies) was detected in 10 (32%) of 31 patients in the CSF; one of them also had Ig antibodies to the herpes simplex virus. There were statistically significant differences between patients with and without anti-VZV IgG antibodies regarding the frequency of convulsive disorder (40% vs. 0%, respectively, <i>p=</i>0.0023<b>)</b>, TIA <b>(</b>60% vs. 90%, respectively, <i>p=</i>0.0483), the insidious onset of stroke symptoms (over several hours to 2-3 days) <b>(</b>30% vs. 0%, respectively, <i>p=</i>0.0092) and the increase in the erythrocyte sedimentation rate [ESR] <b>(</b>0% vs. 33%, respectively, <i>p=</i>0.0412).</p><p><strong>Conclusion: </strong>An increase in anti-VZV IgG antibodies in CSF in 32% of patients suggests VZV activation in the trigeminal ganglion and its transaxonal spread along the branches of the trigeminal nerve into the walls of the ICA and the middle and anterior cerebral arteries, where VZV causes inflammation. It explains the most common lesion of the ICA system (94%), its locality, and the absence of systemic inflammatory signs. In patients without anti-VZV IgG antibodies, it is assumed that PCV is caused by other neurotropic pathogens that can affect hemostasis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of Abobotulinumtoxin A (Dysport) in stump preparation for prosthetic fitting in patients with combat-related limb amputations].","authors":"T V Kuznetsova, O O Ziteva, E B Shakhunova, Yu N Ponomarenko, M E Kasatkina","doi":"10.17116/jnevro202612602177","DOIUrl":"10.17116/jnevro202612602177","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of abobotulinumtoxinA in stump preparation for prosthetic fitting in patients with limb amputations.</p><p><strong>Material and methods: </strong>This prospective open-label study included 88 male patients over 18 years old with lower limb amputations due to mine-blast trauma and phantom limb pain syndrome (PLP) with pain intensity of at least 5 points on the visual analogue scale (VAS), absence of significant effect from pharmacological therapy, stump tenderness, and preserved active movements in the transected muscles. AbobotulinumtoxinA at doses of 500-800 U was used to reduce PLP severity. Examination of all patients included collection of complaints and medical history, neurological examination (including manual muscle testing and muscle tone assessment), pain assessment by VAS, psycho-emotional status assessment using the Hospital Anxiety and Depression Scale (HADS), neuropathic pain assessment using the DN4 questionnaire, and stump ultrasound to assess muscle functional status (presence or absence of movements). The total observation period was 21 days. Seven patients with preserved muscles were additionally examined 3 months after botulinum toxin injection.</p><p><strong>Results: </strong>Baseline VAS pain score was 5.8±0.4 points. Clinically significant anxiety according to HADS was present in 86 patients. The mean anxiety score before botulinum toxin injection in the group was 9.1±1.2 points. Depression scores on the HADS were subclinical in all patients, with a mean of 5.3±1.6 points. The mean DN4 neuropathic pain score was 5.9±0.5 points. Pain intensity decreased in all patients, reaching a mean of 3.7±0.5 points on VAS by day 7 after botulinum toxin therapy (<i>p</i><0.05). By day 14, pain syndrome was completely resolved in all patients. The mean DN4 score was 5.1±0.4 points on day 7 and 2.6±0.9 points on day 14 after injection (<i>p</i><0.05).</p><p><strong>Conclusions: </strong>Early botulinum toxin therapy enables rapid stump preparation for prosthesis fitting, resolves pain syndrome and accelerates patient rehabilitation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}