Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Nutritional care for patients with neurodegenerative diseases in the outpatient practice of a neurologist].","authors":"E V Guzanova, T A Sorokina, A V Zorkova","doi":"10.17116/jnevro202512501176","DOIUrl":"10.17116/jnevro202512501176","url":null,"abstract":"<p><p>Nutrition is a basic factor of health and well-being of people, affecting the quality and duration of life. Meanwhile, patients with neurodegenerative diseases of the central nervous system are particularly at risk of malnutrition and dehydration with serious health consequences. The article presents an analysis of the main causes of malnutrition in patients with neurodegenerative diseases, and considers a clinical case of including additional nutritional support in the comprehensive management of a patient with amyotrophic lateral sclerosis. The importance of screening elderly patients for the risks of malnutrition and dehydration during an outpatient medical appointment and including appropriate additional diagnostic and therapeutic (additional enteral nutrition and fluid regimen) measures in the work of an outpatient neurologist is emphasized.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Aicardi-Goutieres syndrome type 6 associated with a compound heterozygous variant in ADAR: a first case report in the Russian population].","authors":"D V I, S A Seregin, T N Proskokova","doi":"10.17116/jnevro2025125011131","DOIUrl":"10.17116/jnevro2025125011131","url":null,"abstract":"<p><p>Aicardi-Goutieres syndrome (AGS) is a rare hereditary disorder with different types of inheritance manifested by progressive leukoencephalopathy with early onset, sharing common features with autoimmune disease. This article describes the first Russian case of AGS type 6 (AGS6) associated with compound heterozygote c.577C>G (p.Pro193Ala)+c.2304G>A (p.Trp768*) in <i>ADAR</i> and provides a more in-depth understanding of AGS6 by summarizing the worldwide literature and suggesting models for practitioners to diagnose patients with clinically suspected AGS.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Factors of depression according to actigraphy in the fall season].","authors":"D G Gubin, Yu V Boldyreva, S N Kolomeichuk","doi":"10.17116/jnevro202512505227","DOIUrl":"https://doi.org/10.17116/jnevro202512505227","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between sleep parameters, physical activity, and illumination obtained by weekly actigraphy and depression symptoms measured by the Beck Depression Inventory (BDI-II) in young adults in the fall season.</p><p><strong>Material and methods: </strong>The crossover study, conducted during one fall month, included 122 adults (mean age 24.40 years, 76.6% females) from Tyumen (Russia). Participants were monitored for seven days using actigraphy and completed the Russian version of the BDI-II questionnaire to assess depressive symptoms. Actigraphy data were analyzed for quantitative and qualitative sleep parameters, dynamic illumination, and circadian rhythm of motor activity. Both mean values and regularity indicators were recorded. Statistical analysis was performed using linear and multiple linear regression methods, using the Benjamini-Hochberg procedure to control the incidence of false correlations associated with multiple testing.</p><p><strong>Results: </strong>The analysis showed significant correlations between various actigraphic indicators and the level of depression according to BDI-II. In particular, the BDI-II integral score was significantly associated with a decrease in the amplitude of the circadian rhythm of physical activity (PIM A: -0.258; <i>p</i>=0.005), a high instability of sleep efficiency (SL_EFF SD: -0.323; <i>p</i>=0.0003), a high standard deviation of the moment of awakening (WT SD: -0.258; <i>p</i>=0.005), a decrease in the inter-day stability of the activity rhythm (IS: -0.260; <i>p</i>=0.004), and a lower circadian light hygiene index (NA_bl: -0.193; <i>p</i>=0.036). After multiple comparison adjustments, low PIM A, reduced inter-day stability (IS), increased WT SD, and high SL_EFF SD remained significant predictors of depressive symptoms. In age-, sex-, and body mass index (BMI)-adjusted multiple regression, WT SD (β=-0.258; <i>p</i>=0.006), SL_EFF SD (β=-0.302; <i>p</i>=0.0006), and IS (β=-0.225; <i>p</i>=0.013) were significant factors.</p><p><strong>Conclusion: </strong>The data obtained indicate a complex relationship between sleep dynamics and mental health in the context of BDI-II. They emphasize the critical importance of using parameters that assess sleep regularity as one of the markers of biological clock synchrony to increase informative value and improve the interpretation of data obtained using wearable devices.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[High individual stability of daytime sleep EEG characteristics in nighttime sleep restriction settings].","authors":"A N Puchkova, O N Tkachenko, E O Gandina, D E Shumov","doi":"10.17116/jnevro202512505222","DOIUrl":"https://doi.org/10.17116/jnevro202512505222","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the stability of the electroencephalogram (EEG) spectral characteristics of daytime sleep with moderate nighttime sleep deprivation.</p><p><strong>Material and methods: </strong>The study included 44 students without sleep disorders. The participants limited the nighttime sleep the day before the experiment to 5 hours; then, polysomnograms of a 90-minute daytime sleep were recorded in three repeated sessions. The obtained records were visually staged by experts. Spectral analysis of the wave amplitudes in the delta, theta, alpha, and sigma ranges and averaging for N1, N2, and N3 sleep phases in each record were performed. Stability was assessed through intra-group correlation coefficient (ICC).</p><p><strong>Results: </strong>N1 phase showed moderate individual stability (ICC 0.42-0.52) for all wave amplitudes except the sigma waves (ICC=0.68). In N2 phase, stability was increased: the sigma wave amplitude reached ICC=0.91 and 0.7-0.72 for theta and alpha wave amplitudes. In N3 phase, the delta and theta waves showed high stability (ICC=0.92-0.95). Sigma waves in the N3 phase were less stable. The results were consistent with those obtained for nighttime sleep: the sigma and delta waves were highly stable. Sigma waves (associated with sleep spindles) are most stable in N2; the delta and theta activity in N3. These observations show that despite external impacts, daytime sleep maintains intact individual neurophysiological patterns.</p><p><strong>Conclusion: </strong>Daytime sleep demonstrates significant stability in the EEG spectral characteristics, especially in the deeper phases. Single EEG recording can be used in assessing individual sleep patterns, which is important for developing personalized approaches to improve the effects of sleep deprivation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sleep disturbance in patients with chronic nonspecific neck pain before and after radiofrequency denervation].","authors":"M I Gaydash, G Yu Evzikov, M G Zonov, V V Khizhniak, M A Shaykhalov","doi":"10.17116/jnevro202512505287","DOIUrl":"https://doi.org/10.17116/jnevro202512505287","url":null,"abstract":"<p><strong>Objective: </strong>To study the severity of insomnia before and after radiofrequency denervation (RFD) in chronic nonspecific neck pain (CNNP).</p><p><strong>Material and methods: </strong>The study included 25 patients with CNNP (18 females and 7 males) aged 23 to 88, with a mean age of 63.7±16 years. Pain intensity was assessed using a Visual Analog Scale (VAS), and sleep quality was assessed using the Insomnia Severity Index (ISI) before and 3 months after RFD.</p><p><strong>Results: </strong>Chronic insomnia was diagnosed in the majority (18 of 25) of patients with CNNP, and in more than half (13 of 18), it preceded the occurrence of pain. Three months after RFD, the pain intensity according to VAS decreased from 7.1±1.1 to 3.2±2.7 points (<i>p</i><0.001), the severity of insomnia decreased from 16.4±6.3 to 12.2±7.1 points (<i>p</i><0.001). High ISI scores (14.6±3.4 points) 3 months after RFD were found in patients with sleep disorders preceding CNNP.</p><p><strong>Conclusion: </strong>Most patients with CNNP have chronic insomnia. RFD provides a significant reduction in the severity of pain and, as a result, improves sleep quality. Normalization of sleep is less likely in the presence of insomnia before the development of cervical pain; in such cases, cognitive behavioral therapy (CBT) may be effective.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"87-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of cognitive status in patients with different nosologies and clinical variants of very late manifesting schizophreniform psychosis].","authors":"V V Pochueva, I V Kolykhalov","doi":"10.17116/jnevro202512504288","DOIUrl":"https://doi.org/10.17116/jnevro202512504288","url":null,"abstract":"<p><strong>Objective: </strong>To study and compare the features of cognitive functioning in patients with very late-manifesting schizophreniform psychosis (VLMSP) depending on the clinical variants of the disease.</p><p><strong>Material and methods: </strong>The study included 61 patients (58 females, 3 males) aged 63 to 78 years. All patients met the ICD-10 criteria for psychosis and had no signs of dementia. Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA) score and the Mini-Mental State Examination (MMSE). Statistical analysis was performed using non-parametric methods.</p><p><strong>Results: </strong>Patients with severe polymorphic psychotic symptoms had the most pronounced cognitive deficit (MMSE on Day 0 was 22.5 [20; 26] points, MoCA on Day 0 was 16 [12; 19] points, <i>p</i><0.05), which partially improved after treatment, but remained below the reference values (MMSE on Day 28 was 24.5 [22; 26] points, MoCA on Day 28 was 18.5 [17; 22] points). In patients with paranoid symptoms, cognitive impairment was less pronounced (MMSE on Day 0 was 26 [24; 28] points, MoCA on Day 0 was 0 [17; 24.5] points) and stable (MMSE on Day 28 was 27 [25.5; 29.5] points, MoCA on Day 28 was 21 [17; 25] points). In the group where affective-delusional symptoms prevailed, the cognitive deficit was minimal (MMSE on Day 0 was 27.5 [27; 28.5] points, MoCA on Day 0 was 24 [23; 26.5] points) and completely reduced after treatment (MMSE on Day 28 was 29 [28; 30] points, MoCA on Day 28 was 26 [25; 28] points).</p><p><strong>Conclusion: </strong>The study showed significant differences in cognitive status in patients with VLMSP depending on the clinical variant of the disease. The results emphasize the need for an individualized approach to diagnosing and treating VLMSP and the importance of monitoring cognitive functions for early detection of neurodegenerative processes.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 4. Vyp. 2","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Biochemical features of migraine pathogenesis].","authors":"N L Kunel'skaya, Z O Zaoeva, N I Vasilchenko, M A Chugunova, S D Revazishvili","doi":"10.17116/jnevro202512504121","DOIUrl":"https://doi.org/10.17116/jnevro202512504121","url":null,"abstract":"<p><p>The article addresses the main mechanisms of migraine pathogenesis in terms of biochemical features (neurotransmitter metabolism, neurochemistry, neurophysiology, and neurogenetics). The effect of hormones, electrolytes (magnesium, calcium, sodium), vitamins (vitamin D, B₁₂), and other biologically active molecules (melatonin, L-carnitine, L-tryptophan) on the course of the disease is considered. Including some laboratory tests in the migraine diagnostic algorithm helps identify the secondary nature of headache and/or dizziness, manage therapeutic approaches, and adjust the prognosis and treatment outcomes.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 4","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Factors determining postoperative mortality in patients with hypertensive intracerebral hematomas].","authors":"S Ya Zapesotskaya, I M Godkov, V G Dashyan","doi":"10.17116/jnevro202512503235","DOIUrl":"10.17116/jnevro202512503235","url":null,"abstract":"<p><strong>Objective: </strong>To determine the method of prediction of postoperative mortality in patients with hemorrhagic stroke.</p><p><strong>Material and methods: </strong>The study included 264 patients who underwent surgery for a hypertensive intracerebral hematoma at the N.V. Sklifosovsky Research Institute for Emergency Medicine from 1997 to 2020. Of these, 116 (43.9%) had putamen hematomas, 107 (40.5%) had subcortical hematomas, and 41 (15.5%) had cerebellar hematomas.</p><p><strong>Results: </strong>A retrospective analysis identified risk factors affecting the disease prognosis. Univariate and multivariate Cox regression analysis yielded a statistically significant mathematical model (p, Wald <0.0001) with good consistency (concordance coefficient=0.83). A nomogram was plotted to predict the survival of patients after surgery. The final model included the following factors that increase the probability of death: deep coma (HR=542.8; 95% CI 68.2-4321.3), decompression craniotomy (HR=7.64; 95% CI 4.06-14.39), hypertension (HR=6.48; 95% CI 1.80-23.40), recurrent hemorrhage (HR=4.78; 95% CI 2.66-8.59), postoperative infection complications (HR=3.24; 95% CI 1.56-6.71), pyramidal insufficiency (HR=3.34; 95% CI 0.85-13.04), as well as factors that reduce the risk of death: moderate coma, the presence of transverse dislocation, cerebellar symptoms, and moderate severity.</p><p><strong>Conclusions: </strong>The analysis identified predictors of death in this category of patients, thus further narrowing the group of patients with hemorrhagic stroke for whom surgical treatment is indicated.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3. Vyp. 2","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The potential of neurofeedback control in treating insomnia and improving sleep quality (a systematic review)].","authors":"A V Zakharov, I V Shirolapov","doi":"10.17116/jnevro202512505257","DOIUrl":"https://doi.org/10.17116/jnevro202512505257","url":null,"abstract":"<p><p>Chronic sleep disturbance has a pronounced adverse impact on a person's quality of life and physical and mental well-being. Despite the high prevalence of the disorder and the need for therapeutic interventions, the accessibility and effectiveness of conventional insomnia treatments remain limited. The electroencephalography (EEG)-neurofeedback control method is based on objective brain activity data to teach the patient self-regulation. This study performed a systematic analysis of current data on the use of neurofeedback technology for the treatment of sleep disorders, assessing the method's effectiveness and limitations. The search and review of publications from international databases over the past 10 years was performed in accordance with the PRISMA guidelines and the methods described in the RELISH Consortium. The results show that neurofeedback control, in particular, based on individual peak alpha frequency, is a viable and promising therapy. The technology significantly improves subjective and objective sleep parameters, such as reducing sleep latency, increasing total sleep time, and improving sleep quality. With its high efficacy and safety, neurofeedback control can become one of the key components of personalized medicine for the long-term treatment of insomnia and other sleep disorders.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Tongue and epiglottis surgery in the treatment of obstructive sleep apnea syndrome].","authors":"L S Karapetyan, V M Svistushkin, A A Mamedov, I Zh Grigoryan","doi":"10.17116/jnevro202512505270","DOIUrl":"https://doi.org/10.17116/jnevro202512505270","url":null,"abstract":"<p><p>This literature review describes treatments for obstructive sleep apnea syndrome (OSAS) caused by the collapse of the upper respiratory tract soft tissue. The authors emphasize the importance of a thorough examination of patients, including sleep video endoscopy (SVE), to determine the exact level of obstruction and select the optimal surgical strategy. The paper addresses various methods of surgical intervention on the tongue base and epiglottis, including submucosal minimally invasive lingual excision (SMILE), transoral robotic surgery (TORS), low-temperature coblation of the tongue base (LTBR), etc. Indications for surgery on the tongue base and epiglottis are analyzed, as well as the advantages and disadvantages of surgical methods compared to traditional therapy with constant positive airway pressure (CPAP). The results of the literature review support using tongue base and epiglottis surgery in certain adult patients with snoring and OSAS.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}