Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Reorganization of the corticospinal tract and thalamocortical projections in children with sequelae of severe traumatic brain injury].","authors":"D S Kanshina, M V Ublinsky, I A Melnikov, T A Akhadov, O V Bozhko, S A Valliulina, V P Zykov","doi":"10.17116/jnevro202512505156","DOIUrl":"https://doi.org/10.17116/jnevro202512505156","url":null,"abstract":"<p><strong>Objective: </strong>To associate the clinical recovery of locomotor function with the functional and structural viability of corticospinal and thalamocortical projections in children in the intermediate and long-term periods after severe traumatic brain injury (TBI).</p><p><strong>Materials and methods: </strong>The study included 11 children (7 in the intermediate and 4 in the long-term periods of severe TBI). Clinical status was assessed based on muscle strength and tone testing in the distal parts of the hands (using the Muscle Strength Scale and the Modified Ashworth Spasticity Scale) and the classification system for large motor functions. Electrophysiological methods include somatosensory evoked potentials during median nerve stimulation, diagnostic single-pulse transcranial magnetic stimulation (sTMS), and routine electroencephalography with functional tests. Neuroimaging included magnetic resonance tractography from the primary motor cortex and supplementary motor area.</p><p><strong>Results: </strong>Preliminary data indicate the complexity of assessing the dependence of motor deficit (K-coefficient) on the preservation of corticospinal projections from the primary motor cortex and supplementary motor area and amplitudes of motor evoked potentials in the intermediate period; however, they suggest a correlation between these parameters in the long-term period after severe TBI in children.</p><p><strong>Conclusion: </strong>Based on the presented cases, preservation of corticospinal projections according to neuroimaging data and motor evoked potentials according to sTMS are unreliable predictors of locomotor function recovery-their predictive value increases in the long-term after TBI upon completion of structural and functional remodeling.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5","pages":"56-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenetic interrelations of hypogonadism and depression in men].","authors":"V S Bulanov, A V Litvinov, L N Gorobets, A A Akhmedova","doi":"10.17116/jnevro202512501117","DOIUrl":"10.17116/jnevro202512501117","url":null,"abstract":"<p><p>The study of the relationship between depression and functional hypogonadism in men is an interesting and difficult task. The purpose of the presented review was to identify the problem of functional male hypogonadism, to show a complex multi-stage neurohumoral mechanism of regulation of its potential to influence the affective sphere and to address the influence of pharmacotherapy on the formation of sexual disorders in men. The primary search for literature data was conducted using PubMed (Medline), PsycINFO and Cochrane CENTRAL, e-library.ru, databases using the keywords «hypogonadism», «depression», «testosterone», «antidepressants», «antipsychotics». As a result, 63 sources of information were selected and analyzed. Among the selected papers, there were 2 meta-analyses, 12 reviews and 42 comparative studies, including longitudinal, cross-sectional and controlled studies, 7 practical manuals. Based on the data obtained, it is possible to draw conclusions about the relationship between depression and functional hypogonadism as well as about the possibility of pathogenetic mechanisms of depression to cause changes in the state of the hypothalamic-pituitary-gonadal axis, leading to hypogonadism and vice versa, the ability of hypogonadism to form and enhance depressive symptoms. The concept of the mechanisms of regulation of steroidogenesis can allow the development of alternative methods of therapy and augmentation of depressive disorders, minimization of the number of sexual dysfunctions of psychopharmacotherapy. Further large-scale studies are needed for an in-depth study of this topic and the resolution of a number of contradictions.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of sleep and other medical and social factors on a woman's reproductive function].","authors":"Yu V Shkurenko, A D Ibatov, K S Sahakyan, S Z Mirzalieva, A R Shukurlu","doi":"10.17116/jnevro202512505281","DOIUrl":"https://doi.org/10.17116/jnevro202512505281","url":null,"abstract":"<p><p>According to the World Health Organization, infertility affects one in six couples worldwide, highlighting the relevance of strategies to preserve women's reproductive health. In this review, we consider the impact of various medical and social factors, such as sleep quality, anxiety, depression, lifestyle, level of education, income, etc., on fertility. Particular attention is paid to the modifiability of these factors, which opens up additional opportunities for preventing and treating infertility. The association between the adjustment of medical and social factors and improved outcomes of assisted reproductive technologies, such as <i>in vitro</i> fertilization, is emphasized. Attention to medical and social factors and their adjustment is an important direction for improving fertility and the success of infertility prevention and treatment, and further research and implementation in clinical practice are also required.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5. Vyp. 2","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Comparing the efficacy of divozilimab and second-line treatments for relapsing-remitting multiple sclerosis in the Russian Federation: a systematic review and network meta-analysis].","authors":"M N Zakharova, T O Simaniv, K V Sapozhnikov, D G Tolkacheva, V D Sokolova, N A Sableva, O N Mironenko, A A Lazarev, T V Khimich","doi":"10.17116/jnevro202512502158","DOIUrl":"10.17116/jnevro202512502158","url":null,"abstract":"<p><strong>Objective: </strong>To compare efficacy of the new drug divozilimab with other second-line treatment options for relapsing remitting multiple sclerosis (RRMS) that have been already included or submitted application to be included into the «14 high-cost nosologies» program in the Russian Federation.</p><p><strong>Material and methods: </strong>We conducted systematic literature review (PROSPERO ID CRD42022310082) and frequentist network meta-analysis of 2-years efficacy of divozilimab and other second-line therapies to treat RRMS.</p><p><strong>Results: </strong>Annualized relapse rate ratio in divozilimab vs fingolimod was 0.4 (95% CI 0.3-0.7), divozilimab vs cladribin 0.5 (95% CI 0.3-0.9), divozilimab vs alemtuzumab 0.7 (95% CI 0.3-1.7), divozilimab vs ocrelizumab 0.7 (95% CI 0.3-1.6), divozilimab vs ofatumumab 0.7 (95% CI 0.4-1.1), divozilimab vs natalizumab 0.4 (95% CI 0.4-1.1) respectively. Divozilimab had the highest SUCRA rank (0.9) while fingolimod had the lowest (0.4).</p><p><strong>Conclusion: </strong>Systematic literature review and network meta-analysis revealed statistically significant superiority of divozilimab over cladribine and fingolimod and absence of statistically significant differences with alemtuzumab, ocrelizumab, ofatumumab and natalizumab in the annual relapse rate during 2 years of treatment.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 2","pages":"58-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A clinical case of diabulimia in type 1 diabetes mellitus: Psychopathological mechanisms and psychosomatic relationships].","authors":"A V Shchurenkov, P A Kazaryan, V A Rozhdestvenskaya, I V Poluboyarinova, P G Iuzbashian, E I Voronova, V V Fadeev, D V Romanov","doi":"10.17116/jnevro2025125041118","DOIUrl":"10.17116/jnevro2025125041118","url":null,"abstract":"<p><p>In type 1 diabetes mellitus (type 1 DM), an eating disorder (ED) may occur, referred to as «diabulimia,» in which patients use insulin to control body weight, contributing to the decompensation of endocrinopathy. In the presented clinical case, a patient (35 years old) with a 10-year history of type 1 diabetes mellitus intentionally refuses regular insulin administration in order to reduce body weight. The psychopathological qualification of the phenomenon underlying the ED presented as diabulimia in this patient corresponds to grandiose notions as part of schizotypal disorder (F21). The peculiarity of the condition in this clinical case is that the grandiose notion of weight loss was observed before the manifestation of type 1 diabetes mellitus, and later, it was included in the structure of the internal presentation of the disease (endocrinopathy), led to manipulations with insulin therapy, which in turn resulted in late complications of diabetes.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 4","pages":"118-123"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A clinical case of type 1 neurofibromatosis associated with a rare genotype].","authors":"I F Fedoseeva, A V Goncharenko, V A Goncharenko, T V Poponnikova, O S Pinevich, T Yu Bedareva","doi":"10.17116/jnevro2025125061128","DOIUrl":"10.17116/jnevro2025125061128","url":null,"abstract":"<p><p>Type 1 neurofibromatosis is a rare hereditary monogenic disease with an autosomal dominant inheritance associated with a mutation in the NF1 gene on chromosome 17, which encodes neurofibromin, a protein with tumor-suppressive activity. A large genomic deletion of the <i>NF1</i> gene is detected in only 5-10% of patients with type 1 neurofibromatosis. A clinical case of type 1 neurofibromatosis associated with a rare extensive deletion of the <i>NF1</i> gene involving the whole studied gene (exons 1 to 57) in a patient who was observed from early childhood to 17 years of age is presented. The phenotype included early clinical onset with typical skin manifestations, multisystem lesions, sequential progression of diffuse multifocal lesions in the brain and peripheral nervous system, and visual disorders associated with optic glioma.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 6","pages":"128-132"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic variants associated with the development of stress disorders: A systematic review of GWAS].","authors":"Y A Zorkina, E A Golubeva, O I Gurina, A M Reznik, A Y Morozova","doi":"10.17116/jnevro202512503112","DOIUrl":"10.17116/jnevro202512503112","url":null,"abstract":"<p><p>Studying the genetic basis of post-traumatic stress disorder (PTSD) can be useful in predicting its risk in a person with a history of severe traumatic stress and in facilitating earlier diagnosis and referral to a specialist. The aim of the study is to review all GWAS studies related to PTSD. In total, 20 studies were included, of which 5 meta-analyses and 9 included war veterans. The functions of genes and their associations were considered, which included single-cell polymorphisms in different groups of genes involved in embryogenesis, neuron formation, and cell functioning, as well as many DNA sequences with non-coding RNA transcribed. The repeatability of the results between studies and replicative samples was studied. Between the studies, the associations were repeated in the <i>CAMKV, CDHR4, DCC, FAM120A, FOXP2</i> (3 studies)<i>, MAD1L1</i> (3 studies)<i>, MAPT, NCAM1, NOS1, SP4, ZMYM4, TCF4</i> genes<i>.</i> A new large-scale study with many found associations was considered individually. Studies regarding polygenic risk were also studied, and several studies showed genetic comorbidity with anxiety and bipolar disorder. However, the models developed by the authors explain a small percentage of variance and are weakly repeated in other samples. It may be possible to solve this problem by using larger samples and clearer homogeneous inclusion criteria. Thus, at the moment, there are few GWAS studies of PTSD; they are ambiguous and uninformative compared to the same studies for other mental disorders, but they have further potential for assessing the risks of developing the disease.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"12-26"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Personal characteristics of patients with cerebral microangiopathy].","authors":"T A Slyusar, Yu V Abramenko, I N Slyusar, V N Abramova, A B Antoshina","doi":"10.17116/jnevro202512503151","DOIUrl":"https://doi.org/10.17116/jnevro202512503151","url":null,"abstract":"<p><strong>Objective: </strong>To study the personality characteristics of patients with cerebral microangiopathy (CMA) and evaluate the effect of sequential therapy with Mexidol (500 mg injections intravenously for 14 days) and Mexidol FORTE 250 (250 mg tablets 3 times a day for 60 days) on the personal characteristics of patients with CMA.</p><p><strong>Material and methods: </strong>130 patients aged 55-70 years (72 women and 58 men) with CMA, who received Mexidol as part of the complex treatment according to the specified scheme. The neuropsychological study included the study of personality traits using the multifactorial personality questionnaire of R. Cattell and the Freiburg personality questionnaire, MRI. The neuropsychological examination included the study of personality characteristics using the R. Cattell multifactorial personality research questionnaire (form C) and the Freiburg Personality Questionnaire (variant B).</p><p><strong>Results: </strong>Patients with CMA were characterized by heterogeneity of personality characteristics, the severity and diversity of which changed as the disease progressed. The course of treatment with Mexidol led to a decrease in the representation and severity of personality changes.</p><p><strong>Conclusion: </strong>The high efficacy and safety of long-term sequential therapy with Mexidol and Mexidol FORTE 250 has been demonstrated.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"51-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of parameters of cerebral hemodynamics in patients with alcoholism with different flexibility of cognitive functions].","authors":"S A Galkin, T A Oshkina","doi":"10.17116/jnevro202512502196","DOIUrl":"10.17116/jnevro202512502196","url":null,"abstract":"<p><strong>Objective: </strong>To study the parameters of regional cerebral hemodynamics in patients with alcoholism with different flexibility of cognitive functions.</p><p><strong>Material and methods: </strong>Fifty-eight patients with alcoholism were examined. The flexibility of cognitive functions was evaluated using the Stroop test. Regional cerebral hemodynamics was assessed by 4-channel rheoencephalography (REG).</p><p><strong>Results: </strong>It was found that 77.6% (<i>n</i>=45) of patients have low flexibility of cognitive processes. At physiological rest, patients with low cognitive flexibility had a significantly lower value of the rheographic index on the left and right in the carotid and vertebrobasilar basins compared with patients with a high level of cognitive flexibility (<i>p</i><0.05). Also, in patients with a low level of cognitive flexibility, an asymmetry of vascular tone with higher on the right in both brain basins (<i>p</i>=0.079 and <i>p</i>=0.094) was demonstrated.</p><p><strong>Conclusions: </strong>Regardless of the flexibility of cognitive processes, in patients with alcoholism, a hypovolemic, hyper-resistant type of cerebral hemodynamics was detected during withdrawal. In patients with a low level of flexibility of cognitive functioning, more pronounced compression effects on hemodynamics and moderate interhemispheric asymmetry of the tone of the internal carotid and vertebrobasilar arteries were observed.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 2","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gender aspects of attention deficit hyperactivity disorder].","authors":"L S Chutko, S Yu Surushkina, E A Yakovenko, T I Anisimova, A V Sergeev, D V Cherednichenko, M D Didur","doi":"10.17116/jnevro202512501170","DOIUrl":"10.17116/jnevro202512501170","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to clarify the clinical and psychological characteristics of girls with ADHD at different age periods.</p><p><strong>Material and methods: </strong>During the screening study, outpatient records of 1430 children with ADHD were analyzed, among which two age groups were identified (872 children with ADHD aged 7-8 years, 558 adolescents with ADHD aged 13-14 years). The control group consisted of 60 girls without psychoneurological pathology (30 aged 7-8 years and 30 aged 13-14 years). The following research methods were used in the work: the SNAP-IY scale for assessing the severity of the disease, The Strengths and Difficulties Questionnaire (SDQ) for assessing emotional and behavioral disorders, The Children's Form of Manifest Anxiety Scale (CMAS).</p><p><strong>Results: </strong>The ratio of boys to girls in the study group as a whole was 3:1. In the younger age subgroup of children with ADHD, the gender ratio was 3.8:1, and in the older age subgroup - 2.2:1. Evaluation of ADHD manifestations showed that at the age of 7-8 years, boys and girls with ADHD are characterized by approximately the same level of inattention, while girls were distinguished by lower rates of hyperactivity and impulsivity. In the older age group, girls experience a decrease in inattention and hyperactivity, without significant changes in impulsivity. In girls, both in primary school and adolescence, a mild degree of the disease prevails. When assessing emotional and behavioral disorders in the younger age group, it was revealed that the total indicator of the SDQ scale and the indicators for the subscales «general assessment of difficulties», «emotional disorders» and «difficulties in relationships with peers» were significantly higher in boys with ADHD. Girls also showed better results on the subscale «prosocial orientation of behavior».</p><p><strong>Conclusion: </strong>An assessment of the manifestations of ADHD showed that at the age of 7-8 years, boys and girls with ADHD are characterized by approximately the same level of inattention, while girls differ in lower indicators of hyperactivity and impulsivity. In girls, both in primary school and in adolescence, a mild degree of the disease prevails. It has been shown that the ratio of boys and girls with ADHD-H is significantly lower compared to other types of ADHD. Girls with ADHD are characterized by less pronounced behavioral problems and a greater degree of prosocial behavior, while the high level of anxiety in adolescent girls with ADHD is noteworthy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"70-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}