Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

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[Results of the program to preserve cognitive skills and psycho-emotional health in Moscow Longevity Centers]. [莫斯科长寿中心保持认知技能和心理情绪健康项目的结果]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612602145
V V Belousov, Yu S Gureeva, R T Tairova, A N Bogolepova, G E Ivanova, E A Kovalenko, E V Makhnovich, E V Erokhina, M G Khlyustova
{"title":"[Results of the program to preserve cognitive skills and psycho-emotional health in Moscow Longevity Centers].","authors":"V V Belousov, Yu S Gureeva, R T Tairova, A N Bogolepova, G E Ivanova, E A Kovalenko, E V Makhnovich, E V Erokhina, M G Khlyustova","doi":"10.17116/jnevro202612602145","DOIUrl":"10.17116/jnevro202612602145","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of computer cognitive training (CT) and biofeedback training (BFT) based on electroencephalography (EEG) in persons aged 55 and older, using the program's electronic databases on the preservation of cognitive skills and psycho-emotional health at the Moscow Longevity Centers.</p><p><strong>Material and methods: </strong>Electronic databases were analyzed based on the results of two specialized courses, «Neurotraining of Cognitive Skills» (Group 1) and «Neurocorrection of Psychoemotional State» (Group 2), as part of the program at the Moscow Longevity Centers. Group 1 included 13.379 subjects (median age 72 [69.0; 77.0] years), Group 2 included 11 697 subjects (66 [63.0; 73.0] years). Group 1 used computer CT with an assessment of the following indicators of cognitive functions based on the integral score: individual reasoning performance (IRP), memory, attention, and reasoning. For Group 2, EEG-based BFT with neurophysiological parameter assessment was used. All indicators and parameters were followed up on. The effectiveness of the methods was assessed after 10 sessions.</p><p><strong>Results: </strong>In Group 1, a statistically significant increase in all cognitive function indicators by both 5 and 10 CT sessions (<i>p<</i>0.001) was observed. Moreover, the more sessions were completed, the more pronounced the effect was (<i>p<</i>0.001). After CT, improvement in all parameters was observed in most subjects (>90%). In Group 2, the data analysis also showed a statistically significant improvement in neurophysiological parameters after the EEG-based BFT in the vast majority of subjects (89.3%).</p><p><strong>Conclusion: </strong>The results indicate a high potential for the studied non-drug methods to support cognitive and psycho-emotional health. Therefore, these methods should be recommended for wide use in preventive programs for persons 55 years and older.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents]. 脑溶血素对急性脑血管意外患者技能发展的影响。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612602132
A A Shmonin, I Kh Kashaev, E A Luchinin, G S Bakulin
{"title":"[The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents].","authors":"A A Shmonin, I Kh Kashaev, E A Luchinin, G S Bakulin","doi":"10.17116/jnevro202612602132","DOIUrl":"10.17116/jnevro202612602132","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of Cerebrolysin on improving the process of skill formation in patients with acute cerebrovascular accident during medical rehabilitation, based on a systematic review of the literature using elements of meta-analysis.</p><p><strong>Material and methods: </strong>A search of publications was conducted using the keywords «Cerebrolysin; Rehabilitation; Arm; Speech; Occupational therapy; Physical therapy; Ergotherapy» in the PubMed, Google Scholar and Elibrary databases. Original comparative studies investigating the effects of the drug on the human population after acute cerebrovascular accident, using rehabilitation measures and measuring the effectiveness using BI, ARAT, FIM, mRS, RMI, COPM, WAB and FMA were included. Mathematical processing of the arm action test (ARAT) results was performed using the SMD method.</p><p><strong>Results: </strong>The positive effect of potentiating neuroplasticity with Cerebrolysin consists in a significant improvement in daily activity in patients undergoing early comprehensive rehabilitation or physical therapy after a stroke. Patients statistically significantly restore the functionality of the affected upper limb during long-term rehabilitation initiated in the early subacute period. Improvement in speech and social activity is noted due to speech therapy interventions. A decrease in the level of depression and improvement in social adaptation have been proven during occupational therapy and psychological rehabilitation. The best results are observed with the introduction of the drug at a dosage of 30 ml. against the background of comprehensive multidisciplinary rehabilitation. Efficiency decreases with late onset of rehabilitation and a short course of drug administration.</p><p><strong>Conclusion: </strong>The use of Cerebrolysin in a dose of 10 ml to 30 ml during post-stroke rehabilitation leads to an increase in the quantity and quality of restored functions and formed skills, which was shown in a small group of 10 studies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Association of hematological coefficients of inflammation using high-density lipoproteins in evaluating the severity of mood disorders]. [用高密度脂蛋白评价情绪障碍严重程度与炎症血液学系数的关系]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro2026126021116
E S Shchepkin, E D Kasyanov, Ya V Yakovleva, G V Rukavishnikov, D N Kosterin, L V Pavlova, E S Gerasimchuk, M G Yanushko, G E Mazo
{"title":"[Association of hematological coefficients of inflammation using high-density lipoproteins in evaluating the severity of mood disorders].","authors":"E S Shchepkin, E D Kasyanov, Ya V Yakovleva, G V Rukavishnikov, D N Kosterin, L V Pavlova, E S Gerasimchuk, M G Yanushko, G E Mazo","doi":"10.17116/jnevro2026126021116","DOIUrl":"10.17116/jnevro2026126021116","url":null,"abstract":"<p><strong>Objective: </strong>Exploratory analysis of associations of indicators of systemic inflammation and lipid metabolism in males and females with mood disorders.</p><p><strong>Material and methods: </strong>This retrospective study included 177 patients aged 18-60 years diagnosed with depressive episode/recurrent depressive disorder (DE/RDE) and bipolar affective disorder (BAD), of which 61.6% (<i>n=</i>109) were female. Patients were selected based on a review of medical records. From the medical records, data on age, gender, anthropometric indicators, and the results of the blood count (platelets, lymphocytes, neutrophils, monocytes) and blood chemistry (high-density lipoproteins - HDL) tests were collected, as well as the quantitative values of the Montgomery-Asberg Depression Rating Scale (MADRS) and the Young Mania Rating Scale (YMRS). Statistical analysis was performed in RStudio v2025.05.0+496.</p><p><strong>Results: </strong>The results of the correlation analysis showed a significant relationship (<i>p<</i>0.05) between gender and hematological inflammation coefficients (HIC), as well as between gender and the severity of affective symptoms. In females with DE/RDE, the severity of depression was moderately and negatively correlated with the ratio of monocytes to HDL, and a weak but statistically significant positive correlation was found in BAD patients. In addition, women with DE/RDE had significant moderate negative correlations between the severity of depression and the platelet to HDL ratio. In contrast, males with DE/RDE had a significant moderate positive correlation between the severity of depression and the lymphocyte to HDL ratio. There were no associations between the severity of mania and any HICs in patients of either gender.</p><p><strong>Conclusion: </strong>Significant associations were found between indicators of inflammation and lipid metabolism, and affective disorders, with the strongest correlations observed in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The relationship between the aspects of mindfulness and coping strategies in patients with schizophrenic spectrum disorders and anorexia nervosa]. 精神分裂症谱系障碍和神经性厌食症患者正念各方面与应对策略的关系
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612601161
T V Moiseeva, E S Ryauzova, E V Fedorova, D A Chugunov, O V Mikhalevskaya, E D Krasteleva, N V Chernov, G P Kostyuk
{"title":"[The relationship between the aspects of mindfulness and coping strategies in patients with schizophrenic spectrum disorders and anorexia nervosa].","authors":"T V Moiseeva, E S Ryauzova, E V Fedorova, D A Chugunov, O V Mikhalevskaya, E D Krasteleva, N V Chernov, G P Kostyuk","doi":"10.17116/jnevro202612601161","DOIUrl":"10.17116/jnevro202612601161","url":null,"abstract":"<p><strong>Objective: </strong>To study the relationship between mindfulness and coping strategies in patients with schizophrenia, schizotypal disorder, and anorexia nervosa.</p><p><strong>Material and methods: </strong>Seventy-five patients were examined (25 with anorexia nervosa (F50.0), 25 with schizotypal disorder (F21), and 25 with paranoid schizophrenia (F20.0)), who were treated in outpatient units of Psychiatric Clinical Hospital No. 1, named after N.A. Alekseev, Moscow, as well as a control group of 25 mentally healthy volunteers. The clinical-psychopathological, psychometric, and statistical methods were used. Mindfulness was assessed using the Five Facet Mindfulness Questionnaire (FFMQ). Karpov's reflexivity questionnaire was also used. Coping strategies were assessed using the Ways of Coping Questionnaire (WCQ), and a short version of the Difficulties in Emotion Regulation Scale 18 (DERS-18) was used.</p><p><strong>Results: </strong>Significant differences in the relationship between mindfulness and coping strategies between groups have been identified. In the control group, non-judgmentality and description were negatively correlated with self-control (<i>p<</i>0.001 and <i>p=</i>0.018), detachment (<i>p=</i>0.023), acceptance of responsibility (<i>p<</i>0.001), and avoidance (<i>p=</i>0.001). In patients with schizotypal disorder, non-judgmentality was negatively correlated with avoidance (<i>p<</i>0.001), detachment (<i>p=</i>0.017), and clarity (<i>p=</i>0.007). In paranoid schizophrenia patients, non-judgmentality and reflexivity were negatively associated with detachment (<i>p=</i>0.018) and acceptance of responsibility (<i>p=</i>0.021). In patients with anorexia nervosa, non-judgmentality was negatively associated with avoidance (<i>p=</i>0.008) and rejection (<i>p<</i>0.001).</p><p><strong>Conclusion: </strong>There was no direct link between mindfulness components and the choice of coping strategies in clinical groups. In patients with paranoid schizophrenia and schizotypal disorder, these findings are presumably due to emotional ambivalence, dampening of emotional response; in anorexia nervosa patients, due to a lack of emotional self-regulation skills.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Modern methods of treatment and rehabilitation of the post-concussion syndrome]. [脑震荡后综合征的现代治疗和康复方法]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612601126
I I Voronkovsky, P G Shnyakin, M I Zakharova
{"title":"[Modern methods of treatment and rehabilitation of the post-concussion syndrome].","authors":"I I Voronkovsky, P G Shnyakin, M I Zakharova","doi":"10.17116/jnevro202612601126","DOIUrl":"https://doi.org/10.17116/jnevro202612601126","url":null,"abstract":"<p><p>Traumatic brain injury is an urgent problem of modern healthcare, as it affects the most able-bodied part of the population. Mild traumatic brain injury is the most common traumatic brain injury. Generally, clinical recovery after a mild brain injury occurs within two weeks, but in some cases, the symptoms that occur after the injury persist for a prolonged period. This condition is called post-concussion syndrome. A search and review of Russian and foreign literature was conducted using the keywords «treatment of post-concussion syndrome», «rehabilitation of post-concussion syndrome», and «approach to managing patients with post-concussion syndrome» in the search engines PubMed, Google Scholar, and eLibrary for 2013-2024. The review included 21 papers that fit the selection criteria. The actual causes and mechanisms of the development of post-concussion syndrome are not well known. Presumably, both organic damage to the brain substance and psychological factors accompanying the injury or preexisting in the patient's history may be significant risk factors. Therefore, there are no unified algorithms for the treatment of post-concussion syndrome. This literature review provides information on modern methods of treatment and rehabilitation of the post-concussion syndrome. Both drug and non-drug methods are used to treat it. Among the medications, amantadine, methylphenidate, and selective serotonin reuptake inhibitors have a certain effect. However, many patients discontinue their medications due to side effects. Of non-drug methods, subsymptomatic aerobic activity and vestibular physical therapy can be effective. Other methods, such as manual therapy and hyperbaric oxygenation, did not improve post-concussion syndrome. Psychological counseling is also beneficial in the treatment of post-concussion syndrome. There is evidence on the effectiveness of cognitive-behavioral therapy and training patients on the features of the period after traumatic brain injury, and feedback. Post-concussion syndrome is a complex condition that requires a combined approach, involving several specialists to address various symptoms of this syndrome.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Impulsivity as a key to transdiagnostic understanding of mental disorders]. [冲动作为精神障碍跨诊断理解的关键]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612601153
V P Petrovskiy, V Y Skryabin, S I Sokolova, A V Masyakin
{"title":"[Impulsivity as a key to transdiagnostic understanding of mental disorders].","authors":"V P Petrovskiy, V Y Skryabin, S I Sokolova, A V Masyakin","doi":"10.17116/jnevro202612601153","DOIUrl":"https://doi.org/10.17116/jnevro202612601153","url":null,"abstract":"<p><p>Impulsivity has established itself as a key transdiagnostic construct in psychiatry, rethinking ideas about the etiopathogenesis, clinical course, and approaches to the treatment of mental disorders. Epidemiological data indicate its high prevalence and a role as a key pathogenetic factor affecting severity, comorbidity, and suicide risk. This review systematizes the current view on impulsivity. We searched for relevant publications in PubMed, Scopus, ScienceDirect, and Mendeley. Convergent neuroimaging data (structural and functional MRI), genetics, and neuropsychology reveal a common neurobiological substrate, dysfunction of prefrontal-striatal-thalamic control networks and impaired monoaminergic (dopamine, serotonin, norepinephrine) modulation, underlining impulsivity in attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), addictive, and affective disorders. Psychometric models and neurobehavioral studies confirm the heterogeneity of the construct (motor, cognitive, affective impulsivity, sensation-seeking) with differentiated neurocorrelates. High levels of impulsivity are a powerful predictor of adverse outcomes: relapses in dependence, self-injurious, and suicidal behavior in BPD and functional deficits in patients with ADHD. Effective correction requires multilevel strategies tailored to specific features of the phenotype: psychotherapy, neuromodulation, and targeted pharmacotherapy. The review substantiates the need to shift from syndrome-oriented to transdiagnostic models, integrating neuroscience advances to enable a personalized approach and overcome the crisis of traditional diagnostics.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Attention deficit disorder in adults: features of social and family relationships]. 成人的注意力缺陷障碍:社会和家庭关系的特征。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612601113
L S Chutko, S Yu Surushkina, E A Yakovenko, L V Scheglova
{"title":"[Attention deficit disorder in adults: features of social and family relationships].","authors":"L S Chutko, S Yu Surushkina, E A Yakovenko, L V Scheglova","doi":"10.17116/jnevro202612601113","DOIUrl":"https://doi.org/10.17116/jnevro202612601113","url":null,"abstract":"<p><p>This article presents a review of scientific publications devoted to the clinical manifestations of attention deficit hyperactivity disorder (ADHD) in adulthood and their impact on social adaptation. The article focuses on the results of studies examining the interpersonal interactions of adult patients with ADHD and the main social problems characteristic of individuals with this disorder. Current views on the psychophysiological mechanisms underlying interpersonal dysfunction in patients with ADHD are presented. The potential for psychotherapeutic intervention and pharmacological therapy to improve social adaptation in ADHD in adulthood is also discussed.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of immunological and metabolic parameters on the patient's functional outcome in the acute period of ischemic stroke]. [缺血性脑卒中急性期免疫代谢参数对患者功能结局的影响]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612603228
A M Tynterova, E R Barantsevich, N N Shusharina, M S Khoimov, M S Rogovskaya
{"title":"[Effects of immunological and metabolic parameters on the patient's functional outcome in the acute period of ischemic stroke].","authors":"A M Tynterova, E R Barantsevich, N N Shusharina, M S Khoimov, M S Rogovskaya","doi":"10.17116/jnevro202612603228","DOIUrl":"https://doi.org/10.17116/jnevro202612603228","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effect of metabolic disorders and immunological parameters on the functional outcome (FO) of acute ischemic stroke (IS) in patients with metabolic syndrome (MS).</p><p><strong>Material and methods: </strong>298 patients in the acute period of IS were assessed. All patients were divided into two groups: Group 1 included 158 MS patients with a history of IS; Group 2 included 140 post-stroke patients without MS. The assessment included measurements of waist circumference, triglycerides (TG), low and high density lipoproteins (LDL/HDL), glucose, serum interleukins (IL-1b, IL-6, IL-16, IL-8), interferon gamma (IFN-g), tumor necrosis factor-alpha (TNF-<i>α</i>), macrophage migration inhibitory factor (MIF), monocyte chemotactic proteins (MCP-1/CCL2, MCP-3/CCL7), and macrophage inflammatory proteins (MIP-1a/CCL3, MIP-1d/CCL15). Patient disability rates measured by the modified Rankin Scale (mRS) at Day 21 from the IS onset were considered as FO parameters.</p><p><strong>Results: </strong>The FO evaluation revealed a significant (<i>p<</i>0.0001) prevalence of patients with an unfavorable/relatively unfavorable outcome (mRS ≥3) in Group 1. In the cohort of MS patients, multivariate mathematical analysis (correlation analysis and machine learning methods) showed the relationship of FO with the levels of LDL (<i>r=</i>0.520, p.d.=0.055), glucose (<i>r=</i>0.850, p.d.=0.089), the number of metabolic factors (<i>r=</i>0.880, p.d.=0.111), the concentrations of CCL3 (<i>r=</i>0.840, p.d.=0.354), CCL2 (<i>r=</i>0.520, p.d.=0.281), and MIF (<i>r=</i>0.830, p.d.=0.156).</p><p><strong>Conclusion: </strong>A worse FO score was observed in patients with MS than in metabolically healthy patients, and this was associated with hypercholesterolemia, hyperglycemia, the number of metabolic factors, and the expression of CCL3, CCL2, and MIF.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Multiple foci of cerebral ischemia in cancer patients with secondary antiphospholipid syndrome]. 继发性抗磷脂综合征肿瘤患者多灶性脑缺血的研究
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro202612603284
P G Shnyakin, A O Gavrilova
{"title":"[Multiple foci of cerebral ischemia in cancer patients with secondary antiphospholipid syndrome].","authors":"P G Shnyakin, A O Gavrilova","doi":"10.17116/jnevro202612603284","DOIUrl":"https://doi.org/10.17116/jnevro202612603284","url":null,"abstract":"<p><p>Antiphospholipid syndrome (APS) is associated with systemic organ and tissue damage, arterial and venous thrombosis, including in the central nervous system, and the occurrence of multiple ischemic areas. Primary APS occurs predominantly in young females and accounts for 20% of ischemic strokes in patients younger than 45 years. Secondary APS complicates several systemic diseases (systemic lupus erythematosus, lymphoproliferative diseases, HIV infection, etc.), and it can also develop in cancer patients. Multiple foci of cortical ischemia are most often detected by brain MRI in patients with APS. Laboratory tests usually show thrombocytopenia. Thromboses of other localizations are also often detected in patients. APS can be confirmed by detecting a high titer of phospholipid antibodies in blood. The paper presents three clinical cases of multiple cerebral ischemia in patients with a secondary APS and a cancer history, as well as a brief review of current publications on this issue.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Lipoprotein(a) and cerebrovascular diseases]. [脂蛋白(a)与脑血管疾病]。
Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2026-01-01 DOI: 10.17116/jnevro20261260325
N V Pizova, A V Pizov
{"title":"[Lipoprotein(a) and cerebrovascular diseases].","authors":"N V Pizova, A V Pizov","doi":"10.17116/jnevro20261260325","DOIUrl":"https://doi.org/10.17116/jnevro20261260325","url":null,"abstract":"<p><p>Lipoprotein(a) is a genetically regulated low-density lipoprotein-like particle that is gaining increasing attention as an independent pathogenic risk factor for vascular diseases. The accumulation of evidence from epidemiological and genetic studies, as well as studies aimed at clarifying the pathogenetic mechanisms, confirmed the multifaceted role of lipoprotein(a) in atherogenesis, vascular calcification, inflammation, and thrombogenesis in various vascular regions. Elevated lipoprotein(a) levels are associated with an increased risk of cardiovascular and cerebrovascular events, even after controlling for traditional risk factors. Elevated lipoprotein(a) is associated with increased recurrence of stroke and poor functional outcome in stroke patients. Lipoprotein(a) can be a novel therapeutic target for the secondary prevention of stroke and a promising biomarker.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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