Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Efficacy and tolerability of the pharmaconutraceutical complex Theraflex Ultra in the treatment of patients with chronic non-specific lower back pain due toprimarily discogenic pathology (FORSAGE study)].","authors":"I N Samartsev, S A Zhivolupov, M S Parshin, Yu V Denisova","doi":"10.17116/jnevro2026126051108","DOIUrl":"10.17116/jnevro2026126051108","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and tolerability of the pharmaconutraceutical complex, Theraflex Ultra, based on undenatured (native) type II collagen, in the treatment of discogenic chronic low back pain (CLBP).</p><p><strong>Material and methods: </strong>This open, multicenter, observational study included 50 patients (28 women and 22 men; mean age 48.3 years [45.5; 52.2]) diagnosed with CLBP, mostly associated with discogenic pathology, as confirmed by clinical evaluation and neuroimaging. The study group (<i>n</i>=25) received standard therapy comprising non-steroidal anti-inflammatory drugs (NSAIDs) for 10 days, a centrally acting muscle relaxant for 14 days, and a high-dose vitamin B complex for 21 days, combined with Theraflex Ultra at 2 capsules twice daily for 2 months. The control group (<i>n</i>=25) received only the standard therapy. Efficacy was assessed after 1, 2, and 3 months using various scales, including the Numeric Rating Scale for Pain (NRS-P), the Douleur Neuropathique 4 (DN4), the Back Pain Functional Scale (BPFS), and the Medical Outcomes Study Short Form 36 (MOS SF-36). The relapse rate during the first year post-enrollment in the study was also documented.</p><p><strong>Results: </strong>After one month, the study group exhibited a significantly greater reduction in pain intensity, as measured by the NRS-P, compared to the control group (23.2±8.8 versus 35.2±7.4; <i>p</i><0.05). After two months, the study group demonstrated significant improvements in functional activity (BPFS: 51.7±15.7 vs. 40.2±13.1) and the physical component of quality of life (MOS SF-36: 86.8±5.5 vs. 77.2±8.1; <i>p</i><0.05). No intergroup differences were noted on the DN4 scale, indicating nociceptive pain. Treatment adherence in the study group was high, with a score of 9.9±4.2 on the Adherence to Refills and Medications Scale (ARMS-7). A relapse occurred in 20% of patients in the study group and 32% in the control group after one year (relative risk [RR] 1.4 [confidence interval [CI] 0.513-3.824]; number needed to treat [NNT]=8.3). Adverse events were reported in all groups; however, they were mild and did not require treatment discontinuation.</p><p><strong>Conclusion: </strong>The addition of Theraflex Ultra to the standard therapy regimen for discogenic chronic non-specific low back pain yields a significant reduction in pain intensity, enhanced functional activity and quality of life, and a decreased risk of relapse within a year. The product demonstrates high treatment adherence and favorable tolerability. Subsequent randomized studies are warranted to validate these findings.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5","pages":"108-114"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Fresubin Protein module in a second-level rehabilitation program for patients with ischemic stroke: a prospective single-center clinical study].","authors":"V V Silkin, A A Epifanova, V I Ershov","doi":"10.17116/jnevro202612606180","DOIUrl":"https://doi.org/10.17116/jnevro202612606180","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of the Fresubin Protein module within a second-level rehabilitation program for patients diagnosed with ischemic stroke (IS).</p><p><strong>Material and methods: </strong>This prospective clinical study was conducted at a single center. It included 52 participants (27 in the experimental group and 25 in the control group), aged 45-90 years, with 14-35 days post-onset of IS. The experimental group received the Fresubin Protein module in addition to their standard diet for 12 days. Rehabilitation indices, hand muscle strength, and nutritional status were assessed on Day 1 and again on Day 12.</p><p><strong>Results: </strong>The incorporation of the protein module into the diet was associated with a statistically significant improvement in various metrics, including the Barthel Index (BI) of Activities of Daily Living (<i>p</i>=0.0258), muscle strength changes on the paresis side (<i>p</i>=0.0498) as well as the intact side (<i>p</i>=0.0433), and alterations in peripheral blood lymphocyte counts (<i>p</i>=0.0433). No adverse effects related to the protein module were reported.</p><p><strong>Conclusions: </strong>The findings indicate that the inclusion of the Fresubin Protein module as a nutritional supplement in the treatment of patients with IS during a second-level rehabilitation program was linked to enhanced daily functional activity and increased muscle strength. These results substantiate the integration of a high-protein diet into comprehensive rehabilitation strategies for individuals recovering from ischemic stroke.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 6","pages":"80-86"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pediatric clinical and psychopathological aspects of anti-NMDA receptor and glutamate decarboxylase autoimmune encephalitis].","authors":"A V Abramov, A V Goryunov, Yu A Chaika","doi":"10.17116/jnevro20261260617","DOIUrl":"https://doi.org/10.17116/jnevro20261260617","url":null,"abstract":"<p><p>Autoimmune encephalitides (AE) are a diverse group of diseases characterized by different etiological and clinical features, with pathogenesis involving immunological damage to the brain's protein structures. Diagnosing patients with AE who present with mental disorders poses significant challenges. Epidemiological data show an increasing prevalence of AE. In certain subtypes of AE, especially those that manifest during childhood, there are reports of initial presentations that consist solely of psychopathological symptoms. This review summarizes the current state of knowledge regarding AE in children, outlines diagnostic criteria and psychopathological features based on both international and Russian literature.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 6","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Impulsivity as a key to transdiagnostic understanding of mental disorders].","authors":"V P Petrovskiy, V Y Skryabin, S I Sokolova, A V Masyakin","doi":"10.17116/jnevro202612601153","DOIUrl":"10.17116/jnevro202612601153","url":null,"abstract":"<p><p>Impulsivity has established itself as a key transdiagnostic construct in psychiatry, rethinking ideas about the etiopathogenesis, clinical course, and approaches to the treatment of mental disorders. Epidemiological data indicate its high prevalence and a role as a key pathogenetic factor affecting severity, comorbidity, and suicide risk. This review systematizes the current view on impulsivity. We searched for relevant publications in PubMed, Scopus, ScienceDirect, and Mendeley. Convergent neuroimaging data (structural and functional MRI), genetics, and neuropsychology reveal a common neurobiological substrate, dysfunction of prefrontal-striatal-thalamic control networks and impaired monoaminergic (dopamine, serotonin, norepinephrine) modulation, underlining impulsivity in attention deficit hyperactivity disorder (ADHD), borderline personality disorder (BPD), addictive, and affective disorders. Psychometric models and neurobehavioral studies confirm the heterogeneity of the construct (motor, cognitive, affective impulsivity, sensation-seeking) with differentiated neurocorrelates. High levels of impulsivity are a powerful predictor of adverse outcomes: relapses in dependence, self-injurious, and suicidal behavior in BPD and functional deficits in patients with ADHD. Effective correction requires multilevel strategies tailored to specific features of the phenotype: psychotherapy, neuromodulation, and targeted pharmacotherapy. The review substantiates the need to shift from syndrome-oriented to transdiagnostic models, integrating neuroscience advances to enable a personalized approach and overcome the crisis of traditional diagnostics.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The relationship between the aspects of mindfulness and coping strategies in patients with schizophrenic spectrum disorders and anorexia nervosa].","authors":"T V Moiseeva, E S Ryauzova, E V Fedorova, D A Chugunov, O V Mikhalevskaya, E D Krasteleva, N V Chernov, G P Kostyuk","doi":"10.17116/jnevro202612601161","DOIUrl":"10.17116/jnevro202612601161","url":null,"abstract":"<p><strong>Objective: </strong>To study the relationship between mindfulness and coping strategies in patients with schizophrenia, schizotypal disorder, and anorexia nervosa.</p><p><strong>Material and methods: </strong>Seventy-five patients were examined (25 with anorexia nervosa (F50.0), 25 with schizotypal disorder (F21), and 25 with paranoid schizophrenia (F20.0)), who were treated in outpatient units of Psychiatric Clinical Hospital No. 1, named after N.A. Alekseev, Moscow, as well as a control group of 25 mentally healthy volunteers. The clinical-psychopathological, psychometric, and statistical methods were used. Mindfulness was assessed using the Five Facet Mindfulness Questionnaire (FFMQ). Karpov's reflexivity questionnaire was also used. Coping strategies were assessed using the Ways of Coping Questionnaire (WCQ), and a short version of the Difficulties in Emotion Regulation Scale 18 (DERS-18) was used.</p><p><strong>Results: </strong>Significant differences in the relationship between mindfulness and coping strategies between groups have been identified. In the control group, non-judgmentality and description were negatively correlated with self-control (<i>p<</i>0.001 and <i>p=</i>0.018), detachment (<i>p=</i>0.023), acceptance of responsibility (<i>p<</i>0.001), and avoidance (<i>p=</i>0.001). In patients with schizotypal disorder, non-judgmentality was negatively correlated with avoidance (<i>p<</i>0.001), detachment (<i>p=</i>0.017), and clarity (<i>p=</i>0.007). In paranoid schizophrenia patients, non-judgmentality and reflexivity were negatively associated with detachment (<i>p=</i>0.018) and acceptance of responsibility (<i>p=</i>0.021). In patients with anorexia nervosa, non-judgmentality was negatively associated with avoidance (<i>p=</i>0.008) and rejection (<i>p<</i>0.001).</p><p><strong>Conclusion: </strong>There was no direct link between mindfulness components and the choice of coping strategies in clinical groups. In patients with paranoid schizophrenia and schizotypal disorder, these findings are presumably due to emotional ambivalence, dampening of emotional response; in anorexia nervosa patients, due to a lack of emotional self-regulation skills.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Attention deficit disorder in adults: features of social and family relationships].","authors":"L S Chutko, S Yu Surushkina, E A Yakovenko, L V Scheglova","doi":"10.17116/jnevro202612601113","DOIUrl":"10.17116/jnevro202612601113","url":null,"abstract":"<p><p>This article presents a review of scientific publications devoted to the clinical manifestations of attention deficit hyperactivity disorder (ADHD) in adulthood and their impact on social adaptation. The article focuses on the results of studies examining the interpersonal interactions of adult patients with ADHD and the main social problems characteristic of individuals with this disorder. Current views on the psychophysiological mechanisms underlying interpersonal dysfunction in patients with ADHD are presented. The potential for psychotherapeutic intervention and pharmacological therapy to improve social adaptation in ADHD in adulthood is also discussed.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical features of chronic pain and premorbid factors in patients with various phenotypes of metabolic syndrome].","authors":"O V Vorob'eva, A A Gertsog, G M Ashikhmin, T E Morozova","doi":"10.17116/jnevro202612605195","DOIUrl":"10.17116/jnevro202612605195","url":null,"abstract":"<p><strong>Objective: </strong>To identify the clinical features associated with chronic pain and the premorbid factors in patients with metabolic syndrome of various phenotypes.</p><p><strong>Materials and methods: </strong>In this prospective comparative cohort study involving 118 patients with chronic pain, participants were divided into four groups based on the predominant phenotype of their metabolic syndrome: lipocentric (<i>n=</i>41), hypertensive (<i>n=</i>22), mixed (<i>n=</i>18), and control (<i>n=</i>37). We assessed clinical pain characteristics, anthropometric parameters, comorbidities, and behavioral and psychosocial premorbid factors.</p><p><strong>Results: </strong>Patients exhibiting a mixed phenotype of metabolic syndrome demonstrated higher pain intensity (7.5 [6; 8] points on the NRS scale, <i>p=</i>0.003), more pain sites (4 [3; 6], <i>p=</i>0.029), and experienced more frequent (<i>p=</i>0.004) and prolonged exacerbations (<i>p=</i>0.002) compared to the control group. Notably, severe fatigue (FAS scores ³22, <i>p=</i>0.007) was a specific premorbid feature in this group. Additionally, both the hypertensive and mixed phenotypes exhibited a higher prevalence of pain in the lower back and lower extremities.</p><p><strong>Conclusions: </strong>The chronic pain experienced by patients with metabolic syndrome displays phenotype-dependent variations, with the mixed phenotype exhibiting the most unfavorable pain profile. Recognizing the phenotype of metabolic syndrome is essential for personalized evaluation and management of chronic pain in outpatient settings.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Sleep disorders and oxidative stress].","authors":"A B Kozhokaru, V I Shmyrev, D I Lebedeva, G I Nurullina, A S Orlova","doi":"10.17116/jnevro202612605268","DOIUrl":"10.17116/jnevro202612605268","url":null,"abstract":"<p><p>Sleep disorders represent a significant medical and social issue, closely linked to the development of oxidative stress and cognitive impairment. This review summarizes current evidence for a bidirectional association between sleep disorders and oxidative stress. Sleep deprivation and chronic insomnia are associated with the accumulation of reactive oxygen species, mitochondrial dysfunction, neuroinflammation, and lipid damage, which together create a cycle that exacerbates sleep disturbances and contributes to cognitive impairment. The role of intermittent hypoxia in obstructive sleep apnea syndrome, which causes damage to hippocampal and cortical neurons, is highlighted. The involvement of the transcription factor NRF2 and ferroptosis in the pathogenesis of sleep disorders is discussed. The antioxidant properties of melatonin, polyphenols, vitamins C and E, coenzyme Q10, and ergothioneine are reviewed, as these compounds may improve sleep quality by reducing oxidative stress, regulating circadian rhythms, and providing anti-inflammatory effects. The potential for incorporating antioxidants into comprehensive therapy for sleep disorders is also considered.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5. Vyp. 2","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the efficiency of combined neuroprotection and high-intensity magnetotherapy in the medical rehabilitation of patients with ischemic stroke].","authors":"D Yu Butko, A T Davydov, E S Koneva, K V Lyadov, A A Okhotnikova, I A Reutsky, M A Shcheglova, E V Yakovlev","doi":"10.17116/jnevro202612605188","DOIUrl":"10.17116/jnevro202612605188","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a comparative analysis of the effectiveness of combined neuroprotection in conjunction with high-intensity magnetic therapy for patients with ischemic stroke in the vertebrobasilar system.</p><p><strong>Material and methods: </strong>This clinical study was a multicenter, prospective, observational, comparative, parallel-group study conducted in both public and private clinics as well as in rehabilitation facilities in St. Petersburg and Moscow. The study enrolled 98 participants, comprising 59 women and 39 men, aged 40 to 68 years (mean age: 54±1.5 years). Participants were randomized into three groups, each receiving standard therapy comprising exercise therapy, massage, and physiotherapy, as per established clinical guidelines. Group I (<i>n</i>=34) also received Cortexin at a dosage of 10 mg intramuscularly twice daily for 15 days, and Recognan oral solution at 1000 mg, 10 ml, once daily for 21 days, along with high-intensity magnetic muscle stimulation. Participants in Group II (<i>n</i>=33) received Cortexin at the same dosage and schedule, coupled with high-intensity magnetic muscle stimulation. Group III (<i>n</i>=31) received no additional treatment. Treatment effectiveness was evaluated based on clinical and neurological metrics, cognitive function assessments, electroencephalography data, ultrasound dopplerography (USDG) of cervical and cranial vessels, and neuropsychological testing administered on days 14 and 21 post-onset of the stroke.</p><p><strong>Results: </strong>In Group I, a 27% reduction in lower limb spasticity was noted on day 14, whereas Group II exhibited a 25% reduction, with Group III demonstrating a 15% reduction. USDG data indicated that 52% of patients in Group I showed increases in maximum and linear blood flow velocity in both the right and left vertebral arteries after treatment, compared to 41% in Group II and 20% in Group III. The mean score on the NIH Stroke Scale for Group I patients at discharge was 9.3±0.2 points, and the Rankin scale score was 2.1±0.2 points.</p><p><strong>Conclusion: </strong>The findings suggest that a multimodal approach to restorative treatment, combining neuroprotective medications with high-intensity magnetic therapy, demonstrates considerable therapeutic efficacy in the medical rehabilitation of patients with ischemic stroke.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Charcot-Marie-Tooth disease type 1A with late onset].","authors":"D Yu Makarova, V N Karnaukh","doi":"10.17116/jnevro2026126051138","DOIUrl":"10.17116/jnevro2026126051138","url":null,"abstract":"<p><p>There is no clear data available on the prevalence of Charcot-Marie-Tooth disease due to wide genetic diversity, the presence of sporadic cases, and the low awareness among specialists of hereditary diseases in adults. Given the diversity of presentation and age of onset, it is important to report Charcot-Marie-Tooth disease cases to identify triggers and progression factors. The article presents a clinical case of Charcot-Marie-Tooth disease type IA in a patient with late-onset disease (49 years of age). The clinical diagnosis was established according to the classical clinical triad, in combination with signs of diffuse symmetrical demyelination, a significant decrease in conduction along the motor fibers of the extremities measured by electroneuromyography, and the identified duplication of the PMP22 gene on chromosome 17p11.2-p12. The paper focuses on the differential diagnosis with chronic inflammatory polyradiculoneuropathy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5","pages":"138-145"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}