Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[The association of NOS1AP gene polymorphisms with the duration of the QT interval in patients with schizophrenia receiving antipsychotic therapy].","authors":"E G Kornetova, S A Galkin, I A Mednova, V V Tiguntsev, D Z Paderina, S A Ivanova","doi":"10.17116/jnevro202512501198","DOIUrl":"https://doi.org/10.17116/jnevro202512501198","url":null,"abstract":"<p><strong>Objective: </strong>To study the associations of <i>NOS1AP</i> gene polymorphisms with the duration of the QT interval (QTc) in patients with schizophrenia receiving antipsychotics.</p><p><strong>Material and methods: </strong>One hundred and sixty-eight patients (78 men and 90 women) with an established diagnosis of schizophrenia were examined. The patients received basic antipsychotic therapy. At the time of admission to the hospital, a standard 12-lead electrocardiogram recording was performed. The calculation of the QTc interval was carried out using the Bazett formula. Three <i>NOS1AP</i> polymorphisms (rs12029454, rs10494366 and rs12143842) were selected for genotyping.</p><p><strong>Results: </strong>Spearman's correlation revealed a significant relationship between CPZeq and the duration of the QTc interval in the group of men (r_s=0.262; <i>p=</i>0.021; <i>p</i>_Bonf=0.042). CPZeq was positively correlated with the duration of the QTc interval in men with <i>AA</i> and <i>AG</i> rs12029454 (r_s=0.717; <i>p=</i>0.00025; <i>p</i>_bonf=0.0015), <i>GG</i> and <i>GT</i> rs10494366 (r_s=0.381; <i>p=</i>0.008; <i>p</i>_bonf=0.048), <i>TT</i> and <i>CT</i> rs12143842 (r_s=0.389; <i>p=</i>0.003; <i>p</i>_bonf=0.018) genotypes. We did not find any significant correlations in the group of women.</p><p><strong>Conclusion: </strong>Genetic variants rs12029454, rs10494366 and rs12143842 of the <i>NOS1AP</i> gene are associated with the duration of the QTc interval in men with schizophrenia in response to antipsychotics. The <i>AA</i>/<i>AG</i> rs12029454, <i>GG</i>/<i>GT</i> rs10494366 and <i>TT</i>/<i>CT</i> rs12143842 genotypes in men contribute to the prolongation of the QTc interval and the development of undesirable cardiovascular disorders against the background of antipsychotic therapy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"98-104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pathogenetic interrelations of hypogonadism and depression in men].","authors":"V S Bulanov, A V Litvinov, L N Gorobets, A A Akhmedova","doi":"10.17116/jnevro202512501117","DOIUrl":"https://doi.org/10.17116/jnevro202512501117","url":null,"abstract":"<p><p>The study of the relationship between depression and functional hypogonadism in men is an interesting and difficult task. The purpose of the presented review was to identify the problem of functional male hypogonadism, to show a complex multi-stage neurohumoral mechanism of regulation of its potential to influence the affective sphere and to address the influence of pharmacotherapy on the formation of sexual disorders in men. The primary search for literature data was conducted using PubMed (Medline), PsycINFO and Cochrane CENTRAL, e-library.ru, databases using the keywords «hypogonadism», «depression», «testosterone», «antidepressants», «antipsychotics». As a result, 63 sources of information were selected and analyzed. Among the selected papers, there were 2 meta-analyses, 12 reviews and 42 comparative studies, including longitudinal, cross-sectional and controlled studies, 7 practical manuals. Based on the data obtained, it is possible to draw conclusions about the relationship between depression and functional hypogonadism as well as about the possibility of pathogenetic mechanisms of depression to cause changes in the state of the hypothalamic-pituitary-gonadal axis, leading to hypogonadism and vice versa, the ability of hypogonadism to form and enhance depressive symptoms. The concept of the mechanisms of regulation of steroidogenesis can allow the development of alternative methods of therapy and augmentation of depressive disorders, minimization of the number of sexual dysfunctions of psychopharmacotherapy. Further large-scale studies are needed for an in-depth study of this topic and the resolution of a number of contradictions.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiology of multiple sclerosis in the city of Novosibirsk].","authors":"I E Arkhipov, A I Prokaeva, E V Tretyakova, D S Korobko, N A Malkova","doi":"10.17116/jnevro2025125011119","DOIUrl":"https://doi.org/10.17116/jnevro2025125011119","url":null,"abstract":"<p><strong>Objective: </strong>To study the dynamics of the epidemiological characteristics of multiple sclerosis (MS) from 01.01.2003 to 01.01.2024 in Novosibirsk in comparison with the previous 20-year study.</p><p><strong>Material and methods: </strong>The prevalence cohort included 2254 patients with MS living in Novosibirsk on 01.01.2024. The cohort of cases included 1998 patients with the onset of the disease from 01.01.2003 to 31.12.2023 inclusive. In order to level out the influence of heterogeneous sex and age composition of the population of Novosibirsk, the method of standardization of indicators was used in the study (standard European population, 13.07.2013). The results of our analysis were compared with the results of the previous epidemiological study in the city of Novosibirsk (Malkova N.A., 2005).</p><p><strong>Results: </strong>The prevalence of MS as of 01.01.2024 was calculated as 137.83 per 100 thousand population (standardized indicator - 123.43). The average age of the patients with MS was 46.146±0.479 years. The ratio of men to women was 1:2.1. The incidence of MS from 2003 to 2023 shows a trend toward an increase (5.12±0.0662 to 7.71±0.0246 per 100 thousand population/year (<i>p<</i>0.05), which is mainly due to a significant increase in the proportion of women (6.56±0.1118 to 11.01±0.091 per 100 thousand population/year, <i>p<</i>0.05), but not men (<i>p</i>>0.05). The average age of MS onset increased by 0.146 years annually during the study period and amounted to 30.479±0.329 years (<i>r</i>_xy=0.08, <i>p<</i>0.001). An increase in the incidence of early-onset and late-onset MS was also noted (<i>r</i>_xy=0.45, <i>p=</i>0.041 and <i>r</i>_xy=0.622, <i>p=</i>0.003, respectively). A significant decrease in the «onset-diagnosis» interval was recorded (mean 5.28±6.41 years on 01.01.2003; mean 1.77±0.921 years on 01.01.2024).</p><p><strong>Conclusions: </strong>In the era of controlled disease progression, our study showed an increase in the prevalence of MS from 2003 to 2023 (54.4 to 137.83 per 100 thousand population). The dynamics of the sex ratio of patients with MS in Novosibirsk does not demonstrate the global trend with a 3-4-fold increase in the proportion of women. An increase in the incidence of MS was noted from 2003 to 2023 (<i>p<</i>0.05), mainly due to women (<i>p<</i>0.05). The age of MS onset has increased significantly over the 20-year period (27.73±0.6 years in 2003; 30.479±0.329 years in 2023). A separate trend towards an increase in the incidence of early-onset and late-onset MS is shown (<i>r</i>_xy=0.45, <i>p=</i>0.041 and <i>r</i>_xy=0.622, <i>p=</i>0.003, respectively). In part, the increase in the epidemiological characteristics of MS is associated with a decrease in the «onset-diagnosis» interval (<i>p<</i>0.05), which is due to improved diagnostic criteria and health care services.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"119-127"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gender aspects of attention deficit hyperactivity disorder].","authors":"L S Chutko, S Yu Surushkina, E A Yakovenko, T I Anisimova, A V Sergeev, D V Cherednichenko, M D Didur","doi":"10.17116/jnevro202512501170","DOIUrl":"https://doi.org/10.17116/jnevro202512501170","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to clarify the clinical and psychological characteristics of girls with ADHD at different age periods.</p><p><strong>Material and methods: </strong>During the screening study, outpatient records of 1430 children with ADHD were analyzed, among which two age groups were identified (872 children with ADHD aged 7-8 years, 558 adolescents with ADHD aged 13-14 years). The control group consisted of 60 girls without psychoneurological pathology (30 aged 7-8 years and 30 aged 13-14 years). The following research methods were used in the work: the SNAP-IY scale for assessing the severity of the disease, The Strengths and Difficulties Questionnaire (SDQ) for assessing emotional and behavioral disorders, The Children's Form of Manifest Anxiety Scale (CMAS).</p><p><strong>Results: </strong>The ratio of boys to girls in the study group as a whole was 3:1. In the younger age subgroup of children with ADHD, the gender ratio was 3.8:1, and in the older age subgroup - 2.2:1. Evaluation of ADHD manifestations showed that at the age of 7-8 years, boys and girls with ADHD are characterized by approximately the same level of inattention, while girls were distinguished by lower rates of hyperactivity and impulsivity. In the older age group, girls experience a decrease in inattention and hyperactivity, without significant changes in impulsivity. In girls, both in primary school and adolescence, a mild degree of the disease prevails. When assessing emotional and behavioral disorders in the younger age group, it was revealed that the total indicator of the SDQ scale and the indicators for the subscales «general assessment of difficulties», «emotional disorders» and «difficulties in relationships with peers» were significantly higher in boys with ADHD. Girls also showed better results on the subscale «prosocial orientation of behavior».</p><p><strong>Conclusion: </strong>An assessment of the manifestations of ADHD showed that at the age of 7-8 years, boys and girls with ADHD are characterized by approximately the same level of inattention, while girls differ in lower indicators of hyperactivity and impulsivity. In girls, both in primary school and in adolescence, a mild degree of the disease prevails. It has been shown that the ratio of boys and girls with ADHD-H is significantly lower compared to other types of ADHD. Girls with ADHD are characterized by less pronounced behavioral problems and a greater degree of prosocial behavior, while the high level of anxiety in adolescent girls with ADHD is noteworthy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"70-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Indicators of the background spectral power of the EEG in patients with alcohol dependence complicated by exogenous organic brain disease].","authors":"S A Galkin, M M Aksenov, O E Perchatkina, A I Mandel, N A Bokhan","doi":"10.17116/jnevro2025125011112","DOIUrl":"https://doi.org/10.17116/jnevro2025125011112","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a comparative analysis of EEG spectral power indicators in patients with alcoholism with- or without exogenous organic brain disease.</p><p><strong>Material and methods: </strong>An analysis of 119 EEG of patients with alcohol dependence was carried out. The presence of exogenous organic brain disease in patients was assessed retrospectively (through anamnesis). The EEG signals received from 16 electrodes were first divided into 3 frequency spectra (i.e. theta, alpha and beta), then the values of absolute spectral power were calculated, and then they were reordered, combined and topographically transferred to a spectral map. Data analysis was carried out in 5 different ways: electrode analysis, analysis based on cortical regions, lateralization, antero-posterior locus and throughout the whole cortex.</p><p><strong>Results: </strong>In the group of alcohol-dependent patients with comorbid exogenous organic brain damage, significantly (<i>p<</i>0.05) lower values of the spectral power of alpha activity on the Fp2, F3, F4, C3 and C4 electrodes as well as higher values of the spectral power of beta activity on the F8, T5 and T6 electrodes compared with the group of patients with «pure» alcohol dependence were observed. The intergroup data analysis, taking into account the topographic distribution, revealed significant differences in the spectral power of alpha activity in the prefrontal (F=4.201; <i>p=</i>0.043), frontal (F=3.951; <i>p=</i>0.049), central (F=4.033; <i>p=</i>0.047) and parietal (F=3.926; <i>p=</i>0.049) regions, as well as beta activity in the temporal region (F=5.656; <i>p=</i>0.019) of the cerebral cortex. Compared with patients suffering only from alcohol dependence, the group of patients with alcohol dependence and exogenous organic brain damage had significantly lower spectral power of alpha activity on the left (F=5.329; <i>p=</i>0.019) and on the right (F=5.191; <i>p=</i>0.027), as well as in the anterior locus (F=3.975; <i>p=</i>0.049).</p><p><strong>Conclusion: </strong>The results clearly indicate that the presence of exogenous organic brain damage in patients with alcohol dependence is accompanied by a change in the spectral power of the EEG mainly in the alpha frequency range.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"112-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Functional state of the kidneys in patients with various types of cerebrovascular diseases].","authors":"I T Murkamilov, K A Aitbaev, V V Fomin, Sh Sh Hakimov, I N Shchendrigin, J I Solizhonov, T F Yusupova, Z F Yusupova, F A Yusupov","doi":"10.17116/jnevro2025125011105","DOIUrl":"https://doi.org/10.17116/jnevro2025125011105","url":null,"abstract":"<p><strong>Objective: </strong>To study the functional state of the kidneys in men and women with various types of cerebrovascular diseases (CVD).</p><p><strong>Material and methods: </strong>The study included 378 patients with CVD: transient ischemic attack (TIA), stroke (ischemic and hemorrhagic), and chronic brain ischemia. The average age of men and women was 61.4±13.0 and 63.8±11.8 years, respectively. The excretory function of the kidneys was assessed in all participants.</p><p><strong>Results: </strong>TIA was recorded in 20.9% of men and 13.4% of women. Stroke was verified in 35.7% of patients (56.4% men and 34.3% women, <i>p<</i>0.05). Recurrent ischemic stroke was more common in men (12.9%) than in women (6.9%, <i>p<</i>0.05). The frequency of proteinuria was 34.1%, with nephrotic proteinuria and hematuria more often noted in men. The functional state of the kidneys (optimal, slightly reduced, moderately reduced, and significantly reduced excretory function) was identified in 37.8%, 34.1%, 17.7%, and 6.3% of patients, respectively. Severely reduced kidney function was recorded in 3.4% of patients. The glomerular filtration rate according to the CKD-EPI (67.9±24.1 ml/min), MDRD (62.9±22.8 ml/min), and Cockcroft-Gault (67.7±24.4 ml/min) formulas was lower in men compared to women (78.3±25.3 ml/min, 76.3±3.2 ml/min, 81.2±36.5 ml/min, <i>p<</i>0.05). In men and women, a correlation was established between pathomorphological changes on brain MRI and the level of red blood cells, glucose, total cholesterol and creatinine.</p><p><strong>Conclusion: </strong>In patients with CVD, the frequency of proteinuria is 34.1%. Nephrotic proteinuria and hematuria are more common in men. Changes in the functional state of the kidneys are manifested as slight and moderate reductions in excretory function. In women, the excretory function of the kidneys and proteinuria are closely related to pathomorphological changes in the brain.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"105-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].","authors":"L A Strozenko, V S Ponomaryov, O O Sanina, Y F Lobanov","doi":"10.17116/jnevro202512501147","DOIUrl":"https://doi.org/10.17116/jnevro202512501147","url":null,"abstract":"<p><strong>Objective: </strong>To assess the role of genetic polymorphisms in folate metabolism enzyme genes in the manifestation of migraine in children.</p><p><strong>Material and methods: </strong>The study included 54 children aged 7 to 18 years with clinical manifestations of migraine. The control group consisted of 115 children without neurological disorders. Genetic analysis of four polymorphic variants of folate cycle enzyme genes was conducted: <i>MTHFR</i>: 677C>T (A223V C677T, rs1801133); <i>MTHFR</i>: 1298A>C (E429A A1298C, rs1801131); <i>MTR</i>: 2756A>G (A2756G, rs1805087); <i>MTRR</i>: 66A>G (A66G, rs1801394). In addition to genetic testing, data collection included patient complaints, medical and family histories, clinical examinations, determination of vitamin B levels (B₆, B₉, B₁₂), and plasma homocysteine levels. The therapeutic effect of Cortexin (10 mg intramuscularly once daily) on the course of migraine in children was also assessed.</p><p><strong>Results: </strong>The rare homozygous 677TT genotype of the <i>MTHFR</i> gene was significantly more frequent in the study group (<i>p</i>=0.043), while the heterozygous 1298AC genotype of the <i>MTHFR</i> gene and the common homozygous 66AA genotype of the <i>MTRR</i> gene were more prevalent in the control group (<i>p</i><0.05). Furthermore, levels of B vitamins (B₆, B₉, B₁₂) and plasma homocysteine were measured in both groups. Children in the study group received a 10-day course of Cortexin.</p><p><strong>Conclusion: </strong>Patients with migraine showed a higher prevalence of the rare homozygous 677TT genotype of the <i>MTHFR</i> gene, which leads to elevated plasma homocysteine levels, often associated with latent folate deficiency. The use of «Cortexin» significantly improved the patients' condition, reducing complaints of headaches, fatigue, and emotional instability.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"47-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Abobotulinumtoxin A injections for the chronic sialorrhea correction in children: Russian retrospective multicenter study].","authors":"O A Klochkova, A L Kurenkov, G V Argunova, N V Duibanova, T Yu Zatravkina, D A Krasavina, E G Lukyanova, A M Nekrasova, T G Okhapkina, E O Sereda, I V Falkovsky, S E Khrulev","doi":"10.17116/jnevro202512501153","DOIUrl":"https://doi.org/10.17116/jnevro202512501153","url":null,"abstract":"<p><strong>Objective: </strong>Multicenter retrospective analysis of the Russian experience in the use of AbobotulinumtoxinA injections for the correction of chronic sialorrhea of various etiologies in children.</p><p><strong>Material and methods: </strong>608 injections (from 1 to 5 repeated injections) of the AbobotulinumtoxinA into the salivary glands for 226 patients aged 2.0 to 17.8 years (Me - 5.1 years) with various neurological diseases and neurodevelopmental disorders in 12 Russian centers.</p><p><strong>Results: </strong>In 180 patients (79.6%), AbobotulinumtoxinA was the first drug used to correct drooling. 177 (78.3%) children received combined injections into the salivary glands and body muscles to correct spasticity. The total doses of AbobotulinumtoxinA administered into the salivary glands during the first injection were (Med; min-max; 25-75%):150 U (7.7 U/kg); 30-400 U (1.9-27.3); 100-200 units (4.8-15.3). Doses to both parotid glands - 80 units (4.1 units/kg); 18-250 U (0.8-15.4 U/kg); 60-120 U (2.7-8.5 U/kg); in both submandibular - 70 U (3.3 U/kg); 12-160 U (0.5-13.6 U/kg); 40-80 U (2.1-6.1 U/kg). After the first injection of AbobotulinumtoxinA, a significant decrease in salivation was observed in 212 cases (93.8%). The effect lasted for an average of 4.9 months (0.5 to 24 months). Changes in the Drooling Impact Scale and subjective duration of effect were not significantly different after repeated injections. Adverse events were noted in 30 (13.3%) cases and persisted up to 2-3 weeks after injection.</p><p><strong>Conclusion: </strong>AbobotulinumtoxinA injections have shown effectiveness and safety in the correction of chronic sialorrhea in children, also in combination with concomitant spasticity treatment. Further research is needed to determine the optimal dose and treatment protocols.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Arterial hypertension is an oxidative stress, as a pathogenetic target for the treatment of chronic cerebrovascular insufficiency].","authors":"E I Chukanova, A S Chukanova, D D Andrianov","doi":"10.17116/jnevro202512501184","DOIUrl":"https://doi.org/10.17116/jnevro202512501184","url":null,"abstract":"<p><p>The increase in the development of arterial hypertension (AH), as the main modifiable risk factor for the development of acute and chronic cerebral circulatory insufficiency, often leading to a progressive decrease in cognitive status and physical activity, requires early detection and effective pathogenetic therapy. The breadth of therapeutic effects of the drug Mexidol (ethylmethylhydroxypyridine succinate) due to the multifactorial nature of its pathogenetic effects contributes to its widespread use. The safe profile of Mexidol use and the absence of drug interaction makes it relevant in the complex treatment of patients with cardiovascular diseases.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 1","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Progressive multifocal leukoencephalopathy in HIV-positive individuals].","authors":"D O Tarasov, I A Lebedev, E A Seliverstov","doi":"10.17116/jnevro202412408139","DOIUrl":"https://doi.org/10.17116/jnevro202412408139","url":null,"abstract":"<p><p>The article discusses the historical aspect and modern ideas about the etiology and pathogenesis of progressive multifocal leukoencephalopathy in patients with HIV infection. An analysis and synthesis of literature data on the clinical presentation of this pathology was carried out. The possibilities and limitations of laboratory and instrumental diagnostic methods, including neuroimaging methods, are discussed in detail. The pathomorphological signs of the disease in HIV-positive individuals are covered.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 8","pages":"39-46"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}