Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献_第2页

[Neuroinflammatory and neurodegenerative aspects of Parkinson's disease]. [帕金森氏症的神经炎症和神经退行性方面]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125031102

M A Nikitina, E Yu Bragina, M S Nazarenko, S A Ivanova, A S Boyko, L A Levchuk, V M Alifirova

{"title":"[Neuroinflammatory and neurodegenerative aspects of Parkinson's disease].","authors":"M A Nikitina, E Yu Bragina, M S Nazarenko, S A Ivanova, A S Boyko, L A Levchuk, V M Alifirova","doi":"10.17116/jnevro2025125031102","DOIUrl":"https://doi.org/10.17116/jnevro2025125031102","url":null,"abstract":"Objective: To evaluate the clinical features and the level of the inflammatory markers CCL5, slCAM-1, sVCAM-1, NCAM, PAI-1, and MPO in the groups of patients with Parkinson's disease (PD) at various stages according to Hoehn and Yahr.Material and methods: The study included 533 patients with PD. All patients underwent a clinical neurological examination to determine the stage of PD, the severity of motor disorders according to the MDS-UPDRS scale (Unified Parkinson's Disease Rating Scale of the Movement Disorder Society), and testing using validated questionnaires: Montreal Cognitive Assessment, Hospital Anxiety and Depression Rating Scale, Beck Depression Inventory-II, Fatigue Severity Scale, Scale for assessing autonomic disorders in PD patients. Behavioral disorders were evaluated using QUIP-RS. 144 PD patients had their serum concentration of several inflammatory markers measured (CCL5, slCAM-1, sVCAM-1, NCAM, PAI-1, and MPO) on the MAGPIX multiplex analyzer (Luminex, USA) using xMAP Technology. Genotyping of polymorphic variants of CCL5 (rs2107538) and PAI-1 (rs2227631) genes was performed using real-time PCR.Results: The serum levels of slCAM-1, sVCAM-1, CCL5, and NCAM varied in PD patients depending on the Hoehn and Yahr stage and disease duration. Correlations of serum marker levels were found both among themselves and with motor and non-motor disorders, which indicate a systemic inflammatory profile when increased peripheral production of CCL5, slCAM-1, sVCAM-1, NCAM, PAI-1, and MPO may play a role in the neurodegenerative process.Conclusion: The serum level of inflammatory markers, such as CCL5, slCAM-1, sVCAM-1, NCAM, PAI-1, and MPO, in PD patients varies depending on the stage of the progressive neurodegenerative process, indicating the importance of systemic inflammation during PD.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"102-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Intraoperative speech mapping during awake surgery]. [清醒手术中术中语言映射]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro202512504135

E P Dmitrova, E S Krasilova, I V Makarova, O A Tasenko, K V Untila, A Sh Minnigulova, M V Khudyakova, O V Dragoy

引用次数: 0

[The effect of Mexidol on the level of neurogenesis markers in acute cerebrovascular accident in the experiment]. 【墨西多对急性脑血管意外神经发生标志物水平的影响】。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125021107

A V Shchulkin, I V Chernykh, Yu V Abalenikhina, M V Gatsanoga, O A Andryushina, N A Kruzhalov, E N Yakusheva

{"title":"[The effect of Mexidol on the level of neurogenesis markers in acute cerebrovascular accident in the experiment].","authors":"A V Shchulkin, I V Chernykh, Yu V Abalenikhina, M V Gatsanoga, O A Andryushina, N A Kruzhalov, E N Yakusheva","doi":"10.17116/jnevro2025125021107","DOIUrl":"10.17116/jnevro2025125021107","url":null,"abstract":"Objective: To study the effect of Mexidol on the level of factors regulating neuroregenesis.Material and methods: The study was performed on male Wistar rats. Focal cerebral ischemia was reproduced by endovascular occlusion-reperfusion of the right medial cerebral artery. The duration of occlusion was 60 min. During the beginning of reperfusion, the animals were given a single intravenous injection of saline solution or the drug Mexidol at a dose of 50 mg/kg. 4, 8 and 24 hours after the beginning of reperfusion in the ischemic hemisphere, the relative amount of molecules regulating neurogenesis was estimated by Western blot method. Additionally, 24 hours after the start of reperfusion, the size of the brain infarction was analyzed after staining with a 1% solution of 2.3,5,-triphenyltetrazolium.Results: When modeling occlusion-reperfusion of the middle cerebral artery, the volume of necrosis in the affected hemisphere of animals injected with saline was 37.75±7.46%, administration of Mexidol at a dose of 50 mg /kg led to a decrease in the volume of necrosis to 20.48±2.33% (p=0.0006). The simulation of occlusion-reperfusion of the middle cerebral artery was accompanied by activation of neurotrophic factors IGF-1, NGF and vascular factor VEGF. A single intravenous administration of Mexidol at a dose of 50 mg/kg during reperfusion increased the level of neurotrophic factors IGF-1, NGF, BDNF and VEGF in the ischemic area of the brain compared with the administration of saline, which leads to increased neuroregeneration at all follow-up periods (4, 8 and 24 hours after reperfusion), the marker of which is tubulin-3.Conclusion: The results suggest that Mexidol not only has a protective effect on neurons, but can also stimulate neuroregeneration by increasing the level of the main regulatory molecules.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 2","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Hormonal contraception methods and multiple sclerosis]. [激素避孕方法与多发性硬化症]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro202512501124

N Y Lashch, A A Ashikhmina, M I Kislaya, L A Filatova

引用次数: 0

[Development of a diagnostic and treatment algorithm for anxiety associated with somatic pathology in patients in general clinical practice. Resolution of the expert council]. [在一般临床实践中开发与患者躯体病理相关的焦虑的诊断和治疗算法。][专家委员会的决议]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro202512501162

M A Samushiya, A S Al-Shukri, I I Baranov, E V Ekusheva, M A Livzan, N M Nenasheva, G R Tabeeva, O B Tamrazova, A V Tarasov, A A Chernova

引用次数: 0

[XIV All-Russian scientific and practical conference «Actual problems of somnology»]. [第十四届全俄科学与实践会议«睡眠学的实际问题»]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125052103

V A Sursaev, M G Poluektov

引用次数: 0

[Challenges of differential diagnosis in the verification of Behçet's disease with neurological manifestations]. 【具有神经系统表现的behaperet病鉴别诊断的挑战】。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125041108

A I Vlasenko, M P Topuzova, V A Malko, G N Bisaga, T A Pavlova, A P Abramova, A O Chistyakova, T M Alekseeva

引用次数: 0

[Art and creativity in Parkinson's disease: the mysterious effects of dopamine]. 帕金森氏症的艺术和创造力：多巴胺的神秘作用。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro202512504113

E A Katunina, Z A Zalyalova, D V Pokhabov, I A Putyatin

{"title":"[Art and creativity in Parkinson's disease: the mysterious effects of dopamine].","authors":"E A Katunina, Z A Zalyalova, D V Pokhabov, I A Putyatin","doi":"10.17116/jnevro202512504113","DOIUrl":"10.17116/jnevro202512504113","url":null,"abstract":"The article is devoted to the phenomenon of the emergence or enhancement of creative abilities during therapy in some patients with Parkinson's disease (PD). The article discusses the possible pathogenetic causes of this phenomenon, the connection with impulsive-compulsive disorders (ICD). All PD patients who are addicted to one type of creativity are characterized by increased motivation, forcing them to spend hours doing what they love, the time of which coincided with the start of dopaminergic therapy. There is a fine line between the emerging «passion» for art and CAVIAR, which is determined by the dose of Antiparkinsonian drugs, genetic characteristics, and personal characteristics. The issue of the emergence of creativity in the work of patients with PD remains controversial, and most studies indicate a deterioration in divergent thinking, which is a criterion for creativity. The results of the observation of artists suffering from PD showed changes in the style of their work against the background of the disease, the appearance of an emphasis on color, changing the brightness and spectrum of the color palette, moving to more abstract images. Among the factors that can influence creative activities, such as pre-existing skills or abilities in relation to a particular type of art, taking dopaminergic drugs, their dose, the preservation of cognitive functions, family support, and the social environment are discussed.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 4","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Central nervous system involvement in systemic lupus erythematosus]. [系统性红斑狼疮中枢神经系统受累]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125021124

I T Murkamilov, K A Aitbaev, V V Fomin, Sh Sh Hakimov, I N Shchendrigin, J I Solizhonov, T F Yusupova, Z F Yusupova, M Sh Abdykadyrov, F A Yusupov

{"title":"[Central nervous system involvement in systemic lupus erythematosus].","authors":"I T Murkamilov, K A Aitbaev, V V Fomin, Sh Sh Hakimov, I N Shchendrigin, J I Solizhonov, T F Yusupova, Z F Yusupova, M Sh Abdykadyrov, F A Yusupov","doi":"10.17116/jnevro2025125021124","DOIUrl":"10.17116/jnevro2025125021124","url":null,"abstract":"The article presents a rare clinical case of systemic lupus erythematosus (SLE) in a 22-year-old patient at week 33 of pregnancy, complicated by ischemic stroke, secondary antiphospholipid syndrome, thrombosis of the inferior vena cava and vessels of the lower extremities, and polysegmental pneumonia. The patient's medical history (September 2022) showed severe muscle weakness and fever in the early postpartum period. The examination revealed increased levels of C-reactive protein (61.32 mg/L), D-dimer (8.970 mg FEU/L), interleukin-6 (19.48 pg/mL), total bilirubin (29.8 μmol/L, mostly due to the direct fraction - 11.2 μmol/L), fibrinogen (5.3 g/L), as well as a positive titer of antibodies to SARS CoV-2 (IgG=6.82). During the second pregnancy, the patient regularly experienced flu-like symptoms and headaches, for which she took paracetamol and diclofenac until week 33. Instrumental studies showed an ischemia focus in the middle cerebral artery basin on the left, multiCT pegmental right-sided pneumonia, thrombosis of the inferior vena cava and vessels of the lower extremities. Laboratory tests revealed an increase in the erythrocyte sedimentation rate (50-57 mm/h), the level of C-reactive protein (113.0-50.9 mg/L), C3-complement (2.54-2.18 g/L), D-dimer (50.4-25.8 mg U/L), interleukin-6 (14.8-37.6 pg/mL), procalcitonin (0.142 ng/mL), and immunoglobulin E (166 IU/mL). Serological tests revealed the presence of antibodies of M and G classes to SmD1 (Human Small Nuclear Ribonucleoprotein) and cardiolipins.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 2","pages":"124-129"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cerebrovascular disease in clinical practice. Resolution of the Expert Council of the Russian Scientific Medical Society of Therapists]. 脑血管病的临床应用。[俄罗斯科学医学治疗师协会专家委员会决议]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI: 10.17116/jnevro2025125061105

M M Tanashyan, A G Malyavin, K V Antonova, M Yu Maksimova, A A Raskurazhev, O V Lagoda, P I Kuznetsova

引用次数: 0