Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Modern methods of treatment and rehabilitation of the post-concussion syndrome].","authors":"I I Voronkovsky, P G Shnyakin, M I Zakharova","doi":"10.17116/jnevro202612601126","DOIUrl":"10.17116/jnevro202612601126","url":null,"abstract":"<p><p>Traumatic brain injury is an urgent problem of modern healthcare, as it affects the most able-bodied part of the population. Mild traumatic brain injury is the most common traumatic brain injury. Generally, clinical recovery after a mild brain injury occurs within two weeks, but in some cases, the symptoms that occur after the injury persist for a prolonged period. This condition is called post-concussion syndrome. A search and review of Russian and foreign literature was conducted using the keywords «treatment of post-concussion syndrome», «rehabilitation of post-concussion syndrome», and «approach to managing patients with post-concussion syndrome» in the search engines PubMed, Google Scholar, and eLibrary for 2013-2024. The review included 21 papers that fit the selection criteria. The actual causes and mechanisms of the development of post-concussion syndrome are not well known. Presumably, both organic damage to the brain substance and psychological factors accompanying the injury or preexisting in the patient's history may be significant risk factors. Therefore, there are no unified algorithms for the treatment of post-concussion syndrome. This literature review provides information on modern methods of treatment and rehabilitation of the post-concussion syndrome. Both drug and non-drug methods are used to treat it. Among the medications, amantadine, methylphenidate, and selective serotonin reuptake inhibitors have a certain effect. However, many patients discontinue their medications due to side effects. Of non-drug methods, subsymptomatic aerobic activity and vestibular physical therapy can be effective. Other methods, such as manual therapy and hyperbaric oxygenation, did not improve post-concussion syndrome. Psychological counseling is also beneficial in the treatment of post-concussion syndrome. There is evidence on the effectiveness of cognitive-behavioral therapy and training patients on the features of the period after traumatic brain injury, and feedback. Post-concussion syndrome is a complex condition that requires a combined approach, involving several specialists to address various symptoms of this syndrome.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Results of the program to preserve cognitive skills and psycho-emotional health in Moscow Longevity Centers].","authors":"V V Belousov, Yu S Gureeva, R T Tairova, A N Bogolepova, G E Ivanova, E A Kovalenko, E V Makhnovich, E V Erokhina, M G Khlyustova","doi":"10.17116/jnevro202612602145","DOIUrl":"10.17116/jnevro202612602145","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effects of computer cognitive training (CT) and biofeedback training (BFT) based on electroencephalography (EEG) in persons aged 55 and older, using the program's electronic databases on the preservation of cognitive skills and psycho-emotional health at the Moscow Longevity Centers.</p><p><strong>Material and methods: </strong>Electronic databases were analyzed based on the results of two specialized courses, «Neurotraining of Cognitive Skills» (Group 1) and «Neurocorrection of Psychoemotional State» (Group 2), as part of the program at the Moscow Longevity Centers. Group 1 included 13.379 subjects (median age 72 [69.0; 77.0] years), Group 2 included 11 697 subjects (66 [63.0; 73.0] years). Group 1 used computer CT with an assessment of the following indicators of cognitive functions based on the integral score: individual reasoning performance (IRP), memory, attention, and reasoning. For Group 2, EEG-based BFT with neurophysiological parameter assessment was used. All indicators and parameters were followed up on. The effectiveness of the methods was assessed after 10 sessions.</p><p><strong>Results: </strong>In Group 1, a statistically significant increase in all cognitive function indicators by both 5 and 10 CT sessions (<i>p<</i>0.001) was observed. Moreover, the more sessions were completed, the more pronounced the effect was (<i>p<</i>0.001). After CT, improvement in all parameters was observed in most subjects (>90%). In Group 2, the data analysis also showed a statistically significant improvement in neurophysiological parameters after the EEG-based BFT in the vast majority of subjects (89.3%).</p><p><strong>Conclusion: </strong>The results indicate a high potential for the studied non-drug methods to support cognitive and psycho-emotional health. Therefore, these methods should be recommended for wide use in preventive programs for persons 55 years and older.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Association of hematological coefficients of inflammation using high-density lipoproteins in evaluating the severity of mood disorders].","authors":"E S Shchepkin, E D Kasyanov, Ya V Yakovleva, G V Rukavishnikov, D N Kosterin, L V Pavlova, E S Gerasimchuk, M G Yanushko, G E Mazo","doi":"10.17116/jnevro2026126021116","DOIUrl":"10.17116/jnevro2026126021116","url":null,"abstract":"<p><strong>Objective: </strong>Exploratory analysis of associations of indicators of systemic inflammation and lipid metabolism in males and females with mood disorders.</p><p><strong>Material and methods: </strong>This retrospective study included 177 patients aged 18-60 years diagnosed with depressive episode/recurrent depressive disorder (DE/RDE) and bipolar affective disorder (BAD), of which 61.6% (<i>n=</i>109) were female. Patients were selected based on a review of medical records. From the medical records, data on age, gender, anthropometric indicators, and the results of the blood count (platelets, lymphocytes, neutrophils, monocytes) and blood chemistry (high-density lipoproteins - HDL) tests were collected, as well as the quantitative values of the Montgomery-Asberg Depression Rating Scale (MADRS) and the Young Mania Rating Scale (YMRS). Statistical analysis was performed in RStudio v2025.05.0+496.</p><p><strong>Results: </strong>The results of the correlation analysis showed a significant relationship (<i>p<</i>0.05) between gender and hematological inflammation coefficients (HIC), as well as between gender and the severity of affective symptoms. In females with DE/RDE, the severity of depression was moderately and negatively correlated with the ratio of monocytes to HDL, and a weak but statistically significant positive correlation was found in BAD patients. In addition, women with DE/RDE had significant moderate negative correlations between the severity of depression and the platelet to HDL ratio. In contrast, males with DE/RDE had a significant moderate positive correlation between the severity of depression and the lymphocyte to HDL ratio. There were no associations between the severity of mania and any HICs in patients of either gender.</p><p><strong>Conclusion: </strong>Significant associations were found between indicators of inflammation and lipid metabolism, and affective disorders, with the strongest correlations observed in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"116-122"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of aripiprazole on cytokine production by T cells in schizophrenia].","authors":"D A Chugunov, A A Sviridova, A V Lopatina, M V Melnikov","doi":"10.17116/jnevro202612604189","DOIUrl":"10.17116/jnevro202612604189","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the modulatory effect of the antipsychotic agent aripiprazole on <i>ex vivo</i> production of the cytokines interleukin-17 (IL-17) and interferon-<i>γ</i> (IFN-<i>γ</i>) by T-lymphocytes in patients with schizophrenia.</p><p><strong>Material and methods: </strong>The study included 15 patients diagnosed with schizophrenia and 12 healthy donors as the control group. A peripheral blood mononuclear cell (PBMC) model was employed to assess the effects of aripiprazole on cytokine profiles. Cells were stimulated with microparticles coated with antibodies to CD3 and CD28 surface markers. To investigate the roles of D₁ and D₂ dopamine receptors (D₁DR and D₂DR) in the mechanism of action of aripiprazole, PBMCs were stimulated in the presence of aripiprazole alone and in combination with specific antagonists: SCH23390 for D₁DR and sulpiride for D₂DR. Concentrations of IL-17 and IFN-<i>γ</i> in culture supernatants were measured using an enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>In patients with schizophrenia, the induced production of both IL-17 and IFN-<i>γ</i> by PBMC was significantly lower than in the healthy donor group. Aripiprazole exhibited a dose-dependent suppressive effect on cytokine secretion in both groups. Blockade of D₁DR enhanced the inhibitory effect of aripiprazole, whereas blockade of D₂DR diminished it. Isolated blockade of D₁DR, in the absence of aripiprazole, inhibited cytokine production by stimulated PBMCs in both groups, while isolated blockade of D2DR had no significant effect.</p><p><strong>Conclusion: </strong>Aripiprazole may exert anti-inflammatory effects in schizophrenia by inhibiting the secretion of pro-inflammatory cytokines by T cells. This effect is likely mediated through D₂DR activation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prospects for retroelement-targeted therapy of schizophrenia].","authors":"R N Mustafin","doi":"10.17116/jnevro202612604122","DOIUrl":"10.17116/jnevro202612604122","url":null,"abstract":"<p><p>Schizophrenia is a complex disorder with a heritability estimated at 73-79%. It is associated with numerous single-nucleotide polymorphisms (SNPs), predominantly situated in intergenic, intronic, and regulatory genomic regions. These regions harbor the majority of retroelements, and the activity and function of these elements may be influenced by the presence of specific SNPs. A review of the scientific literature revealed reliable data on the activation of the HERV, LINE, and Alu retroelements in peripheral blood, brain tissue, and cerebrospinal fluid samples from schizophrenia patients. These retroelements contribute to disorders through insertional mutagenesis, as new insertions disrupt the expression of brain-specific genes. Protein products of retroelements contribute to immune-inflammatory reactions with upregulation of C-reactive protein, caspase-1, TLR3, IL-1<i>β</i>, IL-2, IL-6, IL-10, TNF-<i>α</i>, IFN-<i>γ</i>, IFN-<i>β</i>, abnormal expression of BDNF, dopamine receptors, ASTC-1/2, GABA1, and 5-HT. Since the activation of retroelements is caused by epigenetic dysregulation, targeted therapy of schizophrenia using specific microRNAs is promising. It is proposed to use antibodies targeting HERV proteins, which have shown efficacy in multiple sclerosis, driven by abnormal HERV activation in the brain. Reverse transcriptase inhibitors can be used to reduce the transposition activity of retroelements.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Therapy prospects for post-stroke aphasia].","authors":"A N Bogolepova","doi":"10.17116/jnevro202612604286","DOIUrl":"10.17116/jnevro202612604286","url":null,"abstract":"<p><p>Stroke remains a leading cause of disability worldwide. Cognitive impairment is a major consequence, with post-stroke aphasia developing in approximately 30% of patients after a first stroke. Speech impairments substantially reduce quality of life, complicate rehabilitation, and hinder reintegration into daily activities. Patients with aphasia exhibit greater cognitive deficits and an increased risk of vascular dementia, regardless of stroke type. Speech therapy is a primary treatment modality. Neuroplasticity is central to post-stroke recovery, and agents that stimulate neuroplasticity represent a promising therapeutic direction. Cerebrolysin, a pleiotropic drug composed of peptides with neurotrophic properties and free amino acids, can activate neuroplasticity. Recent findings from the Efficacy and Safety of Cerebrolysin in the Treatment of Aphasia After Acute Ischemic Stroke study (ESCAS) demonstrate that combined speech therapy and Cerebrolysin use accelerates recovery of speech functions, suggesting its value as an adjunct in stroke rehabilitation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4. Vyp. 2","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Idiopathic tinnitus as part of hypochondriacal disorders].","authors":"P A Stakanov, A V Yakimets, S V Ivanov","doi":"10.17116/jnevro202612603197","DOIUrl":"10.17116/jnevro202612603197","url":null,"abstract":"<p><strong>Objective: </strong>To identify clinical features of psychopathological and pathocharacterological disorders in patients with idiopathic tinnitus and determine the typological and nosological pertinence of this psychopathological entity.</p><p><strong>Material and methods: </strong>Forty-one patients (32 males and 9 females) aged 18 to 65 years diagnosed with tinnitus (H93.1 according to ICD-10) without organic causes were examined. Psychopathological, psychometric, clinical, and statistical methods were used; otolaryngological, neurological, and instrumental examinations were carried out.</p><p><strong>Results: </strong>Idiopathic tinnitus can have variable manifestations: it can be permanent or recurrent, stable or variable, single- or multicomponent, perceived in the ears or «inside the head», uni- or bilateral with variable frequency and volume. In this study, tinnitus was considered in the context of non-delusional hypochondria, presented with disorders of the coenesthesiopathic spectrum and personality disorders. Syndrome-based approach divides these disorders as neurotic, overvalued, circumscripta, and senestopathic hypochondria. Based on the syndromal features of hypochondriacal symptoms, the overall sample of patients was divided into three groups: Group 1 with overvalued hypochondria and tinnitus; Group 2 with neurotic hypochondria and tinnitus; and Group 3 with senestopathic hypochondria and tinnitus.</p><p><strong>Conclusion: </strong>Idiopathic tinnitus, considered a sensory acoustic phenomenon, can present with multiple phenomenological variations and be a part of psychopathological symptoms related to various nosological categories: overvalued, neurotic, or senestopathic hypochondria syndromes within hypochondriacal disorder, recurrent depressive disorder, dysthymia, or schizotypal disorder/schizophrenia according to ICD-10.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lipoprotein(a) and cerebrovascular diseases].","authors":"N V Pizova, A V Pizov","doi":"10.17116/jnevro20261260325","DOIUrl":"10.17116/jnevro20261260325","url":null,"abstract":"<p><p>Lipoprotein(a) is a genetically regulated low-density lipoprotein-like particle that is gaining increasing attention as an independent pathogenic risk factor for vascular diseases. The accumulation of evidence from epidemiological and genetic studies, as well as studies aimed at clarifying the pathogenetic mechanisms, confirmed the multifaceted role of lipoprotein(a) in atherogenesis, vascular calcification, inflammation, and thrombogenesis in various vascular regions. Elevated lipoprotein(a) levels are associated with an increased risk of cardiovascular and cerebrovascular events, even after controlling for traditional risk factors. Elevated lipoprotein(a) is associated with increased recurrence of stroke and poor functional outcome in stroke patients. Lipoprotein(a) can be a novel therapeutic target for the secondary prevention of stroke and a promising biomarker.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of immunological and metabolic parameters on the patient's functional outcome in the acute period of ischemic stroke].","authors":"A M Tynterova, E R Barantsevich, N N Shusharina, M S Khoimov, M S Rogovskaya","doi":"10.17116/jnevro202612603228","DOIUrl":"10.17116/jnevro202612603228","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effect of metabolic disorders and immunological parameters on the functional outcome (FO) of acute ischemic stroke (IS) in patients with metabolic syndrome (MS).</p><p><strong>Material and methods: </strong>298 patients in the acute period of IS were assessed. All patients were divided into two groups: Group 1 included 158 MS patients with a history of IS; Group 2 included 140 post-stroke patients without MS. The assessment included measurements of waist circumference, triglycerides (TG), low and high density lipoproteins (LDL/HDL), glucose, serum interleukins (IL-1b, IL-6, IL-16, IL-8), interferon gamma (IFN-g), tumor necrosis factor-alpha (TNF-<i>α</i>), macrophage migration inhibitory factor (MIF), monocyte chemotactic proteins (MCP-1/CCL2, MCP-3/CCL7), and macrophage inflammatory proteins (MIP-1a/CCL3, MIP-1d/CCL15). Patient disability rates measured by the modified Rankin Scale (mRS) at Day 21 from the IS onset were considered as FO parameters.</p><p><strong>Results: </strong>The FO evaluation revealed a significant (<i>p<</i>0.0001) prevalence of patients with an unfavorable/relatively unfavorable outcome (mRS ≥3) in Group 1. In the cohort of MS patients, multivariate mathematical analysis (correlation analysis and machine learning methods) showed the relationship of FO with the levels of LDL (<i>r=</i>0.520, p.d.=0.055), glucose (<i>r=</i>0.850, p.d.=0.089), the number of metabolic factors (<i>r=</i>0.880, p.d.=0.111), the concentrations of CCL3 (<i>r=</i>0.840, p.d.=0.354), CCL2 (<i>r=</i>0.520, p.d.=0.281), and MIF (<i>r=</i>0.830, p.d.=0.156).</p><p><strong>Conclusion: </strong>A worse FO score was observed in patients with MS than in metabolically healthy patients, and this was associated with hypercholesterolemia, hyperglycemia, the number of metabolic factors, and the expression of CCL3, CCL2, and MIF.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The effect of Cerebrolysin on the development of skills in patients after acute cerebrovascular accidents].","authors":"A A Shmonin, I Kh Kashaev, E A Luchinin, G S Bakulin","doi":"10.17116/jnevro202612602132","DOIUrl":"10.17116/jnevro202612602132","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of Cerebrolysin on improving the process of skill formation in patients with acute cerebrovascular accident during medical rehabilitation, based on a systematic review of the literature using elements of meta-analysis.</p><p><strong>Material and methods: </strong>A search of publications was conducted using the keywords «Cerebrolysin; Rehabilitation; Arm; Speech; Occupational therapy; Physical therapy; Ergotherapy» in the PubMed, Google Scholar and Elibrary databases. Original comparative studies investigating the effects of the drug on the human population after acute cerebrovascular accident, using rehabilitation measures and measuring the effectiveness using BI, ARAT, FIM, mRS, RMI, COPM, WAB and FMA were included. Mathematical processing of the arm action test (ARAT) results was performed using the SMD method.</p><p><strong>Results: </strong>The positive effect of potentiating neuroplasticity with Cerebrolysin consists in a significant improvement in daily activity in patients undergoing early comprehensive rehabilitation or physical therapy after a stroke. Patients statistically significantly restore the functionality of the affected upper limb during long-term rehabilitation initiated in the early subacute period. Improvement in speech and social activity is noted due to speech therapy interventions. A decrease in the level of depression and improvement in social adaptation have been proven during occupational therapy and psychological rehabilitation. The best results are observed with the introduction of the drug at a dosage of 30 ml. against the background of comprehensive multidisciplinary rehabilitation. Efficiency decreases with late onset of rehabilitation and a short course of drug administration.</p><p><strong>Conclusion: </strong>The use of Cerebrolysin in a dose of 10 ml to 30 ml during post-stroke rehabilitation leads to an increase in the quantity and quality of restored functions and formed skills, which was shown in a small group of 10 studies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"32-38"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}