Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Multiple foci of cerebral ischemia in cancer patients with secondary antiphospholipid syndrome].","authors":"P G Shnyakin, A O Gavrilova","doi":"10.17116/jnevro202612603284","DOIUrl":"10.17116/jnevro202612603284","url":null,"abstract":"<p><p>Antiphospholipid syndrome (APS) is associated with systemic organ and tissue damage, arterial and venous thrombosis, including in the central nervous system, and the occurrence of multiple ischemic areas. Primary APS occurs predominantly in young females and accounts for 20% of ischemic strokes in patients younger than 45 years. Secondary APS complicates several systemic diseases (systemic lupus erythematosus, lymphoproliferative diseases, HIV infection, etc.), and it can also develop in cancer patients. Multiple foci of cortical ischemia are most often detected by brain MRI in patients with APS. Laboratory tests usually show thrombocytopenia. Thromboses of other localizations are also often detected in patients. APS can be confirmed by detecting a high titer of phospholipid antibodies in blood. The paper presents three clinical cases of multiple cerebral ischemia in patients with a secondary APS and a cancer history, as well as a brief review of current publications on this issue.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Assessment of the efficacy of Cytoflavin in the acute phase of ischemic stroke: a systematic review and meta-analysis].","authors":"A M Alasheev, T V Kharitonova, N A Shamalov, S N Yanishevskiy, D R Khasanova, N A Marskaya, I A Voznuk","doi":"10.17116/jnevro202612607175","DOIUrl":"10.17116/jnevro202612607175","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of Cytoflavin in conjunction with standard therapy compared to standard therapy alone in patients presenting during the acute phase of ischemic stroke (IS).</p><p><strong>Material and methods: </strong>A systematic literature review and meta-analysis were conducted to assess the efficacy of Cytoflavin (containing inosine, nicotinamide, riboflavin, and succinic acid; STPF POLYSAN, Ltd., Russia) in adult patients diagnosed with IS. The analysis encompassed both randomized and non-randomized controlled trials, assessing outcomes such as hospital mortality, neurological deficit (measured using the National Institutes of Health Stroke Scale, NIHSS), and functional outcomes (assessed using the modified Rankin Scale and Barthel Index).</p><p><strong>Results: </strong>The incorporation of Cytoflavin into standard treatment protocols was associated with a statistically significant reduction in mortality rates when compared to standard therapy alone (hazard ratio [HR]=0.53; 95% confidence interval [CI] 0.37; 0.76, <i>p</i><0.001). Furthermore, there was a notable improvement in the regression of neurological deficits during the acute phase of IS, as evidenced by higher NIHSS scores and better functional outcomes (Barthel Index) in patients receiving Cytoflavin.</p><p><strong>Conclusion: </strong>The findings from this systematic review and meta-analysis indicate that the addition of Cytoflavin to standard therapy for ischemic stroke is associated with more favorable clinical outcomes, including decreased mortality, diminished neurological impairment, and improved functional outcomes at the end of the IS acute phase. It is imperative to consider the high heterogeneity in the functional scales data across studies when interpreting these effects.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"75-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Visual and spatial memory disorders: risk factors and recovery trajectory in the acute phase of ischemic stroke].","authors":"V N Grigoryeva, D I Sundukov, N A Prusakov, A A Zakharova","doi":"10.17116/jnevro202612608237","DOIUrl":"https://doi.org/10.17116/jnevro202612608237","url":null,"abstract":"<p><strong>Objective: </strong>To assess the incidence of severe visual-spatial memory (VSM) disorders, the risk factors contributing to their development, and the changes observed during the acute phase of mild and moderate supratentorial ischemic stroke (IS).</p><p><strong>Material and methods: </strong>A total of 140 patients in the acute phase of mild and moderate IS and 30 patients with chronic cerebral ischemia (CCI) were included in this study. All participants underwent clinical neurological, neuropsychological, and neuroimaging assessments. The patients were categorized into three groups: Group 1 comprised 54 patients with IS localized in the posterior medial and posterolateral regions; Group 2 included 86 patients with IS lesions of other localization; and Group 3 consisted of 30 patients with CCI. Neuropsychological evaluations were conducted using the Addenbrooke's Cognitive Examination III (ACE-III), Corsi Block-Tapping Task (CBTT), and Geriatric Complex Figure (GCF), which included GCF Copy and GCF Recall subtests. Initial testing occurred on days 4-5 of hospitalization (T1), with follow-up assessments performed after 14-16 days (T2) for patients with IS.</p><p><strong>Results: </strong>Severe VSM disorders were detected in 20% of patients diagnosed with IS. In Group 1, the prevalence of such disorders was significantly higher (38.9%) than in Group 2 (8.1%; <i>p<</i>0.001) and Group 3 (10.0%; <i>p=</i>0.005). Analysis during the T1-T2 interval demonstrated a notable improvement in VSM, particularly in GCF Recall, in both Group 1 and Group 2. However, at T2, the GCF Recall scores in Group 1 remained comparatively lower than those in Group 2 (<i>p=</i>0.004). Furthermore, the rate of recovery from VSM in Group 1 was slower than that observed in Group 2 (<i>p<</i>0.001).</p><p><strong>Conclusions: </strong>The study concludes that severe VSM disorders occur in 20% of patients experiencing mild and moderate acute IS, with a higher incidence associated with lesions localized in the posterior regions of the brain. The recovery trajectory from VSM during the acute phase of IS is notably slower in patients with a posterior-medial ischemic focus than in those with a posterolateral ischemic focus.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 8. Vyp. 2","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of long-term carbamazepine therapy on bone metabolism in women with epilepsy].","authors":"G S Rakhimbaeva, F H Muratov, D Y Yusupova","doi":"10.17116/jnevro202612606194","DOIUrl":"https://doi.org/10.17116/jnevro202612606194","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of long-term carbamazepine monotherapy on bone metabolism and bone mineral density in women with epilepsy.</p><p><strong>Material and methods: </strong>The study included 60 women with epilepsy alongside a control group of 55 healthy women. Serum levels of interleukin-7 (IL-7), estradiol, transforming growth factor-beta4 (TGF-<i>β</i>4), alkaline phosphatase, calcium, and phosphorus were measured in all participants. Bone mineral density and structure were assessed using dual-energy X-ray absorptiometry (DEXA).</p><p><strong>Results: </strong>The findings from the early osteoporosis diagnosis examination revealed that the levels of estradiol, IL-7, and TGF-<i>β</i>4 were outside the normal range. In contrast, calcium, phosphorus, and alkaline phosphatase levels remained within reference ranges. Bone mineral density and T-score measurements obtained via DEXA in the lumbar spine, right radius, and right hip exhibited positive correlations with serum levels of estradiol, IL-7, and TGF-<i>β</i>4. Conversely, significant negative correlations were observed with serum calcium, phosphorus, and alkaline phosphatase.</p><p><strong>Conclusions: </strong>Prolonged carbamazepine treatment considerably increases the risk of osteoporosis in women by disrupting hormonal and cytokine regulation, underscoring the critical need to monitor biomarkers such as estradiol, TGF-<i>β</i>4, and IL-7 to facilitate early diagnosis and prevention of osteoporosis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 6","pages":"94-98"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Features of post-stroke speech disorders and the prospects of mirror therapy in the recovery of patients].","authors":"E V Isakova, S V Kotov, E S Guts","doi":"10.17116/jnevro202612601131","DOIUrl":"10.17116/jnevro202612601131","url":null,"abstract":"<p><p>The review describes the features of post-stroke speech disorders, including epidemiological data on their prevalence, spectrum, and characteristics of their various types. The prospects of using mirror therapy for stroke patients as an affordable, simple, safe, inexpensive method are discussed, which is a relatively new direction in the treatment of aphasia. Also, the literature review focuses on various mechanisms underlying a positive therapeutic effect, including the activation of mirror neurons during the performance of specific actions or the observation of hand and facial movements, and the activation of the tongue. Based on the neuroimaging results, we assessed the effectiveness of simultaneous recovery of hand motor function and speech through mirror therapy with visual biofeedback in the rehabilitation of patients with post-stroke speech disorders. The results of numerous clinical studies, meta-analyses, and case reports confirming the effectiveness of mirror therapy for speech disorders after a stroke are presented.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effectiveness of breathing exercises compared to audio signals to improve sleep].","authors":"D E Shumov, D S Sveshnikov, A E Khuurak, E B Yakunina, Z V Bakaeva, O V Mankaeva, V I Torshin, V B Dorokhov, A N Puchkova","doi":"10.17116/jnevro202612605223","DOIUrl":"10.17116/jnevro202612605223","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of three non-pharmacological interventions - binaural beats (BB) combined with suggestive instructions (SI), diaphragmatic breathing (DB), and BB combined with DB - for improving sleep, with consideration of sex differences among participants.</p><p><strong>Material and methods: </strong>The study included 217 healthy participants. Each participant completed four tasks in randomized order on separate nights before bedtime: (1) BB+SI, (2) DB, (3) BB+DB, and (4) monotonous sound without beats as a control (imitation, IM). Sleep latency (SL) was measured using a smartphone screen-touch test. Statistical analyses of SL values were conducted by task and sex factors.</p><p><strong>Results: </strong>Analysis revealed a statistically significant effect of the task factor on sleep latency (SL) (<i>p</i><0.05). Post-hoc comparisons showed that the DB task significantly reduced mean SL compared to IM for the overall group (<i>p</i><0.05). Additionally, a significant decrease in mean SL following the BB+SI intervention was observed in females compared to IM (<i>p</i><0.05). No statistically significant changes were found in males.</p><p><strong>Conclusions: </strong>The findings confirm the effectiveness of deep diaphragmatic breathing (DB) and suggestive instructions (SI) combined with binaural beats (BB) as non-pharmacological interventions for improving sleep in a large sample. The SI combined with BB demonstrated efficacy exclusively in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5. Vyp. 2","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of vitamin D levels on tension headache characteristics: a systematic review].","authors":"O V Vorobyeva, T E Morozova, A A Gertsog, M V Gurjar, M A Kiriakova, S V Sobenina","doi":"10.17116/jnevro20261260417","DOIUrl":"10.17116/jnevro20261260417","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between vitamin D levels and the frequency and intensity of tension headaches, as well as the therapeutic effectiveness of vitamin D.</p><p><strong>Material and methods: </strong>A systematic review of the literature was conducted, including observational and interventional studies on the relationship between vitamin D levels and tension headache characteristics. The review included 8 studies selected from PubMed, ScienceDirect, Google Scholar, eLibrary, and Europe PMC databases that met the inclusion criteria. The study design, clinical parameters of pain, vitamin D levels, and the effect of therapy were assessed.</p><p><strong>Results: </strong>Vitamin D deficiency is associated with a higher incidence and longer duration of headache episodes, but not with increased intensity. Several studies found a significant negative correlation between vitamin D levels and headache frequency or duration. Interventional studies confirmed the clinical benefit of vitamin D therapy in patients with hypovitaminosis.</p><p><strong>Conclusion: </strong>There is strong evidence linking vitamin D deficiency to a more severe course of tension headaches. Assessing and correcting vitamin D levels may be important in comprehensive treatment. However, further randomized controlled trials are needed to confirm causality and establish standardized therapeutic strategies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Herpes infection and primary cerebral vasculitis].","authors":"L A Kalashnikova, A A Shabalina, M V Dreval, S A Zacharchuk, L A Dobrynina","doi":"10.17116/jnevro202612602139","DOIUrl":"10.17116/jnevro202612602139","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the presence of antibodies to herpes viruses (<i>Varicella zoster virus</i> [VZV], herpes simplex virus types I and II, Epstein-Barr virus, and cytomegalovirus) and their DNA in the cerebrospinal fluid (CSF) of patients with a history of ischemic stroke (IS) and/or transient cerebrovascular accident (TIA) caused by primary cerebral vasculitis (PCV); to evaluate their clinical significance.</p><p><strong>Material and methods: </strong>Thirty-one patients (mean age 41.2±8.7 years, 18 males, 58%) with PCV and a history of IS and/or transient cerebrovascular accidents (TIA), which in 94% occurred in the internal carotid artery (ICA) system, were examined. Antibodies were tested by enzyme-linked immunosorbent assay (ELISA) or immunochemiluminescence, and herpesvirus DNA was tested by polymerase chain reaction (PCR).</p><p><strong>Results: </strong>An increase in immunoglobulin (Ig) G antibodies to the VZV virus (anti-VZV IgG antibodies) was detected in 10 (32%) of 31 patients in the CSF; one of them also had Ig antibodies to the herpes simplex virus. There were statistically significant differences between patients with and without anti-VZV IgG antibodies regarding the frequency of convulsive disorder (40% vs. 0%, respectively, <i>p=</i>0.0023<b>)</b>, TIA <b>(</b>60% vs. 90%, respectively, <i>p=</i>0.0483), the insidious onset of stroke symptoms (over several hours to 2-3 days) <b>(</b>30% vs. 0%, respectively, <i>p=</i>0.0092) and the increase in the erythrocyte sedimentation rate [ESR] <b>(</b>0% vs. 33%, respectively, <i>p=</i>0.0412).</p><p><strong>Conclusion: </strong>An increase in anti-VZV IgG antibodies in CSF in 32% of patients suggests VZV activation in the trigeminal ganglion and its transaxonal spread along the branches of the trigeminal nerve into the walls of the ICA and the middle and anterior cerebral arteries, where VZV causes inflammation. It explains the most common lesion of the ICA system (94%), its locality, and the absence of systemic inflammatory signs. In patients without anti-VZV IgG antibodies, it is assumed that PCV is caused by other neurotropic pathogens that can affect hemostasis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of Abobotulinumtoxin A (Dysport) in stump preparation for prosthetic fitting in patients with combat-related limb amputations].","authors":"T V Kuznetsova, O O Ziteva, E B Shakhunova, Yu N Ponomarenko, M E Kasatkina","doi":"10.17116/jnevro202612602177","DOIUrl":"10.17116/jnevro202612602177","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of abobotulinumtoxinA in stump preparation for prosthetic fitting in patients with limb amputations.</p><p><strong>Material and methods: </strong>This prospective open-label study included 88 male patients over 18 years old with lower limb amputations due to mine-blast trauma and phantom limb pain syndrome (PLP) with pain intensity of at least 5 points on the visual analogue scale (VAS), absence of significant effect from pharmacological therapy, stump tenderness, and preserved active movements in the transected muscles. AbobotulinumtoxinA at doses of 500-800 U was used to reduce PLP severity. Examination of all patients included collection of complaints and medical history, neurological examination (including manual muscle testing and muscle tone assessment), pain assessment by VAS, psycho-emotional status assessment using the Hospital Anxiety and Depression Scale (HADS), neuropathic pain assessment using the DN4 questionnaire, and stump ultrasound to assess muscle functional status (presence or absence of movements). The total observation period was 21 days. Seven patients with preserved muscles were additionally examined 3 months after botulinum toxin injection.</p><p><strong>Results: </strong>Baseline VAS pain score was 5.8±0.4 points. Clinically significant anxiety according to HADS was present in 86 patients. The mean anxiety score before botulinum toxin injection in the group was 9.1±1.2 points. Depression scores on the HADS were subclinical in all patients, with a mean of 5.3±1.6 points. The mean DN4 neuropathic pain score was 5.9±0.5 points. Pain intensity decreased in all patients, reaching a mean of 3.7±0.5 points on VAS by day 7 after botulinum toxin therapy (<i>p</i><0.05). By day 14, pain syndrome was completely resolved in all patients. The mean DN4 score was 5.1±0.4 points on day 7 and 2.6±0.9 points on day 14 after injection (<i>p</i><0.05).</p><p><strong>Conclusions: </strong>Early botulinum toxin therapy enables rapid stump preparation for prosthesis fitting, resolves pain syndrome and accelerates patient rehabilitation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Morphofunctional features of the left ventricle in patients with chronic cerebral ischemia].","authors":"I T Murkamilov, K A Aitbaev, V V Fomin, Zh A Murkamilova, Z R Rayimzhanov, A F Yusupov, Z F Yusupova, T F Yusupova, F A Yusupov, K A Gassanov","doi":"10.17116/jnevro202612603212","DOIUrl":"10.17116/jnevro202612603212","url":null,"abstract":"<p><strong>Objective: </strong>To study the features of left ventricle (LV) structural adjustment and comorbidity in patients with chronic cerebral ischemia (CCI) based on gender.</p><p><strong>Material and methods: </strong>The study included 316 patients diagnosed with chronic cerebral ischemia with a mean age of 61.9 years (range 36 to 86 years). All patients underwent a general clinical examination, assessment of echocardiography parameters, and measurement of the thickness of the common carotid artery (CCA) intima-media complex (IMC). The patients were divided into two groups based on gender: Group I included males (<i>n</i>=170), and Group II included females (<i>n</i>=146).</p><p><strong>Results: </strong>In males with CCI, the CCA IMC thickness (1.23±0.14 mm vs 1.16±0.11 mm, <i>p</i><0.05) and the prevalence of atherosclerotic changes (57.6% vs 34.9%, <i>p</i><0.05) were significantly higher than in females. Normal LV geometry was reported in 59.4% of males and only in 37.0% of females (<i>p</i><0.05). The frequency of concentric LV remodeling was 8.8% in males and 6.2% in females. LV hypertrophy (LVH) was detected in 31.8% of males and 56.8% of females (<i>p</i><0.05). The concentric type of LVH was more common in males (68.5%), whereas the eccentric type prevailed in females (74.7%). A statistically significant correlation of CCA IMC thickness with age (<i>r</i>=0.234), systolic (<i>r</i>=0.209) and diastolic blood pressure (<i>r</i>=0.151), hemoglobin concentration (<i>r</i>=-0.245), end-systolic LV size (<i>r</i>=0.125), end-systolic (<i>r</i>=0.151) and end-diastolic (<i>r</i>=0.135) LV volumes, as well as LV myocardial mass index (<i>r</i>=0.132) in the total sample was found. In the male group, CCA IMC thickness correlated with body mass index (<i>r</i>=0.291) and diastolic blood pressure (<i>r</i>=0.210). In the female group, strong correlations were found with hemoglobin concentration (<i>r</i>=-0.732) and end-systolic LV volume (<i>r</i>=0.176).</p><p><strong>Conclusion: </strong>In patients with CCI, the most common morphofunctional LV changes were concentric LVH in males and eccentric LVH in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}