{"title":"[Multiple foci of cerebral ischemia in cancer patients with secondary antiphospholipid syndrome].","authors":"P G Shnyakin, A O Gavrilova","doi":"10.17116/jnevro202612603284","DOIUrl":"10.17116/jnevro202612603284","url":null,"abstract":"<p><p>Antiphospholipid syndrome (APS) is associated with systemic organ and tissue damage, arterial and venous thrombosis, including in the central nervous system, and the occurrence of multiple ischemic areas. Primary APS occurs predominantly in young females and accounts for 20% of ischemic strokes in patients younger than 45 years. Secondary APS complicates several systemic diseases (systemic lupus erythematosus, lymphoproliferative diseases, HIV infection, etc.), and it can also develop in cancer patients. Multiple foci of cortical ischemia are most often detected by brain MRI in patients with APS. Laboratory tests usually show thrombocytopenia. Thromboses of other localizations are also often detected in patients. APS can be confirmed by detecting a high titer of phospholipid antibodies in blood. The paper presents three clinical cases of multiple cerebral ischemia in patients with a secondary APS and a cancer history, as well as a brief review of current publications on this issue.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 3. Vyp. 2","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147629362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A M Alasheev, T V Kharitonova, N A Shamalov, S N Yanishevskiy, D R Khasanova, N A Marskaya, I A Voznuk
{"title":"[Assessment of the efficacy of Cytoflavin in the acute phase of ischemic stroke: a systematic review and meta-analysis].","authors":"A M Alasheev, T V Kharitonova, N A Shamalov, S N Yanishevskiy, D R Khasanova, N A Marskaya, I A Voznuk","doi":"10.17116/jnevro202612607175","DOIUrl":"10.17116/jnevro202612607175","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of Cytoflavin in conjunction with standard therapy compared to standard therapy alone in patients presenting during the acute phase of ischemic stroke (IS).</p><p><strong>Material and methods: </strong>A systematic literature review and meta-analysis were conducted to assess the efficacy of Cytoflavin (containing inosine, nicotinamide, riboflavin, and succinic acid; STPF POLYSAN, Ltd., Russia) in adult patients diagnosed with IS. The analysis encompassed both randomized and non-randomized controlled trials, assessing outcomes such as hospital mortality, neurological deficit (measured using the National Institutes of Health Stroke Scale, NIHSS), and functional outcomes (assessed using the modified Rankin Scale and Barthel Index).</p><p><strong>Results: </strong>The incorporation of Cytoflavin into standard treatment protocols was associated with a statistically significant reduction in mortality rates when compared to standard therapy alone (hazard ratio [HR]=0.53; 95% confidence interval [CI] 0.37; 0.76, <i>p</i><0.001). Furthermore, there was a notable improvement in the regression of neurological deficits during the acute phase of IS, as evidenced by higher NIHSS scores and better functional outcomes (Barthel Index) in patients receiving Cytoflavin.</p><p><strong>Conclusion: </strong>The findings from this systematic review and meta-analysis indicate that the addition of Cytoflavin to standard therapy for ischemic stroke is associated with more favorable clinical outcomes, including decreased mortality, diminished neurological impairment, and improved functional outcomes at the end of the IS acute phase. It is imperative to consider the high heterogeneity in the functional scales data across studies when interpreting these effects.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"75-85"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V N Grigoryeva, D I Sundukov, N A Prusakov, A A Zakharova
{"title":"[Visual and spatial memory disorders: risk factors and recovery trajectory in the acute phase of ischemic stroke].","authors":"V N Grigoryeva, D I Sundukov, N A Prusakov, A A Zakharova","doi":"10.17116/jnevro202612608237","DOIUrl":"https://doi.org/10.17116/jnevro202612608237","url":null,"abstract":"<p><strong>Objective: </strong>To assess the incidence of severe visual-spatial memory (VSM) disorders, the risk factors contributing to their development, and the changes observed during the acute phase of mild and moderate supratentorial ischemic stroke (IS).</p><p><strong>Material and methods: </strong>A total of 140 patients in the acute phase of mild and moderate IS and 30 patients with chronic cerebral ischemia (CCI) were included in this study. All participants underwent clinical neurological, neuropsychological, and neuroimaging assessments. The patients were categorized into three groups: Group 1 comprised 54 patients with IS localized in the posterior medial and posterolateral regions; Group 2 included 86 patients with IS lesions of other localization; and Group 3 consisted of 30 patients with CCI. Neuropsychological evaluations were conducted using the Addenbrooke's Cognitive Examination III (ACE-III), Corsi Block-Tapping Task (CBTT), and Geriatric Complex Figure (GCF), which included GCF Copy and GCF Recall subtests. Initial testing occurred on days 4-5 of hospitalization (T1), with follow-up assessments performed after 14-16 days (T2) for patients with IS.</p><p><strong>Results: </strong>Severe VSM disorders were detected in 20% of patients diagnosed with IS. In Group 1, the prevalence of such disorders was significantly higher (38.9%) than in Group 2 (8.1%; <i>p<</i>0.001) and Group 3 (10.0%; <i>p=</i>0.005). Analysis during the T1-T2 interval demonstrated a notable improvement in VSM, particularly in GCF Recall, in both Group 1 and Group 2. However, at T2, the GCF Recall scores in Group 1 remained comparatively lower than those in Group 2 (<i>p=</i>0.004). Furthermore, the rate of recovery from VSM in Group 1 was slower than that observed in Group 2 (<i>p<</i>0.001).</p><p><strong>Conclusions: </strong>The study concludes that severe VSM disorders occur in 20% of patients experiencing mild and moderate acute IS, with a higher incidence associated with lesions localized in the posterior regions of the brain. The recovery trajectory from VSM during the acute phase of IS is notably slower in patients with a posterior-medial ischemic focus than in those with a posterolateral ischemic focus.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 8. Vyp. 2","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effect of long-term carbamazepine therapy on bone metabolism in women with epilepsy].","authors":"G S Rakhimbaeva, F H Muratov, D Y Yusupova","doi":"10.17116/jnevro202612606194","DOIUrl":"https://doi.org/10.17116/jnevro202612606194","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of long-term carbamazepine monotherapy on bone metabolism and bone mineral density in women with epilepsy.</p><p><strong>Material and methods: </strong>The study included 60 women with epilepsy alongside a control group of 55 healthy women. Serum levels of interleukin-7 (IL-7), estradiol, transforming growth factor-beta4 (TGF-<i>β</i>4), alkaline phosphatase, calcium, and phosphorus were measured in all participants. Bone mineral density and structure were assessed using dual-energy X-ray absorptiometry (DEXA).</p><p><strong>Results: </strong>The findings from the early osteoporosis diagnosis examination revealed that the levels of estradiol, IL-7, and TGF-<i>β</i>4 were outside the normal range. In contrast, calcium, phosphorus, and alkaline phosphatase levels remained within reference ranges. Bone mineral density and T-score measurements obtained via DEXA in the lumbar spine, right radius, and right hip exhibited positive correlations with serum levels of estradiol, IL-7, and TGF-<i>β</i>4. Conversely, significant negative correlations were observed with serum calcium, phosphorus, and alkaline phosphatase.</p><p><strong>Conclusions: </strong>Prolonged carbamazepine treatment considerably increases the risk of osteoporosis in women by disrupting hormonal and cytokine regulation, underscoring the critical need to monitor biomarkers such as estradiol, TGF-<i>β</i>4, and IL-7 to facilitate early diagnosis and prevention of osteoporosis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 6","pages":"94-98"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148341438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Features of post-stroke speech disorders and the prospects of mirror therapy in the recovery of patients].","authors":"E V Isakova, S V Kotov, E S Guts","doi":"10.17116/jnevro202612601131","DOIUrl":"10.17116/jnevro202612601131","url":null,"abstract":"<p><p>The review describes the features of post-stroke speech disorders, including epidemiological data on their prevalence, spectrum, and characteristics of their various types. The prospects of using mirror therapy for stroke patients as an affordable, simple, safe, inexpensive method are discussed, which is a relatively new direction in the treatment of aphasia. Also, the literature review focuses on various mechanisms underlying a positive therapeutic effect, including the activation of mirror neurons during the performance of specific actions or the observation of hand and facial movements, and the activation of the tongue. Based on the neuroimaging results, we assessed the effectiveness of simultaneous recovery of hand motor function and speech through mirror therapy with visual biofeedback in the rehabilitation of patients with post-stroke speech disorders. The results of numerous clinical studies, meta-analyses, and case reports confirming the effectiveness of mirror therapy for speech disorders after a stroke are presented.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 1","pages":"31-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D E Shumov, D S Sveshnikov, A E Khuurak, E B Yakunina, Z V Bakaeva, O V Mankaeva, V I Torshin, V B Dorokhov, A N Puchkova
{"title":"[Effectiveness of breathing exercises compared to audio signals to improve sleep].","authors":"D E Shumov, D S Sveshnikov, A E Khuurak, E B Yakunina, Z V Bakaeva, O V Mankaeva, V I Torshin, V B Dorokhov, A N Puchkova","doi":"10.17116/jnevro202612605223","DOIUrl":"10.17116/jnevro202612605223","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of three non-pharmacological interventions - binaural beats (BB) combined with suggestive instructions (SI), diaphragmatic breathing (DB), and BB combined with DB - for improving sleep, with consideration of sex differences among participants.</p><p><strong>Material and methods: </strong>The study included 217 healthy participants. Each participant completed four tasks in randomized order on separate nights before bedtime: (1) BB+SI, (2) DB, (3) BB+DB, and (4) monotonous sound without beats as a control (imitation, IM). Sleep latency (SL) was measured using a smartphone screen-touch test. Statistical analyses of SL values were conducted by task and sex factors.</p><p><strong>Results: </strong>Analysis revealed a statistically significant effect of the task factor on sleep latency (SL) (<i>p</i><0.05). Post-hoc comparisons showed that the DB task significantly reduced mean SL compared to IM for the overall group (<i>p</i><0.05). Additionally, a significant decrease in mean SL following the BB+SI intervention was observed in females compared to IM (<i>p</i><0.05). No statistically significant changes were found in males.</p><p><strong>Conclusions: </strong>The findings confirm the effectiveness of deep diaphragmatic breathing (DB) and suggestive instructions (SI) combined with binaural beats (BB) as non-pharmacological interventions for improving sleep in a large sample. The SI combined with BB demonstrated efficacy exclusively in females.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 5. Vyp. 2","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O V Vorobyeva, T E Morozova, A A Gertsog, M V Gurjar, M A Kiriakova, S V Sobenina
{"title":"[Effect of vitamin D levels on tension headache characteristics: a systematic review].","authors":"O V Vorobyeva, T E Morozova, A A Gertsog, M V Gurjar, M A Kiriakova, S V Sobenina","doi":"10.17116/jnevro20261260417","DOIUrl":"10.17116/jnevro20261260417","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the relationship between vitamin D levels and the frequency and intensity of tension headaches, as well as the therapeutic effectiveness of vitamin D.</p><p><strong>Material and methods: </strong>A systematic review of the literature was conducted, including observational and interventional studies on the relationship between vitamin D levels and tension headache characteristics. The review included 8 studies selected from PubMed, ScienceDirect, Google Scholar, eLibrary, and Europe PMC databases that met the inclusion criteria. The study design, clinical parameters of pain, vitamin D levels, and the effect of therapy were assessed.</p><p><strong>Results: </strong>Vitamin D deficiency is associated with a higher incidence and longer duration of headache episodes, but not with increased intensity. Several studies found a significant negative correlation between vitamin D levels and headache frequency or duration. Interventional studies confirmed the clinical benefit of vitamin D therapy in patients with hypovitaminosis.</p><p><strong>Conclusion: </strong>There is strong evidence linking vitamin D deficiency to a more severe course of tension headaches. Assessing and correcting vitamin D levels may be important in comprehensive treatment. However, further randomized controlled trials are needed to confirm causality and establish standardized therapeutic strategies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 4","pages":"7-14"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D S Kanshina, I A Melnikov, M V Ublinsky, S B Ivanov, T A Akhadov, V P Zykov, S S Nikitin
{"title":"[Informative value of instrumental methods in assessing the anatomical and functional state of the corticospinal tract in children with severe traumatic brain injury].","authors":"D S Kanshina, I A Melnikov, M V Ublinsky, S B Ivanov, T A Akhadov, V P Zykov, S S Nikitin","doi":"10.17116/jnevro202612607192","DOIUrl":"https://doi.org/10.17116/jnevro202612607192","url":null,"abstract":"<p><strong>Objective: </strong>To compare motor recovery in children with severe traumatic brain injury (TBI) with findings from functional and imaging diagnostic techniques based on the age-dependent theory of motor development.</p><p><strong>Material and methods: </strong>The study included 43 children (26 boys and 17 girls), aged 5 to 17 years, with severe TBI who underwent rehabilitation at the Department of Rehabilitation of the Research Institute of Emergency Pediatric Surgery and Traumatology (Dr. Roshal Clinic) from 2023 to 2024. The clinical evaluation used the Muscle Strength Scale, the Modified Ashworth Scale, and a classification system for gross motor function. Instrumental assessments of the anatomical and functional state of the corticospinal tract (CST) included diagnostic single-pulse transcranial magnetic stimulation (sTMS) and magnetic resonance (MR) tractography, which analyzed corticomotor neuronal pathways originating from the primary motor cortex (PMC) and supplementary motor area.</p><p><strong>Results: </strong>Improvement in motor deficits during both intermediate and long-term phases post-injury was associated with a reduction in the threshold for motor evoked responses (MER) (AUCs of 0.583 and 0.548, respectively) and an increase in MER amplitude (AUCs of 0.5 and 0.508, respectively). A significant correlation was noted between the deviation of the MER threshold from reference values and the patient's age at the time of injury, with deviations of 9.27% for ages 6-12 years and 26.1% for ages 12-18 years (<i>p</i><0.05). Additionally, an increase in the fractional anisotropy coefficient of CST was observed in children with various degrees of motor impairment following severe TBI within the first-year post-trauma.</p><p><strong>Conclusions: </strong>The findings suggest that instrumental diagnostic methods can effectively assess the severity of motor deficits in children with severe TBI and diminished consciousness. The interpretation of these results should incorporate the age-dependent theory of locomotor behavior development.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M V Sinkin, T A Aleksandrova, E A Baranova, A I Belyakova-Bodina, E P Bogdanova, Z K Gorchkhanova, O V Grebennikova, D V Drozdov, O D Elshina, I D Lemeshko, A J Smirnova, A S Smychkov, T R Tomenko, A A Troitskiy, I V Okuneva, A A Sharkov
{"title":"[Guidelines for clinical electroencephalography: Russian professional community development and consensus building].","authors":"M V Sinkin, T A Aleksandrova, E A Baranova, A I Belyakova-Bodina, E P Bogdanova, Z K Gorchkhanova, O V Grebennikova, D V Drozdov, O D Elshina, I D Lemeshko, A J Smirnova, A S Smychkov, T R Tomenko, A A Troitskiy, I V Okuneva, A A Sharkov","doi":"10.17116/jnevro20261260225","DOIUrl":"10.17116/jnevro20261260225","url":null,"abstract":"<p><p>Clinical guidelines based on scientific data are mandatory for clinical practice. However, they only indicate the necessity of diagnostic tests and do not describe how to perform them. Additional methodological documents are therefore necessary to standardize diagnostic and therapeutic processes. The Association of Clinical Neurophysiology Specialists (ASCLIN), in collaboration with the Russian Association of Functional Diagnostics Physicians (RASFD), the All-Russian Society of Neurologists, and the Russian Anti-Epilepsy League (RAEL), has developed methodological guidelines for EEG and EEG with stress tests. Since this term, used in the nomenclature of medical services, is not used in practice, the recommendations use the synonym «functional tests» as the most common and understandable for personnel conducting EEG, corresponding to the English terms 'activating' and «modulating procedures.» The level of evidence was assessed using the GRADE system; more than 6000 functional diagnostics physicians and neurologists participated in the public discussion. Twenty-two recommendations were formulated, three of which are level B2 and eight of which are level C5. The document includes practical appendices with examples of standard operating procedures, a protocol for examinations during attacks, and illustrations of typical artifacts. The developed methodological guidelines align with the Ministry of Health of the Russian Federation's clinical recommendations ecosystem. They aim to standardize EEG procedures and improve diagnosis and treatment quality.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 2. Vyp. 2","pages":"5-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I Yu Dorozhenok, O Yu Olisova, E P Melnik, D A Larionov, D A Koriakin, B A Volel
{"title":"[Prevalence of mental disorders and syndromic mental distress in patients with chronic dermatoses: A cross-sectional epidemiological study].","authors":"I Yu Dorozhenok, O Yu Olisova, E P Melnik, D A Larionov, D A Koriakin, B A Volel","doi":"10.17116/jnevro2026126071107","DOIUrl":"https://doi.org/10.17116/jnevro2026126071107","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prevalence and clinical structure of comorbid mental disorders among patients with chronic dermatoses, to identify associations with specific nosological forms of skin diseases, and to perform a differential analysis of subsyndromal mental distress.</p><p><strong>Material and methods: </strong>A single-center, cross-sectional epidemiological study was conducted, including 500 patients diagnosed with chronic dermatoses at the Clinic for Skin and Venereal Diseases named after V.A. Rakhmanov of the Sechenov First Moscow State Medical University from March 2025 to March 2026. Dermatological and psychiatric diagnoses were validated according to ICD-10 criteria. To assess participants' mental status, a battery of validated assessment scales was used, along with a consultation with a psychiatrist. Participants were stratified into three groups: patients with psychiatric comorbidity, patients with subsyndromal mental distress, and a comparison group.</p><p><strong>Results: </strong>Psychiatric diagnoses conforming to ICD-10 criteria were confirmed in 46.4% of the overall population (<i>n=</i>232). The structure of comorbidity was primarily characterized by a prevalence of adaptation disorders (F43), which accounted for 61.2% of the group diagnosed with mental disorders. The highest risk of comorbid conditions was associated with psoriasis (odds ratio [OR]=2.34; <i>p<</i>0.001), atopic dermatitis (OR=2.18; <i>p</i>=0.002), and vitiligo (OR=2.13; <i>p</i>=0.044). Subsyndromal mental distress was identified in 39.6% of patients (<i>n=</i>198). Quality of life, as measured by the Dermatology Life Quality Index, was significantly reduced in the group with subsyndromal mental distress (median score of 14.0), which was comparable to that of the group with verified psychiatric diagnoses (18.4±6.3). Notably, psychogenic exacerbations of dermatosis were reported in 37.6% of patients, with those receiving psychotropic therapy experiencing significantly fewer exacerbations (median 2.0 vs. 4.0; <i>p</i>=0.018).</p><p><strong>Conclusions: </strong>The prevalence of psychiatric comorbidity among patients with chronic dermatoses is substantial, encompassing 86.0% of the population when considering subsyndromal conditions. The data obtained underscore the necessity for the introduction of systematic screening for psychosomatic status within dermatological protocols and advocate for a transition towards a multidisciplinary care model that integrates both dermatological and psychiatric management.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"126 7","pages":"107-114"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}