Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[Impaired time perception in attention deficit hyperactivity disorder].","authors":"L S Chutko, E A Yakovenko, S Yu Surushkina, T I Anisimova, M D Didur, D V Cherednichenko, L V Scheglova, I B Sosnina, E V Snegova","doi":"10.17116/jnevro202512506155","DOIUrl":"https://doi.org/10.17116/jnevro202512506155","url":null,"abstract":"<p><strong>Objective: </strong>To examine time perception in children with attention deficit hyperactivity disorder (ADHD) and evaluate the effectiveness of Pantogam in relation to the main symptoms of the disease and the disorder of time perception.</p><p><strong>Material and methods: </strong>86 children with ADHD aged 10-13 years were observed. The study group included 56 children with a combined type of ADHD (ADHD-C) and 30 children with a predominance of inattention without hyperactivity (ADD). The control group consisted of 30 children aged 10 to 13 years without psychoneurological disorders. The following research methods were used in the work: the SNAP-IY questionnaire for a quantitative assessment of ADHD manifestations, the «Working Memory» method for assessing working memory, tasks for assessing and measuring time intervals, and a study using the «subjective minute» method to assess time perception disorders. Pantogam was used in a dose of 750 mg per day for 8 weeks to treat children with ADHD.</p><p><strong>Results: </strong>According to the SNAP-IY scale, the level of inattention in the study groups was significantly higher than the level of inattention in the control group, and the level of hyperactivity and impulsivity was significantly higher in children with ADHD-C compared to the ADHD group and the control group. When assessing working memory, a reliable decrease in the level of this indicator was found in children with both types of ADHD compared to the control group. Difficulties with time management, as assessed by parents, were noted in 88.4% of children in the study group and 36.7% of children in the control group. These disorders were especially pronounced in tasks requiring sustained attention (96.4% of children with ADHD-C and 73.3% of children with ADD). According to the results of tests for time perception, disturbances in time perception were revealed in both groups of children with ADHD. In ADHD-C, tachychrony was more pronounced, and for patients with ADD, it was typical to overestimate the elapsed time. When re-evaluating the condition of 56 children with ADHD-C after the end of the course of treatment with Pantogam, an improvement in the form of a reliable decrease in inattention and impulsivity, an improvement in working memory was recorded in 55.4% of cases. During a repeated study after the course of treatment, an improvement in time perception was also recorded.</p><p><strong>Conclusion: </strong>Children with ADHD, in addition to the main symptoms (inattention, hyperactivity, impulsivity), significantly more often have pronounced problems with time management, and the normalizing effect of drugs for the treatment of ADHD is manifested not only in relation to the main symptoms of the disease, but also in relation to the normalization of time perception.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 6","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Early diagnosis and effective therapy of diabetic polyneuropathy].","authors":"L T Akhmedzhanova, E V Mandra, E S Shulakova, O A Solokha","doi":"10.17116/jnevro202512505162","DOIUrl":"https://doi.org/10.17116/jnevro202512505162","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is one of the most urgent key problems of modern medicine with a steadily progressive increase in morbidity. Diabetic polyneuropathy (DPN) is a common complication of diabetes and leads to a decrease in the quality and life expectancy of patients, increases the risk of disability. The painful form of DPN has a particularly negative effect on the quality of life. The article discusses current views on the pathogenesis of DPN, risk factors, clinical manifestations and diagnostic methods of DPN. Most patients with DPN have vegetative disorders that are asymptomatic for a long time, however, the presence of which is associated with increased mortality. An integrated approach is important in the treatment of DPN, including both non-drug treatment methods (diet, lifestyle modification, exercise) and drug therapy aimed at correcting blood glucose levels and other risk factors, mechanisms of development and progression of DPN. The pathogenetic therapy of DPN includes the use of alpha-lipoic acid and benfotiamine, the effectiveness of which has been shown in clinical studies. As a universal antioxidant, alpha-lipoic acid is an absolutely safe drug with proven effectiveness in the treatment of pain DPN and can be recommended for use in clinical practice. Adjuvant analgesics are used as symptomatic therapy, namely drugs from the group of antiepileptic drugs (gabapentin, pregabalin) and antidepressants (duloxetine). Doctors' knowledge of the problem of diagnosis and treatment of DPN will make it possible to detect this disease at an early stage and effectively control the progression of symptoms.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multimodal action of the drug Dimephosphon for the normalization of autonomic homeostasis].","authors":"T V Danilova, A G Iksanova, D R Khasanova","doi":"10.17116/jnevro202512505134","DOIUrl":"https://doi.org/10.17116/jnevro202512505134","url":null,"abstract":"<p><p>This review article presents the spectrum of pharmacological action and aspects of clinical application of the original domestic drug Dimephosphon (international nonproprietary name - dimethyl oxobutylphosphonyl dimethylate) based on a significant number of sources. The article reflects the results of experimental and clinical studies on the efficacy and safety of Dimephosphon, indicating its multimodal action and the possibility of using the drug as a means for normalizing autonomic homeostasis.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5","pages":"34-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevalence and characteristics of risk factors for cerebrovascular disease in overweight].","authors":"I T Murkamilov, K A Aitbaev, V V Fomin, F A Yusupov, Z F Yusupova, T F Yusupova, Zh I Solizhonov, Y R Boymurodov","doi":"10.17116/jnevro2025125051118","DOIUrl":"https://doi.org/10.17116/jnevro2025125051118","url":null,"abstract":"<p><strong>Aim: </strong>To study the frequency of modifiable risk factors for cerebrovascular disease (CVD) in overweight (OW) males and females.</p><p><strong>Materials and methods: </strong>The medical records of 522 overweight somatic patients were reviewed. The mean age was 54 years (18-86 years). The frequency of modifiable risk factors and CVD progression were assessed. Patients were divided into two groups: overweight males (<i>n</i>=258) and females (<i>n</i>=264).</p><p><strong>Results: </strong>Hypertension (36.2%), coronary heart disease (17.2%), and chronic obstructive pulmonary disease (16.4%) were most commonly diagnosed in overweight patients. In males, creatinine [87.0 (74.2; 109.0) µmol/L vs. 69.2 (60.0; 83.4) µmol/L, <i>p<</i>0.05], hemoglobin levels (146.1±25.8 g/L vs. 130.6±19.6 g/L, <i>p<</i>0.05), and red blood cell counts (5.01±0.89·10¹²/L vs. 4.63±0.67·10¹²/L, <i>p<</i>0.05) were significantly higher than in females. Females had higher platelet counts (301.2±106.1·10⁹L vs 270.8±86.2·10⁹L, <i>p<</i>0.05) and high-density lipoprotein cholesterol (1.22±0.25 mmol/L vs 1.08±0.32 mmol/L, <i>p<</i>0.05). In all overweight patients, the most common risk factors were tachycardia (>80 bpm at rest, 41.5%), hypertension (31.2%), hypercholesterolemia (28.9%), and dyslipidemia (26.8%). The prevalence of anemia, hyperglycemia, and hypertriglyceridemia was 13.2%, 14.5%, and 16.2%, respectively. F. Hoek's equations with cystatin C revealed more patients with impaired renal excretory function. Body mass index (BMI) correlated with diastolic blood pressure and triglyceride levels in males. In females, BMI was associated with systolic, mean, and pulse blood pressure, glucose and total cholesterol levels, and proteinuria.</p><p><strong>Conclusion: </strong>In overweight males and females, high blood pressure, impaired lipid-carbohydrate metabolism, reduced renal excretory function, and proteinuria were common modifiable risk factors for CVD. In females, BMI is strongly associated with hypertension, hyperglycemia, hypercholesterolemia, and proteinuria.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5","pages":"118-124"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[FA2H gene-associated spastic paraplegia (SPG35) - familial case with late onset].","authors":"G E Rudenskaya, F M Bostanova, V V Zabnenkova, A F Nikolaeva, V V Musatova, O P Ryzhkova","doi":"10.17116/jnevro2025125051137","DOIUrl":"10.17116/jnevro2025125051137","url":null,"abstract":"<p><p>Autosomal recessive spastic paraplegia type 35 (SPG35), associated with the <i>FA2H</i> gene, is characterized by onset in childhood (usually at 3-5 years) and a «complicated» phenotype: signs associated with spastic paraparesis and MRI changes. We describe a very rare case of late-onset SPG35 with differences in sisters aged 47 and 45 in a non-inbred Russian family. Spastic paraparesis in the older sister manifested at the age of 40 and in the younger sister-at the age of 25; cognitive-personal disorders manifested at the age of 42 and 40, respectively, and rapidly progressed; both developed dysarthria. MRI in both sisters showed periventricular leukopathy (more pronounced in the older one), atrophic changes in the cortex and cerebellum (more pronounced in the younger one) and hypointensity in the area of pale globes, and thinning of the corpus callosum (only in the younger sister). Whole genome sequencing (WGS) followed by family Sanger sequencing for the sisters showed the previously described missense variants c.232G>A, p.Glu78Lys and c.137G>A, p.Gly46Asp in the <i>FA2H</i> gene in a compound-heterozygous state; the mother had a heterozygous variant of p.Glu78Lys (the father died, there are no other siblings). This article is a literature review on the late-onset SPG35.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 5","pages":"137-144"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The study of the behavioral reactions and duration of ultrasonic vocalization in rats from females stressed during pregnancy].","authors":"E A Muzyko, A S Lukina, D A Karelina, A S Tarasov, V N Perfilova, E M Frolov, M Yu Frolov","doi":"10.17116/jnevro2025125031117","DOIUrl":"https://doi.org/10.17116/jnevro2025125031117","url":null,"abstract":"<p><strong>Objective: </strong>To study the psycho-emotional state and its relationship to the duration of ultrasonic vocalization in the offspring of rats with physiological and stress-complicated pregnancy.</p><p><strong>Material and methods: </strong>The experiments were performed on the offspring (<i>n</i>=120) of rats with physiological pregnancy and the offspring of animals stressed during the entire gestation period (21-23 days). Study animals were divided into the following groups: 1 - intact - males and females (<i>n</i>=52) born to healthy rats; 2 - stress - males and females (<i>n</i>=68) born to rats that underwent stress during pregnancy.</p><p><p>At the age of 17 days, the total vocalization duration (at 50 kHz) was recorded in rats. To assess the psycho-emotional state of the offspring, the open field and elevated plus maze tests were performed at 22 days, marble burying at 35 days, and Porsolt forced swimming test at 47 days. To assess cognitive function in the offspring, short-term working memory was examined in the recognition of a new object test at 35 days and long-term memory in the conditioned passive avoidance reflex test at the age of 47 days.</p><p><strong>Results: </strong>The results of the open field and elevated plus maze tests indicated that the offspring of females stressed during pregnancy showed anxious behavior. In addition, animals from stressed rats exhibited compulsive and depressive behaviors in the marble burying and Porsolt forced swimming tests. The offspring of stressed rats showed impaired reproduction of the memory traces in the conditioned passive avoidance reflex test.</p><p><strong>Conclusion: </strong>In the offspring of females stressed during pregnancy, anxious, compulsive, and depressive behavior is observed, accompanied by an increase in the duration of ultrasonic vocalization at 50 kHz.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"117-123"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bone mineral density assessment of women on long-term antiepileptic therapy].","authors":"D Yu Yusupova, F Kh Muratov","doi":"10.17116/jnevro2025125031112","DOIUrl":"https://doi.org/10.17116/jnevro2025125031112","url":null,"abstract":"<p><strong>Objective: </strong>To study the effect of anticonvulsants on bone mineral density in patients with epilepsy.</p><p><strong>Material and methods: </strong>The study included 90 women with epilepsy and a control group of 60 healthy women. The subjects' serum levels of parathyroid hormone, alkaline phosphatase, calcium, phosphorus, and vitamin D were measured. Mineral density and bone structure were assessed using dual-energy X-ray absorptiometry (DEXA).</p><p><strong>Results: </strong>In women with epilepsy, the serum levels of calcium, phosphorus, and vitamin D were significantly lower compared to the control group, and the levels of parathyroid hormone and alkaline phosphatase were significantly higher. There was also a statistically significant difference in the DEXA values between study groups. In women with epilepsy who received enzyme-inducing antiepileptic drugs, calcium, phosphorus, and vitamin D levels were significantly lower compared to patients who received enzyme-inhibiting antiepileptic drugs. Bone mineral density was positively correlated with serum micronutrients (calcium, phosphorus, vitamin D) and negatively with serum alkaline phosphatase and duration of therapy.</p><p><strong>Conclusion: </strong>Bone tissue disorders are common in patients with epilepsy. These disorders may be associated with prolonged use of antiepileptic drugs, especially enzyme inducers.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"112-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cognitive functions assessment of elderly patients with type 2 diabetes mellitus].","authors":"A A Akhmedova, F O Ushanova, T Yu Demidova","doi":"10.17116/jnevro202512503146","DOIUrl":"https://doi.org/10.17116/jnevro202512503146","url":null,"abstract":"<p><strong>Objective: </strong>Comparative assessment of the cognitive status of persons over 60, depending on the presence or absence of type 2 diabetes mellitus (T2DM).</p><p><strong>Material and methods: </strong>The study included 193 patients, of which 93 had no T2DM and 100 had T2DM. The mean age of patients with T2DM was 73 [68; 78] years vs. 69.2 [64; 75] years in patients without T2DM. The cognitive function was assessed using the McNair and Kahn scale, with scores over 42 indicating cognitive dysfunction and Kahn scale: in the group with T2DM, the average score was 27.0±9.36; in the group without T2DM, it was 22.0±9.60 (<i>p<</i>0.043). The absence of T2DM was negatively correlated with the total score on the scale for assessing the risk of cognitive impairment (<i>p</i>=-0.264, <i>p<</i>0.001). In addition, it was found that age over 75 years was significantly associated with the development of cognitive impairment, regardless of the presence of concomitant T2DM (OR=1.247, CI=95%, 1.112-1.40, <i>p<</i>0.001).</p><p><strong>Conclusion: </strong>T2DM increases the risk of developing cognitive dysfunction, which should be taken into account in older patients for the timely detection and prevention of its progression.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Schizophrenic spectrum disorders and Parkinson's disease].","authors":"M R Khommyatov, I G Smolentseva, S A Golubev, A V Goryunov, M A Samushiya","doi":"10.17116/jnevro2025125031136","DOIUrl":"https://doi.org/10.17116/jnevro2025125031136","url":null,"abstract":"<p><p>The case demonstrated the difficulties of differential diagnosis and selection of therapy in patients with Parkinson's disease and schizophrenic spectrum disorders. A clinical case of a 45-year-old male with a 10-year history of paranoid schizophrenia, with hallucinatory paranoid attacks and a steady increase in negative symptoms in the form of apato-abulic defect, is presented. The use of antipsychotics was associated with neuroleptic parkinsonism, well responding to therapy, and reduced when the patient discontinued antipsychotic therapy. However, after 10 years of schizophrenia, Parkinson's syndrome manifested without neuroleptics; the antipsychotic therapy led to a sharp deterioration in motor status. A neurologist specializing in extrapyramidal disorders made the following diagnosis: Parkinson's disease, mixed form, Hoehn and Yahr stage 2. According to the neurologist's recommendation, typical neuroleptics were replaced with quetiapine, and levodopa was added to therapy. During treatment, the parkinsonism symptoms significantly decreased without an increase in psychotic symptoms. The clinical case illustrates the challenges in diagnosing Parkinson's disease in a patient with schizophrenia and the complexity of treating such comorbidities. When managing such patients, close collaboration between psychiatrists and neurologists is necessary to make an accurate diagnosis and select the optimal therapy. The introduction of the multidisciplinarity principle will make it possible to achieve the fastest diagnosis and selection of balanced therapy in this category of patients.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 3","pages":"136-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cognitive vascular disorders and morphometric parameters of the prefrontal, dorsolateral cortex and thalamus in post-stroke patients].","authors":"G A Bulyakova, L R Akhmadeeva, I A Lackman, D E Baikov, M O Isrofilov, E M Mamytova, E O Goldyrev, E F Oko, A S Rakhimkulov, A S Kochezhev","doi":"10.17116/jnevro202512502191","DOIUrl":"10.17116/jnevro202512502191","url":null,"abstract":"<p><strong>Objective: </strong>To assess the relationship between the size of the prefrontal, dorsolateral cortex and the thalamus according to brain CT scans and cognitive functions in patients in the early recovery period of cerebral ischemic stroke.</p><p><strong>Material and methods: </strong>One hundred two patients (67.6% males) in the early recovery period of ischemic stroke were examined using a short scale of mental status and the Montreal scale of cognitive function and morphometry of the dorsolateral cortex and thalamus according to brain CT scans performed in the acute period of ischemic stroke. The mean age was 63 years [59; 69.75].</p><p><strong>Results: </strong>Obtained data indicate a statistically significant direct association between the thickness of the dorsolateral cortex bilaterally and cognitive preservation. The thalamus size was not associated with cognitive functioning assessed in the early recovery period of ischemic stroke.</p><p><strong>Conclusion: </strong>The thalamus sizes of the studied patients were not directly related to cognitive functions, and the thickness of the prefrontal, dorsolateral cortex on both sides was in direct correlation with mental health indicators.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"125 2","pages":"91-95"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}