Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献

{"title":"[A comparative assessment of microbiocenosis of saliva and oropharynx in patients with migraine].","authors":"I L Naydenova, A B Danilov, A V Simonova, A A Pilipovich, E G Filatova","doi":"10.17116/jnevro202412404155","DOIUrl":"https://doi.org/10.17116/jnevro202412404155","url":null,"abstract":"<p><strong>Objective: </strong>To identify changes in the microbiome of saliva and to compare it with the microbiome of the oropharynx of patients with migraine.</p><p><strong>Material and methods: </strong>Sixty patients with migraine (21-56 years old), were examined using a headache diary, MIDAS and VAS. A microbiological examination of saliva and smear from the mucosa of the posterior wall of the oropharynx with evaluation by the method of mass spectrometry of microbial markers (MSMM) with the determination of 57 microorganisms was performed. All patients had comorbid chronic diseases of the gastrointestinal tract and upper respiratory tract (URT), according to anamnestic data and examination by specialists.</p><p><strong>Results: </strong>A significant increase in the content of markers of resident (conditionally pathogenic) microorganisms characteristic of chronic diseases of URT (strepto- and staphylococci); markers of transient microorganisms characteristic of intestinal microflora (clostridia, gram-negative rods, anaerobes) that are normally absent; viral markers of cytomegaloviruses and herpes groups; a decrease in the content of fungi were identified in saliva. A comparative analysis of the microbiome of saliva and oropharynx showed: 1) a significant decrease in the concentration of coccal flora <i>Enterococcus</i> spp., <i>Streptococcus mutans</i>, <i>Staphylococcus aureus</i>, anaerobic bacteria <i>Clostridium difficile</i> and <i>Clostridium perfringens</i> in saliva; enterobacteria <i>Helicobacter pylori</i>; gram-negative rods <i>Kingella</i> spp., fungi and Epstein-Barr virus; 2) an increase in salivary concentrations of <i>Staphylococcus epidermidis</i>, anaerobic <i>Clostridium ramosum</i> and <i>Fusobacterium</i> spp./<i>Haemophilus</i> spp. and gram-negative bacilli <i>Porphyromonas</i> spp.</p><p><strong>Conclusion: </strong>A comparative assessment of the microbiota of a smear from the posterior wall of the oropharynx and saliva using MMSM showed the presence of dysbiosis both in the oropharynx and in the saliva of patients with migraine. However, there were fewer deviations from the norm in saliva, therefore, for diagnostic purposes, a smear from the posterior wall of the oropharynx is more significant as a biomarker for patients with migraine.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 4","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cerebral hemodynamic disorders in patients with schizophrenia with concomitant metabolic syndrome].","authors":"S A Galkin, E G Kornetova, T A Oshkina, I A Mednova, N A Bokhan","doi":"10.17116/jnevro202412404180","DOIUrl":"https://doi.org/10.17116/jnevro202412404180","url":null,"abstract":"<p><strong>Objective: </strong>To identify the differences or comparability of parameters of cerebral hemodynamics between patients with schizophrenia with or without concomitant metabolic syndrome (MS).</p><p><strong>Material and methods: </strong>The study included 94 patients with schizophrenia (48 men and 46 women). A control group consisted of 40 mentally and somatically healthy individuals (17 men and 23 women) comparable in sex and age to the main group of patients. The diagnosis of metabolic syndrome was carried out according to the criteria of the International Diabetes Federation (IDF). Assessment of cerebral hemodynamics was carried out by 4 - channel rheoencephalography (REG) at rest with closed eyes. Data analysis was carried out using the Kraskel-Wallis ANOVA criterion with the procedure of automatic a posteriori pairwise comparison, the χ² criterion and Spearman correlation analysis.</p><p><strong>Results: </strong>According to the IDF criteria, 37 (39.4%) patients were diagnosed with MS. REG results revealed significantly (<i>p</i><0.05) lower indicators of blood filling in the carotid basin, elasticity of the wall of the main arteries, the tone of small-caliber arteries and arterioles, as well as higher values of the tone of medium-caliber arteries in the carotid and vertebrobasilar basins, in both groups of patients with schizophrenia compared with the control group. In patients with schizophrenia with MS, compared with patients without MS, there were lower indicators of blood filling (<i>p</i>=0.044 and <i>p</i>=0.016) and elasticity of the wall of the main arteries (<i>p</i>=0.044 and <i>p</i>=0.028) in the carotid basin on the left and right sides.</p><p><strong>Conclusion: </strong>The presence of MS in patients with schizophrenia was accompanied by more pronounced disorders of cerebral blood flow in the form of a decrease in blood filling and elasticity of the wall of the main arteries in the carotid basin. The results indicate that patients with schizophrenia with MS should be considered as a group at increased risk of cerebrovascular diseases.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 4","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Associations of serum neuromarkers with clinical features of Parkinson's disease].","authors":"M A Nikitina, E S Koroleva, N G Brazovskaya, A S Boyko, L A Levchuk, S A Ivanova, V M Alifirova","doi":"10.17116/jnevro2024124041145","DOIUrl":"https://doi.org/10.17116/jnevro2024124041145","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical and laboratory correlation of biomarkers with anti- and pro-apoptotic activity with the severity of motor and non-motor symptoms depending on the progression rate of Parkinson's disease (PD).</p><p><strong>Material and methods: </strong>A wide range of non-motor symptoms (emotional-affective, cognitive, psychotic and behavioral disorders, fatigue, sleep disorders and autonomic disorders) was evaluated using validated scales and a number of serum neuromarkers responsible for neuroplasticity and neuronal survival processes (BDNF, PDGF, cathepsin D) in 71 patients with PD (mean age 65 (55; 70) years, disease duration 7 (4; 9) years, age of onset 57 (49; 62) years).</p><p><strong>Results: </strong>The concentration of biomarkers (BDNF, PDGF and cathepsin D) was the lowest in the group of patients with a rapid PD progression rate (<i>p</i><0.001, <i>p</i>=0.001 and <i>p</i>=0.031, respectively), the severity of motor and most non-motor symptoms was higher (<i>p</i>=0.023 and <i>p</i>=0.001, respectively) compared to middle and slow progression rate. There were correlations between BDNF concentration and the severity of depression (<i>r</i>=-0.63, <i>p</i><0.001), apathy (<i>r</i>=-0.48, <i>p</i><0.001), impulsive behavioral disorders (<i>r</i>=0.500, <i>p</i><0.001), level of cognitive functions (<i>r</i>=0.54, <i>p</i><0.001), motor symptoms (<i>r</i>=-0.43, <i>p</i><0.001); between PDGF level and the severity of motor manifestations of PD (<i>r</i>=-0.30, <i>p</i>=0.011), depression (<i>r</i>=-0.70, <i>p</i><0.001), apathy (<i>r</i>=-0.460, <i>p</i><0.001), the degree of severity of behavioral disorders (<i>r</i>=0.742, <i>p</i><0.001). No significant correlations were observed between the level of cathepsin D and the severity of clinical manifestations of PD, which indicates the connection of cathepsin D with the general pathogenesis of PD.</p><p><strong>Conclusion: </strong>The possibility of using serum proteins of the neurotrophin subfamily and the protein associated with autophagy, cathepsin D, as biomarkers that determine the prognosis of PD, is considered.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 4","pages":"145-152"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Nocturia in Parkinson's disease].","authors":"A A Pilipovich, O V Vorob'eva, S A Makarov","doi":"10.17116/jnevro202412404148","DOIUrl":"https://doi.org/10.17116/jnevro202412404148","url":null,"abstract":"<p><strong>Objective: </strong>Evaluation of nocturia and its relationship with clinical characteristics of Parkinson's disease (PD) and dopaminergic therapy.</p><p><strong>Material and methods: </strong>One hundred and thirteen patients with PD of I-III Hoehn and Yahr stage (H&Y) were examined using the following scales: IPSS, including nocturia domain, UPDRS, Sch&En, PDQ-39, MMSE, FAB<b>,</b> BDI, STAI-S and STAI-T, PFS-16, NMSQuest, GDSS, GSRS, and orthotest.</p><p><strong>Results: </strong>Nocturia was detected in 93 patients. It depended on the age of the patients (rS=0.345; <i>p</i><0.001) and was more spread among women (<i>p</i>=0.002). We obtained positive correlations of nocturia (<i>p</i><0.05) with: PDQ-39 (rS=0.296), H&Y (rS=0.223), UPDRS (rS=0.265) and its items (speech, walking disorders, standing up from chair, posture and postural stability), NMSQ (rS=0.318), FAB (rS= -0.359), BDI, STAI-S and STAI-T, PFS-16, gastrointestinal parameters and blood pressure in the supine position. No significant effect of dopaminergic therapy on the severity of nocturia was found. According to regression analysis (stepwise method), predictors of nocturia are depression, higher lying blood pressure, constipation and postural instability (R2=0.474).</p><p><strong>Conclusions: </strong>Nocturia is the most common urological symptom in patients with PD and it significantly reduces the quality of life starting from the early stages of the disease. Nocturia increases as PD progresses, it is independent of dopaminergic medications, and it is directly associated with a number of parkinsonian symptoms (postural, frontal cognitive, affective and autonomic), which are partly dopamine-resistant. This indicates the common pathogenesis of nocturia and other symptoms of PD and the significant influence of polytransmitter imbalance.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 4","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The technology of induction of physiological ketosis in asthenia of various origins and decreased resistance to cognitive and physical activity].","authors":"M A Morozova, A G Beniashvili, G P Kostyuk, R A Cheremin, D S Burminsky, T A Lepilkina, S S Potanin, G E Rupchev, A A Alekseev, V A Kulyutkin, I V Ulyanov, L I Zotova","doi":"10.17116/jnevro202412410148","DOIUrl":"https://doi.org/10.17116/jnevro202412410148","url":null,"abstract":"<p><strong>Objective: </strong>To assess the possibility of achieving physiological ketosis with oral administration of beta-hydroxybutyrate salts and, if ketosis is achieved, to assess its effect on cognitive functioning in patients with brain dysfunction during the recovery period after a somatic disease.</p><p><strong>Material and methods: </strong>The study included 86 patients with complaints of asthenic manifestations (ICD-10 diagnoses F06; F07; R53). Half of the patients were included in the study group taking beta-hydroxybutyrate salts, and the other half were included in the control group taking placebo. The duration of administration was 15 days. The content of ketones in the blood was assessed immediately before and after taking the drug on the first and last days of the study. Subjective severity of asthenia manifestations was assessed using a visual-analog scale (VAS). The Montreal Cognitive Assessment and the Trial Making Test (TMT) were used to assess cognitive functions.</p><p><strong>Results: </strong>The control and study groups did not differ significantly in subjective and objective indicators of mental performance before taking the drug. At the end of the study, the blood ketone content in the experimental group was statistically significantly higher than in the control group. Physiological ketosis was achieved in 29 patients of the experimental group (67%). By the end of the study, the experimental group showed a significant improvement in all cognitive tests. At the same time, by the end of the study, only an improvement in TMT-A performance was noted in the control group. Also, in the experimental group, statistically significantly more patients achieved a significant improvement in mental performance on VAS tasks.</p><p><strong>Conclusion: </strong>The results confirm the hypothesis that oral administration of beta-hydroxybutyrate can stimulate physiological ketosis. A significant positive dynamics of cognitive functioning of patients and a decrease in the severity of asthenia during beta-hydroxybutyrate intake are noted.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 10","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Psychoemotional state and sexual function in women with chronic pelvic pain in genital endometriosis].","authors":"A I Fedorova, E V Zhigalova","doi":"10.17116/jnevro20241241015","DOIUrl":"https://doi.org/10.17116/jnevro20241241015","url":null,"abstract":"<p><p>The <b>purpose</b> of this review is to consider current ideas about psychophysiology of chronic pelvic pain (CPP) in external genital endometriosis (GE), as well as the impact of the psychoemotional state and sexual function in women with CPP on its development and maintenance. The review is based on the study of original Russian and English-language articles and our own extensive clinical experience. References are made to statistically reliable, randomized and placebo-controlled studies of the last 20 years, in some cases to small and open-ended studies indicating their low evidence. The analysis shows a variety of opinions on this issue united by an understanding of the promising role of a biopsychosocial approach to the diagnosis and treatment of CPP in GE. Further studies of the role of psychosocial factors in the development of CPP are needed, as well as an assessment of the effectiveness of a comprehensive multidisciplinary approach to the treatment of CPP and associated sexual dysfunctions.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 10","pages":"5-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Molecular genetic causes of epilepsy in children].","authors":"K R Yanin, O I Gumeniuk, A G Korotkov, T A Yanina","doi":"10.17116/jnevro202412411260","DOIUrl":"https://doi.org/10.17116/jnevro202412411260","url":null,"abstract":"<p><p>The molecular genetic approach to the study of epilepsy in childhood allows us to come closer to understanding the role of heredity in the development of epilepsy, as well as provide a personalized approach to the treatment and rehabilitation of severe, often resistant forms of epilepsy. In this article we demonstrate the genetic factors that cause the development of epilepsy in children. The review is devoted to the most common mechanisms of development of genetic epilepsies.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 11. Vyp. 2","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The multidirectional effects of thrombin and the possibility of their control in neurology].","authors":"M D Tran, A N Yasamanova, G G Avakian, A A Nikonova, P R Kamchatnov","doi":"10.17116/jnevro202412403242","DOIUrl":"10.17116/jnevro202412403242","url":null,"abstract":"<p><p>The review presents the main physiological functions of thrombin. The procoagulant and anticoagulant activities of the key serine protease are discussed in both physiological and pathological conditions of hemostasis. The involvement of thrombin in atherogenesis, as well as its role as a mediator of vascular dysfunction and inflammation in both the peripheral and central nervous system, is highlighted. A pronounced imbalance between the pro- and anticoagulant systems leads to an increase in thrombin formation and creates conditions for the development of thrombosis. Tests that allow direct or indirect assessment of thrombin's functional activity are presented. The potential applications of direct thrombin inhibitors and direct blockers of thrombin PAR receptors in vascular neurology are also considered.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 3. Vyp. 2","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Neuroimaging predictors of hemorrhagic transformation of ischemic stroke].","authors":"L T Khasanova, E A Koltsova, M K Zashezova, D K Okhtova, O V Gavrilova, D I Zhitkevich, V K Egorov","doi":"10.17116/jnevro202412412234","DOIUrl":"https://doi.org/10.17116/jnevro202412412234","url":null,"abstract":"<p><p>Hemorrhagic transformation (HT) is a serious complication that worsens outcomes and increases mortality in patients with ischemic stroke (IS). HT can occur both spontaneously and after reperfusion therapy. Severe ischemic injury in IS is not sufficient in itself to cause HT; one of the key elements in its development is reperfusion. Delayed reperfusion in the area of severe ischemic injury mainly increases the likelihood of HT due to disruptions in the blood-brain barrier (BBB), which, in turn, play a key role in the formation of HT in the acute period of IS. Currently, perfusion CT and MRI are the most widely used imaging methods for assessing the patient's condition and predicting clinical outcome. To assess the degree of ischemic injury, there are various neuroimaging indicators that reflect the level of ischemic damage in IS and can be used as predictors of HT. To date, the most reliable tools for assessing the risk of HT include very low cerebral blood volume (VLCBV), time to reach maximum concentration of contrast agent (Tmax), permeability surface-area product (PS), lesion volume in diffusion-weighted images (DWI), and poor collateral circulation.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 12. Vyp. 2","pages":"34-38"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical and genetic associations in patients with non-cardioembolic ischemic stroke].","authors":"S S Galkin, A V Anisimova, A S Gunchenko, T V Nasedkina, M M Makhmudov, I V Kolerova, E V Yutskova","doi":"10.17116/jnevro202412412212","DOIUrl":"https://doi.org/10.17116/jnevro202412412212","url":null,"abstract":"<p><strong>Objective: </strong>To study the associations of genetic markers influencing the residual reactivity of platelets during antiplatelet therapy with acetylsalicylic acid, and clinical and laboratory parameters, including parameters of the platelet hemostasis, in patients with non-cardioembolic ischemic stroke (IS) for a deeper understanding of the pathogenetic mechanisms and prediction of response to therapy and clinical outcome.</p><p><strong>Material and methods: </strong>The study included 296 patients (average age 64.65 [55; 76] years) undergoing treatment at the City Clinical Hospital named after. N.I. Pirogov: 98 patients with atherothrombotic IS and 196 with an unspecified pathogenetic variant of IS according to TOAST criteria. The US National Institutes of Health Stroke Severity Scale (NIHSS) was used. NIHSS scores at discharge (3 [2;7]) were significantly lower than scores at admission - 9 [6;14] (<i>p</i><0.0005). Associations of <i>ITGB3, GPIba, TBXA2R, ITGA2, PLA2G7, HMOX1, PTGS1, PTGS2, ADRA2A, ABCB1, PEAR1</i> polymorphisms and the intergenic region 9p21.3 with clinical and laboratory parameters were studied.</p><p><strong>Results: </strong>In the group with atherothrombotic variant of IS, <i>ITGA2</i> rs1126643 and <i>HMOX1</i> rs2071746 polymorphisms were associated with the degree of carotid artery stenosis, and <i>TBXA2R</i> rs4523 and <i>PTGS2</i> rs689466 polymorphisms were associated with triglyceride levels. Associations between <i>ITGA2</i> rs1062535 polymorphism and adenosine diphosphate (ADP)-induced platelet aggregation (PA), <i>PLA2G7</i> rs1051931 polymorphism and collagen-induced PA as well as <i>PEAR1</i> rs12041331 polymorphism and ristomycin-induced PA were identified. In patients with unspecified IS, <i>ITGB3</i> rs5918 polymorphism was associated with adrenaline-induced PA; <i>TBXA2R</i> rs4523 with ADP-induced PA; <i>ADRA2A</i> rs4311994 was associated with arachidonic acid-induced PA; <i>ITGA2</i> rs1062535 with ristomycin-induced PA and spontaneous aggregation (SA). Also, the SA level was affected by polymorphisms <i>PLA2G7</i> rs1051931, 9p21.3 rs10120688, <i>ABCB1</i> rs1045642 and <i>ITGA2</i> rs1062535 was associated with the dynamics of NIHSS.</p><p><strong>Conclusion: </strong>The results can be used to develop personalized approaches to secondary prevention of IS, including the selection of individual antiplatelet therapy.</p>","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 12. Vyp. 2","pages":"12-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}