[The relationship between the rs6265 polymorphism of the BDNF gene and the level of serum neurotrophic factor in patients with Parkinson's disease].

Q3 Medicine

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI:10.17116/jnevro2024124011114

M A Nikitina, E Yu Bragina, M S Nazarenko, L A Levchuk, S A Ivanova, A S Boiko, D E Gomboeva, E S Koroleva, V M Alifirova

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引用次数: 0

Abstract

Objective: To evaluate the clinical features and the level of serum brain-derived neurotrophic factor (BDNF) in groups of patients with Parkinson's disease (PD) differentiated by the genotypes of BDNF polymorphism (rs6265).

Material and methods: The level of serum BDNF in the biomarkers' multiplex panel of neurodegenerative diseases (HNDG3MAG-36K) was assessed in 134 PD patients. Allele discrimination was carried out by real-time PCR using TaqMan probes for the analysis of BDNF rs6265 polymorphism in groups of patients and controls (n=192) matched for sex, age and ethnicity.

Results: Comparing the distribution of rs6265 genotypes and alleles between groups of patients and controls no significant differences were found (p>0.05). Serum BDNF levels varied significantly by genotype (rs6265) among PD patients. Minimum mean serum BDNF level (320.1±164.6 pg/ml) was noted for individuals with the AA genotype, which significantly differs from the corresponding indicator among individuals with GA (2944.2±1590.6 pg/ml; p=0.0001) and GG genotypes (2949.4±1620.6 pg/ml; p=3.9×10^-5). The concentration of BDNF significantly differed between patients with different forms of PD (p=0.0007) and increased as the stage of the disease progressed according to Hoehn and Yahr staging scale (p=1.0×10^-6).

Conclusion: The BDNF rs6265 polymorphism was not associated with the development of PD in the studied population. The variability of the mean serum BDNF level was established depending on the genotype of the BDNF polymorphism in PD patients and a number of clinical features.

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[帕金森病患者 BDNF 基因 rs6265 多态性与血清神经营养因子水平的关系]。

目的评估根据 BDNF 多态性（rs6265）基因型区分的帕金森病（PD）患者群体的临床特征和血清脑源性神经营养因子（BDNF）水平：对134名帕金森病患者的血清BDNF水平进行了评估。在性别、年龄和种族匹配的患者组和对照组（n=192）中，使用 TaqMan 探针通过实时 PCR 对 BDNF rs6265 多态性进行了等位基因鉴别分析：比较患者组和对照组的 rs6265 基因型和等位基因的分布，未发现明显差异（P>0.05）。在帕金森病患者中，血清 BDNF 水平因基因型（rs6265）的不同而有显著差异。AA基因型个体的血清BDNF平均水平最低（320.1±164.6 pg/ml），与GA基因型（2944.2±1590.6 pg/ml；p=0.0001）和GG基因型（2949.4±1620.6 pg/ml；p=3.9×10-5）个体的相应指标明显不同。不同形式的帕金森病患者的BDNF浓度存在显著差异（p=0.0007），根据Hoehn和Yahr分期量表，随着病情的发展，BDNF浓度也会增加（p=1.0×10-6）：结论：在研究人群中，BDNF rs6265多态性与帕金森病的发病无关。根据帕金森病患者的BDNF多态性基因型和一些临床特征，确定了血清BDNF平均水平的变异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova 医学-精神病学

CiteScore

1.10

自引率

0.00%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.