Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova最新文献_第5页

[Fluvoxamine in the treatment of anxiety-depressive spectrum disorders]. [氟伏沙明治疗焦虑抑郁谱系障碍]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro2024124061101

V E Medvedev, R A Kardashian, V I Frolova

引用次数: 0

[Experience in the use of cladribine for the treatment of patients with highly active forms of multiple sclerosis in the Moscow region]. [莫斯科地区使用克拉利宾治疗高度活跃型多发性硬化症患者的经验]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412406174

T I Yakushina, D M Yakushin, V Yu Lizhdvoy, Yu A Belova

{"title":"[Experience in the use of cladribine for the treatment of patients with highly active forms of multiple sclerosis in the Moscow region].","authors":"T I Yakushina, D M Yakushin, V Yu Lizhdvoy, Yu A Belova","doi":"10.17116/jnevro202412406174","DOIUrl":"https://doi.org/10.17116/jnevro202412406174","url":null,"abstract":"Objective: To assess the efficacy and safety of cladribine in patients with highly active multiple sclerosis (MS) in the Moscow region.Material and methods: The analysis was based on data from 62 patients treated with cladribine between March 2021 and January 2024. The diagnosis of VAMS was confirmed in 51 patients, PPMS in 4 patients, and SPMS with exacerbations was diagnosed in 7 cases. Of these, 3 patients completely completed therapy more than a year ago, 20 people received 2 courses of the drug less than a year ago, 39 patients underwent 1 course of therapy. The effect of cladribine on reducing disease activity and progression, as well as the safety of therapy, was evaluated.Results: After 1 course, the number of patients with activity decreased by 66.4%, after 2 years of therapy - by 72.7%. The mean annual frequency of exacerbations decreased from 1.32 to 0.2 after 12 months, and to 0.086 exacerbations per year after 24 months. The level of disability assessed by the EDSS scale remained virtually unchanged throughout the follow-up. The most common adverse events were haematological abnormalities in the form of lymphopenia and leukopenia. Most patients had mild grade 1-2 lymphopenia on the toxicity scale and recovered to the recommended values (>0.8·109/l) by the beginning of the second course of therapy. No cases of serious adverse events were reported.Conclusions: The results obtained indicate the high efficacy and favorable safety profile of cladribine and are consistent with the data of clinical trials of the drug.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 6","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Management of patients with insomnia and polymorbidity. A draft of the clinical guidelines]. [失眠多症患者的管理。临床指南草案]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412405239

M G Poluektov, E S Akarachkova, E V Dovgan, O V Kotova, T Yu Demidova, A A Klimenko, V A Kokorin, O D Ostroumova, T M Ostroumova

{"title":"[Management of patients with insomnia and polymorbidity. A draft of the clinical guidelines].","authors":"M G Poluektov, E S Akarachkova, E V Dovgan, O V Kotova, T Yu Demidova, A A Klimenko, V A Kokorin, O D Ostroumova, T M Ostroumova","doi":"10.17116/jnevro202412405239","DOIUrl":"10.17116/jnevro202412405239","url":null,"abstract":"Insomnia is a serious and widespread public health problem, but is often undetected and patients do not receive needed treatment. Insomnia is often comorbid with other diseases and conditions, such as arterial hypertension, type 2 diabetes mellitus, pain syndromes, anxiety and depressive disorders, etc. A separate problem is drug-induced insomnia, when patients develop symptoms due to other diseases treatments. Insomnia has a negative effect on the prognosis of comorbid diseases, including an increased risk of death, more severe disease, and decreased quality of life. The presence of sleep disorders makes it difficult to effectively treat the underlying disease, so clinical guidelines draft for the evaluation and treatment of insomnia in multimorbid patients is proposed. Diagnostic methods are reviewed and recommendations are given for the treatment of acute and chronic insomnia and features of the treatment of insomnia in multimorbid patients. A clinical algorithm has been proposed to determine treatment tactics in multimorbid patients.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 5. Vyp. 2","pages":"39-52"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The clinical significance of insomnia in chronic headache]. [慢性头痛患者失眠的临床意义]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro2024124052105

E A Korabelnikova, V D Tkachenko

{"title":"[The clinical significance of insomnia in chronic headache].","authors":"E A Korabelnikova, V D Tkachenko","doi":"10.17116/jnevro2024124052105","DOIUrl":"https://doi.org/10.17116/jnevro2024124052105","url":null,"abstract":"Objective: To study the features of the manifestation of insomnia and its impact on the condition and quality of life in patients with chronic tension-type headache.Material and methods: The study included 65 patients with chronic tension-type headache and insomnia. Patients filled out questionnaires on headache severity, sleep quality, emotional status and quality of life. Seventeen patients underwent polysomnography.Results: Patients with more severe insomnia had significantly more severe anxiety (p<0.001) and depression (p=0.025). Such patients assessed their quality of life worse according to the SF-12 questionnaire (p<0.002) and the Subjective Well-Being Scale (p<0.001), a higher level of central sensitization was observed in patients with more severe insomnia (p<0.001).Conclusion: The negative impact of insomnia on the condition of patients is not so much an increase in pain as such, but rather its influence on the quality of the emotional state and life in general, as well as an increase in the interdependence and mutual influence of other clinical and psychophysiological manifestations of the disease. Therefore, the clinical significance of insomnia is the deterioration of a person's ability to tolerate pain, which is the main prerequisite for a decrease in quality of life.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 5. Vyp. 2","pages":"105-109"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The prospect of using virtual reality technology in combination with psychotherapeutic methods in children with functional abdominalgia]. [在功能性腹痛儿童中结合使用虚拟现实技术和心理治疗方法的前景]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412405140

N S Bofanova, A L Saruhanjan

{"title":"[The prospect of using virtual reality technology in combination with psychotherapeutic methods in children with functional abdominalgia].","authors":"N S Bofanova, A L Saruhanjan","doi":"10.17116/jnevro202412405140","DOIUrl":"10.17116/jnevro202412405140","url":null,"abstract":"Objective: The literature review addresses the effectiveness of psychotherapeutic methods in the treatment of functional abdominal pain syndrome and studying the prospects for using virtual reality technology in combination with psychotherapeutic methods according to the available literature.Material and methods: A search was conducted for available literature in the eLibrary and PubMed databases, published for the period 2017-2022, using the keywords: abdominalgia, psychotherapeutic methods, gut-brain axis, virtual reality technology.Results: Currently, the biopsychosocial concept of the etiopathogenesis of abdominal pain syndrome, which is not associated with an organic disease of the gastrointestinal tract, is used. A significant contribution to the formation of the disease is made by genetic, neuropsychological, neurophysiological factors, and disruption of the interaction of the gut-brain axis. Cognitive behavioral therapy, yoga, and hypnotherapy are applicable as effective psychotherapeutic methods in the complex treatment of abdominal pain syndrome in children. A promising direction is the use of virtual reality technology to increase the effectiveness of psychotherapeutic methods and reduce chronic abdominal pain syndrome by influencing the gut-brain axis. Practical research work devoted to this issue is currently rare.Conclusion: In the complex treatment of functional abdominal pain syndrome in children, various psychotherapeutic methods are used, the most effective are cognitive behavioral therapy and hypnotherapy. It is necessary to stimulate domestic research work studying the joint use of virtual reality technology and psychotherapeutic methods in children aged 7 to 18 years.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 5","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Trait and state anxiety, symptoms of insomnia and their influence on daytime functioning in adolescent girls]. [青春期少女的特质和状态焦虑、失眠症状及其对日间功能的影响]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412405266

I A Kelmanson

{"title":"[Trait and state anxiety, symptoms of insomnia and their influence on daytime functioning in adolescent girls].","authors":"I A Kelmanson","doi":"10.17116/jnevro202412405266","DOIUrl":"https://doi.org/10.17116/jnevro202412405266","url":null,"abstract":"Objective: To investigate the relationship between symptoms of trait anxiety, state anxiety and symptoms of insomnia and the degree of their influence on daytime functioning disorders in adolescent girls.Material and methods: The study included 50 healthy adolescent girls, senior school students, aged 15-17 years, selected as simple random sample. Insomnia symptoms and their impact on daytime functioning were assessed using the SLEEP-50 (S-50) questionnaire. Trait and state anxiety were assessed using the Spielberger questionnaire. The method of path analysis was used to identify significant associations.Results: There was a positive association of the severity of daytime functioning disorders with the severity of insomnia symptoms (β=0.45; p<0.001) and the level of trait anxiety (β=0.34; p=0.004). Trait anxiety was also a significant predictor of state anxiety (p<0.001), with a direct relationship between these parameters (β=0.62). Positive covariation of insomnia symptoms severity and state anxiety was found (β=0.53; p<0.001).Conclusion: Improving sleep quality and daytime functioning in adolescents with insomnia symptoms should take into account personality characteristics. High levels of trait anxiety increase the negative effects of insomnia on the impaired daytime functioning.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 5. Vyp. 2","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis]. [精神病临床高危患者的炎症标志物、疲劳和基于努力的决策之间的关系]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412410185

V V Plakunova, S A Zozulya, M V Alfimova, I N Otman, M A Omelchenko, V V Migalina, V G Kaleda

{"title":"[The relationship between inflammatory markers, fatigue, and effort-based decision-making in patients at clinical high risk for psychosis].","authors":"V V Plakunova, S A Zozulya, M V Alfimova, I N Otman, M A Omelchenko, V V Migalina, V G Kaleda","doi":"10.17116/jnevro202412410185","DOIUrl":"https://doi.org/10.17116/jnevro202412410185","url":null,"abstract":"Objective: To evaluate the associations between peripheral levels of inflammatory markers and willingness to exert effort in individuals at clinical high risk for psychosis (CHR-P) and a role of fatigue as a mediator of these associations.Material and methods: Forty-nine young men admitted for a depressive episode, who met the criteria for CHR-P, had pre-treatment blood tests to determine levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukins IL-6, IL-8 and IL-10. After treatment and normalization of their condition, they completed the EEfRT task of willingness to exert physical effort to receive monetary reward and filled out the Fatigue Assessment Scale (FAS-10). The association between EEfRT scores, fatigue and inflammatory markers was assessed using regression analysis, controlling for residual clinical symptoms.Results: Independent significant predictors of difficult task choices were the levels of CRP (b=-0.14; 95% CI: -0.30 - -0.07; p<0.001), IL-8 (b=-0.05; 95% CI: -0.09 - -0.002; p=0.043) and fatigue (b=0.07; 95% CI: 0.05 - 0.09; p<0.001). These indicators were not associated with the slope of the curve reflecting the dependence of the choice of difficult tasks on the probability and magnitude of reward.Conclusion: In CHR-P, an increase in the levels of CRP and IL-8 before treatment may have prognostic significance regarding the persistence of motivational deficits in the form of a decrease in the willingness to exert efforts after relief of depressive symptoms. Fatigue is not a mediator of the identified relationship.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 10","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Ototoxicity caused by anti-epileptic drugs]. 【抗癫痫药物所致耳毒性】。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412412114

S G Burd, A V Lebedeva, Yu V Rubleva, A P Efimenko, N V Pantina, A V Yurchenko, M A Bogomazova, I I Kovaleva, G A Alekseeva

引用次数: 0

[Natural history of spinal muscular atrophy type I]. [脊髓性肌萎缩I型的自然史]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro202412411134

D V Vlodavets, Yu N Linkova, A V Zinkina-Orikhan, M A Morozova, E A Fokina, A V Saulina, A N Nikiforova

{"title":"[Natural history of spinal muscular atrophy type I].","authors":"D V Vlodavets, Yu N Linkova, A V Zinkina-Orikhan, M A Morozova, E A Fokina, A V Saulina, A N Nikiforova","doi":"10.17116/jnevro202412411134","DOIUrl":"https://doi.org/10.17116/jnevro202412411134","url":null,"abstract":"Spinal muscular atrophy (SMA) is a group of genetically heterogeneous neuromuscular diseases characterized by the progressive loss of motor neurons in the anterior horns of the spinal cord. The prevalence of SMA is approximately 1 in 10.000 live births. The cause of SMA is a mutation in the SMN1 gene, which encodes a neuronal survival protein. The phenotype of the disease depends on the number of copies of the SMN2 gene, which encodes an unstable isoform of the same protein. Despite the emergence of new drugs that increase SMN protein levels, there remains a need to collect and systematize data on the natural history of the disease to evaluate the effectiveness of new therapeutic approaches. This review analyzed the results of 12 retrospective and prospective studies over the past 16 years, which examined the natural history of the disease in 646 children with SMA type I. The mean age of onset of symptoms was 2.1±0.7 months, with the first documented symptoms being muscle hypotonia, respiratory distress, and feeding difficulties. The mean age at death was 19.2±10.1 months, the median age at achievement of the composite endpoint (defined as death or the date of initiation of long-term respiratory support) was 7.7 months (95% CI 3.8; 13.9). For 310 children, the number of copies of the SMN2 gene was known, 81.5% of them had 2 copies, 3.7% had 1 copy, 14.5% had 3 copies, 0.3% had 4 copies. Age at death varied according to SMN2 gene copy number, children with three copies of the SMN2 gene lived on average significantly longer than children with two copies of SMN2 (22.7 months versus 6.6 months). Life expectancy was also positively influenced by the use of maintenance therapy, tracheostomy or gastrostomy.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 11","pages":"34-41"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Stroke: current state of the problem]. [笔划：问题的当前状态]。

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2024-01-01 DOI: 10.17116/jnevro20241241117

E I Gusev, M Yu Martynov

{"title":"[Stroke: current state of the problem].","authors":"E I Gusev, M Yu Martynov","doi":"10.17116/jnevro20241241117","DOIUrl":"https://doi.org/10.17116/jnevro20241241117","url":null,"abstract":"We review the current and emerging topics in ischemic stroke (IS) and intracerebral hemorrhage (ICH). We discuss the association of genetic predisposition and healthy lifestyle, ambient particulate air pollution, weather parameters, variations in the anatomy of cerebral blood vessels, psychological stress, depression, insonmia with the development of IS or ICH. Also, the role of oral anticoagulants (AC) as a new risk factor for ICH is presented. The issues of pathophysiology of IS and ICH are considered, in particular, the discrepancy between blood flow and metabolism and penumbra stability in IS and changes in perfusion and cerebral blood flow (CBF) in stroke, autoimmune mechanisms of brain damage. Widening of therapeutic window, introduction of new generation of thrombolytic medications, tele-thrombolysis and thrombolysis in mobile stroke units are discussed. In patients taking AC, the tactics of prescribing IIa and Xa factor blockers during telethrombolysis and thrombolysis are discussed. The issues of urgent correction of hemostasis in the development of ICH while taking AC, as well as the resumption of their use in the future, are considered. The issues of neuroprotection, including the combination of neuroprotection and telethrombolysis and thrombolysis, and the translation of experimental studies into clinical practice, as well as the implementation of immunomodulatory therapy are discussed.","PeriodicalId":56370,"journal":{"name":"Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova","volume":"124 11","pages":"7-18"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0